trazodone has been researched along with Alcohol Abuse in 12 studies
Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The result of the search of drugs that help people to alcoholism treatment program, were studies involving trazodone." | 4.87 | [Trazodone in the treatment of addiction]. ( Bobińska, K; Florkowski, A; Gałecki, P; Kryszkowski, W; Orzechowska, A; Talarowska, M, 2011) |
| "Trazodone is a commonly prescribed off-label for sleep disturbance in alcohol-dependent patients, but its safety and efficacy for this indication is unknown." | 2.73 | Trazodone for sleep disturbance after alcohol detoxification: a double-blind, placebo-controlled trial. ( Friedmann, PD; Millman, RP; Rose, JS; Stein, MD; Stout, RL; Swift, R, 2008) |
| "Insomnia in patients with alcohol dependence has increasingly become a target of treatment due to its prevalence, persistence, and associations with relapse and suicidal thoughts, as well as randomized controlled studies demonstrating efficacy with behavior therapies and non-addictive medications." | 2.52 | Assessment and treatment of insomnia in adult patients with alcohol use disorders. ( Brower, KJ, 2015) |
| "The threshold for seizures is lowered by tramadol." | 2.41 | Lethal combination of tramadol and multiple drugs affecting serotonin. ( Levine, BS; Pestaner, JP; Ripple, MG; Smialek, JE, 2000) |
| "Trazodone is an approved antidepressant drug for adults and has shown efficacy on symptoms like anxiety and insomnia observed in AUD patients as well." | 1.91 | Update on Pharmacological Treatment for Comorbid Major Depressive and Alcohol Use Disorders: The Role of Extended-release Trazodone. ( Di Nicola, M; Janiri, L; Moccia, L; Panaccione, I; Pepe, M; Sani, G, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Di Nicola, M | 1 |
| Pepe, M | 1 |
| Panaccione, I | 1 |
| Moccia, L | 1 |
| Janiri, L | 1 |
| Sani, G | 1 |
| Funk, S | 1 |
| Brower, KJ | 2 |
| Friedmann, PD | 1 |
| Rose, JS | 1 |
| Swift, R | 1 |
| Stout, RL | 1 |
| Millman, RP | 1 |
| Stein, MD | 1 |
| Kryszkowski, W | 1 |
| Bobińska, K | 1 |
| Talarowska, M | 1 |
| Orzechowska, A | 1 |
| Florkowski, A | 1 |
| Gałecki, P | 1 |
| Le Bon, O | 1 |
| Murphy, JR | 1 |
| Staner, L | 1 |
| Hoffmann, G | 1 |
| Kormoss, N | 1 |
| Kentos, M | 1 |
| Dupont, P | 1 |
| Lion, K | 1 |
| Pelc, I | 1 |
| Verbanck, P | 1 |
| Karam-Hage, M | 1 |
| Borras, L | 1 |
| de Timary, P | 1 |
| Constant, EL | 1 |
| Huguelet, P | 1 |
| Eytan, A | 1 |
| Graux, P | 1 |
| Durocher, AM | 1 |
| Ripple, MG | 1 |
| Pestaner, JP | 1 |
| Levine, BS | 1 |
| Smialek, JE | 1 |
| Liebowitz, NR | 1 |
| el-Mallakh, RS | 1 |
| Lennhoff, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Trazodone for Sleep Disturbance - Early Alcohol Recovery[NCT00027053] | Phase 2 | 173 participants (Actual) | Interventional | 2002-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for trazodone and Alcohol Abuse
| Article | Year |
|---|---|
[Pharmacological treatment in alcohol-, drug- and benzodiazepine-dependent patients - the significance of trazodone].
Topics: Alcoholism; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Benzodiazepines; Cardiova | 2013 |
Assessment and treatment of insomnia in adult patients with alcohol use disorders.
Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Amines; Anti-Anxiety Agents; Anticonvulsants; Antipsych | 2015 |
[Trazodone in the treatment of addiction].
Topics: Alcoholism; Behavior, Addictive; Humans; Selective Serotonin Reuptake Inhibitors; Substance-Related | 2011 |
Lethal combination of tramadol and multiple drugs affecting serotonin.
Topics: Adult; Alcoholism; Analgesics, Opioid; Cyclohexanols; Dibenzothiazepines; Drug Interactions; Fatal O | 2000 |
3 trials available for trazodone and Alcohol Abuse
| Article | Year |
|---|---|
Trazodone for sleep disturbance after alcohol detoxification: a double-blind, placebo-controlled trial.
Topics: Adult; Alcoholism; Anti-Anxiety Agents; Central Nervous System Depressants; Dose-Response Relationsh | 2008 |
Double-blind, placebo-controlled study of the efficacy of trazodone in alcohol post-withdrawal syndrome: polysomnographic and clinical evaluations.
Topics: Adolescent; Adult; Aged; Alcoholism; Antidepressive Agents, Second-Generation; Central Nervous Syste | 2003 |
Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients.
Topics: Acetates; Alcoholism; Amines; Antidepressive Agents, Second-Generation; Cyclohexanecarboxylic Acids; | 2003 |
5 other studies available for trazodone and Alcohol Abuse
| Article | Year |
|---|---|
Update on Pharmacological Treatment for Comorbid Major Depressive and Alcohol Use Disorders: The Role of Extended-release Trazodone.
Topics: Adult; Alcoholism; Antidepressive Agents; Comorbidity; Depressive Disorder, Major; Humans; Quality o | 2023 |
Successful treatment of alcohol withdrawal with trazodone.
Topics: Adult; Alcoholism; Antidepressive Agents, Second-Generation; Central Nervous System Depressants; Eth | 2006 |
[Trazodone in the treatment of the "slipping away" syndrome. Comparison between alcoholic and non-alcoholic subjects].
Topics: Aged; Alcoholism; Anorexia; Feeding and Eating Disorders; Humans; Piperazines; Syndrome; Trazodone; | 1980 |
Trazodone for the treatment of anxiety symptoms in substance abusers.
Topics: Adult; Alcoholism; Anxiety Disorders; Combat Disorders; Humans; Male; Middle Aged; Sleep Initiation | 1989 |
Trazodone-induced mania.
Topics: Alcoholism; Bipolar Disorder; Depressive Disorder; Doxepin; Humans; Male; Middle Aged; Trazodone | 1987 |