Page last updated: 2024-12-07

dt 5461

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

DT 5461: structure given in first source; DT-5461a is the monomeglumine salt [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	119592
MeSH ID	M0207437

Synonyms (7)

Synonym
dt 5461
3-[(2s,3r,4r,5s,6r)-4-[2-(dodecanoylamino)acetyl]oxy-6-[[(2r,3r,4r,5s,6r)-4-[2-(dodecanoylamino)acetyl]oxy-6-(hydroxymethyl)-5-phosphonooxy-3-(tetradecanoylamino)oxan-2-yl]oxymethyl]-5-hydroxy-3-(tetradecanoylamino)oxan-2-yl]oxypentanedioic acid
pentanedioic acid, 3-((2-deoxy-6-o-(2-deoxy-3-o-(((1-oxododecyl)amino)acetyl)-2-((1-oxotetradecyl)amino)-4-o-phosphono-beta-d-glucopyranosyl)-3-o-(((1-oxododecyl)amino)acetyl)-2-((1-oxotetradecyl)amino)-alpha-d-glucopyranosyl)oxy)-
123598-19-6
1,3-dicarboxyisopropyl-2-deoxy-6-o-(2-deoxy-3-o(n-dodecanoylglycyl)-4-o-phosphono-2-tetradecanoylamino-beta-d-glucopyranosyl)-3-o-(n-dodecanoylglycyl)-2-tetradecanoylamino-alpha-d-glucopyranoside
dt-5461
dt-5461a

Research Excerpts

Dosage Studied

Excerpt	Relevance	Reference
" Dose-response studies revealed that LPS-induced IL-1 and TNF-alpha production was apparently totally suppressed in a competitive manner by a 10-fold excess of DT-5461."	( Endotoxin antagonism by a synthetic lipid A analogue, DT-5461, with low endotoxicity in human peripheral blood monocytes. Azuma, I; Choon Yoo, Y; Fujihara, M; Hata, K; Sato, K; Sekiguchi, S; Suzuki, T; Takahashi, TA; Tono-Oka, S, 1995)	0.29

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	13 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.62

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.62 (24.57)
Research Supply Index	2.83 (2.92)
Research Growth Index	4.45 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.62)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	16 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	1.98	1	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
galactosamine 2-amino-2-deoxy-D-galactopyranose : The pyranose form of D-galactosamine.. D-galactosamine : The D-stereoisomer of galactosamine.	1.98	1	D-galactosamine; primary amino compound	toxin
picibanil Picibanil: A lyophilized preparation of a low-virulence strain (SU) of Streptococcus pyogenes (S. hemolyticus), inactivated by heating with penicillin G. It has been proposed as a noncytotoxic antineoplastic agent because of its immune system-stimulating activity.	1.98	1	penicillinate anion
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.39	2	prostaglandins E	human metabolite; mouse metabolite; oxytocic
herbimycin herbimycin: herbicidal antibiotic produced by Streptomyces sp.; see also herbimycin B; structure for herbimycin A in second source. herbimycin : A 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It is an ansamycin antibiotic that induces apoptosis and displays antitumour effects.	1.98	1	1,4-benzoquinones; lactam; macrocycle	antimicrobial agent; apoptosis inducer; herbicide; Hsp90 inhibitor; tyrosine kinase inhibitor
lipid a Lipid A: Lipid A is the biologically active component of lipopolysaccharides. It shows strong endotoxic activity and exhibits immunogenic properties.. lipid A : The glycolipid moiety of bacterial lipopolysaccharide (R can be either hydrogen or a fatty acyl group).	3.93	13	dodecanoate ester; lipid A; tetradecanoate ester	Escherichia coli metabolite

Condition	Relationship Strength	Studies
Cancer of Lung [description not available]	2.67	3
B16 Melanoma [description not available]	1.98	1
Angiogenesis, Pathologic [description not available]	1.98	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.67	3
Experimental Neoplasms [description not available]	2.39	2
Endotoxin Shock [description not available]	1.98	1
Shock, Septic Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.	1.98	1
Cancer of Colon [description not available]	1.98	1
Cancer of Liver [description not available]	1.98	1
Peritoneal Carcinomatosis [description not available]	1.98	1
Colonic Neoplasms Tumors or cancer of the COLON.	1.98	1
Liver Neoplasms Tumors or cancer of the LIVER.	1.98	1
Peritoneal Neoplasms Tumors or cancer of the PERITONEUM.	1.98	1
Fibrosarcoma A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)	2.39	2
Salmonella Infections, Animal Infections in animals with bacteria of the genus SALMONELLA.	1.98	1
Coagulation, Disseminated Intravascular [description not available]	2	1
Enlarged Spleen [description not available]	2	1
Disseminated Intravascular Coagulation A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.	2	1
Hyperplasia An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.	2	1
Ascites Accumulation or retention of free fluid within the peritoneal cavity.	1.98	1
Experimental Hepatoma [description not available]	1.98	1
Germinoblastoma [description not available]	1.98	1
Malignant Melanoma [description not available]	1.98	1
Lymphoma A general term for various neoplastic diseases of the lymphoid tissue.	1.98	1
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	1.98	1

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