enkephalin, leucine and Alcohol Abuse

enkephalin, leucine has been researched along with Alcohol Abuse in 40 studies

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (30.00)	18.7374
1990's	8 (20.00)	18.2507
2000's	6 (15.00)	29.6817
2010's	14 (35.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cifani, C; D'Addario, C; Gunnar, A; Padyukov, L; Pucci, M; Shchetynsky, K; Terenius, L; Vukojević, V	1
Bakalkin, G; Bazov, I; Karpyak, VM; Kononenko, O; Sarkisyan, D; Watanabe, H; Yakovleva, T	1
Bordukalo-Niksic, T; Cicin-Sain, L; Cupic, B; Gabrilovac, J; Matosic, A; Stefulj, J; Zapletal, E	1
Bakalkin, G; Biernacka, JM; Geske, JR; Karpyak, VM; Koller, G; Preuss, UW; Soyka, M; Winham, SJ; Zill, P	1
Faisal, M; Ismatullah, H; Taqi, MM; Waseem, D	1
Bakalkin, G; Biernacka, JM; Geske, JR; Heit, JA; Karpyak, VM; Preuss, UW; Winham, SJ; Zill, P	1
Bilkei-Gorzó, A; Cichon, S; Franke, PE; Fürst, R; Gunnar, A; Karpushova, A; Maier, W; Montag, C; Nöthen, M; Osby, U; Racz, I; Reuter, M; Schürmann, B; Schütz, C; Strohmaier, J; Terenius, L; Wienker, TF; Zimmer, A	1
Ho, A; Kreek, MJ; Nielsen, DA; Rouault, M; Yuferov, V	1
Boerngen-Lacerda, R; Camarini, R; Méndez, M; Pautassi, RM; Quadros, IM; Souza-Formigoni, ML	1
Bakalkin, G; Bazov, I; Nyberg, F; Taqi, MM; Watanabe, H; Yakovleva, T	1
Alkass, K; Bakalkin, G; Bazov, I; Druid, H; Harper, C; Nyberg, F; Sheedy, D; Taqi, MM; Watanabe, H; Wentzel, P; Yakovleva, T	1
Ferrell, RE; Flory, JD; Hurd, Y; Manuck, SB; Pytte, CL	1
Bakalkin, G; Bazov, I; Hussain, MZ; Kononenko, O; Kuntić, V; Nyberg, F; Sarkisyan, D; Taqi, MM; Watanabe, H; Yakovleva, T	1
Barson, JR; Chang, GQ; Karatayev, O; Leibowitz, SF; Liang, SC	1
Abulseoud, OA; Bakalkin, G; Bazov, I; Biernacka, JM; Colby, CL; Cunningham, JM; Frye, MA; Geske, JR; Hall-Flavin, DK; Heit, JA; Karpyak, VM; Lewis, KA; Loukianova, LL; Mrazek, DA; Preuss, UW; Schneekloth, TD; Walker, DL; Winham, SJ; Zill, P	1
Agrawal, A; Begleiter, H; Bierut, L; Bucholz, K; Dick, D; Edenberg, HJ; Flury-Wetherill, L; Foroud, T; Goate, A; Kuperman, S; Nurnberger, J; Porjesz, B; Schuckit, M; Tian, HJ; Tischfield, J; Xuei, X	1
Bart, G; Gordon, D; Kellogg, S; Kreek, MJ; LaForge, KS; Ott, J; Williams, TJ	1
Méndez, M; Morales-Mulia, M; Pérez-Luna, JM	1
Coghlan, JP; Tregear, GW	1
Herz, A	1
Blum, K	1
Burov, IuV; Iukhananov, RIu; Maĭskiĭ, AI	1
Duka, T; Herz, A; Schulz, R; Wüster, M	1
Chan, RJ; Crabb, DW; McBride, AW; Thomasson, HR; Ykenney, A	1
Gulya, K; Hoffman, PL; Orpana, AK; Sikela, JM	1
Geijer, T; Gyllander, A; Jönsson, E; Neiman, J; Rydberg, U; Sedvall, G; Terenius, L	1
Fredholm, BB; Johansson, B; Lindström, K; Wahlström, G	1
Druse, MJ; Tajuddin, NF	1
Colombo, G; Fadda, P; Fratta, W; Tronci, S	1
Gianoulakis, C; Kiianmaa, K; Marinelli, PW	1
Rigter, H	1
Gramsch, C; Herz, A; Höllt, V; Mehraein, P; Pasi, A	1
Lasoń, W; Przewłocka, B; Przewłocki, R	1
Kelesheva, LF; Kotov, AV; Sudakov, KV	1
Balakleevskiĭ, AI; Maslova, IV; Petrenko, SV; Surikov, PM	1
Summers, MC	1
Kato, Y	1
Bemis, KG; Hymson, DL; Hynes, MD; Lochner, MA	1
de Waele, JP; Gianoulakis, C; Kiianmaa, K	1
Adigamov, MM; Beliaeva, VV; Belkin, AI; Moskovichiute, LI	1

Reviews

4 review(s) available for enkephalin, leucine and Alcohol Abuse

Article	Year
Behavioral and neurochemical studies in distinct animal models of ethanol's motivational effects. Current drug abuse reviews, 2010, Volume: 3, Issue:4 Topics: Alcoholism; Animals; Brain; Disease Models, Animal; Enkephalins; Ethanol; Humans; Motivation; Reinforcement, Psychology; Self Administration; Synaptic Transmission	2010
[Alcohol addiction: the role of oligopeptides in its central mechanisms]. Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1989, Issue:3 Topics: Alcoholism; Angiotensin II; Animals; beta-Endorphin; Bradykinin; Brain; Enkephalins; Motivation; Oligopeptides	1989
Structural & biological studies of the acetaldehyde adducts of enkephalins and related peptides: a short review. Progress in clinical and biological research, 1985, Volume: 183 Topics: Acetaldehyde; Alcoholism; Animals; Binding Sites; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Magnetic Resonance Spectroscopy; Oligopeptides; Structure-Activity Relationship	1985
[Methionine-enkephalin (Met-Enk) and leucine-enkephalin (Leu-Enk)]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 8 Topics: Adrenal Gland Neoplasms; Alcoholism; Cerebral Infarction; Craniocerebral Trauma; Diagnostic Techniques, Endocrine; Enkephalin, Leucine; Enkephalin, Methionine; Heroin Dependence; Humans; Kidney Failure, Chronic; Pheochromocytoma; Radioimmunoassay; Reference Values; Specimen Handling	2005

Other Studies

36 other study(ies) available for enkephalin, leucine and Alcohol Abuse

Article	Year
Genetic variation and epigenetic modification of the prodynorphin gene in peripheral blood cells in alcoholism. Progress in neuro-psychopharmacology & biological psychiatry, 2017, 06-02, Volume: 76 Topics: Adult; Age Factors; Alcoholism; CpG Islands; DNA Methylation; Enkephalins; Epigenesis, Genetic; Female; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Protein Precursors; Sex Factors	2017
Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics. Translational psychiatry, 2018, 06-20, Volume: 8, Issue:1 Topics: Alcoholics; Alcoholism; Alleles; Australia; Case-Control Studies; Cognitive Dysfunction; Down-Regulation; Enkephalins; Gene Expression; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Prefrontal Cortex; Protein Precursors; Receptors, Opioid, kappa	2018
Opioid system genes in alcoholism: a case-control study in Croatian population. Neuropeptides, 2013, Volume: 47, Issue:5 Topics: Adolescent; Adult; Aged; Alcoholism; Case-Control Studies; Croatia; Enkephalins; Genetic Association Studies; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Pro-Opiomelanocortin; Protein Precursors; Receptors, Opioid, kappa; Receptors, Opioid, mu; Young Adult	2013
PDYN rs2281285 variant association with drinking to avoid emotional or somatic discomfort. PloS one, 2013, Volume: 8, Issue:11 Topics: Adult; Affect; Alcohol Drinking; Alcoholism; Alleles; Emotions; Enkephalins; Female; Gene Frequency; Genotype; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Polymorphism, Single Nucleotide; Protein Precursors; Risk Factors; Surveys and Questionnaires	2013
A molecular prospective provides new insights into implication of PDYN and OPRK1 genes in alcohol dependence. Computers in biology and medicine, 2014, Volume: 53 Topics: Alcoholism; Binding Sites; Computational Biology; Databases, Genetic; Enkephalins; Humans; Polymorphism, Single Nucleotide; Protein Precursors; Receptors, Opioid, kappa; Transcription Factors; Untranslated Regions	2014
Associations of prodynorphin sequence variation with alcohol dependence and related traits are phenotype-specific and sex-dependent. Scientific reports, 2015, Oct-27, Volume: 5 Topics: Adult; Alcoholism; Enkephalins; Female; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; Humans; Male; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Protein Precursors; Sex Factors; White People	2015
The opioid peptides enkephalin and beta-endorphin in alcohol dependence. Biological psychiatry, 2008, Dec-01, Volume: 64, Issue:11 Topics: Adult; Alcohol Drinking; Alcoholism; Animals; beta-Endorphin; Body Weight; Choice Behavior; Disease Models, Animal; Enkephalins; Female; Food Preferences; Gene Frequency; Genotype; Humans; Linkage Disequilibrium; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Polymorphism, Single Nucleotide; Pro-Opiomelanocortin; Sex Characteristics; Stress, Psychological	2008
Cell-specific effects of variants of the 68-base pair tandem repeat on prodynorphin gene promoter activity. Addiction biology, 2011, Volume: 16, Issue:2 Topics: Alcoholism; Alleles; Base Pairing; Cell Line; Cloning, Molecular; Cocaine-Related Disorders; Enkephalins; Genetic Variation; Genotype; HEK293 Cells; Humans; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Protein Precursors; Tandem Repeat Sequences; Transcription, Genetic; Transfection	2011
Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain. Brain research, 2011, Apr-18, Volume: 1385 Topics: Adult; Aged; Aged, 80 and over; Alcoholism; Binding Sites; Enkephalins; Gene Expression Regulation; Genotype; HeLa Cells; Hippocampus; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Prefrontal Cortex; Promoter Regions, Genetic; Protein Precursors; Transcription Factor AP-1	2011
Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics. Addiction biology, 2011, Volume: 16, Issue:3 Topics: 3' Untranslated Regions; Adult; Aged; Alcoholism; Alleles; CpG Islands; DNA Methylation; Enkephalins; Epigenomics; Genetic Predisposition to Disease; Genotype; Humans; Male; Polymorphism, Single Nucleotide; Prefrontal Cortex; Protein Precursors	2011
Alcohol dependence, disinhibited behavior and variation in the prodynorphin gene. Biological psychology, 2011, Volume: 88, Issue:1 Topics: Adult; Alcoholism; Diagnostic and Statistical Manual of Mental Disorders; Enkephalins; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Impulsive Behavior; Inhibition, Psychological; Male; Middle Aged; Personality; Polymorphism, Genetic; Protein Precursors; Sex Factors	2011
The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction. Addiction biology, 2013, Volume: 18, Issue:1 Topics: Adaptation, Physiological; Adult; Alcoholism; Analysis of Variance; Animals; Behavior, Addictive; Case-Control Studies; Dynorphins; Enkephalins; Hippocampus; Humans; Male; Opioid Peptides; Prefrontal Cortex; Protein Precursors; Radioimmunoassay; Receptors, Opioid; Reverse Transcriptase Polymerase Chain Reaction; Reward; RNA, Messenger; Statistics, Nonparametric; Up-Regulation	2013
Prenatal ethanol exposure stimulates neurogenesis in hypothalamic and limbic peptide systems: possible mechanism for offspring ethanol overconsumption. Neuroscience, 2012, Oct-11, Volume: 222 Topics: Alcoholism; Animals; Antimetabolites; Brain; Bromodeoxyuridine; Central Nervous System Depressants; Digoxigenin; Enkephalins; Ethanol; Female; Fluorescent Antibody Technique; Galanin; Hypothalamus; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Limbic System; Neuropeptides; Orexins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger	2012
Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional states. The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:5 Topics: Alcoholism; Enkephalins; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Linkage Disequilibrium; Male; Mood Disorders; Polymorphism, Single Nucleotide; Protein Precursors; Receptors, Opioid, kappa	2013
Association of the kappa-opioid system with alcohol dependence. Molecular psychiatry, 2006, Volume: 11, Issue:11 Topics: Alcoholism; Enkephalins; Genetic Predisposition to Disease; Haplotypes; Humans; Linkage Disequilibrium; Pedigree; Polymorphism, Single Nucleotide; Protein Precursors; Receptors, Opioid, kappa; Risk Factors; White People	2006
Prodynorphin gene promoter repeat associated with cocaine/alcohol codependence. Addiction biology, 2007, Volume: 12, Issue:3-4 Topics: Alcoholism; Alleles; Base Pairing; Black People; Cocaine-Related Disorders; Comorbidity; DNA; Enkephalins; Female; Gene Frequency; Genotype; Hispanic or Latino; Humans; Male; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Precursors; Tandem Repeat Sequences; White People	2007
Ethanol-induced changes in proenkephalin mRNA expression in the rat nigrostriatal pathway. Journal of molecular neuroscience : MN, 2008, Volume: 34, Issue:3 Topics: Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Central Nervous System Depressants; Corpus Striatum; Dopamine; Enkephalins; Ethanol; Gene Expression Regulation; Male; Neural Pathways; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Substance-Related Disorders; Substantia Nigra; Time Factors; Up-Regulation	2008
Alcohol addiction: are the endogenous opioids involved? Australian and New Zealand journal of medicine, 1981, Volume: 11, Issue:2 Topics: Acetaldehyde; Alcoholism; Animals; Endorphins; Enkephalins; Humans; Isoquinolines; Mice; Naloxone; Rats; Receptors, Opioid; Tetrahydroisoquinolines	1981
Role of endorphins in addiction. Modern problems of pharmacopsychiatry, 1981, Volume: 17 Topics: Alcoholism; Animals; beta-Endorphin; Brain; Corpus Striatum; Endorphins; Enkephalins; Heroin Dependence; Humans; Morphine Dependence; Opioid-Related Disorders; Pituitary Gland; Rats; Receptors, Opioid	1981
Alcohol and central nervous system peptides. Substance and alcohol actions/misuse, 1983, Volume: 4, Issue:2-3 Topics: Alcohol Drinking; Alcoholism; Animals; beta-Endorphin; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Mice; Mice, Inbred C57BL; Rats; Receptors, Opioid; Social Environment	1983
[Effect of ethanol on the concentration of enkephalins in the brain of rats with different levels of alcoholic motivation]. Biulleten' eksperimental'noi biologii i meditsiny, 1983, Volume: 96, Issue:7 Topics: Alcohol Drinking; Alcoholism; Animals; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ethanol; Humans; Injections, Intraperitoneal; Male; Motivation; Rats; Time Factors	1983
Acute and chronic ethanol treatment changes endorphin levels in brain and pituitary. Psychopharmacology, 1980, Volume: 68, Issue:3 Topics: Alcoholism; Animals; Body Weight; Brain Chemistry; Endorphins; Enkephalins; Ethanol; Guinea Pigs; Humans; Hypothalamus; Male; Pituitary Gland; Rats; Time Factors	1980
Allele frequencies of the preproenkephalin A (PENK) gene CA repeat in Asians, African-Americans, and Caucasians: lack of evidence for different allele frequencies in alcoholics. Alcoholism, clinical and experimental research, 1994, Volume: 18, Issue:3 Topics: Alcoholism; Alleles; Asian People; Black People; China; Chromosome Mapping; Cohort Studies; Cross-Cultural Comparison; Enkephalins; Gene Frequency; Genetics, Population; Humans; Liver; Liver Diseases, Alcoholic; Polymorphism, Restriction Fragment Length; Protein Precursors; Repetitive Sequences, Nucleic Acid; United States; White People	1994
Prodynorphin and vasopressin mRNA levels are differentially affected by chronic ethanol ingestion in the mouse. Brain research. Molecular brain research, 1993, Volume: 20, Issue:1-2 Topics: Alcoholism; Amino Acid Sequence; Animals; Base Sequence; Brain; Enkephalins; Ethanol; Gene Expression Regulation; Hypothalamus; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Polymerase Chain Reaction; Protein Precursors; RNA, Messenger; Vasopressins	1993
Prodynorphin allelic distribution in Scandinavian chronic alcoholics. Alcoholism, clinical and experimental research, 1997, Volume: 21, Issue:7 Topics: Adult; Aged; Alcoholism; Alleles; Base Composition; Enkephalins; Exons; Female; Genetic Markers; Humans; Male; Middle Aged; Polymorphism, Genetic; Promoter Regions, Genetic; Protein Precursors	1997
Age-dependent changes in adenosine receptors are not modified by life-long intermittent alcohol administration. Brain research, 1998, Apr-27, Volume: 791, Issue:1-2 Topics: Aging; Alcoholism; Animals; Autoradiography; Brain; Disease Models, Animal; Enkephalins; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Purinergic P1; RNA, Messenger	1998
Effects of chronic ethanol consumption and aging on proenkephalin and neurotensin. Alcoholism, clinical and experimental research, 1998, Volume: 22, Issue:5 Topics: Age Factors; Alcoholism; Animals; Brain; Brain Mapping; Enkephalins; Ethanol; Gene Expression; Male; Neurotensin; Protein Precursors; Rats; Rats, Inbred F344; RNA, Messenger	1998
Differences in the opioid system in selected brain regions of alcohol-preferring and alcohol-nonpreferring rats. Alcoholism, clinical and experimental research, 1999, Volume: 23, Issue:8 Topics: Alcoholism; Animals; Basal Ganglia; Brain Mapping; Breeding; Enkephalins; Genetic Markers; Male; Naloxone; Narcotic Antagonists; Opioid Peptides; Rats; Receptors, Opioid; RNA, Messenger	1999
Opioid propeptide mRNA content and receptor density in the brains of AA and ANA rats. Life sciences, 2000, Apr-07, Volume: 66, Issue:20 Topics: Alcoholism; Animals; Autoradiography; Brain; Enkephalins; In Situ Hybridization; Male; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Mutant Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; RNA, Messenger; Temperance	2000
[Neuropeptides, amnesia and alcohol dependence]. Nederlands tijdschrift voor geneeskunde, 1979, Sep-15, Volume: 123, Issue:37 Topics: Adrenocorticotropic Hormone; Alcoholism; Animals; Endorphins; Enkephalins; Humans; Memory; Mice; Rats; Substance-Related Disorders; Vasopressins	1979
Regional distribution of methionine-enkephalin- and beta-endorphin-like immunoreactivity in human brain and pituitary. Brain research, 1979, Aug-03, Volume: 171, Issue:2 Topics: Adult; Aged; Alcoholism; Brain; Brain Mapping; Chromatography, Affinity; Endorphins; Enkephalins; Female; Humans; Male; Middle Aged; Pituitary Gland; Radioimmunoassay; Substance-Related Disorders	1979
Repeated ethanol administration decreases prodynorphin biosynthesis in the rat hippocampus. Neuroscience letters, 1992, Jan-06, Volume: 134, Issue:2 Topics: Alcoholism; Animals; Autoradiography; Enkephalins; Ethanol; Hippocampus; Male; Neurons; Oligonucleotide Probes; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; Reference Values; RNA, Messenger; Sulfur Radioisotopes	1992
[Enkephalin and cyclic nucleotide content in the brain structures of rats at different stages of the formation and development of alcoholic dependence]. Biulleten' eksperimental'noi biologii i meditsiny, 1986, Volume: 101, Issue:3 Topics: Alcoholism; Animals; Basal Ganglia; Brain; Brain Chemistry; Cyclic AMP; Cyclic GMP; Enkephalins; Female; Hypothalamus; Limbic System; Male; Nucleotides, Cyclic; Rats	1986
Chronic ethanol alters the receptor binding characteristics of the delta opioid receptor ligand, D-Ala2-D-Leu5 enkephalin in mouse brain. Life sciences, 1983, Dec-05, Volume: 33, Issue:23 Topics: Alcoholism; Animals; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethanol; Humans; Male; Mice; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu	1983
Distribution of the mu and delta opioid binding sites in the brain of the alcohol-preferring AA and alcohol-avoiding ANA lines of rats. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:1 Topics: Alcoholism; Analgesics; Animals; Autoradiography; Binding Sites; Brain; Cerebellum; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Leucine; Kinetics; Male; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu	1995
[Effect of a synthetic analog of leu enkephalin on the status of higher mental functions in alcoholism]. Sovetskaia meditsina, 1987, Issue:10 Topics: Adult; Alcoholism; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Higher Nervous Activity; Humans; Memory; Middle Aged; Neuropsychological Tests; Verbal Learning	1987