Page last updated: 2024-10-24

chlordiazepoxide and Alcohol Abuse

chlordiazepoxide has been researched along with Alcohol Abuse in 166 studies

Chlordiazepoxide: An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
chlordiazepoxide : A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.

Research Excerpts

ExcerptRelevanceReference
"Forty patients with primary chronic alcoholism took part in a randomized, double-blind, comparative group study of clobazam and chlordiazepoxide in the treatment of acute alcohol withdrawal."9.05A comparison of the efficacy and tolerability of clobazam and chlordiazepoxide in the treatment of acute withdrawal from alcohol in patients with primary alcoholism. ( Mukherjee, PK, 1983)
"A 27-year-old, Caucasian female with ethanol dependence who had objective symptoms of withdrawal experienced worsening of her delirium after administration of chlordiazepoxide, but improved with lorazepam and cleared with discontinuation of benzodiazepine administration."8.12Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report. ( Arabadjief, MA; Bashir, S; Bergman, CL; El-Mallakh, RS; Elsayed, OH; Gundumalla, MR; Menefee, DS; Moulana, NZ, 2022)
"The pattern of cardiac arrhythmias and their treatment, by propranolol and chlordiazepoxide, during the first 48 hr of alcohol withdrawal has been studied."7.66Propranolol and chlordiazepoxide effects on cardiac arrhythmias during alcohol withdrawal. ( Jacob, MS; MacLeod, SM; Sellers, EM; Ti, TY; Zilm, DH, 1980)
"Forty patients with primary chronic alcoholism took part in a randomized, double-blind, comparative group study of clobazam and chlordiazepoxide in the treatment of acute alcohol withdrawal."5.05A comparison of the efficacy and tolerability of clobazam and chlordiazepoxide in the treatment of acute withdrawal from alcohol in patients with primary alcoholism. ( Mukherjee, PK, 1983)
"A 27-year-old, Caucasian female with ethanol dependence who had objective symptoms of withdrawal experienced worsening of her delirium after administration of chlordiazepoxide, but improved with lorazepam and cleared with discontinuation of benzodiazepine administration."4.12Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report. ( Arabadjief, MA; Bashir, S; Bergman, CL; El-Mallakh, RS; Elsayed, OH; Gundumalla, MR; Menefee, DS; Moulana, NZ, 2022)
"The pattern of cardiac arrhythmias and their treatment, by propranolol and chlordiazepoxide, during the first 48 hr of alcohol withdrawal has been studied."3.66Propranolol and chlordiazepoxide effects on cardiac arrhythmias during alcohol withdrawal. ( Jacob, MS; MacLeod, SM; Sellers, EM; Ti, TY; Zilm, DH, 1980)
"The effect of chronic alcoholism on oral and intramuscular plasma levels of chlordiazepoxide (CDX) was assessed."3.66Absorption of oral intramuscular chlordiazepoxide by alcoholics. ( Caputo, JF; Fowler, RC; Hepler, CD; Perry, PJ; Wilding, DC, 1978)
"Lorazepam treated group showed a significant difference in the rate of improvement over 48 h compared to chlordiazepoxide group (70."2.78A double blind randomised comparison of chlordiazepoxide and lorazepam in alcohol withdrawal. ( Mohandas, E; Rajmohan, V; Sushil, K, 2013)
"One hundred consecutive consenting male inpatients in a state of moderately severe, uncomplicated alcohol withdrawal at screening were randomized to receive either lorazepam (8 mg/day) or chlordiazepoxide (80 mg/day) with dosing down-titrated to zero in a fixed-dose schedule across 8 treatment days."2.74A randomized, double-blind comparison of lorazepam and chlordiazepoxide in patients with uncomplicated alcohol withdrawal. ( Andrade, C; Kumar, CN; Murthy, P, 2009)
"Chlordiazepoxide was administered to only 41 patients (38%), yet 92 (85%) of the 108 enrolled successfully completed outpatient detoxification without medical complications."2.69Individualized treatment for outpatients withdrawing from alcohol. ( Briggs, MJ; Henderson, KL; Wiseman, EJ, 1998)
" A flexible dosage schedule was followed for 5 days with the objective of using the largest dose on the first day, followed by daily reductions as clinically feasible."2.66Halazepam in the management of acute alcohol withdrawal syndrome. ( Fine, EW; Mendels, J; Michals, TJ; Wasserman, TW, 1985)
"The chlordiazepoxide treatment produced suppression of rapid eye movement (REM) sleep lasting for about 4 days and virtually eliminated delta sleep (stages III and IV) during the recovery period."2.64Residual effects of ethanol and chlordiazepoxide treatments for alcohol withdrawal. ( Allen, RP; Funderburk, FR; Wagman, AM, 1978)
" Uncontrolled long-term administration is to be rejected in all circumstances, and supply should be strictly on prescription only in order to prevent uncontrolled acquisition."2.64The use of tranquilizers in the treatment of mixed drug abuse. ( Demel, I; Kryspin-Exner, K, 1975)
"Sedatives are important in treatment of alcohol withdrawal seizures and delirium tremens as well as in the prophylaxis of alcohol withdrawal syndrome."2.46[Diagnostics and therapy of alcohol withdrawal syndrome: focus on delirium tremens and withdrawal seizure]. ( Batra, A; Lutz, UC, 2010)
"Phenobarbital treatment was associated with decreased mortality, which might be confounded by somatic comorbidity among patients receiving chlordiazepoxide."1.43Phenobarbital compared to benzodiazepines in alcohol withdrawal treatment: A register-based cohort study of subsequent benzodiazepine use, alcohol recidivism and mortality. ( Askgaard, G; Fink-Jensen, A; Hallas, J; Madsen, KG; Molander, AC; Pottegård, A, 2016)
" Finally, no significant differences were found between age groups in either the dosage or number of days of detoxification medication, although a trend was found for more days of medication in the elderly."1.29Severity and treatment of alcohol withdrawal in elderly versus younger patients. ( Blow, FC; Brower, KJ; Hill, EM; Mudd, S; Young, JP, 1994)
"Buspirone was without important effects on the high alcohol preferring rats."1.29Effects of various serotonergic agents on alcohol intake and alcohol preference in Wistar rats selected at two different levels of alcohol preference. ( Meert, TF, 1993)
" Drug was most often given on a fixed dosing schedule with additional medication "as needed" (52% of the programs)."1.29Alcohol withdrawal: a nationwide survey of inpatient treatment practices. ( Friedman, LS; Mayo-Smith, MF; Saitz, R, 1995)
" These findings and other results of pharmacokinetic research have clinical implications in terms of dosage schedules, drug accumulation during long-term therapy, antianxiety therapy in the elderly, drug interactions, pharmacotherapy in specific disease states, and the influence of route of administration on drug action."1.26Clinical implications of benzodiazepine pharmacokinetics. ( Greenblatt, DJ; Shader, RI, 1977)
"Oxazepam has no important active metabolites and its net disposition is minimally altered by disulfiram."1.26Interaction of disulfiram with benzodiazepines. ( Billings, BJ; Giles, HG; Greenblatt, DJ; MacLeod, SM; Marshman, JA; Martin, PR; Sellers, EM, 1978)
"Propranolol alone was more effective than either chlordiazepoxide or a combination of chlordiazepoxide and propranolol in alleviating the symptoms of the alcohol withdrawal syndrome."1.26Comparative efficacy of propranolol and chlordiazepoxide in alcohol withdrawal. ( Degani, NC; Sellers, EM; Zilm, DH, 1977)

Research

Studies (166)

TimeframeStudies, this research(%)All Research%
pre-1990138 (83.13)18.7374
1990's13 (7.83)18.2507
2000's5 (3.01)29.6817
2010's7 (4.22)24.3611
2020's3 (1.81)2.80

Authors

AuthorsStudies
Osler, M1
Jørgensen, MB1
Arabadjief, MA1
Elsayed, OH1
Bashir, S1
Gundumalla, MR1
Menefee, DS1
Bergman, CL1
Moulana, NZ1
El-Mallakh, RS1
Pedersen, SA1
Klesse, T1
Findal Andreasen, M1
Dalhoff, KP1
Andersen, CU1
Rajmohan, V1
Sushil, K1
Mohandas, E1
Kaur, N1
Medhi, B1
Stock, CJ1
Carpenter, L1
Ying, J1
Greene, T1
Prakash, S1
Mandal, P1
Ginsburg, BC1
Lamb, RJ1
Askgaard, G1
Hallas, J1
Fink-Jensen, A1
Molander, AC1
Madsen, KG1
Pottegård, A1
Kumar, CN1
Andrade, C1
Murthy, P1
Lutz, UC1
Batra, A1
KAROLUS, HE1
MOONEY, HB1
DITMAN, KS4
COHEN, S1
TICKTIN, HE1
SCHULTZ, JD2
BARTHOLOMEW, AA1
GUILE, LA1
BURKE, GW1
ANDERSON, CW1
CHESROW, EJ1
KAPLITZ, SE1
LEVINE, JM1
MUSCI, JP1
SABATINI, R1
MARGAT, P1
CRETON, M1
FLOYD, JB1
COLLINS, MC1
BAROODY, NB1
BAROODY, WG1
MEAD, WR1
ROY, PB1
MERCURE, J1
LEBEL, G1
BOURQUE, R1
KISSEN, MD2
KOUTSKY, CD1
SLETEN, IW1
MORRISON, JM1
CAPONE, A1
HOLMBERG, M1
HOFF, EC2
CHARNOFF, SM2
KISSIN, B7
REED, JI1
ARMOUR, PS1
SHAFFER, JW1
FREINEK, WR1
WOLF, S2
FOXWELL, NH2
KURLAND, AA2
NIELSEN, J1
GOLDMAN, D1
SCHYNOLL, G1
ACHTE, KA1
ALONSOFERNANDEZ, F1
GUNDRY, LP1
NEWLAND, ED1
GOTTLIEB, L1
SALZBERGER, GJ1
MOORHEAD, HH1
MCKINLEY, RA1
KJOLSTAD, T1
GHISLANDI, E1
CRESPI, G1
MELDMAN, MJ1
SERENY, G1
KALANT, H1
LUTON, EF1
FINCHUM, RN1
CHAMBERS, JF2
MADALENA, JC1
Olesen, OV1
Golbert, TM1
Sanz, CJ1
Rose, HD1
Leitschuh, TH1
Mukherjee, PK1
Targum, SD1
Wheadon, DE1
Chastek, CT1
McCabe, WJ1
Advani, MT1
Panerai, AE1
Martini, A1
De Rosa, A1
Salerno, F1
Di Giulio, AM1
Mantegazza, P1
Bailey, DN1
Lapierre, YD1
Bulmer, DR1
Oyewumi, LK1
Mauguin, ML1
Knott, VJ1
Favazza, AR1
Reilly, EL2
Kelley, JT1
Pena, YM1
Overall, JE2
Faillace, LA2
Zilm, DH3
Jacob, MS1
MacLeod, SM3
Sellers, EM6
Ti, TY1
Chan, AW3
Leong, FW2
Schanley, DL2
Howe, SM1
Mäthner, H1
Gillner, M1
Pelliccioni, R1
Sullivan, JT1
Saitz, R2
Mayo-Smith, MF2
Roberts, MS1
Redmond, HA1
Bernard, DR1
Calkins, DR1
Fuller, RK1
Gordis, E1
Brower, KJ1
Mudd, S1
Blow, FC1
Young, JP1
Hill, EM1
Monti, PM2
Rohsenow, DJ1
Rubonis, AV1
Niaura, RS1
Sirota, AD1
Colby, SM1
Abrams, DB1
Meert, TF1
Friedman, LS1
Hyman, SE1
Wiseman, EJ2
Henderson, KL2
Briggs, MJ2
Wooddell, WJ1
Reoux, JP1
Miller, K1
Ward, RJ1
Martinez, J1
Ball, D1
Marshall, EJ2
De Witte, P1
Gossop, M1
Keaney, F1
Stewart, D1
Strang, J1
Longo, LP1
Campbell, T1
Hubatch, S1
Rosenbaum, AH1
Niven, RG1
Hanson, NP1
Swanson, DW1
Shader, RI4
Greenblatt, DJ6
Fialkov, MJ1
Giles, HG2
Billings, BJ1
Martin, PR1
Marshman, JA1
Ritson, EB1
Edwards, G1
Funderburk, FR2
Allen, RP3
Wagman, AM3
Coleman, JH1
Evans, WE1
Bissell, LC1
Menken, M1
Buonpane, N1
Perly, R1
Runion, HI1
Fowler, FN1
Keeler, MH1
Taylor, CI1
Miller, WC1
Glass, G1
Pena-Ramos, A2
Hornberger, R1
Reed, JR1
Mandell, W1
Desmond, PV1
Schenker, S1
Degani, NC1
Hewitt, M1
Perry, PJ1
Wilding, DC1
Fowler, RC1
Hepler, CD1
Caputo, JF1
Franke, K1
Degani, N1
Robertson, CC1
Nims, RG1
Coleman, CR1
Clerkin, AJ1
Palestine, ML1
Alatorre, E1
Rothstein, E2
Cobble, JC1
Sampson, N1
Glass, GS1
Blum, K1
Eubanks, JD1
Wallace, JE1
Schwertner, H1
Morgan, WW1
Lowenstam, I1
McGrath, SD1
Kryspin-Exner, K2
Demel, I1
Shaw, JA1
Donley, P1
Morgan, DW1
Robinson, JA1
Rada, RT1
Kellner, R1
Buchanan, JG1
Hartviksen, I1
Pistelli, A1
Di Simplicio, P1
Di Bello, MG1
Raspanti, S1
Gambassi, F1
Botti, P1
Caramelli, L1
Peruzzi, S1
Smorlesi, C1
Zorn, AM1
Haigh, R1
Hibbert, G1
Wartenberg, AA1
Nirenberg, TD1
Liepman, MR1
Silvia, LY1
Begin, AM1
Scher, M1
Neppe, V1
Liskow, BI2
Rinck, C1
Campbell, J1
DeSouza, C1
Mendels, J1
Wasserman, TW1
Michals, TJ1
Fine, EW1
Powell, BJ1
Penick, EC1
Rice, AS1
McKnelly, W1
Langan, MC1
Penetrante, ML1
Dackis, CA1
Gold, MS1
Pottash, AL1
Sweeney, DR1
Kaplan, RF1
Glueck, BC1
Hesselbrock, MN1
Reed, HB1
Whitlock, FA1
Price, J1
Gross, MM2
Mello, NK1
Mendelson, JH1
Sedvall, G1
Moss, T2
Forgy, E1
Zunin, L1
Funk, W1
Lynch, R1
Oge, V1
Sampliner, R1
Iber, FL1
Brown, D1
Williams, JD1
Neill, LT1
Rosenberg, CM1
Nantel, A1
Murphy, HB1
Koch-Weser, J1
Knott, DH1
Beard, JD1
Chaftez, ME1
Rosenblatt, SM2
Machover, S1
Forgy, EW1
Zunin, LM1
Lynch, RD1
Funk, WA1
Klett, CJ1
Hollister, LE1
Caffey, EM1
Kaim, SC1
Short, MJ1
Moore, WJ1
Malmgren, G1
Zbinden, G1
Randall, LO1
Hudson, FG2
McGowan, JM2
Renninger, ME1
Foster, CA1
Gallant, DM1
Bishop, MP1
Camp, E1
Tisdale, C1
Fox, RP1
Graham, MB1
Gill, MJ1
Belfer, ML1
Carroll, M1
Harmatz, JS1
Bolzani, L1
Slivar, G1
Victor, M1
Finer, MJ1
Platz, A1
Su, WH1
Devenyi, P1
Iandolo, C1
Parry, RA1
Muller, DJ1
Wegner, ME1
Fink, DW1
Daly, RJ1
Kane, FJ1
Glatt, MM1
Bowman, EH1
Thimann, J1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit[NCT04156464]Phase 4142 participants (Anticipated)Interventional2020-07-06Recruiting
Prospective Assessment of Valproate on Ethanol Withdrawal[NCT03235531]Phase 4210 participants (Anticipated)Interventional2017-07-11Recruiting
5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence[NCT01549652]133 participants (Actual)Interventional2011-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Beck Depression Inventory Score (BDIS) Change From Baseline (Prevention of Opioid Withdrawal)

The Beck Depression Inventory (a 21-item self-report multiple-choice inventory) yields a single summed score between 0 and 63; higher scores indicate more severe depression. Change is from baseline score (taken at the beginning of the first study visit, prior to beginning of titration into morphine) to the score taken after taking morphine for 30 days (score taken prior to receiving ondansetron or placebo, at the beginning of second study visit). (NCT01549652)
Timeframe: 2 study days 1 month apart (at the start of each study visit)

Interventionunits on a scale (Mean)
Prevention of Opioid Withdrawal-0.44

Change in Pain Visual Analog Scale (VAS) From Baseline (Prevention of Opioid Withdrawal)

The VAS is a 0 to 100 millimeter scale where 0 corresponds to no pain and 100 to extreme pain, used by participants to indicated their level of pain over the last two weeks. Change is from baseline score for average level of pain (taken at the beginning of the first study visit, prior to beginning of titration into morphine) to the score taken after taking morphine for 30 days (score taken prior to receiving ondansetron or placebo, at the beginning of second study visit). (NCT01549652)
Timeframe: 2 study days 1 month apart (at the start of each study visit)

Interventionunits on a scale (Mean)
Prevention of Opioid Withdrawal-2.68

Change in Roland-Morris Disability Index (RMDI) From Baseline (Prevention of Opioid Withdrawal)

The Roland-Morris Disability Index is a 24-question instrument used to assess level of disability from lower back pain. Scores range from 0-24 with lower scores corresponding to fewer symptoms. Change is from baseline score (taken at the beginning of the first study visit, prior to beginning of titration into morphine) to the score taken after taking morphine for 30 days (score taken prior to receiving ondansetron or placebo, at the beginning of second study visit). (NCT01549652)
Timeframe: 2 study days 1 month apart (at the start of each study visit)

Interventionunits on a scale (Mean)
Prevention of Opioid Withdrawal-2.59

Beck Depression Inventory Score (BDIS) Change From Baseline (Prevention of Physical Dependence)

The Beck Depression Inventory (a 21-item self-report multiple-choice inventory) yields a single summed score between 0 and 63; higher scores indicate more severe depression. Change is from baseline score (taken at the beginning of the first study visit, prior to beginning of titration into morphine) to the score taken after taking morphine for 30 days (score taken at the beginning of second study visit). (NCT01549652)
Timeframe: 2 study days 1 month apart (at the start of each study visit)

Interventionunits on a scale (Mean)
Change in BDIS (Ondansetron)Change in BDIS (Placebo)
Prevention of Physical Dependence-0.60.2

Change in Objective Opioid Withdrawal Score (OOWS) From Baseline (Prevention of Opioid Withdrawal)

"Originally developed by Handelsman, the Objective Opioid Withdrawal Scale (OOWS) score is a well-characterized measure of opioid withdrawal in humans, calculated as the sum of a 13-item physician assessment documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. The minimum score of 0 means the patient is not showing any signs of opioid withdrawal. The maximum score of 13 signifies all signs of opioid withdrawal to the largest extent possible.~Immediately prior to ondansetron or placebo administration a baseline OOWS score was taken. 30 minutes later participants received naloxone, then 15 minutes later an OOWS score was taken. If deemed necessary by the clinician, participants may have received a second naloxone dose (25 minutes following 1st naloxone dose), then 15 minutes later an OOWS score was taken. Change from the baseline OOWS score to the score assessed following the last naloxone dose is reported." (NCT01549652)
Timeframe: Baseline; 15 minutes following last naloxone dose

Interventionunits on a scale (Mean)
Change in OOWS (Ondansetron)Change in OOWS (Placebo)
Prevention of Opioid Withdrawal3.63.6

Change in Objective Opioid Withdrawal Score From Baseline (Prevention of Physical Dependence)

"Originally developed by Handelsman, the OOWS score is a well-characterized measure of opioid withdrawal in humans, calculated as the sum of a 13-item physician assessment documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. The maximum score is 13 and suggests the patient is showing all signs of opioid withdrawal to the largest extent possible. The minimum score of 0 suggests the patient is not showing any signs of opioid withdrawal.~Immediately prior to ondansetron or placebo administration a baseline OOWS score was taken. 30 minutes later participants received naloxone, then 15 minutes later an OOWS score was taken. If necessary (as deemed by the clinician), participants may have received a second naloxone dose (25 minutes following 1st naloxone dose), then 15 minutes later an OOWS score was taken. Change from the baseline OOWS score to the score assessed following the last naloxone dose is reported." (NCT01549652)
Timeframe: Baseline; 15 minutes following last naloxone dose

Interventionunits on a scale (Mean)
Change in OOWS (Ondansetron)Change in OOWS (Placebo)
Prevention of Physical Dependence4.54.2

Change in Pain Visual Analog Scale (VAS) From Baseline (Prevention of Physical Dependence)

The VAS is a 0 to 100 millimeter scale where 0 corresponds to no pain and 100 to extreme pain, used by participants to indicated their level of pain over the last two weeks. Change is from baseline score for average level of pain (taken at the beginning of the first study visit, prior to beginning of titration into morphine) to the score taken after taking morphine for 30 days (score taken at the beginning of second study visit). (NCT01549652)
Timeframe: 2 study days 1 month apart (at the start of each study visit)

Interventionunits on a scale (Mean)
Change in VAS Score (Ondansetron)Change in VAS Score (Placebo)
Prevention of Physical Dependence-2.9-2.8

Change in Roland-Morris Disability (RMDI) Index From Baseline (Prevention of Physical Dependence)

The Roland-Morris Disability Index is a 24-question instrument used to assess level of disability from lower back pain. Scores range from 0-24 with lower scores corresponding to fewer symptoms. Change is from baseline score (taken at the beginning of the first study visit, prior to beginning of titration into morphine) to the score taken after taking morphine for 30 days (score taken at the beginning of second study visit). (NCT01549652)
Timeframe: 2 study days 1 month apart (at the start of each study visit)

Interventionunits on a scale (Mean)
Change in RMDI (Ondansetron)Change in RMDI (Placebo)
Prevention of Physical Dependence-4.6-2.0

Change in Subjective Opioid Withdrawal Score (SOWS) From Baseline (Prevention of Opioid Withdrawal)

The Subjective Opioid Withdrawal Score (SOWS) score is calculated as the sum of 16 subjective patient-reported symptom scores rated on a scale of 0 to 4 (0=not at all, 4=extremely) based on what subjects were experiencing at the time of testing. A maximum score of 64 would suggest the patient is experiencing the symptoms of withdrawal to the maximum extent possible while the lowest score of 0 would suggest the patient is not experiencing any of the symptoms of withdrawal. Immediately prior to ondansetron or placebo administration a baseline SOWS score was taken. 30 minutes later participants received naloxone, then 15 minutes later an SOWS score was taken. If necessary (as deemed by the clinician), participants may have received a second naloxone dose (25 minutes following 1st naloxone dose), then 15 minutes later an SOWS score was taken. Change from the baseline SOWS score to the score assessed following the last naloxone dose is reported (NCT01549652)
Timeframe: Baseline; 15 minutes following last naloxone dose

Interventionunits on a scale (Mean)
Change in SOWS (Ondansetron)Change in SOWS (Placebo)
Prevention of Opioid Withdrawal12.512.2

Change in Subjective Opioid Withdrawal Score From Baseline (Prevention of Physical Dependence)

The SOWS score is composed of 16 subjective symptoms rated on a scale of 0 to 4 (0=not at all, 4=extremely) based on what subjects were experiencing at the time of testing. A maximum score of 64 would suggest the patient is experiencing the symptoms of withdrawal to the maximum extent possible while the lowest score of 0 would suggest the patient is not experiencing any of the symptoms of withdrawal. Immediately prior to ondansetron or placebo administration a baseline SOWS score was taken. 30 minutes later participants received naloxone, then 15 minutes later an SOWS score was taken. If necessary (as deemed by the clinician), participants may have received a second naloxone dose (25 minutes following 1st naloxone dose), then 15 minutes later an SOWS score was taken. Change from the baseline SOWS score to the score assessed following the last naloxone dose is reported (NCT01549652)
Timeframe: Baseline; 15 minutes following last naloxone dose

Interventionunits on a scale (Mean)
Change in SOWS (Ondansetron)Change in SOWS (Placebo)
Prevention of Physical Dependence16.412.0

Profile of Mood States (POMS) Change in Score From Baseline (Prevention of Opioid Withdrawal)

Profile of Mood States (POMS) is a 65-question survey of how participants have been feeling over the past week, assessing tension, depression, anger, fatigue, confusion and vigor. Each question is on a 5-point scale: 0 (not at all) to 4 (extremely). Overall score range: 0 to 200 (lower scores corresponding to fewer symptoms), calculated by adding total scores for tension, depression, anger, fatigue and confusing, and subtracting that total score from the total score for vigor. Immediately prior to ondansetron or placebo administration a baseline POMS score was taken. 30 minutes later participants received naloxone, then 15 minutes later a POMS score was taken. If necessary (as deemed by the clinician), participants may have received a second naloxone dose (25 minutes following 1st naloxone dose), then 15 minutes later an POMS score was taken. Change from the baseline POMS score to the score assessed following the last naloxone dose is reported. (NCT01549652)
Timeframe: Baseline; 15 minutes following last naloxone dose

Interventionunits on a scale (Mean)
Change in POMS Score (Ondansetron)Change in POMS Score (Placebo)
Prevention of Opioid Withdrawal29.328.3

Profile of Mood States (POMS) Change in Score From Baseline (Prevention of Physical Dependence)

(Profile of Mood States) POMS is a 65-question survey of how participants have been feeling over the past week, assessing tension, depression, anger, fatigue, confusion and vigor. Each question is on a 5-point scale: 0 (not at all) to 4 (extremely). Overall score range: 0 to 200 (lower scores corresponding to fewer symptoms), calculated by adding total scores for tension, depression, anger, fatigue and confusing, and subtracting that total score from the total score for vigor. Immediately prior to ondansetron or placebo administration a baseline POMS score was taken. 30 minutes later participants received naloxone, then 15 minutes later a POMS score was taken. If necessary (as deemed by the clinician), participants may have received a second naloxone dose (25 minutes following 1st naloxone dose), then 15 minutes later an POMS score was taken. Change from the baseline POMS score to the score assessed following the last naloxone dose is reported. (NCT01549652)
Timeframe: Baseline; 15 minutes following last naloxone dose

Interventionunits on a scale (Mean)
Change in POMS (Ondansetron)Change in POMS (Placebo)
Prevention of Physical Dependence36.129.2

Reviews

9 reviews available for chlordiazepoxide and Alcohol Abuse

ArticleYear
[Diagnostics and therapy of alcohol withdrawal syndrome: focus on delirium tremens and withdrawal seizure].
    Psychiatrische Praxis, 2010, Volume: 37, Issue:6

    Topics: Adrenergic beta-Antagonists; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcoholism; A

2010
ALCOHOLISM.
    Progress in neurology and psychiatry, 1963, Volume: 18

    Topics: Alcoholism; Chlordiazepoxide; Chlormethiazole; Chlorpropamide; Culture; Lysergic Acid Diethylamide;

1963
The meaning and treatment of alcohol dependence.
    The British journal of psychiatry : the journal of mental science, 1975, Volume: Spec No 9

    Topics: Alcohol Withdrawal Delirium; Alcoholic Beverages; Alcoholics Anonymous; Alcoholism; Amnesia; Aversiv

1975
Drug therapy. Benzodiazepines (second of two parts).
    The New England journal of medicine, 1974, Dec-05, Volume: 291, Issue:23

    Topics: Affective Symptoms; Alcoholism; Analgesia; Anesthesia, General; Anesthesia, Obstetrical; Anti-Anxiet

1974
Use of beta-adrenergic receptor blocking drugs in psychiatry.
    Drugs, 1974, Volume: 8, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alcoholism; Anxiety; Chlordiazepoxide; Di

1974
Drugs in the treatment of alcoholism.
    The Medical clinics of North America, 1967, Volume: 51, Issue:5

    Topics: Alcohol Deterrents; Alcoholic Intoxication; Alcoholism; Amitriptyline; Antidepressive Agents; Chlord

1967
Prognostic factors in alcoholism.
    Psychiatric research reports, 1968, Volume: 24

    Topics: Adult; Alcoholism; Chlordiazepoxide; Ethnicity; Follow-Up Studies; Humans; Imipramine; Male; Middle

1968
Drug and placebo responses in chronic alcoholics.
    Psychiatric research reports, 1968, Volume: 24

    Topics: Achievement; Alcoholism; Antidepressive Agents; Black or African American; Chlordiazepoxide; Chronic

1968
Pharmacology of benzodiazepines: laboratory and clinical correlations.
    Advances in pharmacology, 1967, Volume: 5

    Topics: Aggression; Alcoholism; Animals; Anticonvulsants; Anxiety; Autonomic Nervous System; Avoidance Learn

1967

Trials

33 trials available for chlordiazepoxide and Alcohol Abuse

ArticleYear
A double blind randomised comparison of chlordiazepoxide and lorazepam in alcohol withdrawal.
    Asian journal of psychiatry, 2013, Volume: 6, Issue:5

    Topics: Adult; Alcoholism; Analysis of Variance; Chlordiazepoxide; Double-Blind Method; Humans; Hypnotics an

2013
A randomized, double-blind comparison of lorazepam and chlordiazepoxide in patients with uncomplicated alcohol withdrawal.
    Journal of studies on alcohol and drugs, 2009, Volume: 70, Issue:3

    Topics: Adolescent; Adult; Alcohol-Induced Disorders; Alcoholism; Chlordiazepoxide; Drug Administration Sche

2009
Comparative evaluation of treatments of alcohol withdrawal syndromes.
    JAMA, 1967, Jul-10, Volume: 201, Issue:2

    Topics: Alcoholism; Chloral Hydrate; Chlordiazepoxide; Drug Synergism; Ethanol; Fever; Humans; Male; Middle

1967
A comparison of the efficacy and tolerability of clobazam and chlordiazepoxide in the treatment of acute withdrawal from alcohol in patients with primary alcoholism.
    The Journal of international medical research, 1983, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Aged; Alcoholism; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Benzodiazepinone

1983
Comparison of chlormethiazole (Heminevrin) and chlordiazepoxide (Librium) in the treatment of acute alcohol withdrawal.
    Neuropsychobiology, 1983, Volume: 10, Issue:2-3

    Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Chlormethiazole; Double-Blind Meth

1983
Individualized treatment for alcohol withdrawal. A randomized double-blind controlled trial.
    JAMA, 1994, Aug-17, Volume: 272, Issue:7

    Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Double-Blind Method; Drug Administ

1994
Individualized treatment for outpatients withdrawing from alcohol.
    The Journal of clinical psychiatry, 1998, Volume: 59, Issue:6

    Topics: Adult; Age Factors; Aged; Alcoholism; Ambulatory Care; Anti-Anxiety Agents; Aspartate Aminotransfera

1998
Divalproex sodium (Depakote) for alcohol withdrawal and relapse prevention.
    Journal of addictive diseases, 2002, Volume: 21, Issue:2

    Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Ambulatory Care; Anti-Anxiety Agents; Anticonvulsant

2002
Residual effects of ethanol and chlordiazepoxide treatments for alcohol withdrawal.
    The Journal of nervous and mental disease, 1978, Volume: 166, Issue:3

    Topics: Adult; Alcoholism; Chlordiazepoxide; Electroencephalography; Ethanol; Humans; Male; Middle Aged; Psy

1978
A double blind study of chlordiazepoxide and hydroxyzine HC1 therapy in acute alcohol withdrawal utilizing chronic electromyography for tremor assessment.
    Proceedings of the Western Pharmacology Society, 1978, Volume: 21

    Topics: Alcoholism; Chlordiazepoxide; Clinical Trials as Topic; Double-Blind Method; Electromyography; Human

1978
MMPI and drug treatment in alcohol withdrawal.
    The Journal of clinical psychiatry, 1979, Volume: 40, Issue:8

    Topics: Adult; Alcoholism; Chlordiazepoxide; Double-Blind Method; Drug Evaluation; Female; Humans; Male; Mid

1979
Control of acute alcoholic withdrawal symptoms: a comparative study of haloperidol and chlordiazepoxide.
    Current therapeutic research, clinical and experimental, 1976, Volume: 20, Issue:3

    Topics: Adult; Aged; Alcoholism; Chlordiazepoxide; Clinical Trials as Topic; Female; Haloperidol; Humans; In

1976
Slow wave sleep changes: alcohol tolerance and treatment implications.
    Advances in experimental medicine and biology, 1977, Volume: 85A

    Topics: Adult; Alcoholism; Chlordiazepoxide; Drug Tolerance; Ethanol; Humans; Male; Middle Aged; Sleep Stage

1977
Drug treatment in a rehabilitation center for chronic alcoholics.
    Journal of chronic diseases, 1975, Volume: 28, Issue:7-8

    Topics: Adult; Alcoholism; Chlordiazepoxide; Chronic Disease; Clinical Trials as Topic; Drug Evaluation; Hos

1975
A controlled trial of chlormethiazole and chlordiazepoxide in the treatment of the acute withdrawal phase of alcoholism.
    The British journal of addiction to alcohol and other drugs, 1975, Volume: 70 Suppl 1

    Topics: Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Chlormethiazole; Clinical Trials as Topic

1975
The use of tranquilizers in the treatment of mixed drug abuse.
    International journal of clinical pharmacology and biopharmacy, 1975, Volume: 12, Issue:1-2

    Topics: Adult; Alcoholism; Analgesics; Barbiturates; Chlordiazepoxide; Clinical Trials as Topic; Diazepam; F

1975
Treatment of depression in alcoholics.
    The American journal of psychiatry, 1975, Volume: 132, Issue:6

    Topics: Adolescent; Adult; Alcoholism; Chlordiazepoxide; Counseling; Depression; Drug Evaluation; Drug Thera

1975
[Contribution of glutathione to detoxification in alcoholism. Biochemical-clinical studies].
    La Clinica terapeutica, 1992, Volume: 140, Issue:5

    Topics: Adult; Alcoholism; Chlordiazepoxide; Erythrocytes; Female; gamma-Glutamyltransferase; Glucaric Acid;

1992
Where and when to detoxify single homeless drinkers.
    BMJ (Clinical research ed.), 1990, Oct-13, Volume: 301, Issue:6756

    Topics: Alcoholism; Ambulatory Care; Appointments and Schedules; Chlordiazepoxide; Humans; Ill-Housed Person

1990
Halazepam in the management of acute alcohol withdrawal syndrome.
    The Journal of clinical psychiatry, 1985, Volume: 46, Issue:5

    Topics: Acute Disease; Adult; Alcoholism; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chlordiaz

1985
Lithium compliance in alcoholic males: a six month followup study.
    Addictive behaviors, 1986, Volume: 11, Issue:2

    Topics: Adult; Alcoholism; Chlordiazepoxide; Follow-Up Studies; Humans; Lithium; Lithium Carbonate; Male; Mi

1986
Diphenylhydantoin control of alcohol withdrawal seizures. Results of a controlled study.
    JAMA, 1974, Dec-04, Volume: 230, Issue:10

    Topics: Administration, Oral; Alcoholism; Chlordiazepoxide; Clinical Trials as Topic; Drug Evaluation; Elect

1974
Drug treatment of anxiety and depression in detoxified alcoholic patients.
    Archives of general psychiatry, 1973, Volume: 29, Issue:2

    Topics: Alcoholism; Amitriptyline; Analysis of Variance; Anxiety; Ascorbic Acid; Chlordiazepoxide; Depressio

1973
Drug maintenance in the outpatient treatment of chronic alcoholism.
    Archives of general psychiatry, 1974, Volume: 30, Issue:3

    Topics: Adult; Alcohol Drinking; Alcoholic Intoxication; Alcoholism; Automobile Driving; Boston; Chlordiazep

1974
A study of drugs in the management of chronic alcoholism.
    GP, 1967, Volume: 36, Issue:3

    Topics: Alcoholism; Chlordiazepoxide; Chronic Disease; Clinical Trials as Topic; Humans; Hydroxyzine; Placeb

1967
Drug therapy in alcoholism.
    The American journal of psychiatry, 1968, Volume: 125, Issue:1

    Topics: Alcoholic Intoxication; Alcoholism; Amitriptyline; Antidepressive Agents; Benactyzine; Carbamates; C

1968
Drug and placebo responses in chronic alcoholics.
    Psychiatric research reports, 1968, Volume: 24

    Topics: Achievement; Alcoholism; Antidepressive Agents; Black or African American; Chlordiazepoxide; Chronic

1968
Dimensions of LSD, methylphenidate and chlordiazepoxide experiences.
    Psychopharmacologia, 1969, Volume: 14, Issue:1

    Topics: Alcoholism; Chlordiazepoxide; Clinical Trials as Topic; Emotions; Hallucinations; Humans; Lysergic A

1969
Evaluating changes in symptoms during acute alcohol withdrawal.
    Archives of general psychiatry, 1971, Volume: 24, Issue:2

    Topics: Affect; Alcoholism; Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; Female; Humans; Hydr

1971
Comparative investigation of the effects of dixyrazine, placebo and chlordiazepoxide on alcoholics during hospital care.
    Acta neurologica et psychiatrica Belgica, 1967, Volume: 67

    Topics: Adult; Aged; Alcoholism; Chemical Phenomena; Chemistry; Chlordiazepoxide; Chronic Disease; Clinical

1967
A six-month controlled evaluation of metronidazole (Flagyl) in chronic alcoholic patients.
    Current therapeutic research, clinical and experimental, 1968, Volume: 10, Issue:2

    Topics: Adult; Age Factors; Alcoholism; Black People; Chlordiazepoxide; Clinical Trials as Topic; Female; Hu

1968
[Clinical study of an anxiolytic antidepressive drug].
    Psychiatria et neurologia, 1967, Volume: 153, Issue:5

    Topics: Adjustment Disorders; Adult; Aged; Alcoholism; Amitriptyline; Bipolar Disorder; Chlordiazepoxide; Cl

1967
Treatment of alcoholism in the subacute stage. (A study of three active agents).
    Diseases of the nervous system, 1966, Volume: 27, Issue:5

    Topics: Adult; Aged; Alcoholism; Antidepressive Agents; Chlordiazepoxide; Humans; Male; Middle Aged; Oxazepa

1966

Other Studies

125 other studies available for chlordiazepoxide and Alcohol Abuse

ArticleYear
Association of benzodiazepines, Z-drugs, pregabalin, and melatonin with traffic accidents: A nationwide cohort and case-crossover study in Danish adults.
    Journal of psychopharmacology (Oxford, England), 2022, Volume: 36, Issue:4

    Topics: Accidents, Traffic; Adolescent; Adult; Aged; Alcoholism; Benzodiazepines; Chlordiazepoxide; Cohort S

2022
Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report.
    Journal of medical case reports, 2022, Jul-07, Volume: 16, Issue:1

    Topics: Adult; Alcoholism; Chlordiazepoxide; Delirium; Ethanol; Female; Humans; Substance Withdrawal Syndrom

2022
Active chlordiazepoxide metabolites in a patient needing life support after treatment of alcohol abstinence.
    Basic & clinical pharmacology & toxicology, 2020, Volume: 127, Issue:5

    Topics: Alcohol Abstinence; Alcoholism; Benzodiazepines; Chlordiazepoxide; Female; Humans; Male; Middle Aged

2020
Comment on "gabapentin versus chlordiazepoxide for outpatient alcohol detoxification treatment".
    The Annals of pharmacotherapy, 2013, Volume: 47, Issue:12

    Topics: Alcoholism; Ambulatory Care; Amines; Chlordiazepoxide; Cyclohexanecarboxylic Acids; Female; gamma-Am

2013
Reply to comment on "gabapentin versus chlordiazepoxide for outpatient alcohol detoxification treatment".
    The Annals of pharmacotherapy, 2013, Volume: 47, Issue:12

    Topics: Alcoholism; Ambulatory Care; Amines; Chlordiazepoxide; Cyclohexanecarboxylic Acids; Female; gamma-Am

2013
Drug trials in psychiatry: methodological issues.
    Asian journal of psychiatry, 2014, Volume: 8

    Topics: Alcoholism; Chlordiazepoxide; Citalopram; Depressive Disorder; Diabetes Mellitus; Female; Humans; Hy

2014
Drug effects on multiple and concurrent schedules of ethanol- and food-maintained behaviour: context-dependent selectivity.
    British journal of pharmacology, 2014, Volume: 171, Issue:14

    Topics: Alcoholism; Amphetamines; Animals; Chlordiazepoxide; Dextroamphetamine; Dose-Response Relationship,

2014
Phenobarbital compared to benzodiazepines in alcohol withdrawal treatment: A register-based cohort study of subsequent benzodiazepine use, alcohol recidivism and mortality.
    Drug and alcohol dependence, 2016, Apr-01, Volume: 161

    Topics: Adult; Alcoholism; Benzodiazepines; Chlordiazepoxide; Cohort Studies; Ethanol; Female; GABA Modulato

2016
Chlordiazepoxide in the treatment of acute alcoholism: a preliminary report.
    The Illinois medical journal, 1961, Volume: 120

    Topics: Alcoholism; Chlordiazepoxide; Tranquilizing Agents

1961
Chlordiazepoxide in the treatment of alcoholics.
    Diseases of the nervous system, 1961, Volume: Suppl 22(7)

    Topics: Alcoholics; Alcoholism; Chlordiazepoxide; Humans

1961
Librium, a new quieting drug for hyperactive alcoholic and psychotic patients. (Preliminary study).
    Diseases of the nervous system, 1960, Volume: 21(3)Suppl

    Topics: Alcoholism; Chlordiazepoxide; Mental Disorders; Psychosurgery; Psychotic Disorders; Tranquilizing Ag

1960
A controlled evaluation of "librium" in the treatment of alcoholics.
    The Medical journal of Australia, 1961, Oct-07, Volume: 48(2)

    Topics: Alcoholics; Alcoholism; Chlordiazepoxide; Tranquilizing Agents

1961
Response to Librium in individuals with a propensity for addiction: a pilot study.
    The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society, 1962, Volume: 114

    Topics: Alcoholism; Chlordiazepoxide; Humans; Pilot Projects; Tranquilizing Agents

1962
The use of chlordiazepoxide (Librium) in the alcoholic patient: a clinical study of forty cases.
    Journal of the American Geriatrics Society, 1962, Volume: 10

    Topics: Alcoholism; Biomedical Research; Chlordiazepoxide; Tranquilizing Agents

1962
[Chlordiazepoxide and the treatment of alcholism].
    Annales medico-psychologiques, 1963, Volume: 121(1)

    Topics: Alcoholism; Chlordiazepoxide; Humans; Mental Disorders; Psychoses, Alcoholic; Psychotic Disorders

1963
Management of alcohol withdrawal.
    Journal of the South Carolina Medical Association, 1963, Volume: 59

    Topics: Alcoholism; Alcohols; Chlordiazepoxide; Disease Management; Humans; Mental Disorders; Rehabilitation

1963
Management of alcoholic withdrawal. Observation using chlordiazepoxide as chief tranquilizing agent.
    Journal of the South Carolina Medical Association, 1962, Volume: 58

    Topics: Alcoholism; Chlordiazepoxide; Disease Management; Humans; Tranquilizing Agents

1962
[Contribution to the study of "Librium" in the treatment of alcoholics].
    L'union medicale du Canada, 1963, Volume: 92

    Topics: Alcoholics; Alcoholism; Chlordiazepoxide; Humans

1963
The management of acute withdrawal symptoms of alcoholism.
    Journal of the American College of Neuropsychiatrists, 1962, Volume: 1

    Topics: Alcoholism; Chlordiazepoxide; Disease Management; Humans; Substance Withdrawal Syndrome

1962
Chlordiazepoxide in alcohol withdrawal-intramuscular effects.
    Minnesota medicine, 1963, Volume: 46

    Topics: Alcoholism; Alcohols; Chlordiazepoxide; Conduct Disorder; Humans; Minnesota; Psychoses, Substance-In

1963
TREATMENT OF CHRONIC ALCOHOLISM.
    Diseases of the nervous system, 1963, Volume: 24

    Topics: Adrenocorticotropic Hormone; Alcoholism; Chlordiazepoxide; Folic Acid; Fructose; Humans; Insulin; Vi

1963
DAY CARE FOR ALCOHOLICS IN ACUTE WITHDRAWAL.
    Rhode Island medical journal, 1963, Volume: 46

    Topics: Alcoholics; Alcoholism; Chlordiazepoxide; Day Care, Medical; Humans; Outpatient Clinics, Hospital; P

1963
CURRENT ADVANCES IN THE AMBULATORY MEDICAL TREATMENT OF ALCOHOLICS.
    Bulletin - Academy of Medicine of New Jersey, 1963, Volume: 9

    Topics: Alcohol Deterrents; Alcoholics; Alcoholism; Chlordiazepoxide; Diazepam; Disulfiram; Humans; Lysergic

1963
AN EVALUATION OF VARIOUS PSYCHOTHERAPEUTIC AGENTS IN THE LONG TERM TREATMENT OF CHRONIC ALCOHOLISM. RESULTS OF A DOUBLE BLIND STUDY.
    The American journal of the medical sciences, 1963, Volume: 246

    Topics: Alcoholism; Benactyzine; Chlordiazepoxide; Double-Blind Method; Humans; Isocarboxazid; Meprobamate;

1963
PHARMACOLOGICAL ADJUNCTS IN THE COMPREHENSIVE CARE AND REHABILITATION OF ALCOHOLICS.
    Virginia medical monthly, 1963, Volume: 90

    Topics: Alcoholics; Alcoholism; Chlordiazepoxide; Comprehensive Health Care; Disulfiram; Metabolism; Rehabil

1963
MANAGEMENT OF ACUTE ALCOHOL BARBITURATE WITHDRAWAL STATES.
    Western medicine; the medical journal of the west, 1963, Volume: 4

    Topics: Alcoholism; Alcohols; Barbiturates; Chlordiazepoxide; Coma; Humans; Psychoses, Alcoholic; Psychotic

1963
A CONTROLLED EVALUATION OF CHLORDIAZEPOXIDE (LIBRIUM) IN THE TREATMENT OF CONVALESCING ALCOHOLICS.
    The Journal of nervous and mental disease, 1963, Volume: 137

    Topics: Alcoholics; Alcoholism; Blood Chemical Analysis; Chlordiazepoxide; Convalescence; Electroencephalogr

1963
MAGNESIUM METABOLISM IN ACUTE ALCOHOLICS.
    Danish medical bulletin, 1963, Volume: 10

    Topics: Alcoholics; Alcoholism; Aspartate Aminotransferases; Barbiturates; Blood Chemical Analysis; Chlordia

1963
THE EFFECT OF CHLORDIAZEPOXIDE ON CONVULSIVE DISORDER.
    Diseases of the nervous system, 1964, Volume: 25

    Topics: Alcoholism; Anticonvulsants; Brain Diseases; Chlordiazepoxide; Electroencephalography; Epilepsy; Hyd

1964
[THE PROBLEM OF SUICIDE].
    Nordisk psykiatrisk tidsskrift. Nordic journal of psychiatry, 1963, Volume: 17

    Topics: Alcoholism; Antidepressive Agents; Chlordiazepoxide; Counseling; Depression; Depressive Disorder; Fi

1963
[THE SELECTIVE INDICATIONS AND THE PSYCHODYNAMIC EFFECT OF CHLORDIAZEPOXIDE (LIBRIUM) AS AN ANTIALCOHOLIC PSYCHOPHARMACOLOGICAL AGENT].
    Schweizer Archiv fur Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie, 1964, Volume: 93

    Topics: Alcoholism; Chlordiazepoxide; Humans; Mental Disorders; Pharmacology; Psychoses, Alcoholic; Psychoti

1964
ALCOHOLISM: A GENERAL MEDICAL APPROACH.
    Maryland state medical journal, 1964, Volume: 13

    Topics: Alcoholism; Chlordiazepoxide; Disulfiram; Hospitals; Hospitals, Psychiatric; Humans; Hydantoins; Mep

1964
TRANSIENT ENURESIS FROM CHLORDIAZEPOXIDE AND DIAZEPAM.
    The American journal of psychiatry, 1964, Volume: 120

    Topics: Alcoholism; Chlordiazepoxide; Diazepam; Enuresis; Neurotic Disorders; Toxicology; Tranquilizing Agen

1964
TREATMENT OF ACUTE ALCOHOL POISONING IN A STATE MENTAL HOSPITAL.
    Diseases of the nervous system, 1964, Volume: 25

    Topics: Alcoholism; Alcohols; Biomedical Research; Chlordiazepoxide; Chlorpromazine; Hospitals, Psychiatric;

1964
[CLOPOXIDE IN ALCOHOLISM THERAPY].
    Nordisk medicin, 1964, Jun-11, Volume: 71

    Topics: Alcoholism; Biomedical Research; Chlordiazepoxide; Chlorpromazine; Drug Therapy; Pharmacology

1964
[VERSATILITY IN THE USE OF LIBRIUM].
    Gazzetta medica italiana, 1964, Volume: 123

    Topics: Adolescent; Alcoholism; Anxiety; Anxiety Disorders; Arteriosclerosis; Chlordiazepoxide; Geriatrics;

1964
PRR STUDY NO. 3. (A METHOD FOR CONTROLLING THE ADMINISTRATION OF TRANYLCYPROMINE).
    Diseases of the nervous system, 1964, Volume: 25

    Topics: Alcoholism; Anxiety; Anxiety Disorders; Chlordiazepoxide; Depression; Depressive Disorder; Drug Ther

1964
COMPARATIVE CLINICAL EVALUATION OF CHLORDIAZEPOXIDE AND PROMAZINE IN TREATMENT OF ALCOHOL-WITHDRAWAL SYNDROME.
    British medical journal, 1965, Jan-09, Volume: 1, Issue:5427

    Topics: Alcohol-Induced Disorders; Alcoholism; Alcohols; Biomedical Research; Blood Pressure Determination;

1965
PHOTOSENSITIVITY REACTION TO CHLORDIAZEPOXIDE.
    Archives of dermatology, 1965, Volume: 91

    Topics: Alcoholism; Chlordiazepoxide; Dermatitis, Phototoxic; Drug Eruptions; Drug Therapy; Humans; Photosen

1965
MANAGEMENT OF PSYCHOMOTOR AGITATION IN ACUTE ALCOHOLISM: A DOUBLE-BLIND STUDY USING CHLORDIAZEPOXIDE.
    Diseases of the nervous system, 1965, Volume: 26

    Topics: Alcoholism; Biomedical Research; Chlordiazepoxide; Depression; Depressive Disorder; Double-Blind Met

1965
INCIDENCE OF DRINKING AMONG HOSPITALIZED CONVALESCING ALCOHOLICS.
    Quarterly journal of studies on alcohol, 1965, Volume: 26

    Topics: Alcohol Drinking; Alcoholics; Alcoholism; Chlordiazepoxide; Convalescence; Hospitalization; Humans;

1965
DOUBLE-BLIND STUDY OF THREE DRUGS IN THE TREATMENT OF ACUTE ALCOHOLIC STATES.
    Quarterly journal of studies on alcohol, 1965, Volume: 26

    Topics: Alcoholism; Biomedical Research; Chlordiazepoxide; Diazepam; Double-Blind Method; Drug Therapy; Prom

1965
[Therapeutic trial of chlordiazepoxide in alcoholism].
    Hospital (Rio de Janeiro, Brazil), 1962, Volume: 62

    Topics: Alcoholism; Chlordiazepoxide; Tranquilizing Agents

1962
The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin. Excretion of HPPH in the urine.
    Archives of neurology, 1967, Volume: 16, Issue:6

    Topics: Acetazolamide; Adult; Aged; Alcoholism; Amitriptyline; Chlordiazepoxide; Chlorpromazine; Chromatogra

1967
Dysregulation of hypothalamic-pituitary-adrenal axis function in depressed alcoholic patients.
    Journal of affective disorders, 1982, Volume: 4, Issue:4

    Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Depressive Disorder; Dexamethasone

1982
Plasma beta-endorphin and met-enkephalin in physiological and pathological conditions.
    Advances in biochemical psychopharmacology, 1982, Volume: 33

    Topics: Alcoholism; beta-Endorphin; Brain; Chlordiazepoxide; Circadian Rhythm; Endorphins; Enkephalin, Methi

1982
Blood concentrations and clinical findings following overdose of chlordiazepoxide alone and chlordiazepoxide plus ethanol.
    Journal of toxicology. Clinical toxicology, 1984, Volume: 22, Issue:5

    Topics: Adolescent; Adult; Alcoholism; Blood Pressure; Chlordiazepoxide; Consciousness; Drug Interactions; F

1984
Alcoholism.
    American family physician, 1983, Volume: 27, Issue:2

    Topics: Alcoholics Anonymous; Alcoholism; Chlordiazepoxide; Disulfiram; Female; Humans; Male; Psychoses, Alc

1983
Short latency brainstem and somatosensory evoked potentials in alcoholics.
    Clinical EEG (electroencephalography), 1983, Volume: 14, Issue:1

    Topics: Alcoholism; Brain Diseases; Brain Stem; Chlordiazepoxide; Disulfiram; Evoked Potentials, Auditory; E

1983
Propranolol and chlordiazepoxide effects on cardiac arrhythmias during alcohol withdrawal.
    Alcoholism, clinical and experimental research, 1980, Volume: 4, Issue:4

    Topics: Alcoholism; Arrhythmias, Cardiac; Chlordiazepoxide; Electroencephalography; Humans; Male; Propranolo

1980
Alcohol withdrawal reactions after chronic intake of chlordiazepoxide and ethanol.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 15, Issue:2

    Topics: Alcoholism; Animals; Body Temperature; Chlordiazepoxide; Diet; Drug Interactions; Ethanol; Half-Life

1981
[Treatment of an alcoholic pre-delirium syndrome with chlormethiazol, methophenazin and chlordiazepoxide].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1980, Volume: 32, Issue:2

    Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Chlormethiazole; Drug Therapy, Com

1980
Individualized treatment of alcohol withdrawal.
    JAMA, 1995, Jan-18, Volume: 273, Issue:3

    Topics: Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Drug Administration Schedule; Ethanol; Hu

1995
Refining the treatment of alcohol withdrawal.
    JAMA, 1994, Aug-17, Volume: 272, Issue:7

    Topics: Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Chlordiazepoxide; Drug Administration Sche

1994
Severity and treatment of alcohol withdrawal in elderly versus younger patients.
    Alcoholism, clinical and experimental research, 1994, Volume: 18, Issue:1

    Topics: Adult; Age Factors; Aged; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Dose-Response R

1994
Alcohol cue reactivity: effects of detoxification and extended exposure.
    Journal of studies on alcohol, 1993, Volume: 54, Issue:2

    Topics: Adaptation, Psychological; Adult; Alcohol Drinking; Alcohol Withdrawal Delirium; Alcoholism; Arousal

1993
Effects of various serotonergic agents on alcohol intake and alcohol preference in Wistar rats selected at two different levels of alcohol preference.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1993, Volume: 28, Issue:2

    Topics: Alcohol Drinking; Alcoholism; Animals; Buspirone; Chlordiazepoxide; Citalopram; Dose-Response Relati

1993
Alcohol withdrawal: a nationwide survey of inpatient treatment practices.
    Journal of general internal medicine, 1995, Volume: 10, Issue:9

    Topics: Adrenergic beta-Antagonists; Alcoholism; Barbiturates; Benzodiazepines; Chlordiazepoxide; Clonidine;

1995
Current treatment for alcohol withdrawal.
    Journal of general internal medicine, 1995, Volume: 10, Issue:9

    Topics: Alcoholism; Benzodiazepines; Chlordiazepoxide; Diazepam; Humans; Substance Withdrawal Syndrome

1995
Outcomes of patients in a VA ambulatory detoxification program.
    Psychiatric services (Washington, D.C.), 1997, Volume: 48, Issue:2

    Topics: Adult; Alcoholism; Anti-Anxiety Agents; Arkansas; Chlordiazepoxide; Cost Savings; Female; Hospitals,

1997
The alcohol withdrawal syndrome.
    Family & community health, 1979, Volume: 2, Issue:2

    Topics: Alcoholism; Chlordiazepoxide; Diazepam; Drug Tolerance; Ethanol; Hospitalization; Humans; Substance

1979
Routine hospital alcohol detoxification practice compared to symptom triggered management with an Objective Withdrawal Scale (CIWA-Ar).
    The American journal on addictions, 2000,Spring, Volume: 9, Issue:2

    Topics: Adult; Aged; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Female; Hospitalization; Hos

2000
Investigation of the therapeutic efficacy of a taurine analogue during the initial stages of ethanol detoxification: preliminary studies in chronic alcohol abusers.
    Advances in experimental medicine and biology, 2000, Volume: 483

    Topics: Acamprosate; Alcoholism; Amino Acids; Chlordiazepoxide; Chronic Disease; Ethanol; GABA Modulators; G

2000
A Short Alcohol Withdrawal Scale (SAWS): development and psychometric properties.
    Addiction biology, 2002, Volume: 7, Issue:1

    Topics: Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Humans; Neurologic Examination; Neuropsyc

2002
Tardive dyskinesia: relationship with a primary affective disorder.
    Diseases of the nervous system, 1977, Volume: 38, Issue:6

    Topics: Adult; Affective Symptoms; Aged; Alcoholism; Amitriptyline; Antipsychotic Agents; Chlordiazepoxide;

1977
Clinical implications of benzodiazepine pharmacokinetics.
    The American journal of psychiatry, 1977, Volume: 134, Issue:6

    Topics: Administration, Oral; Adult; Age Factors; Aged; Alcoholism; Anti-Anxiety Agents; Chlordiazepoxide; C

1977
Recent advances in alcohol withdrawal states.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1977, Nov-26, Volume: 52, Issue:23

    Topics: Adrenergic beta-Antagonists; Adult; Alcoholism; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Hum

1977
Interaction of disulfiram with benzodiazepines.
    Clinical pharmacology and therapeutics, 1978, Volume: 24, Issue:5

    Topics: Adult; Alcoholism; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Disulfiram; Drug Interactions; H

1978
Psychological medicine. Treatment of alcoholism.
    British medical journal, 1975, Apr-19, Volume: 2, Issue:5963

    Topics: Adolescent; Adult; Alcohol Drinking; Alcohol Withdrawal Delirium; Alcoholics Anonymous; Alcoholism;

1975
Pharmacotherapy of the acute alcohol withdrawal syndrome.
    Diseases of the nervous system, 1975, Volume: 36, Issue:4

    Topics: Alcoholism; Anti-Anxiety Agents; Barbiturates; Chemical and Drug Induced Liver Injury; Chloral Hydra

1975
The use of psychoactive drugs in the long-term treatment of chronic alcoholics.
    Annals of the New York Academy of Sciences, 1975, Apr-25, Volume: 252

    Topics: Alcoholism; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Chlordiazepoxide; Chlorpromazine; Ch

1975
The treatment of alcoholism: what do we do about long-term sedatives?
    Annals of the New York Academy of Sciences, 1975, Apr-25, Volume: 252

    Topics: Alcoholics Anonymous; Alcoholism; Anti-Anxiety Agents; Attitude of Health Personnel; Chlordiazepoxid

1975
Alcoholic epilepsy. Effects of treatment on convulsions following the cessation of drinking.
    The Journal of the Medical Society of New Jersey, 1977, Volume: 74, Issue:11

    Topics: Adult; Aged; Alcoholism; Chlordiazepoxide; Female; Humans; Male; Middle Aged; Seizures; Substance Wi

1977
Are all recently detoxified alcoholics depressed?
    The American journal of psychiatry, 1979, Volume: 136, Issue:4B

    Topics: Alcoholism; Chlordiazepoxide; Depression; Diazepam; Humans; Male; Psychological Tests

1979
EEG's in an alcohol detoxification and treatment center.
    Clinical EEG (electroencephalography), 1979, Volume: 10, Issue:2

    Topics: Alcoholism; Chlordiazepoxide; Electroencephalography; Humans; Hyperventilation; Theta Rhythm

1979
Chlordiazepoxide and dropping out of a detoxication service.
    Journal of studies on alcohol, 1979, Volume: 40, Issue:7

    Topics: Adult; Alcoholism; Chlordiazepoxide; Female; Humans; Length of Stay; Male; Maryland; Mental Health S

1979
Chlordiazepoxide in acute alcoholism.
    British journal of clinical pharmacology, 1979, Volume: 8, Issue:1

    Topics: Acute Disease; Adult; Age Factors; Alcoholism; Chlordiazepoxide; Half-Life; Humans; Middle Aged

1979
Comparative efficacy of propranolol and chlordiazepoxide in alcohol withdrawal.
    Journal of studies on alcohol, 1977, Volume: 38, Issue:11

    Topics: Adult; Alcoholism; Catecholamines; Chlordiazepoxide; Dose-Response Relationship, Drug; Drug Evaluati

1977
Nursing care study: the one who got away.
    Nursing times, 1977, Nov-24, Volume: 73, Issue:47

    Topics: Alcoholism; Chlordiazepoxide; Depression; Humans; Male; Psychiatric Nursing

1977
Absorption of oral intramuscular chlordiazepoxide by alcoholics.
    Clinical pharmacology and therapeutics, 1978, Volume: 23, Issue:5

    Topics: Absorption; Administration, Oral; Adult; Aged; Alcoholism; Chlordiazepoxide; Half-Life; Humans; Inje

1978
Absorption of oral and intramuscular chlordiazepoxide.
    European journal of clinical pharmacology, 1978, Jun-19, Volume: 13, Issue:4

    Topics: Absorption; Administration, Oral; Adult; Alcoholism; Biological Availability; Chlordiazepoxide; Deal

1978
Decline in chlordiazepoxide plasma levels during fixed-dose therapy of alcohol withdrawal.
    British journal of clinical pharmacology, 1978, Volume: 6, Issue:4

    Topics: Alcoholism; Chlordiazepoxide; Humans; Substance Withdrawal Syndrome; Time Factors

1978
Alcohol intoxication and the alcohol withdrawal syndrome.
    Postgraduate medicine, 1978, Volume: 64, Issue:6

    Topics: Alcoholic Intoxication; Alcoholism; Benzodiazepines; Chlordiazepoxide; Hallucinations; Humans; Pheny

1978
Investigation of psychological correlates of chlordiazepoxide dependence in recovering alcoholics.
    Currents in alcoholism, 1979, Volume: 5

    Topics: Alcoholism; Chlordiazepoxide; Female; Field Dependence-Independence; Humans; Intelligence Tests; Mal

1979
Chlordiazepoxide: long-term use in alcoholism.
    Annals of the New York Academy of Sciences, 1976, Volume: 273

    Topics: Alcoholism; Chlordiazepoxide; Drug Evaluation; Humans; Long-Term Care; Substance Withdrawal Syndrome

1976
Thioridazine HC1 Vs. chlordiazepoxide HC1 in controlling symptoms attributable to alcohol withdrawal.
    Diseases of the nervous system, 1977, Volume: 38, Issue:3

    Topics: Adult; Aged; Alcoholism; Chlordiazepoxide; Drug Evaluation; Female; Humans; Male; Middle Aged; Psych

1977
Recognizing and managing the outpatient alcoholic.
    American family physician, 1977, Volume: 15, Issue:3

    Topics: Alcoholism; Ambulatory Care; Chlordiazepoxide; Diazepam; Disulfiram; Hospitalization; Humans; Physic

1977
Possible role of tetrahydroisoquinoline alkaloids in postalcohol intoxication states.
    Annals of the New York Academy of Sciences, 1976, Volume: 273

    Topics: Alcoholic Intoxication; Alcoholism; Animals; Brain; Catecholamines; Chlordiazepoxide; Dopamine; Huma

1976
Chlordiazepoxide and alcohol: a fatal overdose.
    Journal of forensic sciences, 1975, Volume: 20, Issue:3

    Topics: Adult; Alcoholic Intoxication; Alcoholism; Autopsy; Chlordiazepoxide; Drug Synergism; Humans; Male

1975
Effects of alcohol ingestion and abstinence on slow wave sleep of alcoholics.
    Advances in experimental medicine and biology, 1975, Volume: 59

    Topics: Adult; Alcoholism; Analysis of Variance; Chlordiazepoxide; Electroencephalography; Ethanol; Humans;

1975
[Letter: Pharmacotherapy in alcoholism].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Feb-10, Volume: 96, Issue:4

    Topics: Alcoholism; Chlordiazepoxide; Humans; Psychology

1976
Detoxification of alcoholics: improving care by symptom-triggered sedation.
    Alcoholism, clinical and experimental research, 1990, Volume: 14, Issue:1

    Topics: Alcoholism; Chlordiazepoxide; Humans; Male; Substance Withdrawal Syndrome

1990
Carbamazepine adjunct for nonresponsive psychosis with prior hallucinogenic abuse.
    The Journal of nervous and mental disease, 1989, Volume: 177, Issue:12

    Topics: Adult; Alcoholism; Antipsychotic Agents; Carbamazepine; Chlordiazepoxide; Drug Therapy, Combination;

1989
Alcohol withdrawal in the elderly.
    Journal of studies on alcohol, 1989, Volume: 50, Issue:5

    Topics: Adult; Age Factors; Aged; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Female; Humans;

1989
Ethanol and chlordiazepoxide cross-dependence.
    Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1987, Volume: 1

    Topics: Alcoholism; Animals; Chlordiazepoxide; Flumazenil; Male; Mice; Mice, Inbred C57BL; Substance Withdra

1987
Does chronic ethanol intake confer full cross-tolerance to chlordiazepoxide?
    Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:2

    Topics: Alcoholism; Animals; Body Temperature; Chlordiazepoxide; Drug Tolerance; Ethanol; Locomotion; Male;

1988
Evaluating depression in alcoholics.
    Psychiatry research, 1986, Volume: 17, Issue:2

    Topics: Adult; Alcoholism; Chlordiazepoxide; Depressive Disorder; Female; Humans; Male; Middle Aged; Psychol

1986
Power and coherence analysis of the EEG in hospitalized alcoholics and nonalcoholic controls.
    Journal of studies on alcohol, 1985, Volume: 46, Issue:2

    Topics: Adult; Alcoholism; Alpha Rhythm; Brain; Chlordiazepoxide; Cognition; Delta Rhythm; Electroencephalog

1985
Drug therapy in alcoholism.
    Current psychiatric therapies, 1970, Volume: 10

    Topics: Adult; Alcoholic Intoxication; Alcoholism; Antidepressive Agents; Anxiety; Carbamates; Chlordiazepox

1970
Behavioral studies of sleep patterns in alcoholics during intoxication and withdrawal.
    The Journal of pharmacology and experimental therapeutics, 1970, Volume: 175, Issue:1

    Topics: Adult; Alcohol Drinking; Alcoholism; Chlordiazepoxide; Ethanol; Hallucinations; Humans; Hypnotics an

1970
[Therapy of anxiety, mental anguish and sleeplessness. 3. Clinical pharmacological viewpoints].
    Lakartidningen, 1969, Mar-17, Volume: 66

    Topics: Alcoholism; Alcohols; Aldehydes; Antidepressive Agents; Azepines; Barbiturates; Bromides; Chlordiaze

1969
Characteristics of alcoholics volunteering for lysergide treatment.
    Quarterly journal of studies on alcohol, 1970, Volume: 31, Issue:2

    Topics: Adult; Aged; Alcoholism; Attitude to Health; Bender-Gestalt Test; Chlordiazepoxide; Educational Stat

1970
Drug therapy in alcoholism. It is especially important in the prevention of such complications as seizures, DT's, Wernicke's encephalopathy, or polyneuritis.
    IMJ. Illinois medical journal, 1971, Volume: 139, Issue:6

    Topics: Alcoholism; Anticonvulsants; Chlordiazepoxide; Chlorpromazine; Diazepam; Disulfiram; Humans; Hydroxy

1971
Prevention of alcohol withdrawal seizures: the roles of diphenylhydantoin and chlordiazepoxide.
    The American journal of psychiatry, 1973, Volume: 130, Issue:12

    Topics: Alcoholism; Anticonvulsants; Chlordiazepoxide; Electroencephalography; Ethanol; Humans; Neurons; Phe

1973
[Treatment of alcohol intoxication].
    L'union medicale du Canada, 1974, Volume: 103, Issue:3

    Topics: Accidents, Home; Adult; Alcohol Amnestic Disorder; Alcoholic Intoxication; Alcoholism; Child; Chlord

1974
Differences between mental disorders of French Canadians and British Canadians.
    Canadian Psychiatric Association journal, 1974, Volume: 19, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Alcoholism; Bipolar Disorder; Canada; Chlordiazepoxide; Cranio

1974
Clinical toxicity of chlordiazepoxide and diazepam in relation to serum albumin concentration: a report from the Boston Collaborative Drug Surveillance Program.
    European journal of clinical pharmacology, 1974, Jul-26, Volume: 7, Issue:4

    Topics: Age Factors; Alcoholism; Anxiety; Chlordiazepoxide; Coffee; Depression; Diazepam; Female; Humans; Le

1974
Treatment of alcoholic withdrawal states with chlordiazepoxide.
    Military medicine, 1965, Volume: 130, Issue:12

    Topics: Adult; Alcoholism; Chlordiazepoxide; Female; Humans; Male; Middle Aged

1965
Grand-mal seizures in two patients in acute alcohol withdrawal after treatment with hydroxyzine.
    Quarterly journal of studies on alcohol, 1967, Volume: 28, Issue:4

    Topics: Alcoholism; Anticonvulsants; Chlordiazepoxide; Epilepsy, Tonic-Clonic; Humans; Hydroxyzine; Injectio

1967
A therapeutic revolving door.
    Archives of general psychiatry, 1972, Volume: 26, Issue:2

    Topics: Adult; Alcoholism; Amines; Chlordiazepoxide; Community Mental Health Services; Forensic Psychiatry;

1972
Alcoholism in women.
    Archives of general psychiatry, 1971, Volume: 25, Issue:6

    Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Anxiety; Chlordiazepoxide; Depression; Diazepam; Female;

1971
[Misuse of bezodiazepin derivatives in alcoholics].
    The British journal of addiction to alcohol and other drugs, 1966, Volume: 61, Issue:3

    Topics: Alcoholism; Chlordiazepoxide; Diazepam; Humans; Substance-Related Disorders

1966
Librium and valium.
    The Medical letter on drugs and therapeutics, 1969, Oct-03, Volume: 11, Issue:20

    Topics: Alcoholism; Anxiety; Chlordiazepoxide; Diazepam; Humans; Mental Disorders; Seizures; Suicide

1969
The alcohol withdrawal syndrome: theory and practice.
    Postgraduate medicine, 1970, Volume: 47, Issue:4

    Topics: Alcoholism; Chlordiazepoxide; Humans; Psychoses, Alcoholic; Substance Withdrawal Syndrome

1970
Habituation to chlordiazepoxide in an alcoholic population.
    JAMA, 1970, Aug-24, Volume: 213, Issue:8

    Topics: Alcoholism; Chlordiazepoxide; Humans; Substance-Related Disorders

1970
Social and psychological factors in the treatment of chronic alcoholism.
    Journal of psychiatric research, 1970, Volume: 8, Issue:1

    Topics: Adult; Age Factors; Alcoholism; Ambulatory Care; Attitude of Health Personnel; Attitude to Health; C

1970
The treatment of acute alcohol intoxication and withdrawal.
    Current psychiatric therapies, 1970, Volume: 10

    Topics: Acute Disease; Adult; Alcoholic Intoxication; Alcoholism; Chlordiazepoxide; Chlormethiazole; Ethanol

1970
[Modern therapy of alcoholism].
    Il Policlinico. Sezione pratica, 1970, Jan-05, Volume: 77, Issue:1

    Topics: Alcoholism; Chlordiazepoxide; Coma; Diazepam; Fructose; Humans; Hypotension; Psychoses, Alcoholic; S

1970
The management of alcoholism in general practice.
    The Journal of the Royal College of General Practitioners, 1970, Volume: 20, Issue:99

    Topics: Alcoholism; Chlordiazepoxide; Chlorpromazine; Citrates; Cyanides; Humans

1970
A comparison of three approaches to alcohol-withdrawal states.
    Southern medical journal, 1969, Volume: 62, Issue:4

    Topics: Adult; Alcoholism; Chloral Hydrate; Chlordiazepoxide; Chlorpromazine; Female; Humans; Male; Paraldeh

1969
Chlordiazepoxide (librium) compared with meprobamate and promazine (prozine) for the withdrawal symptoms of acute alcoholism.
    Wisconsin medical journal, 1965, Volume: 64, Issue:11

    Topics: Alcoholic Intoxication; Alcoholism; Chlordiazepoxide; Humans; Male; Meprobamate; Promazine; Substanc

1965
Outpatient management of acutely ill alcoholics.
    Quarterly journal of studies on alcohol, 1965, Volume: 26, Issue:4

    Topics: Alcoholism; Chlordiazepoxide; Female; Humans; Male; Psychiatry

1965
Two severe reactions to benzodiazepine compounds.
    The American journal of psychiatry, 1965, Volume: 122, Issue:5

    Topics: Adult; Alcoholism; Ataxia; Chlordiazepoxide; Diazepam; Drug Synergism; Humans; Male; Middle Aged; Mu

1965
[Psychological bases of the treatment of alcoholics; a report of experiences of "alcoholic units"].
    Munchener medizinische Wochenschrift (1950), 1965, Dec-03, Volume: 107, Issue:49

    Topics: Alcoholism; Carbamates; Chlordiazepoxide; Chlormethiazole; Disulfiram; England; Halfway Houses; Huma

1965
Management of acute alcohol withdrawal symptoms.
    Maryland state medical journal, 1966, Volume: 15, Issue:6

    Topics: Alcoholism; Chloral Hydrate; Chlordiazepoxide; Humans; Substance Withdrawal Syndrome

1966