1-(3-chlorophenyl)piperazine has been researched along with Alcohol Abuse in 15 studies
1-(3-chlorophenyl)piperazine: supposed metabolite of TRAZODONE; RN given refers to parent cpd; structure
1-(3-chlorophenyl)piperazine : A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Relapse is a frequent problem for recovered alcoholics since up to 80% do so within 6 months of completing treatment." | 2.38 | Possible pharmacological probes for predicting and preventing relapse in treated alcoholics. ( Kadlec, KE; Naranjo, CA, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (80.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ginsburg, BC | 1 |
| Lamb, RJ | 1 |
| Umhau, JC | 1 |
| Schwandt, ML | 1 |
| Usala, J | 1 |
| Geyer, C | 1 |
| Singley, E | 1 |
| George, DT | 3 |
| Heilig, M | 1 |
| Johanson, CE | 1 |
| Kilbey, M | 1 |
| Gatchalian, K | 1 |
| Tancer, M | 1 |
| Aulakh, CS | 1 |
| Mazzola-Pomietto, P | 1 |
| Murphy, DL | 3 |
| Krystal, JH | 3 |
| Webb, E | 3 |
| Cooney, N | 2 |
| Kranzler, HR | 2 |
| Charney, DS | 3 |
| Cooney, NL | 1 |
| Southwick, SW | 1 |
| Heninger, GR | 1 |
| Handelsman, L | 1 |
| Holloway, K | 1 |
| Kahn, RS | 1 |
| Sturiano, C | 1 |
| Rinaldi, PJ | 1 |
| Bernstein, DP | 1 |
| Siever, L | 1 |
| Gabriel, S | 1 |
| Cooper, TB | 1 |
| Benkelfat, C | 2 |
| Rawlings, RR | 1 |
| Eckardt, MJ | 1 |
| Phillips, MJ | 1 |
| Nutt, DJ | 1 |
| Wynne, D | 1 |
| Linnoila, M | 3 |
| Hommer, D | 1 |
| Andreasen, P | 1 |
| Rio, D | 1 |
| Williams, W | 1 |
| Ruttimann, U | 1 |
| Momenan, R | 1 |
| Zametkin, A | 1 |
| Rawlings, R | 1 |
| Buydens-Branchey, L | 1 |
| Branchey, M | 1 |
| Fergeson, P | 1 |
| Hudson, J | 1 |
| McKernin, C | 1 |
| Grillon, C | 1 |
| Casal, L | 1 |
| Morgan, CA | 1 |
| Southwick, SM | 1 |
| Davis, M | 1 |
| Overstreet, DH | 2 |
| Rezvani, AH | 2 |
| Janowsky, DS | 2 |
| Naranjo, CA | 1 |
| Kadlec, KE | 1 |
| Hill, JL | 1 |
| Nutt, D | 1 |
1 review available for 1-(3-chlorophenyl)piperazine and Alcohol Abuse
| Article | Year |
|---|---|
Possible pharmacological probes for predicting and preventing relapse in treated alcoholics.
Topics: Alcohol Drinking; Alcoholism; Humans; Piperazines; Quinolines; Recurrence; Serotonin Antagonists; Se | 1991 |
6 trials available for 1-(3-chlorophenyl)piperazine and Alcohol Abuse
| Article | Year |
|---|---|
Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate.
Topics: Acamprosate; Adrenergic alpha-2 Receptor Antagonists; Adult; Alcohol Deterrents; Alcohol-Induced Dis | 2011 |
Discriminative stimulus effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans trained to discriminate among d-amphetamine, meta-chlorophenylpiperazine and placebo.
Topics: Adult; Alcoholism; Amphetamine-Related Disorders; Arousal; Dextroamphetamine; Discrimination Learnin | 2006 |
Specificity of ethanollike effects elicited by serotonergic and noradrenergic mechanisms.
Topics: Adult; Affect; Alcohol Drinking; Alcoholism; Anxiety; Blood Pressure; Cocaine; Ethanol; Hospitalizat | 1994 |
Serotonergic and noradrenergic dysregulation in alcoholism: m-chlorophenylpiperazine and yohimbine effects in recently detoxified alcoholics and healthy comparison subjects.
Topics: Adult; Affect; Alcoholism; Double-Blind Method; Hospitalization; Humans; Hydrocortisone; Infusions, | 1996 |
Hormonal, psychological, and alcohol craving changes after m-chlorophenylpiperazine administration in alcoholics.
Topics: Adult; Alcoholism; Double-Blind Method; Ethanol; Euphoria; Humans; Hydrocortisone; Male; Middle Aged | 1997 |
Evidence of acoustic startle hyperreflexia in recently detoxified early onset male alcoholics: modulation by yohimbine and m-chlorophenylpiperazine (mCPP).
Topics: Acoustic Stimulation; Adrenergic alpha-Antagonists; Adult; Alcoholism; Humans; Male; Piperazines; Re | 1997 |
8 other studies available for 1-(3-chlorophenyl)piperazine and Alcohol Abuse
| Article | Year |
|---|---|
Drug effects on multiple and concurrent schedules of ethanol- and food-maintained behaviour: context-dependent selectivity.
Topics: Alcoholism; Amphetamines; Animals; Chlordiazepoxide; Dextroamphetamine; Dose-Response Relationship, | 2014 |
Long-term antidepressant treatments alter 5-HT2A and 5-HT2C receptor-mediated hyperthermia in Fawn-Hooded rats.
Topics: Adaptation, Physiological; Alcoholism; Amphetamines; Animals; Antidepressive Agents; Body Temperatur | 1995 |
Hostility is associated with a low prolactin response to meta-chlorophenylpiperazine in abstinent alcoholics.
Topics: Adult; Aggression; Alcoholism; Hostility; Humans; Male; Middle Aged; Personality Disorders; Personal | 1996 |
Behavioral and neuroendocrine responses to m-chlorophenylpiperazine in subtypes of alcoholics and in healthy comparison subjects.
Topics: Adrenocorticotropic Hormone; Adult; Age of Onset; Alcohol Drinking; Alcoholism; Anger; Antisocial Pe | 1997 |
Effects of m-chlorophenylpiperazine on regional brain glucose utilization: a positron emission tomographic comparison of alcoholic and control subjects.
Topics: Adult; Alcoholism; Brain; Deoxyglucose; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Glucose; Hum | 1997 |
Genetic animal models of depression and ethanol preference provide support for cholinergic and serotonergic involvement in depression and alcoholism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Alcoholism; Animals; Arousal; Avoidance Le | 1992 |
Drug-induced reductions in ethanol intake in alcohol preferring and Fawn-Hooded rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Buspirone; Drinking Behavior; Ethanol; Feeding Behavior; Fluo | 1991 |
Ethanollike properties of the serotonergic partial agonist m-chlorophenylpiperazine in chronic alcoholic patients.
Topics: Alcohol Drinking; Alcoholism; Animals; Humans; Infusions, Intravenous; Male; Piperazines; Placebos; | 1991 |