dynorphins and Shock--Septic

dynorphins has been researched along with Shock--Septic* in 2 studies

Other Studies

2 other study(ies) available for dynorphins and Shock--Septic

Article	Year
Dynorphin: cardiovascular consequences of opioid receptor interactions in normal and endotoxemic rats. Proceedings of the Western Pharmacology Society, 1984, Volume: 27 Topics: Animals; Drug Interactions; Dynorphins; Hemodynamics; Injections, Intravenous; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid; Shock, Septic	1984
ICI 174864, a putative delta opioid antagonist, reverses endotoxemic hypotension: pretreatment with dynorphin 1-13, A kappa agonist, blocks this action. Neuropeptides, 1984, Volume: 5, Issue:1-3 The putative delta opioid receptor antagonist ICI 174864 (3 mg/kg, i.v.) significantly reversed endotoxic shock hypotension at a dose which lacked significant pressor actions in normotensive, non-endotoxemic rats. In contrast, dynorphin 1-13, when administered either before (0.1 or 1.0 mg/kg, i.v.) or following (1.0 mg/kg, i.v.) injection of endotoxin, failed to alter the course of ensuing circulatory shock. Additionally, pretreatment with dynorphin 1-13 prevented the subsequent reversal of endotoxemic hypotension by ICI 174864. It is concluded that: 1) delta opioid receptors mediate the endogenous opioid component of endotoxic shock hypotension; and 2) functional interactions occur between ligands for mu, delta, and kappa opioid receptor subtypes, which may predict potential interactions with a common macromolecular opioid receptor complex. Topics: Animals; Blood Pressure; Dynorphins; Enkephalin, Leucine; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Shock, Septic	1984

Article

Year

Dynorphin: cardiovascular consequences of opioid receptor interactions in normal and endotoxemic rats.

Proceedings of the Western Pharmacology Society, 1984, Volume: 27

Topics: Animals; Drug Interactions; Dynorphins; Hemodynamics; Injections, Intravenous; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid; Shock, Septic

1984

ICI 174864, a putative delta opioid antagonist, reverses endotoxemic hypotension: pretreatment with dynorphin 1-13, A kappa agonist, blocks this action.

Neuropeptides, 1984, Volume: 5, Issue:1-3

The putative delta opioid receptor antagonist ICI 174864 (3 mg/kg, i.v.) significantly reversed endotoxic shock hypotension at a dose which lacked significant pressor actions in normotensive, non-endotoxemic rats. In contrast, dynorphin 1-13, when administered either before (0.1 or 1.0 mg/kg, i.v.) or following (1.0 mg/kg, i.v.) injection of endotoxin, failed to alter the course of ensuing circulatory shock. Additionally, pretreatment with dynorphin 1-13 prevented the subsequent reversal of endotoxemic hypotension by ICI 174864. It is concluded that: 1) delta opioid receptors mediate the endogenous opioid component of endotoxic shock hypotension; and 2) functional interactions occur between ligands for mu, delta, and kappa opioid receptor subtypes, which may predict potential interactions with a common macromolecular opioid receptor complex.

Topics: Animals; Blood Pressure; Dynorphins; Enkephalin, Leucine; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Shock, Septic

1984