Page last updated: 2024-12-04

pyridoxamine phosphate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

Pyridoxamine phosphate (PMP) is a derivative of vitamin B6. It is a key cofactor in many enzymatic reactions, particularly those involved in amino acid metabolism. PMP is synthesized from pyridoxine (vitamin B6) through a series of enzymatic steps. In research, PMP is studied for its potential therapeutic benefits. It has been shown to have antioxidant, anti-inflammatory, and neuroprotective effects. PMP is also being investigated for its potential to prevent or treat diabetes, heart disease, and cancer. Due to its involvement in crucial metabolic pathways, PMP's role in various physiological processes makes it a subject of ongoing research.'

pyridoxamine phosphate: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

pyridoxamine 5'-phosphate : A vitamin B6 phosphate that is the phosphoric ester derivative of pyridoxamine. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID1053
CHEMBL ID1235353
CHEBI ID18335
SCHEMBL ID43832
MeSH IDM0056234

Synonyms (55)

Synonym
CHEMBL1235353
CHEBI:18335 ,
pyridoxamine 5'-(dihydrogen phosphate)
pyridoxamine 5'-phosphoric acid
pyridoxamine 5-phosphoric acid
[4-(aminomethyl)-5-hydroxy-6-methylpyridin-3-yl]methyl dihydrogen phosphate
4-(aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol alpha-(dihydrogen phosphate)
pyridoxamine phosphate [jan]
brn 0233653
4-aminomethyl-3-hydroxy-2-methyl-5-((phosphonooxy)methyl)pyridine dihydrate
einecs 208-471-6
3-pyridinemethanol, 4-(aminomethyl)-5-hydroxy-6-methyl-, alpha-(dihydrogen phosphate)
pyridoxamine, dihydrogen phosphate
pyridoxamine, 3-(dihydrogen phosphate)
pyridoxamine-p
NCGC00181045-01
4'-deoxy-4'-aminopyridoxal-5'-phosphate
pyridoxamine-5'-phosphate
[4-(aminomethyl)-5-hydroxy-6-methyl-3-pyridyl]methyl dihydrogen phosphate
C00647
pyridoxamine 5-phosphate
529-96-4
pyridoxamine phosphate
pyridoxamine 5'-phosphate
1ZC9
DB02142
pyridoxamine-5'-phosphate, >=98.0% (hplc)
PZP ,
BMSE000131
NCGC00181045-02
cas-529-96-4
dtxsid3046825 ,
tox21_112693
dtxcid1026825
4-22-00-06065 (beilstein handbook reference)
q05r77uo7p ,
unii-q05r77uo7p
FT-0632315
pyridoxamine phosphate [who-dd]
pyridoxamine 5'-phosphate [mi]
pyridoxamine phosphate anhydrous
4-aminomethyl-3-hydroxy-2-methyl-5-((phosphonooxy)methyl)pyridine
SCHEMBL43832
tert-butyl4-formylphenylcarbonate
3-pyridinemethanol, 4-(aminomethyl)-5-hydroxy-6-methyl-, 3-(dihydrogen phosphate)
{[4-(aminomethyl)-5-hydroxy-6-methylpyridin-3-yl]methoxy}phosphonic acid
ammonium ferric chloride
16774-56-4
pyridoxamine-5-phosphate
(4-(aminomethyl)-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate
Q27093205
pyridoxamine, dihydrogen phosphate (7ci)
pyridoxamine 5 inverted exclamation marka-phosphate
HY-B1746
CS-0013766

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" These findings suggest that UVA-induced vitamin B6 cytotoxicity is caused by toxic photoproducts resulting from irradiated vitamin B6."( Vitamin B6 phototoxicity induced by UVA radiation.
Kosaka, H; Maeda, T; Minami, H; Sato, K; Shiga, T; Taguchi, H; Yoshikawa, K, 2000
)
0.31

Pharmacokinetics

ExcerptReferenceRelevance
" Plasma clearance and volume of distribution of PLP decreased significantly after supplementation, but half-life t 1/2 did not change."( Relationship between body store of vitamin B6 and plasma pyridoxal-P clearance: metabolic balance studies in humans.
Aronoff, GR; Li, TK; Lui, A; Lumeng, L, 1985
)
0.27

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (4)

RoleDescription
human metaboliteAny mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
Saccharomyces cerevisiae metaboliteAny fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae).
Escherichia coli metaboliteAny bacterial metabolite produced during a metabolic reaction in Escherichia coli.
mouse metaboliteAny mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

ClassDescription
vitamin B6 phosphate
aminoalkylpyridine
monohydroxypyridineA hydroxypyridine carrying a single hydroxy substituent.
methylpyridinesAny member of the class of pyridines that carries at least one methyl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (12)

PathwayProteinsCompounds
Metabolism14961108
Metabolism of vitamins and cofactors146155
Metabolism of water-soluble vitamins and cofactors102114
Vitamin B6 activation to pyridoxal phosphate318
Vitamin B6 Metabolism515
Hypophosphatasia515
Vitamin B6228
Vitamin B6 metabolism ( Vitamin B6 metabolism )417
Superpathway of pyridoxal 5'-phosphate biosynthesis and salvage014
Selenium micronutrient network095
Vitamin B6-dependent and responsive disorders219
Pyridoxal 5'-phosphate salvage pathway112

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency28.69540.007215.758889.3584AID624030
GLS proteinHomo sapiens (human)Potency39.81070.35487.935539.8107AID624170
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency39.81070.009610.525035.4813AID1479145
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, 2,2-dialkylglycine decarboxylaseBurkholderia cepaciaKd600.0000600.0000600.0000600.0000AID977611
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
virion membraneSpike glycoproteinSevere acute respiratory syndrome-related coronavirus
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB2005Biochemistry, Dec-20, Volume: 44, Issue:50
Role of Q52 in catalysis of decarboxylation and transamination in dialkylglycine decarboxylase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (152)

TimeframeStudies, This Drug (%)All Drugs %
pre-199059 (38.82)18.7374
1990's42 (27.63)18.2507
2000's23 (15.13)29.6817
2010's21 (13.82)24.3611
2020's7 (4.61)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (0.62%)5.53%
Reviews2 (1.24%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other158 (98.14%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]