streptochlorin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

streptochlorin: inhibits both NF-kappaB activation and angiogenesis; isolated from marine Streptomyces; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	44608049
CHEMBL ID	2252884
SCHEMBL ID	3797259
MeSH ID	M0517876

Synonyms (16)

Synonym
streptochlorin
CHEMBL2252884
SCHEMBL3797259
120191-51-7
J-004273
AKOS027325049
ncgc00380969-01_c11h7cln2o_3-(4-chloro-1,3-oxazol-5-yl)-1h-indole
NCGC00380969-01
4-chloro-5-(1h-indol-3-yl)oxazole
3-(4-chloro-5-oxazolyl)-1h-indole
4-chloro-5-(1h-indol-3-yl)-1,3-oxazole
sf 2583a
HY-124035
CS-0084004
12815a
EX-A7999F

Research Excerpts

Overview

Streptochlorin is a small molecule of indole alkaloid isolated from Streptomyces sp. It is a promising lead compound due to its potent bioactivity in preventing many phytopathogens.

Excerpt	Reference	Relevance
"Streptochlorin is a small molecule of indole alkaloid isolated from marine Streptomyces sp., it is a promising lead compound due to its potent bioactivity in preventing many phytopathogens in our previous study, but further structural modifications are required to improve its antifungal activity. "	( Streptochlorin analogues as potential antifungal agents: Design, synthesis, antifungal activity and molecular docking study. Ali, AS; Deng, Y; Gao, Y; Gu, YC; Guo, D; Guo, SK; Han, X; Huang, DC; Jin, B; Liu, C; Liu, JR; Mulholland, N; Qiu, RL; Song, ZL; Tan, JY; Xia, Q; Zhang, H; Zhang, MZ, 2021)	3.51
"Streptochlorin is a small molecule that produced by marine Streptomyces sp. "	( Induction of apoptosis by streptochlorin isolated from Streptomyces sp. in human leukemic U937 cells. Cheong, J; Choi, IW; Choi, YH; Kim, GY; Kim, SK; Kwon, TK; Nam, TJ; Park, C; Shin, HJ, 2008)	2.09
"Streptochlorin is a small molecule isolated from marine Streptomyces sp. "	( Streptochlorin isolated from Streptomyces sp. Induces apoptosis in human hepatocarcinoma cells through a reactive oxygen species-mediated mitochondrial pathway. Cheong, J; Choi, IW; Choi, YH; Kang, HS; Kim, GY; Kim, SK; Moon, SK; Shin, DY; Shin, HJ, 2008)	3.23

Treatment

Excerpt	Reference	Relevance
"Streptochlorin treatment resulted in concentration- and time-dependent growth inhibition by inducing apoptosis."	( Induction of apoptosis by streptochlorin isolated from Streptomyces sp. in human leukemic U937 cells. Cheong, J; Choi, IW; Choi, YH; Kim, GY; Kim, SK; Kwon, TK; Nam, TJ; Park, C; Shin, HJ, 2008)	1.37

Bioavailability

Excerpt	Reference	Relevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (17)

Assay ID	Title	Year	Journal	Article
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347159	Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347160	Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1092139	Fungicidal activity against Phytophthora infestans infected on compound pre-treated tomato leaf pieces assessed as control of disease or pathogen at 200 ppm measured after 5 to 14 days by leaf-piece assay	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and fungicidal activity of novel pimprinine analogues.
AID1092129	Fungicidal activity against Fusarium graminearum grown on compound supplemented artificial media assessed as control of disease or pathogen at 20 ppm measured after 5 to 14 days by artificial media assay	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and fungicidal activity of novel pimprinine analogues.
AID1092138	Fungicidal activity against Phytophthora infestans infected on compound pre-treated tomato leaf pieces assessed as control of disease or pathogen at 60 ppm measured after 5 to 14 days by leaf-piece assay	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and fungicidal activity of novel pimprinine analogues.
AID1092137	Fungicidal activity against Zymoseptoria tritici infected on compound pre-treated wheat leaf pieces assessed as control of disease or pathogen at 100 ppm measured after 5 to 14 days by leaf-piece assay	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and fungicidal activity of novel pimprinine analogues.
AID1092135	Fungicidal activity against Pythium dissimile grown on compound supplemented artificial media assessed as control of disease or pathogen at 20 ppm measured after 5 to 14 days by artificial media assay	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and fungicidal activity of novel pimprinine analogues.
AID1092134	Fungicidal activity against Pythium dissimile grown on compound supplemented artificial media assessed as control of disease or pathogen at 2 ppm measured after 5 to 14 days by artificial media assay	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and fungicidal activity of novel pimprinine analogues.
AID1092132	Fungicidal activity against Alternaria solani grown on compound supplemented artificial media assessed as control of disease or pathogen at 20 ppm measured after 5 to 14 days by artificial media assay	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and fungicidal activity of novel pimprinine analogues.
AID1092128	Fungicidal activity against Fusarium graminearum grown on compound supplemented artificial media assessed as control of disease or pathogen at 2 ppm measured after 5 to 14 days by artificial media assay	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and fungicidal activity of novel pimprinine analogues.
AID1092131	Fungicidal activity against Botryotinia fuckeliana grown on compound supplemented artificial media assessed as control of disease or pathogen at 20 ppm measured after 5 to 14 days by artificial media assay	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and fungicidal activity of novel pimprinine analogues.
AID1092130	Fungicidal activity against Botryotinia fuckeliana grown on compound supplemented artificial media assessed as control of disease or pathogen at 2 ppm measured after 5 to 14 days by artificial media assay	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and fungicidal activity of novel pimprinine analogues.
AID1092136	Fungicidal activity against Uromyces viciae-fabae infected compound pre-treated bean leaf pieces assessed as control of disease or pathogen at 100 ppm measured after 5 to 14 days by leaf-piece assay	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and fungicidal activity of novel pimprinine analogues.
AID1092133	Fungicidal activity against Alternaria solani grown on compound supplemented artificial media assessed as control of disease or pathogen at 2 ppm measured after 5 to 14 days by artificial media assay	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and fungicidal activity of novel pimprinine analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (20)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (20.00)	29.6817
2010's	12 (60.00)	24.3611
2020's	4 (20.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.62

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	19.62 (24.57)
Research Supply Index	3.04 (2.92)
Research Growth Index	5.03 (4.65)
Search Engine Demand Index	15.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (19.62)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	20 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
indole [no description available]	7.15	1	indole; polycyclic heteroarene	Escherichia coli metabolite
melatonin [no description available]	7.11	1	acetamides; tryptamines	anticonvulsant; central nervous system depressant; geroprotector; hormone; human metabolite; immunological adjuvant; mouse metabolite; radical scavenger
netropsin Netropsin: A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research.	2.08	1
oxazoles Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.	4.24	16	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
nigericin Nigericin: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed). nigericin : A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.	2.17	1	polycyclic ether	antibacterial agent; antimicrobial agent; bacterial metabolite; potassium ionophore
pimprinine pimprinine: structure	2.31	1
1,3,4-oxadiazole 1,3,4-oxadiazole: structure in first source	2.31	1
resistoflavin [no description available]	2.08	1
sulfur Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.	2.08	1	chalcogen; nonmetal atom	macronutrient
piericidin a piericidin A: pyridine-substituted fatty alcohol antibiotic; minor descriptor (75-85); on-line & Index Medicus search ANTIBIOTICS (75-85); RN given refers to (S-(R,R-(all-E)))-isomer. piericidin A : A member of the class of monohydroxypyridines that acts as an irreversible mitochondrial Complex I inhibitor that strongly associates with ubiquinone binding sites in both mitochondrial and bacterial forms of NADH:ubiquinone oxidoreductase	2.17	1	aromatic ether; methylpyridines; monohydroxypyridine; secondary allylic alcohol	antimicrobial agent; bacterial metabolite; EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor; mitochondrial respiratory-chain inhibitor
oxadiazoles Oxadiazoles: Compounds containing five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom which exist in various regioisomeric forms.	2.31	1
altemicidin altemicidin: sulfamino given in first source; monoterpene alkaloid; isolated from Actinomycete	2.08	1
marmycin a marmycin A: cytotoxic compound from a marine sediment-derived actinomycete related to the genus Streptomyces; structure in first source	2.08	1
proximicin a proximicin A: antineoplastic agent isolated from Verrucosispora; structure in first source	2.08	1
heliomycin heliomycin: Russian drug; antibiotic with antiviral properties isolated from Actinomyces flavochromogenes var. heliomycini; structure	2.08	1
echinosporin echinosporin: from Streptomyces echinosporus MK-213; structure given in first source	2.08	1

Condition	Relationship Strength	Studies
Congenital Zika Syndrome [description not available]	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.83	3
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.25	1
Allergic Reaction [description not available]	2.08	1
Dermatitis Any inflammation of the skin.	7.08	1
Hypersensitivity Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.	2.08	1
Lung Injury, Acute [description not available]	2.52	2
Innate Inflammatory Response [description not available]	2.11	1
Endotoxin Shock [description not available]	2.11	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.11	1
Shock, Septic Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.	2.11	1
Acute Lung Injury A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).	2.52	2
Cholangiocellular Carcinoma [description not available]	2.11	1
Metastase [description not available]	2.11	1
Invasiveness, Neoplasm [description not available]	2.11	1
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2.11	1
Cholangiocarcinoma A malignant tumor arising from the epithelium of the BILE DUCTS.	7.11	1
Leucocythaemia [description not available]	2.04	1
Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)	2.04	1
Hepatocellular Carcinoma [description not available]	2.04	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.04	1

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