Compounds > 4-aminopyrazolo(3,4-d)pyrimidine
Page last updated: 2024-09-24

4-aminopyrazolo(3,4-d)pyrimidine

Description

4-aminopyrazolo(3,4-d)pyrimidine: adenine analog which suppresses growth of E coli & Bacillus cereus; inhibits cell growth & purine biosynthesis in rat hepatoma [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID75420
CHEMBL ID388593
SCHEMBL ID11362
MeSH IDM0045478

Synonyms (72)

Synonym
BIDD:GT0454
4-amino-pyrazolo(3,4-d)pyrimidine
4-aminopyrazolo[3,4-d]pyrimidine ,
nsc-1393
4 app
4-aminopyrazole[3,4-d]pyrimidine
nsc1393
4-aminopyrazolopyrimidine
pyrazoloadenine
1h-pyrazolo[3,4-d]pyrimidin-4-amine
2380-63-4
4-app
4-aminopyrazolo(3,4-d)pyrimidine
AB-323/25048512
1h-pyrazolo(3,4-d)pyrimidine, 4-amino-
nsc 1393
4-aminopyrazole(3,4-d)pyrimidine
brn 0005824
1h-pyrazolo(3,4-d)pyrimidin-4-amine
ai3-52467
einecs 219-174-6
1h-pyrazolo[3,4-d]pyrimidin-4-ylamine
8-aza-7-deazaadenine
4-aminopyrazolo[3,4-d]pyrimidine, 98%
A1041
4-amino-1h-pyrazolo[3,4-d]pyrimidine
CHEMBL388593 ,
64834-00-0
F9995-0069
bdbm50208876
STK803066
AKOS004910187
A4965
BBL002049
A814399
2h-pyrazolo[3,4-d]pyrimidin-4-amine
unii-0356mat9lx
0356mat9lx ,
pyrazolo(3,4-d)pyrimidin-4-amine
BP-12357
FT-0617604
AM20090259
AB00505
SCHEMBL11362
SY007560
mfcd00005688
1h-pyrazolo[3, 4-d]pyrimidin-4-amine
4-aminopyrazolo-(3,4-d)pyrimidine
DTXSID3062362
TS-00024
1h-pyrazolo[3,4-d]pyrimidine, 4-amino-
W-201772
W-200546
Z57101323
CS-D1726
7-deaza-8-azaadenine
4-amino-1h-pyrazolo(3,4-d)pyrimidine
1h-pyrazolo(3,4-d)pyrimidin-4-ylamine
AC-8162
FT-0740764
BCP01216
SB12011
Q27247530
AT24508
HY-34595
4-aminopyrazolo[5,4-d]pyrimidine
4-amino-pyrazolo[3,4-d]pyrimidine
1h-pyrazolo[3,4-d]pyrimidine-4-ylamine
2~{h}-pyrazolo[3,4-d]pyrimidin-4-amine
TVW ,
EN300-91349
4-aminopyrazolo[3,4-d] pyrimidine

Protein Targets (6)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Phosphatidylinositol 4-kinase alphaHomo sapiens (human)IC50 (µMol)144.90000.28003.69007.1000AID155650
Xanthine dehydrogenase/oxidaseHomo sapiens (human)IC50 (µMol)30.26000.00132.81389.8200AID287937
Leucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)IC50 (µMol)26.63000.00040.39438.3000AID1817494
Leucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)Ki11.31200.00061.13536.7150AID1817495
Phosphatidylinositol 4-kinase type 2-betaHomo sapiens (human)IC50 (µMol)144.90007.10007.10007.1000AID155650
Phosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)IC50 (µMol)144.90007.10007.10007.1000AID155650
Phosphatidylinositol 4-kinase betaHomo sapiens (human)IC50 (µMol)144.90000.01832.45107.1000AID155650
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (127)

Processvia Protein(s)Taxonomy
phosphorylationPhosphatidylinositol 4-kinase alphaHomo sapiens (human)
phosphatidylinositol biosynthetic processPhosphatidylinositol 4-kinase alphaHomo sapiens (human)
signal transductionPhosphatidylinositol 4-kinase alphaHomo sapiens (human)
modulation by host of viral processPhosphatidylinositol 4-kinase alphaHomo sapiens (human)
phosphatidylinositol phosphate biosynthetic processPhosphatidylinositol 4-kinase alphaHomo sapiens (human)
reorganization of cellular membranes to establish viral sites of replicationPhosphatidylinositol 4-kinase alphaHomo sapiens (human)
phosphatidylinositol-mediated signalingPhosphatidylinositol 4-kinase alphaHomo sapiens (human)
allantoin metabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
negative regulation of protein phosphorylationXanthine dehydrogenase/oxidaseHomo sapiens (human)
negative regulation of endothelial cell proliferationXanthine dehydrogenase/oxidaseHomo sapiens (human)
guanine catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
inosine catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
deoxyinosine catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
adenosine catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
deoxyadenosine catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
deoxyguanosine catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
AMP catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
IMP catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
lactationXanthine dehydrogenase/oxidaseHomo sapiens (human)
hypoxanthine catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
xanthine catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
negative regulation of gene expressionXanthine dehydrogenase/oxidaseHomo sapiens (human)
iron-sulfur cluster assemblyXanthine dehydrogenase/oxidaseHomo sapiens (human)
amide catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
negative regulation of endothelial cell differentiationXanthine dehydrogenase/oxidaseHomo sapiens (human)
GMP catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
dGMP catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
dAMP catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionXanthine dehydrogenase/oxidaseHomo sapiens (human)
positive regulation of p38MAPK cascadeXanthine dehydrogenase/oxidaseHomo sapiens (human)
negative regulation of vascular endothelial growth factor signaling pathwayXanthine dehydrogenase/oxidaseHomo sapiens (human)
positive regulation of reactive oxygen species metabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
negative regulation of vasculogenesisXanthine dehydrogenase/oxidaseHomo sapiens (human)
negative regulation of GTPase activityLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
MAPK cascadeLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
negative regulation of protein phosphorylationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
positive regulation of protein phosphorylationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
protein phosphorylationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
protein import into nucleusLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
endocytosisLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
autophagyLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
response to oxidative stressLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
mitochondrion organizationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
endoplasmic reticulum organizationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
Golgi organizationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
lysosome organizationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
JNK cascadeLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
Rho protein signal transductionLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
spermatogenesisLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
neuromuscular junction developmentLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
protein localizationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
determination of adult lifespanLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
cellular response to starvationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of autophagyLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
positive regulation of autophagyLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of protein kinase A signalingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
negative regulation of protein processingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
negative regulation of neuron projection developmentLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of neuron maturationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
negative regulation of macroautophagyLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
phosphorylationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
peptidyl-serine phosphorylationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
peptidyl-threonine phosphorylationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
calcium-mediated signalingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
striatum developmentLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
olfactory bulb developmentLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
tangential migration from the subventricular zone to the olfactory bulbLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
positive regulation of protein ubiquitinationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of protein stabilityLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
negative regulation of protein bindingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
positive regulation of protein bindingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
positive regulation of proteasomal ubiquitin-dependent protein catabolic processLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
positive regulation of tumor necrosis factor productionLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
cellular response to oxidative stressLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
cellular response to reactive oxygen speciesLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
intracellular signal transductionLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of kidney sizeLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
exploration behaviorLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
locomotory exploration behaviorLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of lysosomal lumen pHLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of locomotionLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of membrane potentialLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
positive regulation of programmed cell deathLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
positive regulation of MAP kinase activityLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
positive regulation of protein kinase activityLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
GTP metabolic processLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
protein autophosphorylationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
intracellular distribution of mitochondriaLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
neuron projection morphogenesisLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
mitochondrion localizationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
positive regulation of nitric-oxide synthase biosynthetic processLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of mitochondrial depolarizationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of synaptic transmission, glutamatergicLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
canonical Wnt signaling pathwayLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
excitatory postsynaptic potentialLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of dopamine receptor signaling pathwayLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
positive regulation of dopamine receptor signaling pathwayLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of ER to Golgi vesicle-mediated transportLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of canonical Wnt signaling pathwayLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of dendritic spine morphogenesisLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
protein localization to mitochondrionLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
protein localization to endoplasmic reticulum exit siteLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
cellular response to manganese ionLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of mitochondrial fissionLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
positive regulation of canonical Wnt signaling pathwayLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
negative regulation of excitatory postsynaptic potentialLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
neuron projection arborizationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
positive regulation of synaptic vesicle endocytosisLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
positive regulation of protein autoubiquitinationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of neuroblast proliferationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of synaptic vesicle transportLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
negative regulation of late endosome to lysosome transportLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
negative regulation of autophagosome assemblyLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
negative regulation of protein targeting to mitochondrionLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
negative regulation of protein processing involved in protein targeting to mitochondrionLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
cellular response to dopamineLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
positive regulation of microglial cell activationLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
Wnt signalosome assemblyLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of retrograde transport, endosome to GolgiLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of CAMKK-AMPK signaling cascadeLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of branching morphogenesis of a nerveLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of synaptic vesicle exocytosisLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
regulation of reactive oxygen species metabolic processLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
signal transductionLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
phosphatidylinositol biosynthetic processPhosphatidylinositol 4-kinase type 2-betaHomo sapiens (human)
phosphatidylinositol phosphate biosynthetic processPhosphatidylinositol 4-kinase type 2-betaHomo sapiens (human)
endosome organizationPhosphatidylinositol 4-kinase type 2-betaHomo sapiens (human)
Golgi organizationPhosphatidylinositol 4-kinase type 2-betaHomo sapiens (human)
phosphatidylinositol biosynthetic processPhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
phosphatidylinositol phosphate biosynthetic processPhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
endosome organizationPhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
Golgi organizationPhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
lysosome organizationPhosphatidylinositol 4-kinase betaHomo sapiens (human)
phosphatidylinositol biosynthetic processPhosphatidylinositol 4-kinase betaHomo sapiens (human)
receptor-mediated endocytosisPhosphatidylinositol 4-kinase betaHomo sapiens (human)
signal transductionPhosphatidylinositol 4-kinase betaHomo sapiens (human)
inner ear developmentPhosphatidylinositol 4-kinase betaHomo sapiens (human)
phosphatidylinositol phosphate biosynthetic processPhosphatidylinositol 4-kinase betaHomo sapiens (human)
phosphatidylinositol-mediated signalingPhosphatidylinositol 4-kinase betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (41)

Processvia Protein(s)Taxonomy
1-phosphatidylinositol 4-kinase activityPhosphatidylinositol 4-kinase alphaHomo sapiens (human)
protein bindingPhosphatidylinositol 4-kinase alphaHomo sapiens (human)
ATP bindingPhosphatidylinositol 4-kinase alphaHomo sapiens (human)
kinase activityPhosphatidylinositol 4-kinase alphaHomo sapiens (human)
cadherin bindingPhosphatidylinositol 4-kinase alphaHomo sapiens (human)
xanthine dehydrogenase activityXanthine dehydrogenase/oxidaseHomo sapiens (human)
xanthine oxidase activityXanthine dehydrogenase/oxidaseHomo sapiens (human)
iron ion bindingXanthine dehydrogenase/oxidaseHomo sapiens (human)
protein bindingXanthine dehydrogenase/oxidaseHomo sapiens (human)
protein homodimerization activityXanthine dehydrogenase/oxidaseHomo sapiens (human)
molybdopterin cofactor bindingXanthine dehydrogenase/oxidaseHomo sapiens (human)
flavin adenine dinucleotide bindingXanthine dehydrogenase/oxidaseHomo sapiens (human)
2 iron, 2 sulfur cluster bindingXanthine dehydrogenase/oxidaseHomo sapiens (human)
hypoxanthine dehydrogenase activityXanthine dehydrogenase/oxidaseHomo sapiens (human)
hypoxanthine oxidase activityXanthine dehydrogenase/oxidaseHomo sapiens (human)
FAD bindingXanthine dehydrogenase/oxidaseHomo sapiens (human)
SNARE bindingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
magnesium ion bindingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
actin bindingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
GTPase activityLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
protein kinase activityLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
protein serine/threonine kinase activityLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
JUN kinase kinase kinase activityLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
MAP kinase kinase kinase activityLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
GTPase activator activityLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
protein bindingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
ATP bindingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
GTP bindingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
microtubule bindingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
tubulin bindingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
kinase activityLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
syntaxin-1 bindingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
signaling receptor complex adaptor activityLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
clathrin bindingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
small GTPase bindingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
GTP-dependent protein kinase activityLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
peroxidase inhibitor activityLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
co-receptor bindingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
identical protein bindingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
protein homodimerization activityLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
transmembrane transporter bindingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
protein kinase A bindingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
protein serine kinase activityLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
beta-catenin destruction complex bindingLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
1-phosphatidylinositol 4-kinase activityPhosphatidylinositol 4-kinase type 2-betaHomo sapiens (human)
ATP bindingPhosphatidylinositol 4-kinase type 2-betaHomo sapiens (human)
magnesium ion bindingPhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
1-phosphatidylinositol 4-kinase activityPhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
protein bindingPhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
ATP bindingPhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
AP-3 adaptor complex bindingPhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
1-phosphatidylinositol 4-kinase activityPhosphatidylinositol 4-kinase betaHomo sapiens (human)
protein bindingPhosphatidylinositol 4-kinase betaHomo sapiens (human)
ATP bindingPhosphatidylinositol 4-kinase betaHomo sapiens (human)
14-3-3 protein bindingPhosphatidylinositol 4-kinase betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (55)

Processvia Protein(s)Taxonomy
cytoplasmPhosphatidylinositol 4-kinase alphaHomo sapiens (human)
cytosolPhosphatidylinositol 4-kinase alphaHomo sapiens (human)
plasma membranePhosphatidylinositol 4-kinase alphaHomo sapiens (human)
focal adhesionPhosphatidylinositol 4-kinase alphaHomo sapiens (human)
membranePhosphatidylinositol 4-kinase alphaHomo sapiens (human)
Golgi-associated vesicle membranePhosphatidylinositol 4-kinase alphaHomo sapiens (human)
extracellular exosomePhosphatidylinositol 4-kinase alphaHomo sapiens (human)
plasma membranePhosphatidylinositol 4-kinase alphaHomo sapiens (human)
cytoplasmPhosphatidylinositol 4-kinase alphaHomo sapiens (human)
cytosolXanthine dehydrogenase/oxidaseHomo sapiens (human)
extracellular spaceXanthine dehydrogenase/oxidaseHomo sapiens (human)
peroxisomeXanthine dehydrogenase/oxidaseHomo sapiens (human)
cytosolXanthine dehydrogenase/oxidaseHomo sapiens (human)
sarcoplasmic reticulumXanthine dehydrogenase/oxidaseHomo sapiens (human)
extracellular spaceXanthine dehydrogenase/oxidaseHomo sapiens (human)
Golgi membraneLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
extracellular spaceLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
cytoplasmLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
mitochondrionLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
mitochondrial outer membraneLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
mitochondrial inner membraneLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
mitochondrial matrixLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
lysosomeLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
endosomeLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
endoplasmic reticulumLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
endoplasmic reticulum membraneLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
Golgi apparatusLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
Golgi-associated vesicleLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
trans-Golgi networkLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
cytosolLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
cytoskeletonLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
plasma membraneLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
microvillusLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
axonLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
dendriteLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
growth coneLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
synaptic vesicle membraneLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
cytoplasmic vesicleLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
mitochondrial membraneLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
cytoplasmic side of mitochondrial outer membraneLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
dendrite cytoplasmLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
neuron projectionLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
neuronal cell bodyLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
terminal boutonLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
perikaryonLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
intracellular membrane-bounded organelleLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
amphisomeLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
autolysosomeLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
extracellular exosomeLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
endoplasmic reticulum exit siteLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
multivesicular body, internal vesicleLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
postsynapseLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
glutamatergic synapseLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
caveola neckLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
presynaptic cytosolLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
ribonucleoprotein complexLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
Wnt signalosomeLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)
Golgi membranePhosphatidylinositol 4-kinase type 2-betaHomo sapiens (human)
endoplasmic reticulum membranePhosphatidylinositol 4-kinase type 2-betaHomo sapiens (human)
cytosolPhosphatidylinositol 4-kinase type 2-betaHomo sapiens (human)
plasma membranePhosphatidylinositol 4-kinase type 2-betaHomo sapiens (human)
membranePhosphatidylinositol 4-kinase type 2-betaHomo sapiens (human)
early endosome membranePhosphatidylinositol 4-kinase type 2-betaHomo sapiens (human)
endosomePhosphatidylinositol 4-kinase type 2-betaHomo sapiens (human)
trans-Golgi networkPhosphatidylinositol 4-kinase type 2-betaHomo sapiens (human)
plasma membranePhosphatidylinositol 4-kinase type 2-betaHomo sapiens (human)
BLOC-1 complexPhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
Golgi membranePhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
mitochondrionPhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
lysosomal membranePhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
endosomePhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
cytosolPhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
plasma membranePhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
membranePhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
dendritePhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
cytoplasmic vesiclePhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
early endosome membranePhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
growing cell tipPhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
presynaptic membranePhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
neuron projectionPhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
neuronal cell bodyPhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
perikaryonPhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
membrane raftPhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
trans-Golgi networkPhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
plasma membranePhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
endosomePhosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)
Golgi membranePhosphatidylinositol 4-kinase betaHomo sapiens (human)
mitochondrial outer membranePhosphatidylinositol 4-kinase betaHomo sapiens (human)
endosomePhosphatidylinositol 4-kinase betaHomo sapiens (human)
Golgi apparatusPhosphatidylinositol 4-kinase betaHomo sapiens (human)
cytosolPhosphatidylinositol 4-kinase betaHomo sapiens (human)
rough endoplasmic reticulum membranePhosphatidylinositol 4-kinase betaHomo sapiens (human)
perinuclear region of cytoplasmPhosphatidylinositol 4-kinase betaHomo sapiens (human)
membranePhosphatidylinositol 4-kinase betaHomo sapiens (human)
cytoplasmPhosphatidylinositol 4-kinase betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID1817495Binding affinity to human GST tagged truncated LRRK2 G2019S mutant incubated for 2 hrs by TR-FRET based Lanthascreen kinase activity assay
AID1753482Selectivity index, ratio of CC50 for human MRC-5 SV2 cells to IC50 for antitrypanosomal activity against nifurtimox-sensitive Trypanosoma cruzi Tulahuen CL2 infected in human MRC-5 SV2 cells2021Journal of medicinal chemistry, 04-08, Volume: 64, Issue:7
Revisiting Pyrazolo[3,4-
AID287938Inhibition of human xanthine oxidase at 30 uM2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors.
AID1753481Cytotoxicity against human MRC-5 SV2 cells assessed as reduction in cell growth measured after 3 days by resazurin dye based fluorometric analysis2021Journal of medicinal chemistry, 04-08, Volume: 64, Issue:7
Revisiting Pyrazolo[3,4-
AID1753485Selectivity index, ratio of CC50 for Swiss mouse peritoneal macrophages to IC50 for antileishmanial activity against amastigote form of Leishmania infantum MHOM/MA(BE)/67 infected in Swiss mouse peritoneal macrophages2021Journal of medicinal chemistry, 04-08, Volume: 64, Issue:7
Revisiting Pyrazolo[3,4-
AID155653Binding affinity (Ki) against human phosphatidylinositol 4-kinase1990Journal of medicinal chemistry, Aug, Volume: 33, Issue:8
Purine derivatives as competitive inhibitors of human erythrocyte membrane phosphatidylinositol 4-kinase.
AID1753484Cytotoxicity against Swiss mouse peritoneal macrophages assessed as cell detachment, lysis and granulation measured after 5 days by microscopic analysis2021Journal of medicinal chemistry, 04-08, Volume: 64, Issue:7
Revisiting Pyrazolo[3,4-
AID287937Inhibition of human xanthine oxidase2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors.
AID1817494Inhibition of recombinant human GST tagged truncated LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate in presence of ATP preincubated for 50 mins followed by anti-phospho-LRRKtide antibody addition and measured after 30 mins by TR-FRET
AID1753480Antitrypanosomal activity against nifurtimox-sensitive Trypanosoma cruzi Tulahuen CL2 infected in human MRC-5 SV2 cells assessed as inhibition of parasite growth measured after 7 days by spectrophotometric analysis2021Journal of medicinal chemistry, 04-08, Volume: 64, Issue:7
Revisiting Pyrazolo[3,4-
AID1753483Antileishmanial activity against amastigote form of Leishmania infantum MHOM/MA(BE)/67 infected in Swiss mouse peritoneal macrophages assessed as reduction in parasite growth treated at 2 hrs post-infection and measured after 5 days by Giemsa staining bas2021Journal of medicinal chemistry, 04-08, Volume: 64, Issue:7
Revisiting Pyrazolo[3,4-
AID155650Inhibitory activity (IC50) against human phosphatidylinositol 4-kinase at the ATP binding site1990Journal of medicinal chemistry, Aug, Volume: 33, Issue:8
Purine derivatives as competitive inhibitors of human erythrocyte membrane phosphatidylinositol 4-kinase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (100)

TimeframeStudies, This Drug (%)All Drugs %
pre-199061 (61.00)18.7374
1990's21 (21.00)18.2507
2000's5 (5.00)29.6817
2010's11 (11.00)24.3611
2020's2 (2.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (0.96%)5.53%
Reviews2 (1.92%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other101 (97.12%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
9-ethyladenine[no description available]medium10
purine[no description available]medium30purine
n(6),n(6)-dimethyladenine[no description available]medium20tertiary amine
1-phenyl-4-pyrazolo[3,4-d]pyrimidinamine[no description available]medium10pyrazoles;
ring assembly
sq 22536[no description available]medium10nucleoside analogue;
oxolanes		EC 4.6.1.1 (adenylate cyclase) inhibitor
adenosine diphosphate[no description available]medium10adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		fundamental metabolite;
human metabolite
adenosine monophosphate[no description available]medium10adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
2-aminopurine[no description available]medium202-aminopurines;
nucleobase analogue		antimetabolite
alpha-aminopyridine[no description available]medium10
9-benzyladenine[no description available]medium10
adenosine[no description available]medium20adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
benzylaminopurine[no description available]medium106-aminopurinescytokinin;
plant metabolite
4-aminopyrimidine[no description available]medium10aminopyrimidine
9-methyladenine[no description available]medium10methyladeninemetabolite
6-methoxypurine[no description available]medium10
7-methyladenine[no description available]medium10methyladeninemetabolite
1-aminoisoquinoline[no description available]medium10
4-aminoquinazoline[no description available]medium10
3-deazaadenine[no description available]medium10
6-methylpurine[no description available]medium10purinesEC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor
1-methyladenine[no description available]medium10
3-methyladenine[no description available]medium10
adenine[no description available]medium10206-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
adenine[no description available]medium10216-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
5,6-dimethylbenzimidazole[no description available]medium10dimethylbenzimidazoleEscherichia coli metabolite;
human metabolite
5-methylbenzimidazole[no description available]medium10imidazoles
2,6-diaminopurine[no description available]medium102,6-diaminopurines;
primary amino compound		antineoplastic agent
o-(6)-methylguanine[no description available]medium10methylguaninemutagen
1-methylxanthine[no description available]medium101-methylxanthinemouse metabolite
thioguanine anhydrous[no description available]medium102-aminopurinesanticoronaviral agent;
antimetabolite;
antineoplastic agent
2-amino-6-chloropurine[no description available]medium102-aminopurines;
organochlorine compound
allopurinol[no description available]medium90nucleobase analogue;
organic heterobicyclic compound		antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger
miltefosine[no description available]medium10phosphocholines;
phospholipid		anti-inflammatory agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
apoptosis inducer;
immunomodulator;
protein kinase inhibitor
tubercidin[no description available]medium10antibiotic antifungal agent;
N-glycosylpyrrolopyrimidine;
ribonucleoside		antimetabolite;
antineoplastic agent;
bacterial metabolite
benzonidazole[no description available]medium10C-nitro compound;
imidazoles;
monocarboxylic acid amide		antiprotozoal drug
allopurinol riboside[no description available]medium40nucleoside analoguemetabolite
ly2584702[no description available]medium21
pyrimidine[no description available]medium40diazine;
pyrimidines		Daphnia magna metabolite
tetrahexylammonium[no description available]medium10
2-aminopyrimidine[no description available]medium10aminopyrimidine
substance p[no description available]medium20peptideneurokinin-1 receptor agonist;
neurotransmitter;
vasodilator agent
neurotensin[no description available]medium20peptide hormonehuman metabolite;
mitogen;
neurotransmitter;
vulnerary
corticosterone[no description available]medium8011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
cycloheximide[no description available]medium20antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
8-bromo cyclic adenosine monophosphate[no description available]medium103',5'-cyclic purine nucleotide;
adenyl ribonucleotide;
organobromine compound		antidepressant;
protein kinase agonist
aldosterone[no description available]medium1011beta-hydroxy steroid;
18-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
mineralocorticoid;
primary alpha-hydroxy ketone;
steroid aldehyde		human metabolite;
mouse metabolite
tisopurine[no description available]medium30pyrazolopyrimidine
formycins[no description available]medium30
formycin b[no description available]medium30formycin
thiopurinol ribonucleoside[no description available]medium30
inosine[no description available]medium10inosines;
purines D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
phosphatidylcholines[no description available]medium101,2-diacyl-sn-glycero-3-phosphocholine
ethinyl estradiol[no description available]medium4017-hydroxy steroid;
3-hydroxy steroid;
terminal acetylenic compound		xenoestrogen
tyloxapol[no description available]medium30
leucine[no description available]medium10amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
mevalonic acid[no description available]medium103,5-dihydroxy-3-methylpentanoic acid
pregnenolone[no description available]medium1020-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
C21-steroid		human metabolite;
mouse metabolite
aminoglutethimide[no description available]medium50dicarboximide;
piperidones;
substituted aniline		adrenergic agent;
anticonvulsant;
antineoplastic agent;
EC 1.14.14.14 (aromatase) inhibitor
cholesteryl oleate[no description available]medium10CE(18:1);
cholesteryl octadec-9-enoate		mouse metabolite
d-alpha tocopherol[no description available]medium10alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
metallothionein[no description available]medium20
dimethyl sulfoxide[no description available]medium10sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
simvastatin[no description available]medium10delta-lactone;
fatty acid ester;
hexahydronaphthalenes;
statin (semi-synthetic)		EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor;
EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor;
ferroptosis inducer;
geroprotector;
prodrug
lovastatin[no description available]medium20delta-lactone;
fatty acid ester;
hexahydronaphthalenes;
polyketide;
statin (naturally occurring)		anticholesteremic drug;
antineoplastic agent;
Aspergillus metabolite;
prodrug
azaguanine[no description available]medium10nucleobase analogue;
triazolopyrimidines		antimetabolite;
antineoplastic agent;
EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor
riboflavin[no description available]medium10flavin;
vitamin B2		anti-inflammatory agent;
antioxidant;
cofactor;
Escherichia coli metabolite;
food colouring;
fundamental metabolite;
human urinary metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite
oleic acid[no description available]medium10octadec-9-enoic acidantioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent
uridine triphosphate[no description available]medium10pyrimidine ribonucleoside 5'-triphosphate;
uridine 5'-phosphate		Escherichia coli metabolite;
mouse metabolite
glycogen[no description available]medium10
cholesteryl linoleyl ether[no description available]medium10
tyramine[no description available]medium10monoamine molecular messenger;
primary amino compound;
tyramines		EC 3.1.1.8 (cholinesterase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter
dilactitol tyramine[no description available]medium10
iodine[no description available]medium10diatomic iodinenutrient
phenyl acetate[no description available]medium10benzenes;
phenyl acetates
1-anilino-8-naphthalenesulfonate[no description available]medium10aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
formycin[no description available]medium10formycinantineoplastic agent
adenosine kinase[no description available]medium10
naloxone[no description available]medium10morphinane alkaloid;
organic heteropentacyclic compound;
tertiary alcohol		antidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist
oligonucleotides[no description available]medium50
phosphoramidite[no description available]medium30
uracil[no description available]medium20pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
glycosides[no description available]medium10
silver[no description available]medium10copper group element atom;
elemental silver		Escherichia coli metabolite
7-deazapurine[no description available]medium10
azides[no description available]medium10pseudohalide anionmitochondrial respiratory-chain inhibitor
azauracil[no description available]medium101,2,4-triazines;
nucleobase analogue		antimetabolite
pyrroles[no description available]medium10pyrrole;
secondary amine
guanine[no description available]medium102-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
7-deazaguanine[no description available]medium10organic molecular entity
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Liver Injury, Drug-Induced0low10
Adenocarcinoma0low10
Adenocarcinoma, Basal Cell0low10
Adenocarcinoma, Granular Cell0low10
Adenocarcinoma, Oxyphilic0low10
Adenocarcinoma, Tubular0low10
Adenoma, Malignant0low10
Aging0low10
Alloxan Diabetes0low20
American Trypanosomiasis0low30
Apolipoprotein B-100, Familial Defective0low10
Apolipoprotein B-100, Familial Ligand-Defective0low10
Ascites0low10
Benign Neoplasms0low30
Body Weight0low40
Cancer0low30
Cancer of Testis0low10
Cancer of the Testes0low10
Cancer of the Testis0low10
Carcinoma, Cribriform0low10
Carcinoma, Granular Cell0low10
Carcinoma, Tubular0low10
Chagas Disease0low30
Chagas' Disease0low30
Chemical and Drug Induced Liver Injury0low10
Chemically-Induced Liver Toxicity0low10
Diabetes Mellitus, Experimental0low20
Drug-Induced Acute Liver Injury0low10
Drug-Induced Liver Disease0low10
Drug-Induced Liver Injury0low10
Dyslipidemia0medium21
Dyslipidemias0medium21
Dyslipoproteinemias0medium21
Elevated Cholesterol0low10
Endotoxin Shock0low10
Experimental Diabetes Mellitus0low20
Experimental Neoplasms0low10
Familial Combined Hyperlipoproteinemia0low10
Fatty Liver0low10
Hepatitis, Drug-Induced0low10
Hepatitis, Toxic0low10
High Cholesterol Levels0low10
Hyper-beta-Lipoproteinemia0low10
Hyper-Low Density Lipoproteinemia0low10
Hyper-Low-Density-Lipoproteinemia0low10
Hyperbetalipoproteinemia0low10
Hypercholesteremia0low10
Hypercholesterolemia0low10
Hypercholesterolemia, Autosomal Dominant0low10
Hypercholesterolemia, Autosomal Dominant, Type B0low10
Hypercholesterolemia, Essential0low10
Hypercholesterolemia, Familial0low10
Hypercholesterolemic Xanthomatosis, Familial0low10
Hyperlipoproteinemia Type 20low10
Hyperlipoproteinemia Type II0low10
Hyperlipoproteinemia Type IIa0low10
Hyperlipoproteinemia Type IIb0low10
Hyperlipoproteinemia, Type II0low10
Hyperlipoproteinemia, Type IIa0low10
Hyperplasia0low10
Hypolipoproteinemia0low10
Hypolipoproteinemias0low10
Hypoprebetalipoproteinemia0low10
Interstitial Cell Tumor0low10
LDL Receptor Disorder0low10
Leishmaniasis, Mucocutaneous0low10
Leydig Cell Tumor0low10
Liver Injury, Drug-Induced0low10
Liver Injury, Drug-Induced, Acute0low10
Liver Steatosis0low10
Malignancy0low30
Malignant Neoplasms0low30
Neoplasia0low30
Neoplasm0low30
Neoplasms0low30
Neoplasms, Benign0low30
Neoplasms, Experimental0low10
Neoplasms, Testicular0low10
Neoplasms, Testis0low10
Obesity0low10
Pregnancy0low50
Septic Shock0low10
Shock, Endotoxic0low10
Shock, Septic0low10
Shock, Toxic0low10
Starvation0low10
Steatohepatitis0low10
Steatosis of Liver0low10
Streptozocin Diabetes0low20
Streptozotocin Diabetes0low20
Testicular Cancer0low10
Testicular Neoplasm0low10
Testicular Neoplasms0low10
Testicular Tumor0low10
Testicular Tumors0low10
Testis Cancer0low10
Testis Neoplasms0low10
Toxic Hepatitis0low10
Toxic Shock0low10
Toxic Shock Syndrome0low10
Trypanosoma cruzi Infection0low30
Trypanosomiasis, South American0low30
Tumor of Rete Testis0low10
Tumors0low30
Visceral Steatosis0low10

Research Highlights

Safety/Toxicity (1)

ArticleYear
Role for circulating lipoproteins in protection from endotoxin toxicity.
Infection and immunity, Volume: 63, Issue: 5		1995
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (2)

ArticleYear
Nephrotoxicity induced by a single dose of adenine: effects of 4-aminopyrazolo[3,4-d]pyrimidine and allopurinol.
Biological & pharmaceutical bulletin, Volume: 17, Issue: 2		1994
Ultrastructural changes in rat adrenocortical cells produced by a 4-aminopyrazolopyrimidine (4-APP) dosage.
Cell structure and function, Volume: 9, Issue: 1		1984
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]