flm-5011 and Shock--Septic

flm-5011 has been researched along with Shock--Septic* in 1 studies

Other Studies

1 other study(ies) available for flm-5011 and Shock--Septic

Article	Year
Inhibition of lipoxygenase (LOX) or of cyclooxygenase (COX) improves survival of rats in endotoxin shock. Biomedica biochimica acta, 1988, Volume: 47, Issue:10-11 In a well defined endotoxin (ET) shock model we compared the influence of a selective LOX-inhibitor FLM 5011 and the COX-inhibitor Acetylsalicylic acid (ASA) on survival as well as on their effects on TXB2 and 6-oxo-PGF1 and on selected parameters characterizing the shock syndrome. Pretreatment with both substances reduced the lethality rate. Neither TXB2 nor the PGF1 concentration revealed a consistent trend after therapeutic intervention. None of the investigated mediators could be identified as the primary "shock mediator". Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Cyclooxygenase Inhibitors; Disease Models, Animal; Lauric Acids; Leukocyte Count; Lipoxygenase; Lipoxygenase Inhibitors; Male; Oximes; Platelet Count; Rats; Rats, Inbred Strains; Shock, Septic; Thromboxane B2	1988

Article

Year

Inhibition of lipoxygenase (LOX) or of cyclooxygenase (COX) improves survival of rats in endotoxin shock.

Biomedica biochimica acta, 1988, Volume: 47, Issue:10-11

In a well defined endotoxin (ET) shock model we compared the influence of a selective LOX-inhibitor FLM 5011 and the COX-inhibitor Acetylsalicylic acid (ASA) on survival as well as on their effects on TXB2 and 6-oxo-PGF1 and on selected parameters characterizing the shock syndrome. Pretreatment with both substances reduced the lethality rate. Neither TXB2 nor the PGF1 concentration revealed a consistent trend after therapeutic intervention. None of the investigated mediators could be identified as the primary "shock mediator".

Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Cyclooxygenase Inhibitors; Disease Models, Animal; Lauric Acids; Leukocyte Count; Lipoxygenase; Lipoxygenase Inhibitors; Male; Oximes; Platelet Count; Rats; Rats, Inbred Strains; Shock, Septic; Thromboxane B2

1988