chlordiazepoxide has been researched along with Alcohol Abuse in 166 studies
Chlordiazepoxide: An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
chlordiazepoxide : A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty patients with primary chronic alcoholism took part in a randomized, double-blind, comparative group study of clobazam and chlordiazepoxide in the treatment of acute alcohol withdrawal." | 9.05 | A comparison of the efficacy and tolerability of clobazam and chlordiazepoxide in the treatment of acute withdrawal from alcohol in patients with primary alcoholism. ( Mukherjee, PK, 1983) |
| "A 27-year-old, Caucasian female with ethanol dependence who had objective symptoms of withdrawal experienced worsening of her delirium after administration of chlordiazepoxide, but improved with lorazepam and cleared with discontinuation of benzodiazepine administration." | 8.12 | Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report. ( Arabadjief, MA; Bashir, S; Bergman, CL; El-Mallakh, RS; Elsayed, OH; Gundumalla, MR; Menefee, DS; Moulana, NZ, 2022) |
| "The pattern of cardiac arrhythmias and their treatment, by propranolol and chlordiazepoxide, during the first 48 hr of alcohol withdrawal has been studied." | 7.66 | Propranolol and chlordiazepoxide effects on cardiac arrhythmias during alcohol withdrawal. ( Jacob, MS; MacLeod, SM; Sellers, EM; Ti, TY; Zilm, DH, 1980) |
| "Forty patients with primary chronic alcoholism took part in a randomized, double-blind, comparative group study of clobazam and chlordiazepoxide in the treatment of acute alcohol withdrawal." | 5.05 | A comparison of the efficacy and tolerability of clobazam and chlordiazepoxide in the treatment of acute withdrawal from alcohol in patients with primary alcoholism. ( Mukherjee, PK, 1983) |
| "A 27-year-old, Caucasian female with ethanol dependence who had objective symptoms of withdrawal experienced worsening of her delirium after administration of chlordiazepoxide, but improved with lorazepam and cleared with discontinuation of benzodiazepine administration." | 4.12 | Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report. ( Arabadjief, MA; Bashir, S; Bergman, CL; El-Mallakh, RS; Elsayed, OH; Gundumalla, MR; Menefee, DS; Moulana, NZ, 2022) |
| "The pattern of cardiac arrhythmias and their treatment, by propranolol and chlordiazepoxide, during the first 48 hr of alcohol withdrawal has been studied." | 3.66 | Propranolol and chlordiazepoxide effects on cardiac arrhythmias during alcohol withdrawal. ( Jacob, MS; MacLeod, SM; Sellers, EM; Ti, TY; Zilm, DH, 1980) |
| "The effect of chronic alcoholism on oral and intramuscular plasma levels of chlordiazepoxide (CDX) was assessed." | 3.66 | Absorption of oral intramuscular chlordiazepoxide by alcoholics. ( Caputo, JF; Fowler, RC; Hepler, CD; Perry, PJ; Wilding, DC, 1978) |
| "Lorazepam treated group showed a significant difference in the rate of improvement over 48 h compared to chlordiazepoxide group (70." | 2.78 | A double blind randomised comparison of chlordiazepoxide and lorazepam in alcohol withdrawal. ( Mohandas, E; Rajmohan, V; Sushil, K, 2013) |
| "One hundred consecutive consenting male inpatients in a state of moderately severe, uncomplicated alcohol withdrawal at screening were randomized to receive either lorazepam (8 mg/day) or chlordiazepoxide (80 mg/day) with dosing down-titrated to zero in a fixed-dose schedule across 8 treatment days." | 2.74 | A randomized, double-blind comparison of lorazepam and chlordiazepoxide in patients with uncomplicated alcohol withdrawal. ( Andrade, C; Kumar, CN; Murthy, P, 2009) |
| "Chlordiazepoxide was administered to only 41 patients (38%), yet 92 (85%) of the 108 enrolled successfully completed outpatient detoxification without medical complications." | 2.69 | Individualized treatment for outpatients withdrawing from alcohol. ( Briggs, MJ; Henderson, KL; Wiseman, EJ, 1998) |
| " A flexible dosage schedule was followed for 5 days with the objective of using the largest dose on the first day, followed by daily reductions as clinically feasible." | 2.66 | Halazepam in the management of acute alcohol withdrawal syndrome. ( Fine, EW; Mendels, J; Michals, TJ; Wasserman, TW, 1985) |
| "The chlordiazepoxide treatment produced suppression of rapid eye movement (REM) sleep lasting for about 4 days and virtually eliminated delta sleep (stages III and IV) during the recovery period." | 2.64 | Residual effects of ethanol and chlordiazepoxide treatments for alcohol withdrawal. ( Allen, RP; Funderburk, FR; Wagman, AM, 1978) |
| " Uncontrolled long-term administration is to be rejected in all circumstances, and supply should be strictly on prescription only in order to prevent uncontrolled acquisition." | 2.64 | The use of tranquilizers in the treatment of mixed drug abuse. ( Demel, I; Kryspin-Exner, K, 1975) |
| "Sedatives are important in treatment of alcohol withdrawal seizures and delirium tremens as well as in the prophylaxis of alcohol withdrawal syndrome." | 2.46 | [Diagnostics and therapy of alcohol withdrawal syndrome: focus on delirium tremens and withdrawal seizure]. ( Batra, A; Lutz, UC, 2010) |
| "Phenobarbital treatment was associated with decreased mortality, which might be confounded by somatic comorbidity among patients receiving chlordiazepoxide." | 1.43 | Phenobarbital compared to benzodiazepines in alcohol withdrawal treatment: A register-based cohort study of subsequent benzodiazepine use, alcohol recidivism and mortality. ( Askgaard, G; Fink-Jensen, A; Hallas, J; Madsen, KG; Molander, AC; Pottegård, A, 2016) |
| " Finally, no significant differences were found between age groups in either the dosage or number of days of detoxification medication, although a trend was found for more days of medication in the elderly." | 1.29 | Severity and treatment of alcohol withdrawal in elderly versus younger patients. ( Blow, FC; Brower, KJ; Hill, EM; Mudd, S; Young, JP, 1994) |
| "Buspirone was without important effects on the high alcohol preferring rats." | 1.29 | Effects of various serotonergic agents on alcohol intake and alcohol preference in Wistar rats selected at two different levels of alcohol preference. ( Meert, TF, 1993) |
| " Drug was most often given on a fixed dosing schedule with additional medication "as needed" (52% of the programs)." | 1.29 | Alcohol withdrawal: a nationwide survey of inpatient treatment practices. ( Friedman, LS; Mayo-Smith, MF; Saitz, R, 1995) |
| " These findings and other results of pharmacokinetic research have clinical implications in terms of dosage schedules, drug accumulation during long-term therapy, antianxiety therapy in the elderly, drug interactions, pharmacotherapy in specific disease states, and the influence of route of administration on drug action." | 1.26 | Clinical implications of benzodiazepine pharmacokinetics. ( Greenblatt, DJ; Shader, RI, 1977) |
| "Oxazepam has no important active metabolites and its net disposition is minimally altered by disulfiram." | 1.26 | Interaction of disulfiram with benzodiazepines. ( Billings, BJ; Giles, HG; Greenblatt, DJ; MacLeod, SM; Marshman, JA; Martin, PR; Sellers, EM, 1978) |
| "Propranolol alone was more effective than either chlordiazepoxide or a combination of chlordiazepoxide and propranolol in alleviating the symptoms of the alcohol withdrawal syndrome." | 1.26 | Comparative efficacy of propranolol and chlordiazepoxide in alcohol withdrawal. ( Degani, NC; Sellers, EM; Zilm, DH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 138 (83.13) | 18.7374 |
| 1990's | 13 (7.83) | 18.2507 |
| 2000's | 5 (3.01) | 29.6817 |
| 2010's | 7 (4.22) | 24.3611 |
| 2020's | 3 (1.81) | 2.80 |
| Authors | Studies |
|---|---|
| Osler, M | 1 |
| Jørgensen, MB | 1 |
| Arabadjief, MA | 1 |
| Elsayed, OH | 1 |
| Bashir, S | 1 |
| Gundumalla, MR | 1 |
| Menefee, DS | 1 |
| Bergman, CL | 1 |
| Moulana, NZ | 1 |
| El-Mallakh, RS | 1 |
| Pedersen, SA | 1 |
| Klesse, T | 1 |
| Findal Andreasen, M | 1 |
| Dalhoff, KP | 1 |
| Andersen, CU | 1 |
| Rajmohan, V | 1 |
| Sushil, K | 1 |
| Mohandas, E | 1 |
| Kaur, N | 1 |
| Medhi, B | 1 |
| Stock, CJ | 1 |
| Carpenter, L | 1 |
| Ying, J | 1 |
| Greene, T | 1 |
| Prakash, S | 1 |
| Mandal, P | 1 |
| Ginsburg, BC | 1 |
| Lamb, RJ | 1 |
| Askgaard, G | 1 |
| Hallas, J | 1 |
| Fink-Jensen, A | 1 |
| Molander, AC | 1 |
| Madsen, KG | 1 |
| Pottegård, A | 1 |
| Kumar, CN | 1 |
| Andrade, C | 1 |
| Murthy, P | 1 |
| Lutz, UC | 1 |
| Batra, A | 1 |
| KAROLUS, HE | 1 |
| MOONEY, HB | 1 |
| DITMAN, KS | 4 |
| COHEN, S | 1 |
| TICKTIN, HE | 1 |
| SCHULTZ, JD | 2 |
| BARTHOLOMEW, AA | 1 |
| GUILE, LA | 1 |
| BURKE, GW | 1 |
| ANDERSON, CW | 1 |
| CHESROW, EJ | 1 |
| KAPLITZ, SE | 1 |
| LEVINE, JM | 1 |
| MUSCI, JP | 1 |
| SABATINI, R | 1 |
| MARGAT, P | 1 |
| CRETON, M | 1 |
| FLOYD, JB | 1 |
| COLLINS, MC | 1 |
| BAROODY, NB | 1 |
| BAROODY, WG | 1 |
| MEAD, WR | 1 |
| ROY, PB | 1 |
| MERCURE, J | 1 |
| LEBEL, G | 1 |
| BOURQUE, R | 1 |
| KISSEN, MD | 2 |
| KOUTSKY, CD | 1 |
| SLETEN, IW | 1 |
| MORRISON, JM | 1 |
| CAPONE, A | 1 |
| HOLMBERG, M | 1 |
| HOFF, EC | 2 |
| CHARNOFF, SM | 2 |
| KISSIN, B | 7 |
| REED, JI | 1 |
| ARMOUR, PS | 1 |
| SHAFFER, JW | 1 |
| FREINEK, WR | 1 |
| WOLF, S | 2 |
| FOXWELL, NH | 2 |
| KURLAND, AA | 2 |
| NIELSEN, J | 1 |
| GOLDMAN, D | 1 |
| SCHYNOLL, G | 1 |
| ACHTE, KA | 1 |
| ALONSOFERNANDEZ, F | 1 |
| GUNDRY, LP | 1 |
| NEWLAND, ED | 1 |
| GOTTLIEB, L | 1 |
| SALZBERGER, GJ | 1 |
| MOORHEAD, HH | 1 |
| MCKINLEY, RA | 1 |
| KJOLSTAD, T | 1 |
| GHISLANDI, E | 1 |
| CRESPI, G | 1 |
| MELDMAN, MJ | 1 |
| SERENY, G | 1 |
| KALANT, H | 1 |
| LUTON, EF | 1 |
| FINCHUM, RN | 1 |
| CHAMBERS, JF | 2 |
| MADALENA, JC | 1 |
| Olesen, OV | 1 |
| Golbert, TM | 1 |
| Sanz, CJ | 1 |
| Rose, HD | 1 |
| Leitschuh, TH | 1 |
| Mukherjee, PK | 1 |
| Targum, SD | 1 |
| Wheadon, DE | 1 |
| Chastek, CT | 1 |
| McCabe, WJ | 1 |
| Advani, MT | 1 |
| Panerai, AE | 1 |
| Martini, A | 1 |
| De Rosa, A | 1 |
| Salerno, F | 1 |
| Di Giulio, AM | 1 |
| Mantegazza, P | 1 |
| Bailey, DN | 1 |
| Lapierre, YD | 1 |
| Bulmer, DR | 1 |
| Oyewumi, LK | 1 |
| Mauguin, ML | 1 |
| Knott, VJ | 1 |
| Favazza, AR | 1 |
| Reilly, EL | 2 |
| Kelley, JT | 1 |
| Pena, YM | 1 |
| Overall, JE | 2 |
| Faillace, LA | 2 |
| Zilm, DH | 3 |
| Jacob, MS | 1 |
| MacLeod, SM | 3 |
| Sellers, EM | 6 |
| Ti, TY | 1 |
| Chan, AW | 3 |
| Leong, FW | 2 |
| Schanley, DL | 2 |
| Howe, SM | 1 |
| Mäthner, H | 1 |
| Gillner, M | 1 |
| Pelliccioni, R | 1 |
| Sullivan, JT | 1 |
| Saitz, R | 2 |
| Mayo-Smith, MF | 2 |
| Roberts, MS | 1 |
| Redmond, HA | 1 |
| Bernard, DR | 1 |
| Calkins, DR | 1 |
| Fuller, RK | 1 |
| Gordis, E | 1 |
| Brower, KJ | 1 |
| Mudd, S | 1 |
| Blow, FC | 1 |
| Young, JP | 1 |
| Hill, EM | 1 |
| Monti, PM | 2 |
| Rohsenow, DJ | 1 |
| Rubonis, AV | 1 |
| Niaura, RS | 1 |
| Sirota, AD | 1 |
| Colby, SM | 1 |
| Abrams, DB | 1 |
| Meert, TF | 1 |
| Friedman, LS | 1 |
| Hyman, SE | 1 |
| Wiseman, EJ | 2 |
| Henderson, KL | 2 |
| Briggs, MJ | 2 |
| Wooddell, WJ | 1 |
| Reoux, JP | 1 |
| Miller, K | 1 |
| Ward, RJ | 1 |
| Martinez, J | 1 |
| Ball, D | 1 |
| Marshall, EJ | 2 |
| De Witte, P | 1 |
| Gossop, M | 1 |
| Keaney, F | 1 |
| Stewart, D | 1 |
| Strang, J | 1 |
| Longo, LP | 1 |
| Campbell, T | 1 |
| Hubatch, S | 1 |
| Rosenbaum, AH | 1 |
| Niven, RG | 1 |
| Hanson, NP | 1 |
| Swanson, DW | 1 |
| Shader, RI | 4 |
| Greenblatt, DJ | 6 |
| Fialkov, MJ | 1 |
| Giles, HG | 2 |
| Billings, BJ | 1 |
| Martin, PR | 1 |
| Marshman, JA | 1 |
| Ritson, EB | 1 |
| Edwards, G | 1 |
| Funderburk, FR | 2 |
| Allen, RP | 3 |
| Wagman, AM | 3 |
| Coleman, JH | 1 |
| Evans, WE | 1 |
| Bissell, LC | 1 |
| Menken, M | 1 |
| Buonpane, N | 1 |
| Perly, R | 1 |
| Runion, HI | 1 |
| Fowler, FN | 1 |
| Keeler, MH | 1 |
| Taylor, CI | 1 |
| Miller, WC | 1 |
| Glass, G | 1 |
| Pena-Ramos, A | 2 |
| Hornberger, R | 1 |
| Reed, JR | 1 |
| Mandell, W | 1 |
| Desmond, PV | 1 |
| Schenker, S | 1 |
| Degani, NC | 1 |
| Hewitt, M | 1 |
| Perry, PJ | 1 |
| Wilding, DC | 1 |
| Fowler, RC | 1 |
| Hepler, CD | 1 |
| Caputo, JF | 1 |
| Franke, K | 1 |
| Degani, N | 1 |
| Robertson, CC | 1 |
| Nims, RG | 1 |
| Coleman, CR | 1 |
| Clerkin, AJ | 1 |
| Palestine, ML | 1 |
| Alatorre, E | 1 |
| Rothstein, E | 2 |
| Cobble, JC | 1 |
| Sampson, N | 1 |
| Glass, GS | 1 |
| Blum, K | 1 |
| Eubanks, JD | 1 |
| Wallace, JE | 1 |
| Schwertner, H | 1 |
| Morgan, WW | 1 |
| Lowenstam, I | 1 |
| McGrath, SD | 1 |
| Kryspin-Exner, K | 2 |
| Demel, I | 1 |
| Shaw, JA | 1 |
| Donley, P | 1 |
| Morgan, DW | 1 |
| Robinson, JA | 1 |
| Rada, RT | 1 |
| Kellner, R | 1 |
| Buchanan, JG | 1 |
| Hartviksen, I | 1 |
| Pistelli, A | 1 |
| Di Simplicio, P | 1 |
| Di Bello, MG | 1 |
| Raspanti, S | 1 |
| Gambassi, F | 1 |
| Botti, P | 1 |
| Caramelli, L | 1 |
| Peruzzi, S | 1 |
| Smorlesi, C | 1 |
| Zorn, AM | 1 |
| Haigh, R | 1 |
| Hibbert, G | 1 |
| Wartenberg, AA | 1 |
| Nirenberg, TD | 1 |
| Liepman, MR | 1 |
| Silvia, LY | 1 |
| Begin, AM | 1 |
| Scher, M | 1 |
| Neppe, V | 1 |
| Liskow, BI | 2 |
| Rinck, C | 1 |
| Campbell, J | 1 |
| DeSouza, C | 1 |
| Mendels, J | 1 |
| Wasserman, TW | 1 |
| Michals, TJ | 1 |
| Fine, EW | 1 |
| Powell, BJ | 1 |
| Penick, EC | 1 |
| Rice, AS | 1 |
| McKnelly, W | 1 |
| Langan, MC | 1 |
| Penetrante, ML | 1 |
| Dackis, CA | 1 |
| Gold, MS | 1 |
| Pottash, AL | 1 |
| Sweeney, DR | 1 |
| Kaplan, RF | 1 |
| Glueck, BC | 1 |
| Hesselbrock, MN | 1 |
| Reed, HB | 1 |
| Whitlock, FA | 1 |
| Price, J | 1 |
| Gross, MM | 2 |
| Mello, NK | 1 |
| Mendelson, JH | 1 |
| Sedvall, G | 1 |
| Moss, T | 2 |
| Forgy, E | 1 |
| Zunin, L | 1 |
| Funk, W | 1 |
| Lynch, R | 1 |
| Oge, V | 1 |
| Sampliner, R | 1 |
| Iber, FL | 1 |
| Brown, D | 1 |
| Williams, JD | 1 |
| Neill, LT | 1 |
| Rosenberg, CM | 1 |
| Nantel, A | 1 |
| Murphy, HB | 1 |
| Koch-Weser, J | 1 |
| Knott, DH | 1 |
| Beard, JD | 1 |
| Chaftez, ME | 1 |
| Rosenblatt, SM | 2 |
| Machover, S | 1 |
| Forgy, EW | 1 |
| Zunin, LM | 1 |
| Lynch, RD | 1 |
| Funk, WA | 1 |
| Klett, CJ | 1 |
| Hollister, LE | 1 |
| Caffey, EM | 1 |
| Kaim, SC | 1 |
| Short, MJ | 1 |
| Moore, WJ | 1 |
| Malmgren, G | 1 |
| Zbinden, G | 1 |
| Randall, LO | 1 |
| Hudson, FG | 2 |
| McGowan, JM | 2 |
| Renninger, ME | 1 |
| Foster, CA | 1 |
| Gallant, DM | 1 |
| Bishop, MP | 1 |
| Camp, E | 1 |
| Tisdale, C | 1 |
| Fox, RP | 1 |
| Graham, MB | 1 |
| Gill, MJ | 1 |
| Belfer, ML | 1 |
| Carroll, M | 1 |
| Harmatz, JS | 1 |
| Bolzani, L | 1 |
| Slivar, G | 1 |
| Victor, M | 1 |
| Finer, MJ | 1 |
| Platz, A | 1 |
| Su, WH | 1 |
| Devenyi, P | 1 |
| Iandolo, C | 1 |
| Parry, RA | 1 |
| Muller, DJ | 1 |
| Wegner, ME | 1 |
| Fink, DW | 1 |
| Daly, RJ | 1 |
| Kane, FJ | 1 |
| Glatt, MM | 1 |
| Bowman, EH | 1 |
| Thimann, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit[NCT04156464] | Phase 4 | 142 participants (Anticipated) | Interventional | 2020-07-06 | Recruiting | ||
| Prospective Assessment of Valproate on Ethanol Withdrawal[NCT03235531] | Phase 4 | 210 participants (Anticipated) | Interventional | 2017-07-11 | Recruiting | ||
| 5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence[NCT01549652] | 133 participants (Actual) | Interventional | 2011-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Beck Depression Inventory (a 21-item self-report multiple-choice inventory) yields a single summed score between 0 and 63; higher scores indicate more severe depression. Change is from baseline score (taken at the beginning of the first study visit, prior to beginning of titration into morphine) to the score taken after taking morphine for 30 days (score taken prior to receiving ondansetron or placebo, at the beginning of second study visit). (NCT01549652)
Timeframe: 2 study days 1 month apart (at the start of each study visit)
| Intervention | units on a scale (Mean) |
|---|---|
| Prevention of Opioid Withdrawal | -0.44 |
The VAS is a 0 to 100 millimeter scale where 0 corresponds to no pain and 100 to extreme pain, used by participants to indicated their level of pain over the last two weeks. Change is from baseline score for average level of pain (taken at the beginning of the first study visit, prior to beginning of titration into morphine) to the score taken after taking morphine for 30 days (score taken prior to receiving ondansetron or placebo, at the beginning of second study visit). (NCT01549652)
Timeframe: 2 study days 1 month apart (at the start of each study visit)
| Intervention | units on a scale (Mean) |
|---|---|
| Prevention of Opioid Withdrawal | -2.68 |
The Roland-Morris Disability Index is a 24-question instrument used to assess level of disability from lower back pain. Scores range from 0-24 with lower scores corresponding to fewer symptoms. Change is from baseline score (taken at the beginning of the first study visit, prior to beginning of titration into morphine) to the score taken after taking morphine for 30 days (score taken prior to receiving ondansetron or placebo, at the beginning of second study visit). (NCT01549652)
Timeframe: 2 study days 1 month apart (at the start of each study visit)
| Intervention | units on a scale (Mean) |
|---|---|
| Prevention of Opioid Withdrawal | -2.59 |
The Beck Depression Inventory (a 21-item self-report multiple-choice inventory) yields a single summed score between 0 and 63; higher scores indicate more severe depression. Change is from baseline score (taken at the beginning of the first study visit, prior to beginning of titration into morphine) to the score taken after taking morphine for 30 days (score taken at the beginning of second study visit). (NCT01549652)
Timeframe: 2 study days 1 month apart (at the start of each study visit)
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Change in BDIS (Ondansetron) | Change in BDIS (Placebo) | |
| Prevention of Physical Dependence | -0.6 | 0.2 |
"Originally developed by Handelsman, the Objective Opioid Withdrawal Scale (OOWS) score is a well-characterized measure of opioid withdrawal in humans, calculated as the sum of a 13-item physician assessment documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. The minimum score of 0 means the patient is not showing any signs of opioid withdrawal. The maximum score of 13 signifies all signs of opioid withdrawal to the largest extent possible.~Immediately prior to ondansetron or placebo administration a baseline OOWS score was taken. 30 minutes later participants received naloxone, then 15 minutes later an OOWS score was taken. If deemed necessary by the clinician, participants may have received a second naloxone dose (25 minutes following 1st naloxone dose), then 15 minutes later an OOWS score was taken. Change from the baseline OOWS score to the score assessed following the last naloxone dose is reported." (NCT01549652)
Timeframe: Baseline; 15 minutes following last naloxone dose
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Change in OOWS (Ondansetron) | Change in OOWS (Placebo) | |
| Prevention of Opioid Withdrawal | 3.6 | 3.6 |
"Originally developed by Handelsman, the OOWS score is a well-characterized measure of opioid withdrawal in humans, calculated as the sum of a 13-item physician assessment documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. The maximum score is 13 and suggests the patient is showing all signs of opioid withdrawal to the largest extent possible. The minimum score of 0 suggests the patient is not showing any signs of opioid withdrawal.~Immediately prior to ondansetron or placebo administration a baseline OOWS score was taken. 30 minutes later participants received naloxone, then 15 minutes later an OOWS score was taken. If necessary (as deemed by the clinician), participants may have received a second naloxone dose (25 minutes following 1st naloxone dose), then 15 minutes later an OOWS score was taken. Change from the baseline OOWS score to the score assessed following the last naloxone dose is reported." (NCT01549652)
Timeframe: Baseline; 15 minutes following last naloxone dose
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Change in OOWS (Ondansetron) | Change in OOWS (Placebo) | |
| Prevention of Physical Dependence | 4.5 | 4.2 |
The VAS is a 0 to 100 millimeter scale where 0 corresponds to no pain and 100 to extreme pain, used by participants to indicated their level of pain over the last two weeks. Change is from baseline score for average level of pain (taken at the beginning of the first study visit, prior to beginning of titration into morphine) to the score taken after taking morphine for 30 days (score taken at the beginning of second study visit). (NCT01549652)
Timeframe: 2 study days 1 month apart (at the start of each study visit)
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Change in VAS Score (Ondansetron) | Change in VAS Score (Placebo) | |
| Prevention of Physical Dependence | -2.9 | -2.8 |
The Roland-Morris Disability Index is a 24-question instrument used to assess level of disability from lower back pain. Scores range from 0-24 with lower scores corresponding to fewer symptoms. Change is from baseline score (taken at the beginning of the first study visit, prior to beginning of titration into morphine) to the score taken after taking morphine for 30 days (score taken at the beginning of second study visit). (NCT01549652)
Timeframe: 2 study days 1 month apart (at the start of each study visit)
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Change in RMDI (Ondansetron) | Change in RMDI (Placebo) | |
| Prevention of Physical Dependence | -4.6 | -2.0 |
The Subjective Opioid Withdrawal Score (SOWS) score is calculated as the sum of 16 subjective patient-reported symptom scores rated on a scale of 0 to 4 (0=not at all, 4=extremely) based on what subjects were experiencing at the time of testing. A maximum score of 64 would suggest the patient is experiencing the symptoms of withdrawal to the maximum extent possible while the lowest score of 0 would suggest the patient is not experiencing any of the symptoms of withdrawal. Immediately prior to ondansetron or placebo administration a baseline SOWS score was taken. 30 minutes later participants received naloxone, then 15 minutes later an SOWS score was taken. If necessary (as deemed by the clinician), participants may have received a second naloxone dose (25 minutes following 1st naloxone dose), then 15 minutes later an SOWS score was taken. Change from the baseline SOWS score to the score assessed following the last naloxone dose is reported (NCT01549652)
Timeframe: Baseline; 15 minutes following last naloxone dose
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Change in SOWS (Ondansetron) | Change in SOWS (Placebo) | |
| Prevention of Opioid Withdrawal | 12.5 | 12.2 |
The SOWS score is composed of 16 subjective symptoms rated on a scale of 0 to 4 (0=not at all, 4=extremely) based on what subjects were experiencing at the time of testing. A maximum score of 64 would suggest the patient is experiencing the symptoms of withdrawal to the maximum extent possible while the lowest score of 0 would suggest the patient is not experiencing any of the symptoms of withdrawal. Immediately prior to ondansetron or placebo administration a baseline SOWS score was taken. 30 minutes later participants received naloxone, then 15 minutes later an SOWS score was taken. If necessary (as deemed by the clinician), participants may have received a second naloxone dose (25 minutes following 1st naloxone dose), then 15 minutes later an SOWS score was taken. Change from the baseline SOWS score to the score assessed following the last naloxone dose is reported (NCT01549652)
Timeframe: Baseline; 15 minutes following last naloxone dose
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Change in SOWS (Ondansetron) | Change in SOWS (Placebo) | |
| Prevention of Physical Dependence | 16.4 | 12.0 |
Profile of Mood States (POMS) is a 65-question survey of how participants have been feeling over the past week, assessing tension, depression, anger, fatigue, confusion and vigor. Each question is on a 5-point scale: 0 (not at all) to 4 (extremely). Overall score range: 0 to 200 (lower scores corresponding to fewer symptoms), calculated by adding total scores for tension, depression, anger, fatigue and confusing, and subtracting that total score from the total score for vigor. Immediately prior to ondansetron or placebo administration a baseline POMS score was taken. 30 minutes later participants received naloxone, then 15 minutes later a POMS score was taken. If necessary (as deemed by the clinician), participants may have received a second naloxone dose (25 minutes following 1st naloxone dose), then 15 minutes later an POMS score was taken. Change from the baseline POMS score to the score assessed following the last naloxone dose is reported. (NCT01549652)
Timeframe: Baseline; 15 minutes following last naloxone dose
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Change in POMS Score (Ondansetron) | Change in POMS Score (Placebo) | |
| Prevention of Opioid Withdrawal | 29.3 | 28.3 |
(Profile of Mood States) POMS is a 65-question survey of how participants have been feeling over the past week, assessing tension, depression, anger, fatigue, confusion and vigor. Each question is on a 5-point scale: 0 (not at all) to 4 (extremely). Overall score range: 0 to 200 (lower scores corresponding to fewer symptoms), calculated by adding total scores for tension, depression, anger, fatigue and confusing, and subtracting that total score from the total score for vigor. Immediately prior to ondansetron or placebo administration a baseline POMS score was taken. 30 minutes later participants received naloxone, then 15 minutes later a POMS score was taken. If necessary (as deemed by the clinician), participants may have received a second naloxone dose (25 minutes following 1st naloxone dose), then 15 minutes later an POMS score was taken. Change from the baseline POMS score to the score assessed following the last naloxone dose is reported. (NCT01549652)
Timeframe: Baseline; 15 minutes following last naloxone dose
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Change in POMS (Ondansetron) | Change in POMS (Placebo) | |
| Prevention of Physical Dependence | 36.1 | 29.2 |
9 reviews available for chlordiazepoxide and Alcohol Abuse
| Article | Year |
|---|---|
[Diagnostics and therapy of alcohol withdrawal syndrome: focus on delirium tremens and withdrawal seizure].
Topics: Adrenergic beta-Antagonists; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcoholism; A | 2010 |
ALCOHOLISM.
Topics: Alcoholism; Chlordiazepoxide; Chlormethiazole; Chlorpropamide; Culture; Lysergic Acid Diethylamide; | 1963 |
The meaning and treatment of alcohol dependence.
Topics: Alcohol Withdrawal Delirium; Alcoholic Beverages; Alcoholics Anonymous; Alcoholism; Amnesia; Aversiv | 1975 |
Drug therapy. Benzodiazepines (second of two parts).
Topics: Affective Symptoms; Alcoholism; Analgesia; Anesthesia, General; Anesthesia, Obstetrical; Anti-Anxiet | 1974 |
Use of beta-adrenergic receptor blocking drugs in psychiatry.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alcoholism; Anxiety; Chlordiazepoxide; Di | 1974 |
Drugs in the treatment of alcoholism.
Topics: Alcohol Deterrents; Alcoholic Intoxication; Alcoholism; Amitriptyline; Antidepressive Agents; Chlord | 1967 |
Prognostic factors in alcoholism.
Topics: Adult; Alcoholism; Chlordiazepoxide; Ethnicity; Follow-Up Studies; Humans; Imipramine; Male; Middle | 1968 |
Drug and placebo responses in chronic alcoholics.
Topics: Achievement; Alcoholism; Antidepressive Agents; Black or African American; Chlordiazepoxide; Chronic | 1968 |
Pharmacology of benzodiazepines: laboratory and clinical correlations.
Topics: Aggression; Alcoholism; Animals; Anticonvulsants; Anxiety; Autonomic Nervous System; Avoidance Learn | 1967 |
33 trials available for chlordiazepoxide and Alcohol Abuse
| Article | Year |
|---|---|
A double blind randomised comparison of chlordiazepoxide and lorazepam in alcohol withdrawal.
Topics: Adult; Alcoholism; Analysis of Variance; Chlordiazepoxide; Double-Blind Method; Humans; Hypnotics an | 2013 |
A randomized, double-blind comparison of lorazepam and chlordiazepoxide in patients with uncomplicated alcohol withdrawal.
Topics: Adolescent; Adult; Alcohol-Induced Disorders; Alcoholism; Chlordiazepoxide; Drug Administration Sche | 2009 |
Comparative evaluation of treatments of alcohol withdrawal syndromes.
Topics: Alcoholism; Chloral Hydrate; Chlordiazepoxide; Drug Synergism; Ethanol; Fever; Humans; Male; Middle | 1967 |
A comparison of the efficacy and tolerability of clobazam and chlordiazepoxide in the treatment of acute withdrawal from alcohol in patients with primary alcoholism.
Topics: Adolescent; Adult; Aged; Alcoholism; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Benzodiazepinone | 1983 |
Comparison of chlormethiazole (Heminevrin) and chlordiazepoxide (Librium) in the treatment of acute alcohol withdrawal.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Chlormethiazole; Double-Blind Meth | 1983 |
Individualized treatment for alcohol withdrawal. A randomized double-blind controlled trial.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Double-Blind Method; Drug Administ | 1994 |
Individualized treatment for outpatients withdrawing from alcohol.
Topics: Adult; Age Factors; Aged; Alcoholism; Ambulatory Care; Anti-Anxiety Agents; Aspartate Aminotransfera | 1998 |
Divalproex sodium (Depakote) for alcohol withdrawal and relapse prevention.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Ambulatory Care; Anti-Anxiety Agents; Anticonvulsant | 2002 |
Residual effects of ethanol and chlordiazepoxide treatments for alcohol withdrawal.
Topics: Adult; Alcoholism; Chlordiazepoxide; Electroencephalography; Ethanol; Humans; Male; Middle Aged; Psy | 1978 |
A double blind study of chlordiazepoxide and hydroxyzine HC1 therapy in acute alcohol withdrawal utilizing chronic electromyography for tremor assessment.
Topics: Alcoholism; Chlordiazepoxide; Clinical Trials as Topic; Double-Blind Method; Electromyography; Human | 1978 |
MMPI and drug treatment in alcohol withdrawal.
Topics: Adult; Alcoholism; Chlordiazepoxide; Double-Blind Method; Drug Evaluation; Female; Humans; Male; Mid | 1979 |
Control of acute alcoholic withdrawal symptoms: a comparative study of haloperidol and chlordiazepoxide.
Topics: Adult; Aged; Alcoholism; Chlordiazepoxide; Clinical Trials as Topic; Female; Haloperidol; Humans; In | 1976 |
Slow wave sleep changes: alcohol tolerance and treatment implications.
Topics: Adult; Alcoholism; Chlordiazepoxide; Drug Tolerance; Ethanol; Humans; Male; Middle Aged; Sleep Stage | 1977 |
Drug treatment in a rehabilitation center for chronic alcoholics.
Topics: Adult; Alcoholism; Chlordiazepoxide; Chronic Disease; Clinical Trials as Topic; Drug Evaluation; Hos | 1975 |
A controlled trial of chlormethiazole and chlordiazepoxide in the treatment of the acute withdrawal phase of alcoholism.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Chlormethiazole; Clinical Trials as Topic | 1975 |
The use of tranquilizers in the treatment of mixed drug abuse.
Topics: Adult; Alcoholism; Analgesics; Barbiturates; Chlordiazepoxide; Clinical Trials as Topic; Diazepam; F | 1975 |
Treatment of depression in alcoholics.
Topics: Adolescent; Adult; Alcoholism; Chlordiazepoxide; Counseling; Depression; Drug Evaluation; Drug Thera | 1975 |
[Contribution of glutathione to detoxification in alcoholism. Biochemical-clinical studies].
Topics: Adult; Alcoholism; Chlordiazepoxide; Erythrocytes; Female; gamma-Glutamyltransferase; Glucaric Acid; | 1992 |
Where and when to detoxify single homeless drinkers.
Topics: Alcoholism; Ambulatory Care; Appointments and Schedules; Chlordiazepoxide; Humans; Ill-Housed Person | 1990 |
Halazepam in the management of acute alcohol withdrawal syndrome.
Topics: Acute Disease; Adult; Alcoholism; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chlordiaz | 1985 |
Lithium compliance in alcoholic males: a six month followup study.
Topics: Adult; Alcoholism; Chlordiazepoxide; Follow-Up Studies; Humans; Lithium; Lithium Carbonate; Male; Mi | 1986 |
Diphenylhydantoin control of alcohol withdrawal seizures. Results of a controlled study.
Topics: Administration, Oral; Alcoholism; Chlordiazepoxide; Clinical Trials as Topic; Drug Evaluation; Elect | 1974 |
Drug treatment of anxiety and depression in detoxified alcoholic patients.
Topics: Alcoholism; Amitriptyline; Analysis of Variance; Anxiety; Ascorbic Acid; Chlordiazepoxide; Depressio | 1973 |
Drug maintenance in the outpatient treatment of chronic alcoholism.
Topics: Adult; Alcohol Drinking; Alcoholic Intoxication; Alcoholism; Automobile Driving; Boston; Chlordiazep | 1974 |
A study of drugs in the management of chronic alcoholism.
Topics: Alcoholism; Chlordiazepoxide; Chronic Disease; Clinical Trials as Topic; Humans; Hydroxyzine; Placeb | 1967 |
Drug therapy in alcoholism.
Topics: Alcoholic Intoxication; Alcoholism; Amitriptyline; Antidepressive Agents; Benactyzine; Carbamates; C | 1968 |
Drug and placebo responses in chronic alcoholics.
Topics: Achievement; Alcoholism; Antidepressive Agents; Black or African American; Chlordiazepoxide; Chronic | 1968 |
Dimensions of LSD, methylphenidate and chlordiazepoxide experiences.
Topics: Alcoholism; Chlordiazepoxide; Clinical Trials as Topic; Emotions; Hallucinations; Humans; Lysergic A | 1969 |
Evaluating changes in symptoms during acute alcohol withdrawal.
Topics: Affect; Alcoholism; Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; Female; Humans; Hydr | 1971 |
Comparative investigation of the effects of dixyrazine, placebo and chlordiazepoxide on alcoholics during hospital care.
Topics: Adult; Aged; Alcoholism; Chemical Phenomena; Chemistry; Chlordiazepoxide; Chronic Disease; Clinical | 1967 |
A six-month controlled evaluation of metronidazole (Flagyl) in chronic alcoholic patients.
Topics: Adult; Age Factors; Alcoholism; Black People; Chlordiazepoxide; Clinical Trials as Topic; Female; Hu | 1968 |
[Clinical study of an anxiolytic antidepressive drug].
Topics: Adjustment Disorders; Adult; Aged; Alcoholism; Amitriptyline; Bipolar Disorder; Chlordiazepoxide; Cl | 1967 |
Treatment of alcoholism in the subacute stage. (A study of three active agents).
Topics: Adult; Aged; Alcoholism; Antidepressive Agents; Chlordiazepoxide; Humans; Male; Middle Aged; Oxazepa | 1966 |
125 other studies available for chlordiazepoxide and Alcohol Abuse
| Article | Year |
|---|---|
Association of benzodiazepines, Z-drugs, pregabalin, and melatonin with traffic accidents: A nationwide cohort and case-crossover study in Danish adults.
Topics: Accidents, Traffic; Adolescent; Adult; Aged; Alcoholism; Benzodiazepines; Chlordiazepoxide; Cohort S | 2022 |
Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report.
Topics: Adult; Alcoholism; Chlordiazepoxide; Delirium; Ethanol; Female; Humans; Substance Withdrawal Syndrom | 2022 |
Active chlordiazepoxide metabolites in a patient needing life support after treatment of alcohol abstinence.
Topics: Alcohol Abstinence; Alcoholism; Benzodiazepines; Chlordiazepoxide; Female; Humans; Male; Middle Aged | 2020 |
Comment on "gabapentin versus chlordiazepoxide for outpatient alcohol detoxification treatment".
Topics: Alcoholism; Ambulatory Care; Amines; Chlordiazepoxide; Cyclohexanecarboxylic Acids; Female; gamma-Am | 2013 |
Reply to comment on "gabapentin versus chlordiazepoxide for outpatient alcohol detoxification treatment".
Topics: Alcoholism; Ambulatory Care; Amines; Chlordiazepoxide; Cyclohexanecarboxylic Acids; Female; gamma-Am | 2013 |
Drug trials in psychiatry: methodological issues.
Topics: Alcoholism; Chlordiazepoxide; Citalopram; Depressive Disorder; Diabetes Mellitus; Female; Humans; Hy | 2014 |
Drug effects on multiple and concurrent schedules of ethanol- and food-maintained behaviour: context-dependent selectivity.
Topics: Alcoholism; Amphetamines; Animals; Chlordiazepoxide; Dextroamphetamine; Dose-Response Relationship, | 2014 |
Phenobarbital compared to benzodiazepines in alcohol withdrawal treatment: A register-based cohort study of subsequent benzodiazepine use, alcohol recidivism and mortality.
Topics: Adult; Alcoholism; Benzodiazepines; Chlordiazepoxide; Cohort Studies; Ethanol; Female; GABA Modulato | 2016 |
Chlordiazepoxide in the treatment of acute alcoholism: a preliminary report.
Topics: Alcoholism; Chlordiazepoxide; Tranquilizing Agents | 1961 |
Chlordiazepoxide in the treatment of alcoholics.
Topics: Alcoholics; Alcoholism; Chlordiazepoxide; Humans | 1961 |
Librium, a new quieting drug for hyperactive alcoholic and psychotic patients. (Preliminary study).
Topics: Alcoholism; Chlordiazepoxide; Mental Disorders; Psychosurgery; Psychotic Disorders; Tranquilizing Ag | 1960 |
A controlled evaluation of "librium" in the treatment of alcoholics.
Topics: Alcoholics; Alcoholism; Chlordiazepoxide; Tranquilizing Agents | 1961 |
Response to Librium in individuals with a propensity for addiction: a pilot study.
Topics: Alcoholism; Chlordiazepoxide; Humans; Pilot Projects; Tranquilizing Agents | 1962 |
The use of chlordiazepoxide (Librium) in the alcoholic patient: a clinical study of forty cases.
Topics: Alcoholism; Biomedical Research; Chlordiazepoxide; Tranquilizing Agents | 1962 |
[Chlordiazepoxide and the treatment of alcholism].
Topics: Alcoholism; Chlordiazepoxide; Humans; Mental Disorders; Psychoses, Alcoholic; Psychotic Disorders | 1963 |
Management of alcohol withdrawal.
Topics: Alcoholism; Alcohols; Chlordiazepoxide; Disease Management; Humans; Mental Disorders; Rehabilitation | 1963 |
Management of alcoholic withdrawal. Observation using chlordiazepoxide as chief tranquilizing agent.
Topics: Alcoholism; Chlordiazepoxide; Disease Management; Humans; Tranquilizing Agents | 1962 |
[Contribution to the study of "Librium" in the treatment of alcoholics].
Topics: Alcoholics; Alcoholism; Chlordiazepoxide; Humans | 1963 |
The management of acute withdrawal symptoms of alcoholism.
Topics: Alcoholism; Chlordiazepoxide; Disease Management; Humans; Substance Withdrawal Syndrome | 1962 |
Chlordiazepoxide in alcohol withdrawal-intramuscular effects.
Topics: Alcoholism; Alcohols; Chlordiazepoxide; Conduct Disorder; Humans; Minnesota; Psychoses, Substance-In | 1963 |
TREATMENT OF CHRONIC ALCOHOLISM.
Topics: Adrenocorticotropic Hormone; Alcoholism; Chlordiazepoxide; Folic Acid; Fructose; Humans; Insulin; Vi | 1963 |
DAY CARE FOR ALCOHOLICS IN ACUTE WITHDRAWAL.
Topics: Alcoholics; Alcoholism; Chlordiazepoxide; Day Care, Medical; Humans; Outpatient Clinics, Hospital; P | 1963 |
CURRENT ADVANCES IN THE AMBULATORY MEDICAL TREATMENT OF ALCOHOLICS.
Topics: Alcohol Deterrents; Alcoholics; Alcoholism; Chlordiazepoxide; Diazepam; Disulfiram; Humans; Lysergic | 1963 |
AN EVALUATION OF VARIOUS PSYCHOTHERAPEUTIC AGENTS IN THE LONG TERM TREATMENT OF CHRONIC ALCOHOLISM. RESULTS OF A DOUBLE BLIND STUDY.
Topics: Alcoholism; Benactyzine; Chlordiazepoxide; Double-Blind Method; Humans; Isocarboxazid; Meprobamate; | 1963 |
PHARMACOLOGICAL ADJUNCTS IN THE COMPREHENSIVE CARE AND REHABILITATION OF ALCOHOLICS.
Topics: Alcoholics; Alcoholism; Chlordiazepoxide; Comprehensive Health Care; Disulfiram; Metabolism; Rehabil | 1963 |
MANAGEMENT OF ACUTE ALCOHOL BARBITURATE WITHDRAWAL STATES.
Topics: Alcoholism; Alcohols; Barbiturates; Chlordiazepoxide; Coma; Humans; Psychoses, Alcoholic; Psychotic | 1963 |
A CONTROLLED EVALUATION OF CHLORDIAZEPOXIDE (LIBRIUM) IN THE TREATMENT OF CONVALESCING ALCOHOLICS.
Topics: Alcoholics; Alcoholism; Blood Chemical Analysis; Chlordiazepoxide; Convalescence; Electroencephalogr | 1963 |
MAGNESIUM METABOLISM IN ACUTE ALCOHOLICS.
Topics: Alcoholics; Alcoholism; Aspartate Aminotransferases; Barbiturates; Blood Chemical Analysis; Chlordia | 1963 |
THE EFFECT OF CHLORDIAZEPOXIDE ON CONVULSIVE DISORDER.
Topics: Alcoholism; Anticonvulsants; Brain Diseases; Chlordiazepoxide; Electroencephalography; Epilepsy; Hyd | 1964 |
[THE PROBLEM OF SUICIDE].
Topics: Alcoholism; Antidepressive Agents; Chlordiazepoxide; Counseling; Depression; Depressive Disorder; Fi | 1963 |
[THE SELECTIVE INDICATIONS AND THE PSYCHODYNAMIC EFFECT OF CHLORDIAZEPOXIDE (LIBRIUM) AS AN ANTIALCOHOLIC PSYCHOPHARMACOLOGICAL AGENT].
Topics: Alcoholism; Chlordiazepoxide; Humans; Mental Disorders; Pharmacology; Psychoses, Alcoholic; Psychoti | 1964 |
ALCOHOLISM: A GENERAL MEDICAL APPROACH.
Topics: Alcoholism; Chlordiazepoxide; Disulfiram; Hospitals; Hospitals, Psychiatric; Humans; Hydantoins; Mep | 1964 |
TRANSIENT ENURESIS FROM CHLORDIAZEPOXIDE AND DIAZEPAM.
Topics: Alcoholism; Chlordiazepoxide; Diazepam; Enuresis; Neurotic Disorders; Toxicology; Tranquilizing Agen | 1964 |
TREATMENT OF ACUTE ALCOHOL POISONING IN A STATE MENTAL HOSPITAL.
Topics: Alcoholism; Alcohols; Biomedical Research; Chlordiazepoxide; Chlorpromazine; Hospitals, Psychiatric; | 1964 |
[CLOPOXIDE IN ALCOHOLISM THERAPY].
Topics: Alcoholism; Biomedical Research; Chlordiazepoxide; Chlorpromazine; Drug Therapy; Pharmacology | 1964 |
[VERSATILITY IN THE USE OF LIBRIUM].
Topics: Adolescent; Alcoholism; Anxiety; Anxiety Disorders; Arteriosclerosis; Chlordiazepoxide; Geriatrics; | 1964 |
PRR STUDY NO. 3. (A METHOD FOR CONTROLLING THE ADMINISTRATION OF TRANYLCYPROMINE).
Topics: Alcoholism; Anxiety; Anxiety Disorders; Chlordiazepoxide; Depression; Depressive Disorder; Drug Ther | 1964 |
COMPARATIVE CLINICAL EVALUATION OF CHLORDIAZEPOXIDE AND PROMAZINE IN TREATMENT OF ALCOHOL-WITHDRAWAL SYNDROME.
Topics: Alcohol-Induced Disorders; Alcoholism; Alcohols; Biomedical Research; Blood Pressure Determination; | 1965 |
PHOTOSENSITIVITY REACTION TO CHLORDIAZEPOXIDE.
Topics: Alcoholism; Chlordiazepoxide; Dermatitis, Phototoxic; Drug Eruptions; Drug Therapy; Humans; Photosen | 1965 |
MANAGEMENT OF PSYCHOMOTOR AGITATION IN ACUTE ALCOHOLISM: A DOUBLE-BLIND STUDY USING CHLORDIAZEPOXIDE.
Topics: Alcoholism; Biomedical Research; Chlordiazepoxide; Depression; Depressive Disorder; Double-Blind Met | 1965 |
INCIDENCE OF DRINKING AMONG HOSPITALIZED CONVALESCING ALCOHOLICS.
Topics: Alcohol Drinking; Alcoholics; Alcoholism; Chlordiazepoxide; Convalescence; Hospitalization; Humans; | 1965 |
DOUBLE-BLIND STUDY OF THREE DRUGS IN THE TREATMENT OF ACUTE ALCOHOLIC STATES.
Topics: Alcoholism; Biomedical Research; Chlordiazepoxide; Diazepam; Double-Blind Method; Drug Therapy; Prom | 1965 |
[Therapeutic trial of chlordiazepoxide in alcoholism].
Topics: Alcoholism; Chlordiazepoxide; Tranquilizing Agents | 1962 |
The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin. Excretion of HPPH in the urine.
Topics: Acetazolamide; Adult; Aged; Alcoholism; Amitriptyline; Chlordiazepoxide; Chlorpromazine; Chromatogra | 1967 |
Dysregulation of hypothalamic-pituitary-adrenal axis function in depressed alcoholic patients.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Depressive Disorder; Dexamethasone | 1982 |
Plasma beta-endorphin and met-enkephalin in physiological and pathological conditions.
Topics: Alcoholism; beta-Endorphin; Brain; Chlordiazepoxide; Circadian Rhythm; Endorphins; Enkephalin, Methi | 1982 |
Blood concentrations and clinical findings following overdose of chlordiazepoxide alone and chlordiazepoxide plus ethanol.
Topics: Adolescent; Adult; Alcoholism; Blood Pressure; Chlordiazepoxide; Consciousness; Drug Interactions; F | 1984 |
Alcoholism.
Topics: Alcoholics Anonymous; Alcoholism; Chlordiazepoxide; Disulfiram; Female; Humans; Male; Psychoses, Alc | 1983 |
Short latency brainstem and somatosensory evoked potentials in alcoholics.
Topics: Alcoholism; Brain Diseases; Brain Stem; Chlordiazepoxide; Disulfiram; Evoked Potentials, Auditory; E | 1983 |
Propranolol and chlordiazepoxide effects on cardiac arrhythmias during alcohol withdrawal.
Topics: Alcoholism; Arrhythmias, Cardiac; Chlordiazepoxide; Electroencephalography; Humans; Male; Propranolo | 1980 |
Alcohol withdrawal reactions after chronic intake of chlordiazepoxide and ethanol.
Topics: Alcoholism; Animals; Body Temperature; Chlordiazepoxide; Diet; Drug Interactions; Ethanol; Half-Life | 1981 |
[Treatment of an alcoholic pre-delirium syndrome with chlormethiazol, methophenazin and chlordiazepoxide].
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Chlormethiazole; Drug Therapy, Com | 1980 |
Individualized treatment of alcohol withdrawal.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Drug Administration Schedule; Ethanol; Hu | 1995 |
Refining the treatment of alcohol withdrawal.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Chlordiazepoxide; Drug Administration Sche | 1994 |
Severity and treatment of alcohol withdrawal in elderly versus younger patients.
Topics: Adult; Age Factors; Aged; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Dose-Response R | 1994 |
Alcohol cue reactivity: effects of detoxification and extended exposure.
Topics: Adaptation, Psychological; Adult; Alcohol Drinking; Alcohol Withdrawal Delirium; Alcoholism; Arousal | 1993 |
Effects of various serotonergic agents on alcohol intake and alcohol preference in Wistar rats selected at two different levels of alcohol preference.
Topics: Alcohol Drinking; Alcoholism; Animals; Buspirone; Chlordiazepoxide; Citalopram; Dose-Response Relati | 1993 |
Alcohol withdrawal: a nationwide survey of inpatient treatment practices.
Topics: Adrenergic beta-Antagonists; Alcoholism; Barbiturates; Benzodiazepines; Chlordiazepoxide; Clonidine; | 1995 |
Current treatment for alcohol withdrawal.
Topics: Alcoholism; Benzodiazepines; Chlordiazepoxide; Diazepam; Humans; Substance Withdrawal Syndrome | 1995 |
Outcomes of patients in a VA ambulatory detoxification program.
Topics: Adult; Alcoholism; Anti-Anxiety Agents; Arkansas; Chlordiazepoxide; Cost Savings; Female; Hospitals, | 1997 |
The alcohol withdrawal syndrome.
Topics: Alcoholism; Chlordiazepoxide; Diazepam; Drug Tolerance; Ethanol; Hospitalization; Humans; Substance | 1979 |
Routine hospital alcohol detoxification practice compared to symptom triggered management with an Objective Withdrawal Scale (CIWA-Ar).
Topics: Adult; Aged; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Female; Hospitalization; Hos | 2000 |
Investigation of the therapeutic efficacy of a taurine analogue during the initial stages of ethanol detoxification: preliminary studies in chronic alcohol abusers.
Topics: Acamprosate; Alcoholism; Amino Acids; Chlordiazepoxide; Chronic Disease; Ethanol; GABA Modulators; G | 2000 |
A Short Alcohol Withdrawal Scale (SAWS): development and psychometric properties.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Humans; Neurologic Examination; Neuropsyc | 2002 |
Tardive dyskinesia: relationship with a primary affective disorder.
Topics: Adult; Affective Symptoms; Aged; Alcoholism; Amitriptyline; Antipsychotic Agents; Chlordiazepoxide; | 1977 |
Clinical implications of benzodiazepine pharmacokinetics.
Topics: Administration, Oral; Adult; Age Factors; Aged; Alcoholism; Anti-Anxiety Agents; Chlordiazepoxide; C | 1977 |
Recent advances in alcohol withdrawal states.
Topics: Adrenergic beta-Antagonists; Adult; Alcoholism; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Hum | 1977 |
Interaction of disulfiram with benzodiazepines.
Topics: Adult; Alcoholism; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Disulfiram; Drug Interactions; H | 1978 |
Psychological medicine. Treatment of alcoholism.
Topics: Adolescent; Adult; Alcohol Drinking; Alcohol Withdrawal Delirium; Alcoholics Anonymous; Alcoholism; | 1975 |
Pharmacotherapy of the acute alcohol withdrawal syndrome.
Topics: Alcoholism; Anti-Anxiety Agents; Barbiturates; Chemical and Drug Induced Liver Injury; Chloral Hydra | 1975 |
The use of psychoactive drugs in the long-term treatment of chronic alcoholics.
Topics: Alcoholism; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Chlordiazepoxide; Chlorpromazine; Ch | 1975 |
The treatment of alcoholism: what do we do about long-term sedatives?
Topics: Alcoholics Anonymous; Alcoholism; Anti-Anxiety Agents; Attitude of Health Personnel; Chlordiazepoxid | 1975 |
Alcoholic epilepsy. Effects of treatment on convulsions following the cessation of drinking.
Topics: Adult; Aged; Alcoholism; Chlordiazepoxide; Female; Humans; Male; Middle Aged; Seizures; Substance Wi | 1977 |
Are all recently detoxified alcoholics depressed?
Topics: Alcoholism; Chlordiazepoxide; Depression; Diazepam; Humans; Male; Psychological Tests | 1979 |
EEG's in an alcohol detoxification and treatment center.
Topics: Alcoholism; Chlordiazepoxide; Electroencephalography; Humans; Hyperventilation; Theta Rhythm | 1979 |
Chlordiazepoxide and dropping out of a detoxication service.
Topics: Adult; Alcoholism; Chlordiazepoxide; Female; Humans; Length of Stay; Male; Maryland; Mental Health S | 1979 |
Chlordiazepoxide in acute alcoholism.
Topics: Acute Disease; Adult; Age Factors; Alcoholism; Chlordiazepoxide; Half-Life; Humans; Middle Aged | 1979 |
Comparative efficacy of propranolol and chlordiazepoxide in alcohol withdrawal.
Topics: Adult; Alcoholism; Catecholamines; Chlordiazepoxide; Dose-Response Relationship, Drug; Drug Evaluati | 1977 |
Nursing care study: the one who got away.
Topics: Alcoholism; Chlordiazepoxide; Depression; Humans; Male; Psychiatric Nursing | 1977 |
Absorption of oral intramuscular chlordiazepoxide by alcoholics.
Topics: Absorption; Administration, Oral; Adult; Aged; Alcoholism; Chlordiazepoxide; Half-Life; Humans; Inje | 1978 |
Absorption of oral and intramuscular chlordiazepoxide.
Topics: Absorption; Administration, Oral; Adult; Alcoholism; Biological Availability; Chlordiazepoxide; Deal | 1978 |
Decline in chlordiazepoxide plasma levels during fixed-dose therapy of alcohol withdrawal.
Topics: Alcoholism; Chlordiazepoxide; Humans; Substance Withdrawal Syndrome; Time Factors | 1978 |
Alcohol intoxication and the alcohol withdrawal syndrome.
Topics: Alcoholic Intoxication; Alcoholism; Benzodiazepines; Chlordiazepoxide; Hallucinations; Humans; Pheny | 1978 |
Investigation of psychological correlates of chlordiazepoxide dependence in recovering alcoholics.
Topics: Alcoholism; Chlordiazepoxide; Female; Field Dependence-Independence; Humans; Intelligence Tests; Mal | 1979 |
Chlordiazepoxide: long-term use in alcoholism.
Topics: Alcoholism; Chlordiazepoxide; Drug Evaluation; Humans; Long-Term Care; Substance Withdrawal Syndrome | 1976 |
Thioridazine HC1 Vs. chlordiazepoxide HC1 in controlling symptoms attributable to alcohol withdrawal.
Topics: Adult; Aged; Alcoholism; Chlordiazepoxide; Drug Evaluation; Female; Humans; Male; Middle Aged; Psych | 1977 |
Recognizing and managing the outpatient alcoholic.
Topics: Alcoholism; Ambulatory Care; Chlordiazepoxide; Diazepam; Disulfiram; Hospitalization; Humans; Physic | 1977 |
Possible role of tetrahydroisoquinoline alkaloids in postalcohol intoxication states.
Topics: Alcoholic Intoxication; Alcoholism; Animals; Brain; Catecholamines; Chlordiazepoxide; Dopamine; Huma | 1976 |
Chlordiazepoxide and alcohol: a fatal overdose.
Topics: Adult; Alcoholic Intoxication; Alcoholism; Autopsy; Chlordiazepoxide; Drug Synergism; Humans; Male | 1975 |
Effects of alcohol ingestion and abstinence on slow wave sleep of alcoholics.
Topics: Adult; Alcoholism; Analysis of Variance; Chlordiazepoxide; Electroencephalography; Ethanol; Humans; | 1975 |
[Letter: Pharmacotherapy in alcoholism].
Topics: Alcoholism; Chlordiazepoxide; Humans; Psychology | 1976 |
Detoxification of alcoholics: improving care by symptom-triggered sedation.
Topics: Alcoholism; Chlordiazepoxide; Humans; Male; Substance Withdrawal Syndrome | 1990 |
Carbamazepine adjunct for nonresponsive psychosis with prior hallucinogenic abuse.
Topics: Adult; Alcoholism; Antipsychotic Agents; Carbamazepine; Chlordiazepoxide; Drug Therapy, Combination; | 1989 |
Alcohol withdrawal in the elderly.
Topics: Adult; Age Factors; Aged; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Female; Humans; | 1989 |
Ethanol and chlordiazepoxide cross-dependence.
Topics: Alcoholism; Animals; Chlordiazepoxide; Flumazenil; Male; Mice; Mice, Inbred C57BL; Substance Withdra | 1987 |
Does chronic ethanol intake confer full cross-tolerance to chlordiazepoxide?
Topics: Alcoholism; Animals; Body Temperature; Chlordiazepoxide; Drug Tolerance; Ethanol; Locomotion; Male; | 1988 |
Evaluating depression in alcoholics.
Topics: Adult; Alcoholism; Chlordiazepoxide; Depressive Disorder; Female; Humans; Male; Middle Aged; Psychol | 1986 |
Power and coherence analysis of the EEG in hospitalized alcoholics and nonalcoholic controls.
Topics: Adult; Alcoholism; Alpha Rhythm; Brain; Chlordiazepoxide; Cognition; Delta Rhythm; Electroencephalog | 1985 |
Drug therapy in alcoholism.
Topics: Adult; Alcoholic Intoxication; Alcoholism; Antidepressive Agents; Anxiety; Carbamates; Chlordiazepox | 1970 |
Behavioral studies of sleep patterns in alcoholics during intoxication and withdrawal.
Topics: Adult; Alcohol Drinking; Alcoholism; Chlordiazepoxide; Ethanol; Hallucinations; Humans; Hypnotics an | 1970 |
[Therapy of anxiety, mental anguish and sleeplessness. 3. Clinical pharmacological viewpoints].
Topics: Alcoholism; Alcohols; Aldehydes; Antidepressive Agents; Azepines; Barbiturates; Bromides; Chlordiaze | 1969 |
Characteristics of alcoholics volunteering for lysergide treatment.
Topics: Adult; Aged; Alcoholism; Attitude to Health; Bender-Gestalt Test; Chlordiazepoxide; Educational Stat | 1970 |
Drug therapy in alcoholism. It is especially important in the prevention of such complications as seizures, DT's, Wernicke's encephalopathy, or polyneuritis.
Topics: Alcoholism; Anticonvulsants; Chlordiazepoxide; Chlorpromazine; Diazepam; Disulfiram; Humans; Hydroxy | 1971 |
Prevention of alcohol withdrawal seizures: the roles of diphenylhydantoin and chlordiazepoxide.
Topics: Alcoholism; Anticonvulsants; Chlordiazepoxide; Electroencephalography; Ethanol; Humans; Neurons; Phe | 1973 |
[Treatment of alcohol intoxication].
Topics: Accidents, Home; Adult; Alcohol Amnestic Disorder; Alcoholic Intoxication; Alcoholism; Child; Chlord | 1974 |
Differences between mental disorders of French Canadians and British Canadians.
Topics: Adolescent; Adult; Age Factors; Aged; Alcoholism; Bipolar Disorder; Canada; Chlordiazepoxide; Cranio | 1974 |
Clinical toxicity of chlordiazepoxide and diazepam in relation to serum albumin concentration: a report from the Boston Collaborative Drug Surveillance Program.
Topics: Age Factors; Alcoholism; Anxiety; Chlordiazepoxide; Coffee; Depression; Diazepam; Female; Humans; Le | 1974 |
Treatment of alcoholic withdrawal states with chlordiazepoxide.
Topics: Adult; Alcoholism; Chlordiazepoxide; Female; Humans; Male; Middle Aged | 1965 |
Grand-mal seizures in two patients in acute alcohol withdrawal after treatment with hydroxyzine.
Topics: Alcoholism; Anticonvulsants; Chlordiazepoxide; Epilepsy, Tonic-Clonic; Humans; Hydroxyzine; Injectio | 1967 |
A therapeutic revolving door.
Topics: Adult; Alcoholism; Amines; Chlordiazepoxide; Community Mental Health Services; Forensic Psychiatry; | 1972 |
Alcoholism in women.
Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Anxiety; Chlordiazepoxide; Depression; Diazepam; Female; | 1971 |
[Misuse of bezodiazepin derivatives in alcoholics].
Topics: Alcoholism; Chlordiazepoxide; Diazepam; Humans; Substance-Related Disorders | 1966 |
Librium and valium.
Topics: Alcoholism; Anxiety; Chlordiazepoxide; Diazepam; Humans; Mental Disorders; Seizures; Suicide | 1969 |
The alcohol withdrawal syndrome: theory and practice.
Topics: Alcoholism; Chlordiazepoxide; Humans; Psychoses, Alcoholic; Substance Withdrawal Syndrome | 1970 |
Habituation to chlordiazepoxide in an alcoholic population.
Topics: Alcoholism; Chlordiazepoxide; Humans; Substance-Related Disorders | 1970 |
Social and psychological factors in the treatment of chronic alcoholism.
Topics: Adult; Age Factors; Alcoholism; Ambulatory Care; Attitude of Health Personnel; Attitude to Health; C | 1970 |
The treatment of acute alcohol intoxication and withdrawal.
Topics: Acute Disease; Adult; Alcoholic Intoxication; Alcoholism; Chlordiazepoxide; Chlormethiazole; Ethanol | 1970 |
[Modern therapy of alcoholism].
Topics: Alcoholism; Chlordiazepoxide; Coma; Diazepam; Fructose; Humans; Hypotension; Psychoses, Alcoholic; S | 1970 |
The management of alcoholism in general practice.
Topics: Alcoholism; Chlordiazepoxide; Chlorpromazine; Citrates; Cyanides; Humans | 1970 |
A comparison of three approaches to alcohol-withdrawal states.
Topics: Adult; Alcoholism; Chloral Hydrate; Chlordiazepoxide; Chlorpromazine; Female; Humans; Male; Paraldeh | 1969 |
Chlordiazepoxide (librium) compared with meprobamate and promazine (prozine) for the withdrawal symptoms of acute alcoholism.
Topics: Alcoholic Intoxication; Alcoholism; Chlordiazepoxide; Humans; Male; Meprobamate; Promazine; Substanc | 1965 |
Outpatient management of acutely ill alcoholics.
Topics: Alcoholism; Chlordiazepoxide; Female; Humans; Male; Psychiatry | 1965 |
Two severe reactions to benzodiazepine compounds.
Topics: Adult; Alcoholism; Ataxia; Chlordiazepoxide; Diazepam; Drug Synergism; Humans; Male; Middle Aged; Mu | 1965 |
[Psychological bases of the treatment of alcoholics; a report of experiences of "alcoholic units"].
Topics: Alcoholism; Carbamates; Chlordiazepoxide; Chlormethiazole; Disulfiram; England; Halfway Houses; Huma | 1965 |
Management of acute alcohol withdrawal symptoms.
Topics: Alcoholism; Chloral Hydrate; Chlordiazepoxide; Humans; Substance Withdrawal Syndrome | 1966 |