| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347059 | CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347049 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347410 | qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library | 2019 | Cellular signalling, 08, Volume: 60 | A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening. |
| AID1347152 | Confirmatory screen NINDS AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347169 | Tertiary RLuc qRT-PCR qHTS assay for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347045 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347057 | CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID504836 | Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation | 2002 | The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. |
| AID1347405 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347161 | Confirmatory screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347149 | Furin counterscreen qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347151 | Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1347168 | HepG2 cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347050 | Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347058 | CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID588349 | qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay | | | |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID588378 | qHTS for Inhibitors of ATXN expression: Validation | | | |
| AID1347167 | Vero cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347153 | Confirmatory screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID269024 | Selectivity for human D4 receptor over 5HT1A receptor | 2006 | Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17
| 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction. |
| AID63054 | Binding affinity towards cloned human Dopamine receptor D2 | 2001 | Bioorganic & medicinal chemistry letters, Jan-22, Volume: 11, Issue:2
| Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand. |
| AID1526875 | Displacement of [3H] Spiperone from human D2L receptor expressed in CHO cells by competitive radioligand binding assay | | | |
| AID1526877 | Displacement of [3H] Spiperone from human D3 receptor expressed in CHO cells by competitive radioligand binding assay | | | |
| AID62488 | Affinity for Dopamine receptor D2 using [3H]-YM-09151-2 was carried out on bovine striatal membrane preparations | 2003 | Journal of medicinal chemistry, Jan-02, Volume: 46, Issue:1
| New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor. |
| AID232373 | Ratio of D2-D3 like receptor to D4 like receptor | 2001 | Bioorganic & medicinal chemistry letters, Jan-22, Volume: 11, Issue:2
| Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand. |
| AID1526881 | Selectivity index, ratio of Ki for displacement of [3H] Spiperone from human D3 receptor expressed in CHO cells to Ki for displacement of [3H] Spiperone from human D4.4 receptor expressed in CHO cells | | | |
| AID62486 | Affinity for Dopamine receptor D2 using [3H]YM-09151-2 was carried out on bovine retinal membrane preparations (high-affinity) | 2003 | Journal of medicinal chemistry, Jan-02, Volume: 46, Issue:1
| New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor. |
| AID1526880 | Selectivity index, ratio of Ki for displacement of [3H] Spiperone from human D2S receptor expressed in CHO cells to Ki for displacement of [3H] Spiperone from human D4.4 receptor expressed in CHO cells | | | |
| AID64981 | Binding affinity for human Dopamine receptor D3 expressed in CHO K1 transfected cells using [3H]spiperone as radioligand | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists. |
| AID269022 | Selectivity for human D4 receptor over alpha-1 receptor | 2006 | Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17
| 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction. |
| AID243285 | Binding affinity towards human dopamine receptor D4 expressed in CHO cells was determined by using [3H]thymidine as radioligand | 2005 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 15, Issue:8
| The role of QSAR in dopamine interactions. |
| AID243277 | Binding affinity of compound towards human dopamine receptor D4 was determined | 2005 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 15, Issue:8
| The role of QSAR in dopamine interactions. |
| AID1526876 | Displacement of [3H] Spiperone from human D2S receptor expressed in CHO cells by competitive radioligand binding assay | | | |
| AID63520 | Binding affinity for human Dopamine receptor D4 expressed in CHO K1 transfected cells using [3H]spiperone as radioligand | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists. |
| AID268996 | Activity against penile erection in Wistar rat at 0.3 umol/kg, sc | 2006 | Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17
| 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction. |
| AID63198 | Affinity for Dopamine receptor D1 using [3H]SCH-23390 was carried out on bovine retinal membrane preparations | 2003 | Journal of medicinal chemistry, Jan-02, Volume: 46, Issue:1
| New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor. |
| AID243284 | Binding affinity towards human dopamine receptor D2 was determined by using [3H]spiperone as radioligand | 2005 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 15, Issue:8
| The role of QSAR in dopamine interactions. |
| AID4469 | Binding affinity at 5-hydroxytryptamine 1A receptor | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists. |
| AID269009 | Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assay | 2006 | Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17
| 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction. |
| AID36324 | Binding affinity at alpha-1 adrenergic receptor | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists. |
| AID5369 | Binding affinity at 5-hydroxytryptamine 2A receptor | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists. |
| AID268991 | Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assay | 2006 | Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17
| 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction. |
| AID274440 | Agonist activity at human D4.4 receptor in HEK293 cells co-expressing Galphaqo5 by FLIPR with relative to dopamine | 2006 | Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25
| Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. |
| AID269023 | Selectivity for human D4 receptor over alpha-2 receptor | 2006 | Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17
| 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction. |
| AID62487 | Affinity for Dopamine receptor D2 using [3H]YM-09151-2 was carried out on bovine retinal membrane preparations (low-affinity) | 2003 | Journal of medicinal chemistry, Jan-02, Volume: 46, Issue:1
| New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor. |
| AID266797 | Selectivity for human dopamine D4.4 receptor over adrenergic alpha-1 receptor | 2006 | Journal of medicinal chemistry, Jun-29, Volume: 49, Issue:13
| 2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist. |
| AID61856 | Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina; Not determined | 2001 | Bioorganic & medicinal chemistry letters, Jan-22, Volume: 11, Issue:2
| Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand. |
| AID1526879 | Selectivity index, ratio of Ki for displacement of [3H] Spiperone from human D2L receptor expressed in CHO cells to Ki for displacement of [3H] Spiperone from human D4.4 receptor expressed in CHO cells | | | |
| AID243283 | Binding affinity towards dopamine receptor D2 was determined by using [3H]spiperone as radioligand | 2005 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 15, Issue:8
| The role of QSAR in dopamine interactions. |
| AID268995 | Selectivity for human D4 receptor over D2 receptor | 2006 | Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17
| 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction. |
| AID63853 | Binding affinity for dopamine D4-like receptor labelled with [3H]YM-09151-2 in retina | 2001 | Bioorganic & medicinal chemistry letters, Jan-22, Volume: 11, Issue:2
| Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand. |
| AID35784 | Binding affinity at Alpha-2 adrenergic receptor | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists. |
| AID63687 | Agonist action was estimated by measuring the cellular uptake of [3H]thymidine by comparing with the full Dopamine receptor D4 agonist quinpirole (100%) | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists. |
| AID62925 | Binding affinity for human Dopamine receptor D2 expressed in CHO K1 transfected cells using [3H]spiperone as radioligand | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists. |
| AID274437 | Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR | 2006 | Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25
| Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. |
| AID269021 | Selectivity for human D4 receptor over D3 receptor | 2006 | Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17
| 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction. |
| AID269011 | Antagonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assay | 2006 | Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17
| 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction. |
| AID63530 | Binding affinity towards cloned human Dopamine receptor D4 | 2001 | Bioorganic & medicinal chemistry letters, Jan-22, Volume: 11, Issue:2
| Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand. |
| AID269025 | Selectivity for human D4 receptor over 5HT2A receptor | 2006 | Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17
| 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction. |
| AID1526878 | Displacement of [3H] Spiperone from human D4.4 receptor expressed in CHO cells by competitive radioligand binding assay | | | |
| AID64302 | Binding affinity for dopamine D2-D3 like receptor labelled with [3H]YM-09151-2 in striatum | 2001 | Bioorganic & medicinal chemistry letters, Jan-22, Volume: 11, Issue:2
| Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand. |
| AID65922 | Agonist activation of human dopamine receptor stimulating mitogenesis in Dopamine receptor D4-transfected CHO pro-5 cells using [3H]thymidine as radioligand | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists. |
| AID269020 | Selectivity for human D4 receptor over D1 receptor | 2006 | Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17
| 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction. |
| AID268992 | Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assay relative to dopamine | 2006 | Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17
| 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1347024 | Rat D4 receptor (Dopamine receptors) | 2004 | Molecular pharmacology, Dec, Volume: 66, Issue:6
| Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |