antimicrobial-peptide-ib-367 and Shock--Septic

antimicrobial-peptide-ib-367 has been researched along with Shock--Septic* in 1 studies

Other Studies

1 other study(ies) available for antimicrobial-peptide-ib-367 and Shock--Septic

Article	Year
Antiendotoxin activity of protegrin analog IB-367 alone or in combination with piperacillin in different animal models of septic shock. Peptides, 2003, Volume: 24, Issue:11 The therapeutic efficacy of protegrin peptide IB-367 was investigated in three rat models of septic shock: (i) rats injected intraperitoneally with 1mg Escherichia coli 0111:B4 lipopolysaccharide, (ii) rats given an intraperitoneal injection of 2 X 10(10) CFU of E. coli ATCC 25922, and (iii) rats in which intra-abdominal sepsis was induced via cecal ligation and puncture. All animals were randomized to receive parenterally isotonic sodium chloride solution, 1mg/kg of IB-367, 60mg/kg piperacillin and 1mg/kg of IB-367 plus 60mg/kg piperacillin. The peptide demonstrated lower level of antimicrobial activity than piperacillin, nevertheless it exhibited the dual properties of antimicrobial and antiendotoxin agent. Finally IB-367 and piperacillin association showed to be the most effective therapeutic approach. Topics: Animals; Antimicrobial Cationic Peptides; Cecum; Disease Models, Animal; Drug Therapy, Combination; Escherichia coli Infections; Ligation; Lipopolysaccharides; Male; Microbial Sensitivity Tests; Peptides; Peritonitis; Piperacillin; Proteins; Punctures; Rats; Rats, Wistar; Shock, Septic	2003

Article

Year

Antiendotoxin activity of protegrin analog IB-367 alone or in combination with piperacillin in different animal models of septic shock.

Peptides, 2003, Volume: 24, Issue:11

The therapeutic efficacy of protegrin peptide IB-367 was investigated in three rat models of septic shock: (i) rats injected intraperitoneally with 1mg Escherichia coli 0111:B4 lipopolysaccharide, (ii) rats given an intraperitoneal injection of 2 X 10(10) CFU of E. coli ATCC 25922, and (iii) rats in which intra-abdominal sepsis was induced via cecal ligation and puncture. All animals were randomized to receive parenterally isotonic sodium chloride solution, 1mg/kg of IB-367, 60mg/kg piperacillin and 1mg/kg of IB-367 plus 60mg/kg piperacillin. The peptide demonstrated lower level of antimicrobial activity than piperacillin, nevertheless it exhibited the dual properties of antimicrobial and antiendotoxin agent. Finally IB-367 and piperacillin association showed to be the most effective therapeutic approach.

Topics: Animals; Antimicrobial Cationic Peptides; Cecum; Disease Models, Animal; Drug Therapy, Combination; Escherichia coli Infections; Ligation; Lipopolysaccharides; Male; Microbial Sensitivity Tests; Peptides; Peritonitis; Piperacillin; Proteins; Punctures; Rats; Rats, Wistar; Shock, Septic

2003