1-((beta-mercapto-beta)beta cyclopentamethylenepropionic acid)-2-(o-ethyl-tyr)-4-val-9-des-gly-arginine vasopressin profile

Let's break down the name and understand the importance of this compound:

**1. Name Breakdown**

The full name describes a modified version of the hormone vasopressin:

* **Vasopressin:** A hormone that regulates blood pressure, water reabsorption in the kidneys, and other bodily functions.
* **Des-Gly-arginine vasopressin:** This indicates that the arginine (Arg) at position 8 and the glycine (Gly) at position 9 of the vasopressin molecule have been removed.
* **(beta-mercapto-beta)beta cyclopentamethylenepropionic acid:** This is a complex modification at position 1. It involves replacing the usual amino acid with a cyclic structure containing a sulfur atom (mercapto).
* **2-(o-ethyl-tyr):** This indicates that the tyrosine (Tyr) at position 2 has been modified with an ethyl group at the ortho position.
* **4-Val:** The valine (Val) at position 4 is unchanged.

**2. Importance for Research**

This modified vasopressin is likely a synthetic analog designed for research purposes. Here's why it's important:

* **Understanding Vasopressin Function:** Modifications like these help researchers understand how specific amino acid residues in vasopressin contribute to its activity. By changing the chemical structure, they can see how different parts of the molecule interact with receptors and affect various biological processes.
* **Pharmacological Tools:** These analogs might be useful in developing new drugs for treating conditions related to vasopressin's functions, such as:
* **Diabetes insipidus:** A condition where the kidneys cannot concentrate urine properly, leading to excessive urination.
* **Bleeding disorders:** Vasopressin can help constrict blood vessels and promote clotting.
* **Heart failure:** Vasopressin can play a role in regulating blood pressure and cardiac output.
* **Neurological Research:** Vasopressin is also involved in social behavior, memory, and stress responses. Modified analogs could help researchers probe these roles in greater detail.

**Important Note:** This is a hypothetical example, and it's crucial to remember that researchers synthesize and study a wide array of vasopressin analogs with varying modifications. The specific purpose of the compound you described depends on the context of the research study it's used in.

**Further Research:** If you'd like to learn more about this specific analog, you'll need to search for it in scientific databases or research articles, possibly using keywords like vasopressin analog or cyclopentamethylenepropionic acid vasopressin.

1-((beta-mercapto-beta)beta cyclopentamethylenepropionic acid)-2-(O-ethyl-Tyr)-4-Val-9-des-Gly-arginine vasopressin: vasopressin receptor antagonist; RN given refers to (D-Tyr)-isomer; RN for cpd without isomeric designation not available 8/89 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	122322
MeSH ID	M0145067

Synonym
gtpl2217
(2s)-n-[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(10r,13s,16s,19s,22r)-13-(2-amino-2-oxoethyl)-22-[(4-ethoxyphenyl)methyl]-12,15,18,21,24-pentaoxo-19-(phenylmethyl)-16-propan-2-yl7,8-dithia-11,14,17,20,23-pentazaspiro[5.19]pentacosane
d(ch2)5[tyr(et)2,val4,des-gly9]avp
dgtyr(et)vavp
skf 101926
1-(beta-mercapto-beta-cyclopentamethylenepropionic acid)-2-(o-ethyl-tyr)-4-val-9-des-gly-argipressin
vasopressin, beta-mercapto-beta,beta-cyclopentamethylenepropionic acid(1)-o-ethyltyrosyl(2)-valyl(4)-arginyl(8)-deslycine(9)-
l-argininamide, o-ethyl-n-((1-mercaptocyclohexyl)acetyl)-d-tyrosyl-l-phenylalanyl-l-valyl-l-asparaginyl-l-cysteinyl-l-prolyl-, cyclic (1-5)-disulfide
d(ch2)5(1),tyr(et)(2),val(4),des-gly(9)-avp
desgly-d(ch2)5-tyr(et)vavp
sk&f 10196
argipressin, beta-mercapto-(beta,beta)-cyclopentamethylenepropionic acid(1)-o-ethyltyrosyl(2)-valyl(4)-deglycine(9)-
desgly-d(ch2)5-tyr(et)valavp
mcp-tva-argipressin
sk&f 101926
sk&f-101926
1-((beta-mercapto-beta)beta cyclopentamethylenepropionic acid)-2-(o-ethyl-tyr)-4-val-9-des-gly-arginine vasopressin
vasopressin,(beta-mercapto-beta)beta-cyclopentamethylenepropionic acid(1)-o-ethyl-tyr(2)-val(4)-arg(8)-des-gly(9)-
90332-82-4
unii-4s4la22apy
4s4la22apy ,
skf-101926
DTXSID10238094
mfcd00076751
(d(ch2)51,d-tyr(et)2,val4,arg8,des-gly9)-vasopressin
(2s)-n-[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(10r,13s,16s,19s,22r)-13-(2-amino-2-oxoethyl)-19-benzyl-22-[(4-ethoxyphenyl)methyl]-12,15,18,21,24-pentaoxo-16-propan-2-yl-7,8-dithia-11,14,17,20,23-pentazaspiro[5.19]pentacosane-10-car
Q27077001
o-ethyl-n-((1-mercaptocyclohexyl)acetyl)-d-tyr-phe-val-asn-cys-pro-arg-nh2 cyclic(1-5)-disulfide
l-argininamide, o-ethyl-n-(2-(1-mercaptocyclohexyl)acetyl)-d-tyrosyl-l-phenylalanyl-l-valyl-l-asparaginyl-l-cysteinyl-l-prolyl-, cyclic (1->5)-disulfide
PD048891

Excerpt	Relevance	Reference
" To define the relationships between respiratory failure, cardiovascular collapse, and death, respiratory and cardiovascular parameters were monitored in anesthetized rats following the intravenous administration of SK&F 101926 at a dosage (3 mg/kg) which resulted in 70% mortality."	( Respiratory and cardiovascular changes associated with toxic doses of a peptide antagonist of vasopressin in the rat. Joran, ME; Murphy, DJ, 1992)	0.28
"The dosage form (drop or spray) and site of administration (dorsal or ventral surface of the nostril) profoundly affect the distribution and clearance of a gamma-emitting 99mTc-labeled diethylenetriamine pentaacetic acid (99mTc-DTPA) solution in dogs."	( Nasal delivery of a vasopressin antagonist in dogs. Kinter, LB; Liversidge, GG; Sternson, WL; Wilson, CG, 1988)	0.27

Assay ID	Title	Year	Journal	Article
AID1346453	Human V2 receptor (Vasopressin and oxytocin receptors)	1998	British journal of pharmacology, Dec, Volume: 125, Issue:7	Pharmacological characterization of the human vasopressin receptor subtypes stably expressed in Chinese hamster ovary cells.
AID1346432	Human V1A receptor (Vasopressin and oxytocin receptors)	1998	British journal of pharmacology, Dec, Volume: 125, Issue:7	Pharmacological characterization of the human vasopressin receptor subtypes stably expressed in Chinese hamster ovary cells.
AID1346453	Human V2 receptor (Vasopressin and oxytocin receptors)	2000	Kidney international, Oct, Volume: 58, Issue:4	Binding properties of a selective tritiated vasopressin V2 receptor antagonist, [H]-SR 121463.
AID1346460	Human V1B receptor (Vasopressin and oxytocin receptors)	1998	British journal of pharmacology, Dec, Volume: 125, Issue:7	Pharmacological characterization of the human vasopressin receptor subtypes stably expressed in Chinese hamster ovary cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	13 (46.43)	18.7374
1990's	13 (46.43)	18.2507
2000's	2 (7.14)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.57%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	27 (96.43%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
iodine Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.. diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..	1.97	1	diatomic iodine	nutrient
pentetic acid Pentetic Acid: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.	1.97	1	pentacarboxylic acid	copper chelator
furosemide Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.. furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.	1.97	1	chlorobenzoic acid; furans; sulfonamide	environmental contaminant; loop diuretic; xenobiotic
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	2.67	3	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
ethylmaleimide Ethylmaleimide: A sulfhydryl reagent that is widely used in experimental biochemical studies.	1.97	1	maleimides	anticoronaviral agent; EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor; EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor; EC 2.7.1.1 (hexokinase) inhibitor
arginine Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.	1.98	1	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	2	1	pyrrole; secondary amine
azides Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.	1.97	1	pseudohalide anion	mitochondrial respiratory-chain inhibitor
ng-nitroarginine methyl ester NG-Nitroarginine Methyl Ester: A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.	2.39	2	alpha-amino acid ester; L-arginine derivative; methyl ester; N-nitro compound	EC 1.14.13.39 (nitric oxide synthase) inhibitor
relcovaptan relcovaptan: a nonpeptide vasopressin V1 receptor antagonist; structure given in first source	2.4	2	proline derivative
quin2 Quin2: fluorescent highly selective Ca indicator, binding Ca 1:1; structure given in first source	1.97	1
mozavaptan mozavaptan: aquaretic agent; vasopressin V2 receptor antagonist; structure given in first source	2.4	2	benzamides	aquaretic
argipressin, deaminopenicillamine(1)-o-methyl-tyr(2)- argipressin, deaminopenicillamine(1)-O-methyl-Tyr(2)-: vasopressin antagonist; RN refers to (L-Tyr-L-Arg)-isomer	2.4	2
conivaptan conivaptan : The amide resulting from the formal condensation of 4-[(biphenyl-2-ylcarbonyl)amino]benzoic acid with the benzazepine nitrogen of 2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2. It is used as its hydrochloride salt for the treatment of hyponatraemia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH).	1.99	1	benzazepine	aquaretic; vasopressin receptor antagonist
satavaptan satavaptan: a vasopressin V2 receptor antagonist; structure given in first source	2.69	3
technetium tc 99m pentetate Technetium Tc 99m Pentetate: A technetium imaging agent used in renal scintigraphy, computed tomography, lung ventilation imaging, gastrointestinal scintigraphy, and many other procedures which employ radionuclide imaging agents.	1.97	1
argipressin,beta-mercapto-beta,beta-cyclopentamethylenepropionic acid(1)-val(4)- argipressin,beta-mercapto-beta,beta-cyclopentamethylenepropionic acid(1)-Val(4)-: potent, selective inhibitor of vasopressor response to arginine vasopressin	1.98	1
angiotensin ii Giapreza: injectable form of angiotensin II used to increase blood pressure in adult patients with septic or other distributive shock. Ile(5)-angiotensin II : An angiotensin II that acts on the central nervous system (PDB entry: 1N9V).	1.97	1	amino acid zwitterion; angiotensin II	human metabolite
lixivaptan [no description available]	2.41	2
oxytocin Oxytocin: A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.. oxytocin : A cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain; the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary. Together with the neuropeptide vasopressin, it is believed to influence social cognition and behaviour.	2.39	2	heterodetic cyclic peptide; peptide hormone	oxytocic; vasodilator agent
lypressin Lypressin: The porcine antidiuretic hormone (VASOPRESSINS). It is a cyclic nonapeptide that differs from ARG-VASOPRESSIN by one amino acid, containing a LYSINE at residue 8 instead of an ARGININE. Lys-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.	2.39	2	cyclic peptide
arginine vasopressin Arginine Vasopressin: The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.. argipressin : The predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6.	5.75	28	vasopressin	cardiovascular drug; hematologic agent; mitogen
oxytocin, thr(4)-gly(7)- oxytocin, Thr(4)-Gly(7)-: RN given refers to parent cpd	1.99	1
argipressin, beta-mercapto(beta,beta)-cyclopentamethylenepropionic acid(1)-ile(2,4)- argipressin, beta-mercapto(beta,beta)-cyclopentamethylenepropionic acid(1)-Ile(2,4)-: RN refers to (L-Ile-D-Ile-L-Arg)-isomer; vasopressin and vasopressin (2) receptor antagonist	2	1
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	1.97	1	prostaglandins E	human metabolite; mouse metabolite; oxytocic
deamino arginine vasopressin Deamino Arginine Vasopressin: A synthetic analog of the pituitary hormone, ARGININE VASOPRESSIN. Its action is mediated by the VASOPRESSIN receptor V2. It has prolonged antidiuretic activity, but little pressor effects. It also modulates levels of circulating FACTOR VIII and VON WILLEBRAND FACTOR.	3.99	4	heterodetic cyclic peptide	diagnostic agent; renal agent; vasopressin receptor agonist
vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(o- methyl-l-tyrosine)-8-l-arginine- vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine-: highly potent antagonist of vasopressor response to arginine-vasopressin; structure in first source	2.67	3
pituitrin Pituitrin: A substance or extract from the neurohypophysis (PITUITARY GLAND, POSTERIOR).	5.02	13
guanylyl imidodiphosphate Guanylyl Imidodiphosphate: A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of ADENYLYL CYCLASES.. guanosine 5'-[beta,gamma-imido]triphosphate : A nucleoside triphosphate analogue that is GTP in which the oxygen atom bridging the beta- to the gamma- phosphate is replaced by a nitrogen atom A non-hydrolyzable analog of GTP, it binds tightly to G-protein in the presence of Mg(2+).	2.37	2	nucleoside triphosphate analogue

Condition	Relationship Strength	Studies
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	1.98	1
Muscle Relaxation That phase of a muscle twitch during which a muscle returns to a resting position.	1.98	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	1.98	1
Electrolytes Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)	1.98	1
Acquired Nephrogenic Diabetes Insipidus [description not available]	2	1
Anasarca [description not available]	1.97	1
Blood Pressure, Low [description not available]	2.38	2
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	1.97	1
Hypotension Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.	2.38	2
Dehydration The condition that results from excessive loss of water from a living organism.	1.96	1
Endotoxin Shock [description not available]	1.96	1
Antidiuretic Hormone, Inappropriate Secretion [description not available]	1.96	1
Inappropriate ADH Syndrome A condition of HYPONATREMIA and renal salt loss attributed to overexpansion of BODY FLUIDS resulting from sustained release of ANTIDIURETIC HORMONES which stimulates renal resorption of water. It is characterized by normal KIDNEY function, high urine OSMOLALITY, low serum osmolality, and neurological dysfunction. Etiologies include ADH-producing neoplasms, injuries or diseases involving the HYPOTHALAMUS, the PITUITARY GLAND, and the LUNG. This syndrome can also be drug-induced.	1.96	1
Shock, Septic Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.	1.96	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	1.97	1
Flushing A transient reddening of the face that may be due to fever, certain drugs, exertion, or stress.	1.97	1

1-((beta-mercapto-beta)beta cyclopentamethylenepropionic acid)-2-(o-ethyl-tyr)-4-val-9-des-gly-arginine vasopressin

Description

Cross-References

Synonyms (30)

Research Excerpts

Dosage Studied

Bioassays (4)

Research

Studies (28)

Market Indicators

Research Demand Index: 11.11

Study Types