acetaminophen has been researched along with Shock, Septic in 11 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with acute liver failure (ALF) have defects in innate immune responses to microbes (immune paresis) and are susceptible to sepsis." | 1.46 | Increased Expression of Cytotoxic T-Lymphocyte-Associated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure. ( Abeles, RD; Anderson, AE; Antoniades, CG; Auzinger, G; Bernal, W; Bernsmeier, C; El-Masry, A; Hou, TZ; Khamri, W; Kudo, N; Larsen, FS; Lebosse, F; Lombardi, G; Possamai, LA; Singanayagam, A; Thursz, M; Triantafyllou, E; Wendon, J; Weston, CJ; Willars, C, 2017) |
| "Menstrual toxic shock syndrome is a rare but potentially life-threatening illness manifest through the actions of Staphylococcus aureus toxic shock syndrome toxin 1 (TSST-1)." | 1.35 | Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1. ( Frolova, O; Hoang, T; Kidder, J; McNamara, PJ; Milligan-Myhre, K; Proctor, RA; Schroeder, S; Syverson, RE, 2009) |
| "In this clinically relevant septic shock model, the febrile response thus resulted in better respiratory function, lower blood lactate concentration, and prolonged survival time." | 1.33 | Fever control in septic shock: beneficial or harmful? ( Cai, Y; Nguyen, ND; Rogiers, P; Su, F; Vincent, JL; Wang, Z, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| McNamara, PJ | 1 |
| Syverson, RE | 1 |
| Milligan-Myhre, K | 1 |
| Frolova, O | 1 |
| Schroeder, S | 1 |
| Kidder, J | 1 |
| Hoang, T | 1 |
| Proctor, RA | 1 |
| Scorcella, C | 1 |
| Domizi, R | 1 |
| Amoroso, S | 1 |
| Carsetti, A | 1 |
| Casarotta, E | 1 |
| Castaldo, P | 1 |
| D'angelo, C | 1 |
| Damiani, E | 1 |
| Gasparri, F | 1 |
| Donati, A | 1 |
| Adrario, E | 1 |
| Khamri, W | 1 |
| Abeles, RD | 1 |
| Hou, TZ | 1 |
| Anderson, AE | 1 |
| El-Masry, A | 1 |
| Triantafyllou, E | 1 |
| Bernsmeier, C | 1 |
| Larsen, FS | 1 |
| Singanayagam, A | 1 |
| Kudo, N | 1 |
| Possamai, LA | 1 |
| Lebosse, F | 1 |
| Auzinger, G | 1 |
| Bernal, W | 1 |
| Willars, C | 1 |
| Weston, CJ | 1 |
| Lombardi, G | 1 |
| Wendon, J | 1 |
| Thursz, M | 1 |
| Antoniades, CG | 1 |
| Xiahou, Z | 1 |
| Wang, X | 1 |
| Shen, J | 1 |
| Zhu, X | 1 |
| Xu, F | 1 |
| Hu, R | 1 |
| Guo, D | 1 |
| Li, H | 1 |
| Tian, Y | 1 |
| Liu, Y | 1 |
| Liang, H | 1 |
| Huebener, P | 1 |
| Pradere, JP | 1 |
| Hernandez, C | 1 |
| Gwak, GY | 1 |
| Caviglia, JM | 1 |
| Mu, X | 1 |
| Loike, JD | 1 |
| Schwabe, RF | 1 |
| Lanoy, C | 1 |
| Bouckaert, Y | 1 |
| Mrozek, S | 1 |
| Constantin, JM | 1 |
| Futier, E | 1 |
| Zenut, M | 1 |
| Ghardes, G | 1 |
| Cayot-Constantin, S | 1 |
| Bonnard, M | 1 |
| Ait-Bensaid, N | 1 |
| Eschalier, A | 1 |
| Bazin, JE | 1 |
| Mohr, NM | 1 |
| Fuller, BM | 1 |
| Skrupky, LP | 1 |
| Moy, H | 1 |
| Alunday, R | 1 |
| Micek, ST | 1 |
| Fagley, RE | 1 |
| Pagano, MB | 1 |
| Hobbs, W | 1 |
| Linenberger, M | 1 |
| Delaney, M | 1 |
| Su, F | 1 |
| Nguyen, ND | 1 |
| Wang, Z | 1 |
| Cai, Y | 1 |
| Rogiers, P | 1 |
| Vincent, JL | 1 |
| Ahola, T | 1 |
| Lapatto, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety and Antipyretic Efficacy of Acetaminophen in the Febrile Intensive Care Unit Patient.[NCT02280239] | Phase 4 | 10 participants (Actual) | Interventional | 2015-05-31 | Terminated (stopped due to Only enrolled 10 participants over 9 months which is less then anticipated (75).) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Clinically significant hypotension is defined as an acute drop in mean arterial pressure requiring treatment. Treatment is defined as either a 500 cc (or greater) fluid bolus and/or an increase in inotrope support of greater than 5 mcg/min over baseline. (NCT02280239)
Timeframe: 4 hours post acetaminophen administration
| Intervention | Participants (Count of Participants) |
|---|---|
| Control Group | 0 |
| Acetaminophen Group | 0 |
systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressures (MAP) will be monitored for 4 hours post intervention (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mmHg (Mean) | |||||
|---|---|---|---|---|---|---|
| SBP: Pre-Intervention (2 hours) | SBP: Post-Intervention (4 hours) | DBP: Pre-Intervention (2 hours) | DBP: Post-Intervention (4 hours) | MAP: Pre-Intervention (2 hours) | MAP: Post-Intervention (4 hours) | |
| Acetaminophen Group | 122.6 | 119.5 | 66.2 | 65.4 | 84.1 | 82.4 |
| Control Group | 141.6 | 141.5 | 57.4 | 51.0 | 80.8 | 75.5 |
"Total dose of all vasoactive medications will be converted to total Equidose value (with the formula 10 mcg/min norepinephrine ≈ 5 mcg/kg/min dopamine ≈ 10 mcg/min epinephrine ≈ 1 mcg/min phenylephrine ≈ 0.02 u/min vasopressin as per Russell et al. (2008)) before comparing the treatment and control groups~Only 2 of the 6 participants were on low-dose vasoactive medications, (i.e., one was on norepinephrine and the other was on milrinone) therefore the pre-planned conversion calculation was not done." (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mcg (Number) | |||
|---|---|---|---|---|
| Pre-Intervention (2 hours) TOTAL Norepinephrine | Pre-Intervention (2 hours) TOTAL Milrinone | Post-Intervention (4 hours) TOTAL Norepinephrine | Post-Intervention (4 hours) TOTAL Milrinone | |
| Acetaminophen Group | NA | 6000.0 | NA | 7000.0 |
| Control Group | 167.0 | NA | 576.0 | NA |
Total crystalloid and colloid fluid will be converted the the equi-volume dose (with the ratio 1.4:1 (as per Finfer et al.(2004) & Vincent and Weil (2006) before making comparisons between the treatment and control groups. (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mL (Mean) | |||
|---|---|---|---|---|
| Pre-Intervention (2 hours) Total fluid INTAKE | Pre-Intervention (2 hours) Total fluid OUTPUT | Post-Intervention (4 hours) Total Fluid INTAKE | Post-Intervention (4 hours) Total Fluid OUTPUT | |
| Acetaminophen Group | 298 | 370 | 612 | 852 |
| Control Group | 235 | 80 | 734 | 245 |
"Continuous measurements of core body temperature will be recorded for 6 hours. Fever burden (FB) is defined as area between the 6 hour temperature curve and 38.3°C cut-off and it is reported in °C-hour.~PRE-INTERVENTION FB: is reported for a 2 hour period. POST-INTERVENTION FB: post-intervention fever burden is reported for a 6 hour period and average hourly fever burden.~Peak Temperature: is the highest recorded temperature for the study period in °C Minimum Temperature: is the lowest recorded temperature for the study period in °C" (NCT02280239)
Timeframe: 6 hours post intervention
| Intervention | °C*hours (Mean) | |
|---|---|---|
| Pre-Intervention FB (2 hours) | Post-Intervention FB (6 hours) | |
| Acetaminophen Group | 2.16 | 5.65 |
| Control Group | 0.97 | 0.74 |
1 review available for acetaminophen and Shock, Septic
| Article | Year |
|---|---|
[N-Acetylcysteine: new possibilities to use an old substance].
Topics: Acetaminophen; Acetylcysteine; Antioxidants; Free Radical Scavengers; Glutathione; Humans; Liver Fai | 1999 |
10 other studies available for acetaminophen and Shock, Septic
| Article | Year |
|---|---|
Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1.
Topics: Bacterial Toxins; Benzyl Alcohols; Culture Media; Enterotoxins; Fatty Acid Synthesis Inhibitors; Fem | 2009 |
Pharmacogenetics in critical care: association between CYP3A5 rs776746 A/G genotype and acetaminophen response in sepsis and septic shock.
Topics: Acetaminophen; Adult; Critical Care; Cytochrome P-450 CYP3A; Genotype; Humans; Pharmacogenetics; Sep | 2023 |
Increased Expression of Cytotoxic T-Lymphocyte-Associated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure.
Topics: Acetaminophen; Acute-On-Chronic Liver Failure; Adaptive Immunity; Adult; Animals; Antibodies; B7-1 A | 2017 |
NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.
Topics: Acetaminophen; Alarmins; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Cytokines; Huma | 2017 |
The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; fas Recept | 2015 |
Metabolic acidosis and 5-oxoprolinuria induced by flucloxacillin and acetaminophen: a case report.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged, 80 and over; Amino Acid Metabolism, Inborn Err | 2016 |
[Acetaminophene-induced hypotension in intensive care unit: a prospective study].
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Brain Injuries; Endpoint Determinatio | 2009 |
Clinical and demographic factors associated with antipyretic use in gram-negative severe sepsis and septic shock.
Topics: Academic Medical Centers; Acetaminophen; Adult; Aged; Antipyretics; Bacteremia; Cohort Studies; Fema | 2011 |
Plasma and red cell exchange transfusions for erythropoietic protoporphyria: a case report and review of the literature.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Arthroplasty, Replacement, Knee; Cholestasis, Intrahepatic; | 2012 |
Fever control in septic shock: beneficial or harmful?
Topics: Acetaminophen; Animals; Body Temperature; Body Weight; Female; Fever; HSP70 Heat-Shock Proteins; Iso | 2005 |