Compounds > 2-amino-5,6-dihydro-4h-1,3-thiazine
Page last updated: 2024-12-08

2-amino-5,6-dihydro-4h-1,3-thiazine

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Description

2-amino-5,6-dihydro-4H-1,3-thiazine: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID189081
CHEMBL ID306541
SCHEMBL ID30950
MeSH IDM0070007

Synonyms (15)

Synonym
5,6-dihydro-4h-1,3-thiazin-2-amine
[1,3]thiazinan-(2e)-ylideneamine
bdbm50049250
[1,3]thiazinan-(2z)-ylideneamine
2-amino-5,6-dihydro-4h-1,3-thiazine
CHEMBL306541 ,
AKOS003362396
AKOS006347653
30480-64-9
A822793
SCHEMBL30950
2-iminotetrahydro-1,3-thiazine
DTXSID60184552
EN300-203949
CS-0284766
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (5)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)IC50 (µMol)160.00000.00030.30952.3000AID220121
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)IC50 (µMol)160.00000.00030.32092.3000AID220121
Nitric oxide synthase, endothelialHomo sapiens (human)IC50 (µMol)7.10000.07202.58738.7000AID68136
Nitric oxide synthase, brainHomo sapiens (human)IC50 (µMol)3.20000.03502.711910.0000AID146117
Nitric oxide synthase, inducibleHomo sapiens (human)IC50 (µMol)2.90000.00022.319010.0000AID92005
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (89)

Processvia Protein(s)Taxonomy
positive regulation of gene expressionNitric oxide synthase, endothelialHomo sapiens (human)
angiogenesisNitric oxide synthase, endothelialHomo sapiens (human)
ovulation from ovarian follicleNitric oxide synthase, endothelialHomo sapiens (human)
in utero embryonic developmentNitric oxide synthase, endothelialHomo sapiens (human)
blood vessel remodelingNitric oxide synthase, endothelialHomo sapiens (human)
regulation of sodium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
regulation of the force of heart contraction by chemical signalNitric oxide synthase, endothelialHomo sapiens (human)
regulation of systemic arterial blood pressure by endothelinNitric oxide synthase, endothelialHomo sapiens (human)
aortic valve morphogenesisNitric oxide synthase, endothelialHomo sapiens (human)
pulmonary valve morphogenesisNitric oxide synthase, endothelialHomo sapiens (human)
endocardial cushion morphogenesisNitric oxide synthase, endothelialHomo sapiens (human)
arginine catabolic processNitric oxide synthase, endothelialHomo sapiens (human)
nitric oxide biosynthetic processNitric oxide synthase, endothelialHomo sapiens (human)
potassium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
calcium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
mitochondrion organizationNitric oxide synthase, endothelialHomo sapiens (human)
regulation of blood pressureNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of cell population proliferationNitric oxide synthase, endothelialHomo sapiens (human)
response to heatNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of platelet activationNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of muscle hyperplasiaNitric oxide synthase, endothelialHomo sapiens (human)
smooth muscle hyperplasiaNitric oxide synthase, endothelialHomo sapiens (human)
removal of superoxide radicalsNitric oxide synthase, endothelialHomo sapiens (human)
lung developmentNitric oxide synthase, endothelialHomo sapiens (human)
positive regulation of guanylate cyclase activityNitric oxide synthase, endothelialHomo sapiens (human)
regulation of nervous system processNitric oxide synthase, endothelialHomo sapiens (human)
lipopolysaccharide-mediated signaling pathwayNitric oxide synthase, endothelialHomo sapiens (human)
response to fluid shear stressNitric oxide synthase, endothelialHomo sapiens (human)
vasodilationNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of potassium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
positive regulation of blood vessel endothelial cell migrationNitric oxide synthase, endothelialHomo sapiens (human)
endothelial cell migrationNitric oxide synthase, endothelialHomo sapiens (human)
cell redox homeostasisNitric oxide synthase, endothelialHomo sapiens (human)
positive regulation of Notch signaling pathwayNitric oxide synthase, endothelialHomo sapiens (human)
positive regulation of angiogenesisNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of smooth muscle cell proliferationNitric oxide synthase, endothelialHomo sapiens (human)
homeostasis of number of cells within a tissueNitric oxide synthase, endothelialHomo sapiens (human)
establishment of localization in cellNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of calcium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
ventricular septum morphogenesisNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of biomineral tissue developmentNitric oxide synthase, endothelialHomo sapiens (human)
blood vessel diameter maintenanceNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsNitric oxide synthase, endothelialHomo sapiens (human)
nitric oxide mediated signal transductionNitric oxide synthase, endothelialHomo sapiens (human)
response to hormoneNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of blood pressureNitric oxide synthase, endothelialHomo sapiens (human)
response to lipopolysaccharideNitric oxide synthase, endothelialHomo sapiens (human)
response to hypoxiaNitric oxide synthase, brainHomo sapiens (human)
regulation of sodium ion transportNitric oxide synthase, brainHomo sapiens (human)
arginine catabolic processNitric oxide synthase, brainHomo sapiens (human)
nitric oxide biosynthetic processNitric oxide synthase, brainHomo sapiens (human)
striated muscle contractionNitric oxide synthase, brainHomo sapiens (human)
myoblast fusionNitric oxide synthase, brainHomo sapiens (human)
response to heatNitric oxide synthase, brainHomo sapiens (human)
negative regulation of calcium ion transport into cytosolNitric oxide synthase, brainHomo sapiens (human)
regulation of cardiac muscle contraction by calcium ion signalingNitric oxide synthase, brainHomo sapiens (human)
peptidyl-cysteine S-nitrosylationNitric oxide synthase, brainHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylationNitric oxide synthase, brainHomo sapiens (human)
multicellular organismal response to stressNitric oxide synthase, brainHomo sapiens (human)
xenobiotic catabolic processNitric oxide synthase, brainHomo sapiens (human)
vasodilationNitric oxide synthase, brainHomo sapiens (human)
negative regulation of potassium ion transportNitric oxide synthase, brainHomo sapiens (human)
cell redox homeostasisNitric oxide synthase, brainHomo sapiens (human)
positive regulation of DNA-templated transcriptionNitric oxide synthase, brainHomo sapiens (human)
positive regulation of transcription by RNA polymerase IINitric oxide synthase, brainHomo sapiens (human)
negative regulation of hydrolase activityNitric oxide synthase, brainHomo sapiens (human)
negative regulation of serotonin uptakeNitric oxide synthase, brainHomo sapiens (human)
negative regulation of calcium ion transportNitric oxide synthase, brainHomo sapiens (human)
regulation of cardiac muscle contractionNitric oxide synthase, brainHomo sapiens (human)
regulation of ryanodine-sensitive calcium-release channel activityNitric oxide synthase, brainHomo sapiens (human)
cellular response to growth factor stimulusNitric oxide synthase, brainHomo sapiens (human)
positive regulation of the force of heart contractionNitric oxide synthase, brainHomo sapiens (human)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwayNitric oxide synthase, brainHomo sapiens (human)
positive regulation of sodium ion transmembrane transportNitric oxide synthase, brainHomo sapiens (human)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channelNitric oxide synthase, brainHomo sapiens (human)
positive regulation of membrane repolarization during ventricular cardiac muscle cell action potentialNitric oxide synthase, brainHomo sapiens (human)
positive regulation of guanylate cyclase activityNitric oxide synthase, brainHomo sapiens (human)
nitric oxide mediated signal transductionNitric oxide synthase, brainHomo sapiens (human)
response to hormoneNitric oxide synthase, brainHomo sapiens (human)
negative regulation of blood pressureNitric oxide synthase, brainHomo sapiens (human)
response to lipopolysaccharideNitric oxide synthase, brainHomo sapiens (human)
response to hypoxiaNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of leukocyte mediated cytotoxicityNitric oxide synthase, inducibleHomo sapiens (human)
innate immune response in mucosaNitric oxide synthase, inducibleHomo sapiens (human)
arginine catabolic processNitric oxide synthase, inducibleHomo sapiens (human)
superoxide metabolic processNitric oxide synthase, inducibleHomo sapiens (human)
nitric oxide biosynthetic processNitric oxide synthase, inducibleHomo sapiens (human)
circadian rhythmNitric oxide synthase, inducibleHomo sapiens (human)
response to bacteriumNitric oxide synthase, inducibleHomo sapiens (human)
negative regulation of gene expressionNitric oxide synthase, inducibleHomo sapiens (human)
peptidyl-cysteine S-nitrosylationNitric oxide synthase, inducibleHomo sapiens (human)
prostaglandin secretionNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of interleukin-6 productionNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of interleukin-8 productionNitric oxide synthase, inducibleHomo sapiens (human)
regulation of cell population proliferationNitric oxide synthase, inducibleHomo sapiens (human)
negative regulation of protein catabolic processNitric oxide synthase, inducibleHomo sapiens (human)
defense response to bacteriumNitric oxide synthase, inducibleHomo sapiens (human)
regulation of cellular respirationNitric oxide synthase, inducibleHomo sapiens (human)
cell redox homeostasisNitric oxide synthase, inducibleHomo sapiens (human)
regulation of insulin secretionNitric oxide synthase, inducibleHomo sapiens (human)
defense response to Gram-negative bacteriumNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of killing of cells of another organismNitric oxide synthase, inducibleHomo sapiens (human)
cellular response to lipopolysaccharideNitric oxide synthase, inducibleHomo sapiens (human)
cellular response to type II interferonNitric oxide synthase, inducibleHomo sapiens (human)
cellular response to xenobiotic stimulusNitric oxide synthase, inducibleHomo sapiens (human)
regulation of cytokine production involved in inflammatory responseNitric oxide synthase, inducibleHomo sapiens (human)
negative regulation of blood pressureNitric oxide synthase, inducibleHomo sapiens (human)
response to hormoneNitric oxide synthase, inducibleHomo sapiens (human)
nitric oxide mediated signal transductionNitric oxide synthase, inducibleHomo sapiens (human)
response to lipopolysaccharideNitric oxide synthase, inducibleHomo sapiens (human)
inflammatory responseNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of guanylate cyclase activityNitric oxide synthase, inducibleHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (18)

Processvia Protein(s)Taxonomy
actin monomer bindingNitric oxide synthase, endothelialHomo sapiens (human)
nitric-oxide synthase activityNitric oxide synthase, endothelialHomo sapiens (human)
protein bindingNitric oxide synthase, endothelialHomo sapiens (human)
calmodulin bindingNitric oxide synthase, endothelialHomo sapiens (human)
FMN bindingNitric oxide synthase, endothelialHomo sapiens (human)
heme bindingNitric oxide synthase, endothelialHomo sapiens (human)
tetrahydrobiopterin bindingNitric oxide synthase, endothelialHomo sapiens (human)
arginine bindingNitric oxide synthase, endothelialHomo sapiens (human)
cadmium ion bindingNitric oxide synthase, endothelialHomo sapiens (human)
flavin adenine dinucleotide bindingNitric oxide synthase, endothelialHomo sapiens (human)
NADP bindingNitric oxide synthase, endothelialHomo sapiens (human)
scaffold protein bindingNitric oxide synthase, endothelialHomo sapiens (human)
nitric-oxide synthase activityNitric oxide synthase, brainHomo sapiens (human)
calcium channel regulator activityNitric oxide synthase, brainHomo sapiens (human)
protein bindingNitric oxide synthase, brainHomo sapiens (human)
calmodulin bindingNitric oxide synthase, brainHomo sapiens (human)
FMN bindingNitric oxide synthase, brainHomo sapiens (human)
sodium channel regulator activityNitric oxide synthase, brainHomo sapiens (human)
heme bindingNitric oxide synthase, brainHomo sapiens (human)
tetrahydrobiopterin bindingNitric oxide synthase, brainHomo sapiens (human)
arginine bindingNitric oxide synthase, brainHomo sapiens (human)
transmembrane transporter bindingNitric oxide synthase, brainHomo sapiens (human)
cadmium ion bindingNitric oxide synthase, brainHomo sapiens (human)
calcium-dependent protein bindingNitric oxide synthase, brainHomo sapiens (human)
flavin adenine dinucleotide bindingNitric oxide synthase, brainHomo sapiens (human)
NADP bindingNitric oxide synthase, brainHomo sapiens (human)
scaffold protein bindingNitric oxide synthase, brainHomo sapiens (human)
nitric-oxide synthase activityNitric oxide synthase, inducibleHomo sapiens (human)
protein bindingNitric oxide synthase, inducibleHomo sapiens (human)
calmodulin bindingNitric oxide synthase, inducibleHomo sapiens (human)
FMN bindingNitric oxide synthase, inducibleHomo sapiens (human)
heme bindingNitric oxide synthase, inducibleHomo sapiens (human)
tetrahydrobiopterin bindingNitric oxide synthase, inducibleHomo sapiens (human)
arginine bindingNitric oxide synthase, inducibleHomo sapiens (human)
protein homodimerization activityNitric oxide synthase, inducibleHomo sapiens (human)
metal ion bindingNitric oxide synthase, inducibleHomo sapiens (human)
flavin adenine dinucleotide bindingNitric oxide synthase, inducibleHomo sapiens (human)
NADP bindingNitric oxide synthase, inducibleHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (24)

Processvia Protein(s)Taxonomy
Golgi membraneNitric oxide synthase, endothelialHomo sapiens (human)
nucleusNitric oxide synthase, endothelialHomo sapiens (human)
cytoplasmNitric oxide synthase, endothelialHomo sapiens (human)
Golgi apparatusNitric oxide synthase, endothelialHomo sapiens (human)
cytosolNitric oxide synthase, endothelialHomo sapiens (human)
cytoskeletonNitric oxide synthase, endothelialHomo sapiens (human)
plasma membraneNitric oxide synthase, endothelialHomo sapiens (human)
caveolaNitric oxide synthase, endothelialHomo sapiens (human)
endocytic vesicle membraneNitric oxide synthase, endothelialHomo sapiens (human)
nucleusNitric oxide synthase, endothelialHomo sapiens (human)
plasma membraneNitric oxide synthase, endothelialHomo sapiens (human)
cytosolNitric oxide synthase, endothelialHomo sapiens (human)
photoreceptor inner segmentNitric oxide synthase, brainHomo sapiens (human)
nucleoplasmNitric oxide synthase, brainHomo sapiens (human)
cytoplasmNitric oxide synthase, brainHomo sapiens (human)
mitochondrionNitric oxide synthase, brainHomo sapiens (human)
cytosolNitric oxide synthase, brainHomo sapiens (human)
cytoskeletonNitric oxide synthase, brainHomo sapiens (human)
plasma membraneNitric oxide synthase, brainHomo sapiens (human)
sarcoplasmic reticulumNitric oxide synthase, brainHomo sapiens (human)
sarcolemmaNitric oxide synthase, brainHomo sapiens (human)
dendritic spineNitric oxide synthase, brainHomo sapiens (human)
membrane raftNitric oxide synthase, brainHomo sapiens (human)
synapseNitric oxide synthase, brainHomo sapiens (human)
perinuclear region of cytoplasmNitric oxide synthase, brainHomo sapiens (human)
cell peripheryNitric oxide synthase, brainHomo sapiens (human)
protein-containing complexNitric oxide synthase, brainHomo sapiens (human)
plasma membraneNitric oxide synthase, brainHomo sapiens (human)
postsynaptic densityNitric oxide synthase, brainHomo sapiens (human)
cytosolNitric oxide synthase, brainHomo sapiens (human)
nucleusNitric oxide synthase, brainHomo sapiens (human)
nucleusNitric oxide synthase, inducibleHomo sapiens (human)
nucleoplasmNitric oxide synthase, inducibleHomo sapiens (human)
cytoplasmNitric oxide synthase, inducibleHomo sapiens (human)
peroxisomeNitric oxide synthase, inducibleHomo sapiens (human)
peroxisomal matrixNitric oxide synthase, inducibleHomo sapiens (human)
cytosolNitric oxide synthase, inducibleHomo sapiens (human)
cortical cytoskeletonNitric oxide synthase, inducibleHomo sapiens (human)
perinuclear region of cytoplasmNitric oxide synthase, inducibleHomo sapiens (human)
plasma membraneNitric oxide synthase, inducibleHomo sapiens (human)
nucleusNitric oxide synthase, inducibleHomo sapiens (human)
cytosolNitric oxide synthase, inducibleHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID234272Selectivity is defined as the ratio of the IC50(hncNOS) to IC50(hiNOS)1996Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.
AID92005Inhibitory activity against human inducible nitric oxide synthase1996Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.
AID68136Inhibitory activity against human Endothelial nitric oxide synthase1996Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.
AID220121Inhibition of [3H](-)-nicotine binding to recombinant rat alpha4-beta2 nAChR.1999Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
Novel and potent 6-chloro-3-pyridinyl ligands for the alpha4beta2 neuronal nicotinic acetylcholine receptor.
AID234271Selectivity is defined as the ratio of the IC50(hecNOS) to IC50(hiNOS)1996Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.
AID146117Inhibitory activity against human Neuronal nitric oxide synthase1996Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.09

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.09 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.29 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.09)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
molsidomine
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.. molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.		210ethyl ester;
morpholines;
oxadiazole;
zwitterion		antioxidant;
apoptosis inhibitor;
cardioprotective agent;
nitric oxide donor;
vasodilator agent
linsidomine
linsidomine: RN given refers to parent cpd; structure		210morpholines
ng-nitroarginine methyl ester
NG-Nitroarginine Methyl Ester: A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.		210alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor
pyrrolidine dithiocarbamate
pyrrolidine dithiocarbamic acid: spelled pyrolidine in J Nutr 1979 reference; RN given refers to parent cpd. pyrrolidine dithiocarbamate : A member of the class of dithiocarbamic acids that is the N-dithiocarboxy derivative of pyrrolidine.		210dithiocarbamic acids;
pyrrolidines		anticonvulsant;
antineoplastic agent;
geroprotector;
neuroprotective agent;
NF-kappaB inhibitor;
radical scavenger
nicotine
(S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.		2103-(1-methylpyrrolidin-2-yl)pyridineanxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic
delta-n-methylarginine
N(5)-methyl-L-arginine : A non-proteinogenic L-alpha-amino acid that is L-arginine substituted by a methyl group at N(5)-position.		1.9910guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid
n(6)-(1-iminoethyl)lysine
N(6)-acetimidoyl-L-lysine : An L-lysine derivative that is L-lysine in which one of the hydrogens attached to N(6) is substituted by an acetimidoyl group		1.9910L-lysine derivative;
non-proteinogenic L-alpha-amino acid
nadp
[no description available]		1.9910
desnitroimidacloprid
desnitroimidacloprid: a nicotinic receptor agonist; structure in first source		210
noc 18
NOC 18: releases nitric oxide; structure in first source		210
ConditionIndicatedRelationship StrengthStudiesTrials
Endotoxin Shock
[description not available]		02.0210
Shock, Septic
Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.		02.0210
Infections, Helicobacter
[description not available]		0210
Helicobacter Infections
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.		0210