cimetidine has been researched along with Shock, Septic in 7 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was designed to use the H2 antagonist cimetidine and the H1 antagonist diphenhydramine alone and in combination to clarify the role of histamine in the development of endotoxin shock." | 3.67 | The effects of H1 and H2 histamine receptor antagonists on the development of endotoxemia in the conscious, unrestrained rat. ( Brackett, DJ; Schaefer, CF; Wilson, MF, 1985) |
| "Especially patients with severe sepsis or septic shock are prone to develop lesions of the upper gastrointestinal tract with consecutive bleeding." | 1.35 | [Stress ulcer prophylaxis in septic patients. Evidence-based overview]. ( Elke, G; Schädler, D; Scholz, J; Weiler, N; Zick, G, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Elke, G | 1 |
| Schädler, D | 1 |
| Zick, G | 1 |
| Scholz, J | 1 |
| Weiler, N | 1 |
| McKindley, DS | 1 |
| Chichester, C | 1 |
| Raymond, R | 1 |
| Bond, RF | 1 |
| Vildibill, HD | 1 |
| Krech, LH | 1 |
| Hershey, JC | 1 |
| Numata, M | 1 |
| Ito, N | 1 |
| Urayama, H | 1 |
| Nishimaki, K | 1 |
| Byrne, K | 2 |
| Sielaff, TD | 2 |
| Michna, B | 1 |
| Carey, PD | 2 |
| Blocher, CR | 2 |
| Vasquez, A | 2 |
| Sugerman, HJ | 2 |
| Tatum, JL | 1 |
| Hirsh, JI | 1 |
| Brackett, DJ | 1 |
| Schaefer, CF | 1 |
| Wilson, MF | 1 |
7 other studies available for cimetidine and Shock, Septic
| Article | Year |
|---|---|
[Stress ulcer prophylaxis in septic patients. Evidence-based overview].
Topics: Anti-Ulcer Agents; Cimetidine; Duodenal Ulcer; Evidence-Based Medicine; Gastric Acid; Gastrointestin | 2008 |
Effect of endotoxin shock on the clearance of lidocaine and indocyanine green in the perfused rat liver.
Topics: Anesthetics, Local; Animals; Cimetidine; Coloring Agents; Cytochrome P-450 Enzyme Inhibitors; Cytoch | 1999 |
Influence of histaminergic receptors on denervated canine gracilis muscle vascular tone during endotoxemia.
Topics: Adenosine; Animals; Blood Pressure; Cimetidine; Diphenhydramine; Dogs; Endotoxins; Escherichia coli; | 1991 |
The role of neostigmine in development of acute gastric mucosal lesion in dogs with live bacterial flora-induced shock.
Topics: Animals; Cimetidine; Dogs; Escherichia coli Infections; Female; Gastric Mucosa; Hydrochloric Acid; M | 1990 |
Increased survival time after delayed histamine and prostaglandin blockade in a porcine model of severe sepsis-induced lung injury.
Topics: Animals; Cimetidine; Diphenhydramine; Drug Therapy, Combination; Extravascular Lung Water; Hemodynam | 1990 |
Ranitidine compared to cimetidine in multiagent pharmacological treatment of porcine Pseudomonas ARDS.
Topics: Animals; Cimetidine; Diphenhydramine; Drug Therapy, Combination; Hemodynamics; Ibuprofen; Pseudomona | 1990 |
The effects of H1 and H2 histamine receptor antagonists on the development of endotoxemia in the conscious, unrestrained rat.
Topics: Analysis of Variance; Animals; Blood Gas Analysis; Blood Pressure; Cimetidine; Diphenhydramine; Enfl | 1985 |