glyburide has been researched along with Shock, Septic in 10 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We enrolled 30 patients with septic shock requiring invasive hemodynamic monitoring and norepinephrine infusion of 0." | 2.73 | Glibenclamide dose response in patients with septic shock: effects on norepinephrine requirements, cardiopulmonary performance, and global oxygen transport. ( Bachetoni, A; Broeking, K; Ertmer, C; Landoni, G; Lange, M; Morelli, A; Orecchioni, A; Pietropaoli, P; Rocco, M; Traber, DL; Van Aken, H; Westphal, M, 2007) |
| "Ten patients with septic shock requiring invasive hemodynamic monitoring and infusion of norepinephrine to maintain adequate mean arterial pressure." | 2.72 | Randomized, double-blind, placebo-controlled crossover pilot study of a potassium channel blocker in patients with septic shock. ( Bellomo, R; Egi, M; Warrillow, S, 2006) |
| "This event may be triggered during septic shock by increased nitric oxide (NO) production, by a decreased intracellular content of ATP, or by a change in the transmembrane electrical potential." | 1.32 | Hemodynamic effects of glibenclamide during endotoxemia: contrasting findings in vitro versus in vivo. ( Debelle, F; Fesler, P; Kafi, SA; Naeije, R; Preiser, JC; Vincent, JL; Zhang, H, 2003) |
| "Thus, vasodilation and hypotension in septic shock are, at least in part, due to activation of the K+ATP channel in vascular smooth muscle, and anaerobic metabolism with acidosis is a sufficient stimulus for channel activation." | 1.28 | The ATP-sensitive K+ channel mediates hypotension in endotoxemia and hypoxic lactic acidosis in dog. ( Landry, DW; Oliver, JA, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 8 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| O'Brien, A | 1 |
| Stidwill, RP | 1 |
| Clapp, LH | 1 |
| Singer, M | 1 |
| Preiser, JC | 1 |
| Zhang, H | 1 |
| Debelle, F | 1 |
| Fesler, P | 1 |
| Kafi, SA | 1 |
| Naeije, R | 1 |
| Vincent, JL | 1 |
| Warrillow, S | 1 |
| Egi, M | 1 |
| Bellomo, R | 1 |
| Oliver, JA | 2 |
| Landry, DW | 2 |
| Eisenhut, M | 1 |
| Morelli, A | 1 |
| Lange, M | 1 |
| Ertmer, C | 1 |
| Broeking, K | 1 |
| Van Aken, H | 1 |
| Orecchioni, A | 1 |
| Rocco, M | 1 |
| Bachetoni, A | 1 |
| Traber, DL | 1 |
| Landoni, G | 1 |
| Pietropaoli, P | 1 |
| Westphal, M | 1 |
| Wu, CC | 2 |
| Thiemermann, C | 1 |
| Vane, JR | 1 |
| Chen, CC | 1 |
| Lin, YC | 1 |
| Chen, SA | 1 |
| Luk, HN | 1 |
| Ding, PY | 1 |
| Chang, MS | 1 |
| Chiang, CE | 1 |
| Chen, SJ | 1 |
| Yang, SN | 1 |
| Lin, CI | 1 |
| Yen, MH | 1 |
2 trials available for glyburide and Shock, Septic
| Article | Year |
|---|---|
Randomized, double-blind, placebo-controlled crossover pilot study of a potassium channel blocker in patients with septic shock.
Topics: Aged; Aged, 80 and over; Cross-Over Studies; Double-Blind Method; Female; Glyburide; Humans; Male; N | 2006 |
Glibenclamide dose response in patients with septic shock: effects on norepinephrine requirements, cardiopulmonary performance, and global oxygen transport.
Topics: Adenosine Triphosphate; Aged; Biological Transport; Blood Glucose; Catecholamines; Dose-Response Rel | 2007 |
8 other studies available for glyburide and Shock, Septic
| Article | Year |
|---|---|
Variable effects of inhibiting iNOS and closing the vascular ATP-sensitive potassium channel (via its pore-forming and sulfonylurea receptor subunits) in endotoxic shock.
Topics: Animals; Glyburide; Hemodynamics; KATP Channels; Lipopolysaccharides; Male; Nitric Oxide Synthase Ty | 2009 |
Hemodynamic effects of glibenclamide during endotoxemia: contrasting findings in vitro versus in vivo.
Topics: Animals; Aorta, Thoracic; Dogs; Endotoxemia; Endotoxins; Glyburide; Hemodynamics; In Vitro Technique | 2003 |
Potassium channels and septic shock.
Topics: Glyburide; Humans; Potassium Channel Blockers; Potassium Channels; Shock, Septic | 2006 |
Systemic potassium transport in septic shock.
Topics: Child; Glyburide; Humans; Meningococcal Infections; Potassium Channel Blockers; Potassium Channels; | 2006 |
Glibenclamide-induced inhibition of the expression of inducible nitric oxide synthase in cultured macrophages and in the anaesthetized rat.
Topics: Amino Acid Oxidoreductases; Anesthetics; Animals; Cell Line; Endotoxins; Enzyme Induction; Glyburide | 1995 |
Shortening of cardiac action potentials in endotoxic shock in guinea pigs is caused by an increase in nitric oxide activity and activation of the adenosine triphosphate-sensitive potassium channel.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Cyclic GMP; Enzyme Inhibitors; Glyburide; Guanid | 2000 |
Abnormal activation of K(+) channels in aortic smooth muscle of rats with endotoxic shock: electrophysiological and functional evidence.
Topics: Animals; Aorta; Apamin; Benzimidazoles; Charybdotoxin; Drug Interactions; Enzyme Inhibitors; Glyburi | 2000 |
The ATP-sensitive K+ channel mediates hypotension in endotoxemia and hypoxic lactic acidosis in dog.
Topics: Acidosis, Lactic; Adenosine Triphosphate; Animals; Blood Pressure; Dogs; Endotoxins; Glyburide; Hypo | 1992 |