Page last updated: 2024-09-03

omega-n-methylarginine and Shock, Septic

omega-n-methylarginine has been researched along with Shock, Septic in 83 studies

Research

Studies (83)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	58 (69.88)	18.2507
2000's	23 (27.71)	29.6817
2010's	2 (2.41)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Brillante, DG; Howes, LG	1
Astiz, ME; Berna, G; Griffin, K; Khan, R; Kirschenbaum, LA; LaRow, C	1
Cheng, ZQ; Jacobs, H; Kasian, K; Light, RB; Mink, SN; Santos-Martinez, LE	1
Matejovic, M; Radermacher, P; Stahl, W	1
Evans, TW; Mitchell, JA; Price, S	1
Andersson, J; Bakker, J; Donaldson, J; Grossman, S; Grover, R; Holzapfel, L; Lodato, R; McLuckie, A; Takala, J; Watson, D	1
Anzueto, A; Bellomo, R; Donaldson, J; Grossman, S; Grover, R; Guntupalli, K; Le Gall, JR; Lorente, J; Smithies, M; Watson, D	1
Anzueto, A; Arneson, C; Bakker, J; Breen, D; Brockway, M; Donaldson, J; Grossman, S; Grove, G; Grover, R; Holzapfel, L; López, A; Lorente, JA; McLuckie, A; Silverman, MS; Steingrub, J; Takala, J; Willatts, S	1
Parrillo, JE; Phillip Dellinger, R	1
Møller, K; Skinhøj, P	1
Renes, MH; van der Hoeven, JG	1
Mitaka, C	1
Antonioli, L; Bernardini, N; Blandizzi, C; Colucci, R; Del Tacca, M; Duranti, E; Fornai, M; Pinto, S; Salvetti, A; Segnani, C; Taddei, S; Virdis, A	1
Mayr, FB; Spiel, AO	1
Boer, R; Ghofrani, HA; Grimminger, F; Lehner, M; Maring, D; Mayer, K; Pullamsetti, SS; Rosengarten, B; Schermuly, RT; Schudt, C; Seeger, W; Weissmann, N	1
Deguchi, Y; Fukuda, M; Imamura, Y; Miyoshi, N; Nakagawa, T; Soga, Y; Suga, H; Suzuki, T	1
Chelly, B; Chelly, JE; Doursout, MF; Fischer, UM; Hartley, CJ; Liang, Y; Oguchi, T	1
Gómez Jiménez, J; Salgado Remigio, A	1
Carpenter, A; Cohen, J; Evans, T; Silva, A	1
Bennett, D; Lamb, G; Leone, A; Moncada, S; Petros, A; Vallance, P	1
Boeynaems, JM; Buurman, W; Preiser, JC; Vincent, JL; Wachel, D; Zhang, H	1
Blantz, RC	1
Economidou, D; Leontsini, M; Margari, P; Papadimitriou, M; Raidis, C; Vakianis, P; Vrettos, M	1
Bach, TJ; Grant, SK; Hom, GJ; Hutchinson, NI; MacIntyre, DE; Wolfe, G	1
Henning, R; Klemm, P; Martorana, PA; Thiemermann, C; Winklmaier, G	1
Dasta, JF; Wolfe, TA	1
Chang, CH; Chang, JP; Lin, PJ	1
Kotake, Y; Miyajima, T	1
Komarov, AM; Lai, CS	2
Bättig, U; Cakmakci, M; Geroulanos, S; Schilling, J	1
Szabó, C; Thiemermann, C; Vane, JR	1
Banks, S; Cobb, JP; Correa, R; Elin, RJ; Hoffman, WD; Hosseini, JM; Koev, CA; Levi, R; Natanson, C; Quezado, ZM	1
Brackett, DJ; Lerner, MR; Wilson, MF	1
Bune, AJ; Cammack, R; Cook, HT; Shergill, JK	1
Crake, T; Lefroy, DC; Tousoulis, D	1
Chelly, FD; Cromeens, DM; Griffith, OW; Kilbourn, RG	1
Broner, CW; O'Dorisio, MS; Rosenberg, RB	1
Baker, CH; Price, JM; Sutton, ET; Zhou, Z	1
Thiemermann, C	2
Adams, HR; Jones, JJ; Keller, RS; Kim, KF; Myers, PR; Parker, JL; Rubin, LJ	1
Rees, DD	1
Howard, KM; Mustafa, SB; Olson, MS	1
Ceppi, ED; Smith, FS; Titheradge, MA	2
Haefeli, WE; Linder, L; Simper, D; Strobel, WM	1
Kilbourn, RG	1
Belladonna, ML; Campanile, F; Fioretti, MC; Giampietri, A; Grohmann, U; Puccetti, P	1
Fink, MP	1
Burgmann, H; Frass, M; Knapp, S; Laczika, KF; Locker, GJ; Staudinger, T	1
Dohi, K; Fukuma, K; Ito, H; Koyama, S; Maeda, T; Marubayashi, S; Sugino, K; Yamada, K	1
Eigler, A; Endres, S	1
Cabral, A; Peny, MO; Preiser, JC; Rogiers, P; Smail, N; Vincent, JL; Zhang, H	1
Adler, J; Georgieff, M; Iber, T; Radermacher, P; Santak, B; Vassilev, D; Vogt, J; Wachter, U	1
Cambridge, D; Moncada, S; Monkhouse, JE; Rees, DD	1
Brar, R; Dee, L; Khadour, F; Kumar, A; Parrillo, JE; Schulz, R; Skorupa, G; Wang, P	1
Beerahee, M; Colice, G; Donaldson, J; Grover, R; Guntupalli, K; Hussein, Z; Jeffs, R; Jordan, B; Vincent, JL; Watson, D; Zaccardelli, D	1
Bollaert, PE; Cane, D; de Chillou, C; Levy, B; Mallie, JP; Valtier, M	1
Balk, RA; Symeonides, S	1
Adler, J; Georgieff, M; Grover, R; Iber, T; Radermacher, P; Rieger, KM; Santak, B; Träger, K; Vlatten, A; Vogt, J; Wachter, U	1
Cobb, JP	1
Dhillon, J; Dubbels, AM; Galley, HF; Nelson, SJ; Webster, NR	1
Hao, G; Jing, D; Shen, X; Wang, S	1
Bhagat, K; Charles, IG; Hingorani, AD; Palacios, M; Vallance, P	1
Chelly, JE; Doursout, MF; Hartley, CJ; Kilbourn, RG	1
Bahrami, S; Banerjee, A; Fitzal, F; Fuerst, W; Gasser, H; Peichl, G; Redl, H; Strohmaier, W; Werner, ER; Werner-Felmayer, G	1
Cho, E; Ekelund, UE; Hare, JM; Harrison, RW; Kass, DA; Senzaki, H; Thakkar, RN	1
Adler, J; Georgieff, M; Grover, R; Iber, T; Radermacher, P; Rieger, KM; Santak, B; Träger, K; Vlatten, A	1
Broccard, A; Eckert, P; Feihl, F; Hurni, JM; Lazor, R; Liaudet, L; Perret, C; Schaller, MD	1
Lamarque, D; Whittle, BJ	1
Banks, SM; Danner, RL; Freeman, BD; Natanson, C	1
Jackson, SK; James, PE; Madhani, M; Roebuck, W; Swartz, HM	1
Moncada, S; Nava, E; Palmer, RM	1
Adams, HR; Hotchkiss, RS; Karl, IE; Parker, JL	1
Cakmakci, M; Geroulanos, S; Jung, HH; Largiader, F; Schilling, J	1
Cohen, J; Silva, A	1
Griffith, OW; Kilbourn, RG	1
Moncada, S; Radomski, MW; Smith, RE	1
Moncada, S; Rees, DD; Wright, CE	1
Estrada, C; Fernandez, A; Gonzalez, C; Martin, C; Moncada, S	1
Klabunde, RE; Ritger, RC	1
Adams, J; Griffith, OW; Gross, SS; Jubran, A; Kilbourn, RG; Levi, R; Lodato, RF	1

Reviews

13 review(s) available for omega-n-methylarginine and Shock, Septic

Article	Year
Expert opinion on tilarginine in the treatment of shock. Expert opinion on investigational drugs, 2008, Volume: 17, Issue:10 Topics: Animals; Enzyme Inhibitors; Heart; Humans; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Cardiogenic; Shock, Septic; Sympathetic Nervous System	2008
[Septic shock and NO]. Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 9 Topics: Animals; Biomarkers; Guanidines; Guanylate Cyclase; Hemodynamics; Humans; Methylene Blue; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; omega-N-Methylarginine; Receptors, Cytoplasmic and Nuclear; Shock, Septic; Soluble Guanylyl Cyclase	2004
[Nitric oxide and sepsis]. Medicina clinica, 1993, Dec-04, Volume: 101, Issue:19 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Bacterial Infections; Humans; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic	1993
Vascular biology: relevance of nitric oxide in vascular and nonvascular tissue with normal and decreased renal function. Blood purification, 1994, Volume: 12, Issue:1 Topics: Amino Acid Oxidoreductases; Arginine; Endothelium, Vascular; Enzyme Induction; Hemodynamics; Humans; Hypotension; Inflammation; Kidney Diseases; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic	1994
Use of nitric oxide synthase inhibitors as a novel treatment for septic shock. The Annals of pharmacotherapy, 1995, Volume: 29, Issue:1 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Clinical Trials as Topic; Humans; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic	1995
Selective inhibition of the activity of inducible nitric oxide synthase in septic shock. Progress in clinical and biological research, 1995, Volume: 392 Topics: Animals; Arginine; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Guanidines; Humans; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Shock, Septic; Thiourea	1995
Role of nitric oxide in the vascular dysfunction of septic shock. Biochemical Society transactions, 1995, Volume: 23, Issue:4 Topics: Animals; Arginine; Blood Vessels; Endotoxins; Enzyme Inhibitors; Humans; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic	1995
Just say no to NO., yes? Critical care medicine, 1996, Volume: 24, Issue:11 Topics: Animals; Critical Care; Enzyme Inhibitors; Humans; Nitric Oxide; omega-N-Methylarginine; Shock, Septic	1996
[Inhibition of nitric oxide synthase in septic shock. Therapeutic limits and perspectives]. Der Internist, 1997, Volume: 38, Issue:5 Topics: Animals; Enzyme Inhibitors; Hemodynamics; Humans; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic	1997
Nitric oxide, sepsis and liver metabolism. Biochemical Society transactions, 1997, Volume: 25, Issue:3 Topics: Animals; Cytokines; Gluconeogenesis; Glucose; Humans; Liver; Liver Glycogen; Nitric Oxide; omega-N-Methylarginine; Postoperative Complications; Reactive Oxygen Species; Sepsis; Shock, Septic	1997
Nitric oxide in the pathogenesis of sepsis. Infectious disease clinics of North America, 1999, Volume: 13, Issue:2 Topics: Animals; Cardiovascular System; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Sepsis; Shock, Septic	1999
Use of nitric oxide synthase inhibitors to treat septic shock: the light has changed from yellow to red. Critical care medicine, 1999, Volume: 27, Issue:5 Topics: Animals; Clinical Trials, Phase III as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Hemodynamics; Humans; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic	1999
Overproduction of nitric oxide in cytokine-mediated and septic shock. Journal of the National Cancer Institute, 1992, Jun-03, Volume: 84, Issue:11 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cytokines; Humans; Interleukin-2; Neoplasms; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic	1992

Trials

4 trial(s) available for omega-n-methylarginine and Shock, Septic

Article	Year
Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo Critical care medicine, 2004, Volume: 32, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Critical Care; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Hemodynamics; Humans; Infusions, Intravenous; Intensive Care Units; Male; Middle Aged; Nitric Oxide Synthase; omega-N-Methylarginine; Oxygen Consumption; Probability; Reference Values; Risk Assessment; Severity of Illness Index; Shock, Septic; Survival Analysis; Treatment Outcome	2004
Cardiovascular effects of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) in patients with septic shock: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Critical care medicine, 2004, Volume: 32, Issue:1 Topics: Adult; Aged; Cardiac Output; Cardiovascular System; Critical Care; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Hemodynamics; Humans; Intensive Care Units; Male; Middle Aged; Nitric Oxide Synthase; omega-N-Methylarginine; Probability; Pulmonary Circulation; Reference Values; Risk Assessment; Severity of Illness Index; Shock, Septic; Survival Analysis; Treatment Outcome; Vasoconstrictor Agents	2004
Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Critical care medicine, 2004, Volume: 32, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cause of Death; Critical Care; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Intensive Care Units; Male; Middle Aged; Multiple Organ Failure; Nitric Oxide Synthase; omega-N-Methylarginine; Reference Values; Risk Assessment; Severity of Illness Index; Shock, Septic; Survival Analysis; Treatment Outcome	2004
Effects of a nitric oxide synthase inhibitor in humans with septic shock. Cardiovascular research, 1994, Volume: 28, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Amino Acid Oxidoreductases; Arginine; Blood Pressure; Cardiac Output; Double-Blind Method; Female; Heart Rate; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic; Vascular Resistance	1994

Other Studies

66 other study(ies) available for omega-n-methylarginine and Shock, Septic

Article	Year
Augmentation of platelet and endothelial cell eNOS activity decreases sepsis-related neutrophil-endothelial cell interactions. Shock (Augusta, Ga.), 2010, Volume: 33, Issue:3 Topics: Adult; Aged; Arginine; Endothelial Cells; Humans; Imines; Middle Aged; Neutrophils; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Platelet Activation; Platelet Aggregation; Shock, Septic	2010
Lysozyme, a mediator of sepsis that intrinsically generates hydrogen peroxide to cause cardiovascular dysfunction. American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:3 Topics: Animals; Aspergillus niger; Cardiovascular Diseases; Catalase; Dogs; Enzyme Inhibitors; Hydrogen Peroxide; Muramidase; Myocardial Contraction; Nitric Oxide; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Oxygen Consumption; Reactive Oxygen Species; Shock, Septic	2009
Inhibition of nitric oxide synthase during sepsis: revival because of isoform selectivity? Shock (Augusta, Ga.), 2010, Volume: 34, Issue:3 Topics: Acidosis; Animals; Blood Circulation; Clinical Trials, Phase II as Topic; Early Termination of Clinical Trials; Endotoxemia; Fluid Therapy; Humans; Imidazoles; Mice; Mice, Knockout; Molsidomine; Nitric Oxide Synthase Type II; Norepinephrine; omega-N-Methylarginine; Protein Isoforms; Pyridines; Sepsis; Shock, Septic; Swine	2010
Nitric oxide supports atrial function in sepsis: relevance to side effects of inhibitors in shock. European journal of pharmacology, 2002, Aug-09, Volume: 449, Issue:3 Topics: Animals; Atrial Natriuretic Factor; Cell Death; Electric Stimulation; Enzyme Inhibitors; Heart; Heart Atria; L-Lactate Dehydrogenase; Lipopolysaccharides; Male; Myocardial Contraction; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Organ Culture Techniques; Rats; Salmonella enteritidis; Sepsis; Shock, Septic	2002
Mediator modulation therapy of severe sepsis and septic shock: does it work? Critical care medicine, 2004, Volume: 32, Issue:1 Topics: Bacteremia; Critical Care; Critical Illness; Female; Follow-Up Studies; Humans; Male; omega-N-Methylarginine; Prognosis; Randomized Controlled Trials as Topic; Risk Assessment; Shock, Septic; Survival Analysis; Systemic Inflammatory Response Syndrome; Treatment Outcome	2004
[Nitric-oxide synthase inhibitor treatment in septic shock]. Ugeskrift for laeger, 2004, Mar-08, Volume: 166, Issue:11 Topics: Hemodynamics; Humans; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic; Vasoconstrictor Agents	2004
Administration of nitric oxide synthase inhibitor 546C88 in septic shock. Critical care medicine, 2004, Volume: 32, Issue:7 Topics: Cardiac Output; Humans; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic	2004
Cyclooxygenase-2 inhibition improves vascular endothelial dysfunction in a rat model of endotoxic shock: role of inducible nitric-oxide synthase and oxidative stress. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:3 Topics: Acetylcholine; Animals; Ascorbic Acid; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytokines; Endothelium, Vascular; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Norepinephrine; omega-N-Methylarginine; Oxidative Stress; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Shock, Septic; Superoxide Dismutase; Vascular Resistance; Vasoconstriction	2005
NO-synthase inhibition in sepsis. Thrombosis and haemostasis, 2006, Volume: 95, Issue:4 Topics: Amidines; Animals; Benzylamines; Disease Models, Animal; Enzyme Inhibitors; Hemodynamics; Humans; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Sepsis; Shock, Septic	2006
Effect of nitric oxide synthase (NOS) inhibition on macro- and microcirculation in a model of rat endotoxic shock. Thrombosis and haemostasis, 2006, Volume: 95, Issue:4 Topics: Amidines; Animals; Benzylamines; Disease Models, Animal; Enzyme Inhibitors; Epinephrine; Hemoglobins; Male; Microcirculation; Nitric Oxide Synthase; Norepinephrine; omega-N-Methylarginine; Rats; Rats, Wistar; Shock, Septic	2006
Reinforcement therapy using nitric oxide synthase inhibitors against endotoxin shock in dogs. Surgery today, 2006, Volume: 36, Issue:9 Topics: Animals; Catecholamines; Dogs; Endotoxins; Enzyme Inhibitors; Isothiuronium; Models, Animal; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic	2006
Distribution of NOS isoforms in a porcine endotoxin shock model. Shock (Augusta, Ga.), 2008, Volume: 29, Issue:6 Topics: Animals; Cardiomyopathies; Coronary Circulation; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Guanidines; Hemodynamics; Hypotension; Isoenzymes; Lipopolysaccharides; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Organ Specificity; Shock, Septic; Swine; Vasoconstriction; Vasodilation; Vasodilator Agents	2008
Inhibition of nitric oxide synthase in experimental gram-negative sepsis. The Journal of infectious diseases, 1994, Volume: 169, Issue:2 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Escherichia coli; Escherichia coli Infections; Liver; Mice; Nitrates; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Shock, Septic; Tumor Necrosis Factor-alpha	1994
Is endotoxin-induced hypotension related to nitric oxide formation? European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1994, Volume: 26, Issue:1 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Dogs; Endotoxins; Hemodynamics; Hypotension; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Oxygen; Random Allocation; Shock, Septic; Tumor Necrosis Factor-alpha	1994
Effect of inhibition of nitric oxide synthase in acute renal failure due to endotoxin shock in dogs. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1994, Volume: 9 Suppl 4 Topics: Acute Kidney Injury; Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Disease Models, Animal; Dogs; Hemodynamics; Kidney; Lipopolysaccharides; Liver; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic	1994
Lipopolysaccharide-induced hypotension and vascular hyporeactivity in the rat: tissue analysis of nitric oxide synthase mRNA and protein expression in the presence and absence of dexamethasone, NG-monomethyl-L-arginine or indomethacin. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:1 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Dexamethasone; Female; Gene Expression; Indomethacin; Lipopolysaccharides; Nitric Oxide Synthase; Norepinephrine; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Shock, Septic; Tissue Distribution; Vasodilation	1995
Effects of nitric oxide synthase inhibition combined with nitric oxide inhalation in a porcine model of endotoxin shock. British journal of pharmacology, 1995, Volume: 114, Issue:2 Topics: Administration, Inhalation; Amino Acid Oxidoreductases; Animals; Arginine; Blood Gas Analysis; Escherichia coli; Hemodynamics; Hydrogen-Ion Concentration; Leukocyte Count; Lipopolysaccharides; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Platelet Count; Shock, Septic; Swine; Tumor Necrosis Factor-alpha	1995
Reversal of refractory hypotension in septic shock by inhibitor of nitric oxide synthase. Chest, 1994, Volume: 106, Issue:2 Topics: Amino Acid Oxidoreductases; Arginine; Cardiac Output, High; Fatal Outcome; Humans; Hypotension; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic	1994
Spin trapping agent, phenyl N-tert-butyl nitrone, inhibits induction of nitric oxide synthase in endotoxin-induced shock in mice. Biochemical and biophysical research communications, 1995, Oct-04, Volume: 215, Issue:1 Topics: Animals; Arginine; Blotting, Western; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Enzyme Induction; Enzyme Inhibitors; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase; Nitrogen Oxides; omega-N-Methylarginine; Shock, Septic; Spin Labels	1995
Detection of nitric oxide production in mice by spin-trapping electron paramagnetic resonance spectroscopy. Biochimica et biophysica acta, 1995, Aug-15, Volume: 1272, Issue:1 Topics: Animals; Arginine; Chelating Agents; Electron Spin Resonance Spectroscopy; Female; Ferrous Compounds; Kidney; Lipopolysaccharides; Liver; Mice; Mice, Inbred ICR; Nitrates; Nitric Oxide; Nitrites; Nitrogen Isotopes; omega-N-Methylarginine; Shock, Septic; Sorbitol; Spin Labels; Thiocarbamates	1995
A new approach in the treatment of hypotension in human septic shock by NG-monomethyl-L-arginine, an inhibitor of the nitric oxide synthetase. Intensive care medicine, 1993, Volume: 19, Issue:4 Topics: Adult; Amino Acid Oxidoreductases; Arginine; Blood Pressure; Cardiac Output; Combined Modality Therapy; Critical Care; Dose-Response Relationship, Drug; Humans; Hypotension; Male; Necrosis; Nitric Oxide Synthase; omega-N-Methylarginine; Pancreatitis; Pseudomonas aeruginosa; Pseudomonas Infections; Recurrence; Shock, Septic; Staphylococcal Infections	1993
Inhibition of the production of nitric oxide and vasodilator prostaglandins attenuates the cardiovascular response to bacterial endotoxin in adrenalectomized rats. Proceedings. Biological sciences, 1993, Sep-22, Volume: 253, Issue:1338 Topics: Adrenalectomy; Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Calcium; Dexamethasone; Escherichia coli; Glucocorticoids; Indomethacin; Lipopolysaccharides; Male; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; omega-N-Methylarginine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Shock, Septic; Time Factors	1993
Differential hemodynamic effects of L-NMMA in endotoxemic and normal dogs. The American journal of physiology, 1995, Volume: 268, Issue:4 Pt 2 Topics: Animals; Arginine; Dogs; Endotoxins; Hemodynamics; Nitric Oxide; omega-N-Methylarginine; Reference Values; Shock, Septic	1995
The role of nitric oxide in endotoxin-elicited hypodynamic circulatory failure. Advances in experimental medicine and biology, 1994, Volume: 366 Topics: Animals; Arginine; Blood Pressure; Cardiac Output; Endotoxins; Hemodynamics; Male; Nitric Oxide; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Shock, Septic; Vascular Resistance; Vasoconstriction	1994
L-arginine depletion by arginase reduces nitric oxide production in endotoxic shock: an electron paramagnetic resonance study. FEBS letters, 1995, Jun-12, Volume: 366, Issue:2-3 Topics: Animals; Arginase; Arginine; Ditiocarb; Electron Spin Resonance Spectroscopy; Ferrous Compounds; Kidney; Lipopolysaccharides; Liver; Lung; Male; Nitric Oxide; omega-N-Methylarginine; Rats; Rats, Inbred Lew; Shock, Septic; Spleen	1995
Inhibition of nitric oxide synthesis. Lancet (London, England), 1993, Dec-11, Volume: 342, Issue:8885 Topics: Arginine; Blood Pressure; Coronary Circulation; Heart Rate; Hemodynamics; Humans; Nitric Oxide; omega-N-Methylarginine; Shock, Septic	1993
NG-methyl-L-arginine, an inhibitor of nitric oxide formation, acts synergistically with dobutamine to improve cardiovascular performance in endotoxemic dogs. Critical care medicine, 1994, Volume: 22, Issue:11 Topics: Animals; Arginine; Cardiovascular System; Dobutamine; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Male; Nitric Oxide; omega-N-Methylarginine; Prospective Studies; Random Allocation; Shock, Septic; Time Factors	1994
Modulation of cyclic guanosine monophosphate production during Escherichia coli septic shock. Biochemical medicine and metabolic biology, 1994, Volume: 51, Issue:2 Topics: Animals; Arginine; Bacteremia; Carbon Dioxide; Cyclic GMP; Escherichia coli Infections; Lactates; Lactic Acid; Male; Nitric Oxide; omega-N-Methylarginine; Rabbits; Shock, Septic	1994
Spin trapping of nitric oxide produced in vivo in septic-shock mice. FEBS letters, 1994, May-30, Volume: 345, Issue:2-3 Topics: Animals; Arginine; Chelating Agents; Electron Spin Resonance Spectroscopy; Female; Kidney; Lipopolysaccharides; Liver; Mice; Mice, Inbred ICR; Nitric Oxide; omega-N-Methylarginine; Organ Specificity; Shock, Septic; Sorbitol; Spin Labels; Thiocarbamates; Time Factors	1994
In vitro femoral arterial responses to vasoconstrictor and vasodilator agents in endotoxin shock. Life sciences, 1994, Volume: 54, Issue:1 Topics: Acetylcholine; Animals; Arginine; Arginine Vasopressin; Bradykinin; Femoral Artery; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; omega-N-Methylarginine; Phenylephrine; Potassium Chloride; Rats; Rats, Wistar; Shock, Septic; Vasoconstrictor Agents; Vasodilator Agents	1994
Drugs which modulate nitric oxide homeostasis are likely to provide therapeutic benefit in cardiovascular disease. Cardiovascular research, 1993, Volume: 27, Issue:12 Topics: Animals; Arginine; Cardiovascular Diseases; Homeostasis; Humans; Mice; Nitric Oxide; omega-N-Methylarginine; Rats; Shock, Septic; Vasodilation	1993
Endotoxin-induced myocardial dysfunction: is there a role for nitric oxide? Shock (Augusta, Ga.), 1995, Volume: 4, Issue:5 Topics: Animals; Arginine; Enzyme Inhibitors; Guanidines; Guinea Pigs; Heart Atria; Immunoenzyme Techniques; Lipopolysaccharides; Male; Myocardial Contraction; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic	1995
Platelet-activating factor augments lipopolysaccharide-induced nitric oxide formation by rat Kupffer cells. Hepatology (Baltimore, Md.), 1996, Volume: 23, Issue:6 Topics: Animals; Arginine; Biological Transport, Active; Cells, Cultured; Cyclic GMP; Cycloheximide; Dactinomycin; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; Kinetics; Kupffer Cells; Lipopolysaccharides; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Platelet Activating Factor; Protein Synthesis Inhibitors; Rats; RNA, Messenger; Shock, Septic	1996
Effect of multiple cytokines plus bacterial endotoxin on glucose and nitric oxide production by cultured hepatocytes. The Biochemical journal, 1996, Jul-15, Volume: 317 ( Pt 2) Topics: Animals; Arginine; Cells, Cultured; Cytokines; Drug Interactions; Enzyme Inhibitors; Glucose; Lipopolysaccharides; Liver; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Shock, Septic; Time Factors	1996
Indirect evidence for stimulation of nitric oxide release by tumour necrosis factor-alpha in human veins in vivo. Cardiovascular research, 1995, Volume: 30, Issue:6 Topics: Adult; Arginine; Dose-Response Relationship, Drug; Humans; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phenylephrine; Shock, Septic; Tumor Necrosis Factor-alpha; Vasodilation; Veins	1995
Nitric oxide: moving towards the clinic. Molecular medicine today, 1996, Volume: 2, Issue:8 Topics: Animals; Arteriosclerosis; Clinical Trials, Phase I as Topic; Enzyme Inhibitors; Humans; Hypertension, Pulmonary; Inflammation; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic	1996
Evidence for tumor necrosis factor alpha as a mediator of the toxicity of a cyclooxygenase inhibitor in Gram-negative sepsis. European journal of pharmacology, 1996, Jun-27, Volume: 307, Issue:2 Topics: Animals; Cyclooxygenase Inhibitors; Female; Gene Amplification; Gene Expression; Indomethacin; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Nitric Oxide; omega-N-Methylarginine; Pentoxifylline; Polymerase Chain Reaction; Pseudomonas aeruginosa; Pseudomonas Infections; RNA, Messenger; Shock, Septic; Tumor Necrosis Factor-alpha	1996
Fatal cardiac side effects of L-NMMA? Critical care medicine, 1996, Volume: 24, Issue:11 Topics: Adult; Aged; Enzyme Inhibitors; Fatal Outcome; Hemodynamics; Humans; Male; omega-N-Methylarginine; Shock, Septic	1996
Effect of antileukocyte adhesion molecule antibodies, nitric oxide synthase inhibitor, and corticosteroids on endotoxin shock in mice. Surgery today, 1997, Volume: 27, Issue:1 Topics: Animals; Antibodies, Monoclonal; CD18 Antigens; Cell Adhesion Molecules; Endotoxemia; Granulocytes; Liver; Male; Methylprednisolone; Mice; Mice, Inbred ICR; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic	1997
Effects of nitric oxide on blood flow distribution and O2 extraction capabilities during endotoxic shock. Journal of applied physiology (Bethesda, Md. : 1985), 1997, Volume: 83, Issue:4 Topics: Animals; Blood Pressure; Cardiac Output; Cardiac Tamponade; Dogs; Endotoxins; Enzyme Inhibitors; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxygen Consumption; Regional Blood Flow; Shock, Septic; Sodium-Potassium-Exchanging ATPase; Vascular Resistance	1997
In vivo quantification of endotoxin-induced nitric oxide production in pigs from Na15NO3-infusion. British journal of pharmacology, 1997, Volume: 122, Issue:8 Topics: Animals; Blood Pressure; Carcinogens; Endotoxins; Enzyme Inhibitors; Infusions, Intravenous; Nitrates; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic; Swine; Vascular Resistance	1997
Nitric oxide and the haemodynamic profile of endotoxin shock in the conscious mouse. British journal of pharmacology, 1998, Volume: 124, Issue:3 Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Enzyme Inhibitors; Female; Hemodynamics; Interleukin-6; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Norepinephrine; omega-N-Methylarginine; Shock, Septic; Tumor Necrosis Factor-alpha	1998
Role of nitric oxide and cGMP in human septic serum-induced depression of cardiac myocyte contractility. The American journal of physiology, 1999, Volume: 276, Issue:1 Topics: Animals; Arginine; Blood Physiological Phenomena; Cyclic GMP; Drug Combinations; Enzyme Inhibitors; Humans; Interleukin-1; Methylene Blue; Myocardial Contraction; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nucleotides, Cyclic; omega-N-Methylarginine; Rats; Shock, Septic; Tumor Necrosis Factor-alpha	1999
Pharmacokinetics of the nitric oxide synthase inhibitor L-NG-methylarginine hydrochloride in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group. Clinical pharmacology and therapeutics, 1999, Volume: 65, Issue:1 Topics: Adult; Aged; Area Under Curve; Cohort Studies; Enzyme Inhibitors; Female; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Middle Aged; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic	1999
Beneficial effects of L-canavanine, a selective inhibitor of inducible nitric oxide synthase, on lactate metabolism and muscle high energy phosphates during endotoxic shock in rats. Shock (Augusta, Ga.), 1999, Volume: 11, Issue:2 Topics: Adenosine Triphosphate; Animals; Canavanine; Energy Metabolism; Enzyme Inhibitors; Hydrogen-Ion Concentration; Lactic Acid; Lipopolysaccharides; Muscle, Skeletal; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Phosphates; Phosphocreatine; Phosphorus Isotopes; Rats; Rats, Sprague-Dawley; Shock, Septic; Sodium Chloride; Spectrum Analysis	1999
Norepinephrine and nomega-monomethyl-L-arginine in porcine septic shock: effects on hepatic O2 exchange and energy balance. American journal of respiratory and critical care medicine, 1999, Volume: 159, Issue:6 Topics: Animals; Blood Pressure; Endotoxins; Energy Metabolism; Enzyme Inhibitors; Female; Glucose; Liver; Liver Circulation; Male; Norepinephrine; omega-N-Methylarginine; Oxygen Consumption; Shock, Septic; Swine; Vascular Resistance	1999
Effect of the nitric oxide inhibitor, L-N(G)-monomethylarginine, on accumulation of interleukin-6 and interleukin-8, and nuclear factor-kappaB activity in a human endothelial cell line. Critical care medicine, 1999, Volume: 27, Issue:5 Topics: Cell Line; Culture Media; Drug Evaluation, Preclinical; Endothelium; Humans; Interleukin-1; Interleukin-6; Interleukin-8; NF-kappa B; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic; Time Factors; Tumor Necrosis Factor-alpha	1999
Dynamic study of nitric oxide and endothelin-1 during endotoxin shock and effects of their antagonists on hemodynamics. Chinese medical journal, 1998, Volume: 111, Issue:3 Topics: Animals; Blood Pressure; Dexamethasone; Endothelin-1; Glycopeptides; Hemodynamics; Male; Nitric Oxide; omega-N-Methylarginine; Rabbits; Random Allocation; Shock, Septic	1998
Cytokine-induced venodilatation in humans in vivo: eNOS masquerading as iNOS. Cardiovascular research, 1999, Volume: 41, Issue:3 Topics: Adult; Arginine; Biopterins; Bradykinin; Endothelium, Vascular; Enzyme Inhibitors; Female; Gene Expression; Guanidines; Humans; Interleukin-1; Interleukin-6; Intracellular Signaling Peptides and Proteins; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Norepinephrine; omega-N-Methylarginine; Proteins; Reverse Transcriptase Polymerase Chain Reaction; Shock, Septic; Tumor Necrosis Factor-alpha; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents	1999
Effects of N-methyl-L-arginine on cardiac and regional blood flow in a dog endotoxin shock model. Journal of critical care, 2000, Volume: 15, Issue:1 Topics: Animals; Coronary Vessels; Disease Models, Animal; Dogs; Enzyme Inhibitors; Nitric Oxide Synthase; omega-N-Methylarginine; Regional Blood Flow; Shock, Septic; Vascular Resistance	2000
Protection against endotoxemia in rats by a novel tetrahydrobiopterin analogue. Shock (Augusta, Ga.), 2000, Volume: 13, Issue:5 Topics: Animals; Biopterins; Cell Line; Endotoxemia; Enzyme Inhibitors; Interleukin-6; Lipopolysaccharides; Male; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Shock, Septic; Tumor Necrosis Factor-alpha	2000
Relative contribution of preload and afterload to the reduction in cardiac output caused by nitric oxide synthase inhibition with L-N(G)-methylarginine hydrochloride 546C88. Critical care medicine, 2000, Volume: 28, Issue:5 Topics: Animals; Blood Pressure; Cardiac Output; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Humans; Male; Nitric Oxide Synthase; omega-N-Methylarginine; Phenylephrine; Shock, Septic; Vascular Resistance; Vasoconstrictor Agents; Ventricular Function, Left	2000
Norepinephrine and N(G)-monomethyl-L-arginine in hyperdynamic septic shock in pigs: effects on intestinal oxygen exchange and energy balance. Critical care medicine, 2000, Volume: 28, Issue:6 Topics: Animals; Energy Metabolism; Enzyme Inhibitors; Female; Intestinal Mucosa; Intestines; Male; Norepinephrine; omega-N-Methylarginine; Oxygen; Shock, Septic; Swine; Vasoconstrictor Agents	2000
Tissue oxygenation and hemodynamic response to NO synthase inhibition in septic shock. Shock (Augusta, Ga.), 2000, Volume: 14, Issue:1 Topics: Adrenergic Agonists; Adult; Aged; Cell Hypoxia; Drug Evaluation; Drug Therapy, Combination; Enzyme Inhibitors; Female; Hemodynamics; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-N-Methylarginine; Oxygen Consumption; Prospective Studies; Shock, Septic; Treatment Outcome	2000
Increase in gastric intramucosal hydrogen ion concentration following endotoxin challenge in the rat and the actions of nitric oxide synthase inhibitors. Clinical and experimental pharmacology & physiology, 2001, Volume: 28, Issue:3 Topics: Animals; Endotoxins; Enzyme Inhibitors; Gastric Mucosa; Hydrogen-Ion Concentration; Lipopolysaccharides; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Rats; Shock, Septic	2001
Safeguarding patients in clinical trials with high mortality rates. American journal of respiratory and critical care medicine, 2001, Jul-15, Volume: 164, Issue:2 Topics: Aspirin; Blood Substitutes; Clinical Trials as Topic; Critical Illness; Hemoglobins; Human Growth Hormone; Humans; omega-N-Methylarginine; Shock, Hemorrhagic; Shock, Septic	2001
Endotoxin-induced liver hypoxia: defective oxygen delivery versus oxygen consumption. Nitric oxide : biology and chemistry, 2002, Volume: 6, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Endotoxins; Hemodynamics; Hypoxia; Interleukin-13; Lipopolysaccharides; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; omega-N-Methylarginine; Oxygen; Partial Pressure; Shock, Septic	2002
The role of nitric oxide in endotoxic shock: effects of NG-monomethyl-L-arginine. Journal of cardiovascular pharmacology, 1992, Volume: 20 Suppl 12 Topics: Alanine Transaminase; Animals; Arginine; Blood Pressure; Dexamethasone; Lipopolysaccharides; Male; Nitrates; Nitric Oxide; Nitrites; omega-N-Methylarginine; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Shock, Septic	1992
Inhibition of NO synthesis in septic shock. Lancet (London, England), 1992, Feb-15, Volume: 339, Issue:8790 Topics: Arginine; Hemodynamics; Humans; Nitric Oxide; omega-N-Methylarginine; Shock, Septic	1992
Inhibition of NO synthesis in septic shock. Lancet (London, England), 1992, Feb-15, Volume: 339, Issue:8790 Topics: Adult; Arginine; Hemodynamics; Humans; Male; omega-N-Methylarginine; Shock, Septic	1992
NO inhibitors and septic shock. Lancet (London, England), 1992, Mar-21, Volume: 339, Issue:8795 Topics: Animals; Arginine; Humans; Nitric Oxide; omega-N-Methylarginine; Rats; Shock, Septic	1992
Nitric oxide mediates the vascular actions of cytokines in septic shock. European journal of clinical investigation, 1992, Volume: 22, Issue:6 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cytokines; Humans; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Shock, Septic; Vasodilation	1992
Protective and pathological roles of nitric oxide in endotoxin shock. Cardiovascular research, 1992, Volume: 26, Issue:1 Topics: Animals; Arginine; Blood Pressure; Dexamethasone; Disease Models, Animal; Heart Rate; Male; Nitric Oxide; omega-N-Methylarginine; Penicillamine; Rabbits; Regional Blood Flow; S-Nitroso-N-Acetylpenicillamine; Shock, Septic	1992
Nitric oxide from endothelium and smooth muscle modulates responses to sympathetic nerve stimulation: implications for endotoxin shock. Biochemical and biophysical research communications, 1992, Jul-15, Volume: 186, Issue:1 Topics: Acetylcholine; Animals; Arginine; Cycloheximide; Dexamethasone; Dinoprost; Endothelium, Vascular; Endotoxins; Iliac Artery; In Vitro Techniques; Interferon-gamma; Isometric Contraction; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Phentolamine; Prazosin; Rats; Rats, Inbred Strains; Shock, Septic	1992
NG-monomethyl-l-arginine (NMA) restores arterial blood pressure but reduces cardiac output in a canine model of endotoxic shock. Biochemical and biophysical research communications, 1991, Aug-15, Volume: 178, Issue:3 Topics: Animals; Arginine; Blood Pressure; Cardiac Output; Dogs; Endotoxins; Femoral Artery; Hemodynamics; Male; omega-N-Methylarginine; Regional Blood Flow; Shock, Septic; Vascular Resistance	1991
Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis. Biochemical and biophysical research communications, 1990, Nov-15, Volume: 172, Issue:3 Topics: Animals; Arginine; Blood Pressure; Cytokines; Dogs; Endotoxins; Female; Hypertension; Kinetics; Male; Nitric Oxide; omega-N-Methylarginine; Shock, Septic; Vascular Resistance	1990