dexamethasone-21-sulfobenzoate profile

Dexamethasone-21-sulfobenzoate is a synthetic corticosteroid that is a prodrug of dexamethasone. It is a water-soluble derivative of dexamethasone that is designed to improve its pharmacokinetic properties. It has been studied for its potential therapeutic uses in various conditions, including inflammatory disorders and cancer. The sulfobenzoate ester is hydrolyzed in vivo to release free dexamethasone. Research indicates that it has similar anti-inflammatory effects to dexamethasone. However, it has a longer duration of action and a more favorable pharmacokinetic profile, which makes it potentially useful for chronic inflammatory conditions.'

dexamethasone-21-sulfobenzoate: structure given in first source; RN given for (11beta,16-alpha)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	63046
CHEMBL ID	3305965
SCHEMBL ID	9562205
MeSH ID	M0213282

Synonym
dexamethasone-21-sulfobenzoate
c67221cb9q ,
unii-c67221cb9q
16978-57-7
dexamethasone 21-(sodium 3-sulphobenzoate)
einecs 241-057-3
dexamethasone metasulfobenzoate
dexamethasone m-sulfobenzoate
pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-((3-sulfobenzoyl)oxy)-, (11.beta.,16.alpha.)-
DTXSID9048308
CHEMBL3305965
SCHEMBL9562205
DB14703
Q27275240
EN300-33389614
3-({2-[(1r,2r,3as,3bs,9as,9br,10s,11as)-9b-fluoro-1,10-dihydroxy-2,9a,11a-trimethyl-7-oxo-1h,2h,3h,3ah,3bh,4h,5h,7h,9ah,9bh,10h,11h,11ah-cyclopenta[a]phenanthren-1-yl]-2-oxoethoxy}carbonyl)benzene-1-sulfonic acid

Excerpt	Reference	Relevance
"Registered nurses (RNs) play a pivotal role in treating pain and preventing and recognizing the adverse effects (AEs) of analgesics in patients with dementia."	( Registered Nurses' Knowledge about Adverse Effects of Analgesics when Treating Postoperative Pain in Patients with Dementia. Hartikainen, S; Kankkunen, P; Kvist, T; Rantala, M, 2015)	0.42

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (33.33)	18.2507
2000's	2 (33.33)	29.6817
2010's	2 (33.33)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (14.29%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (85.71%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
lactic acid Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.	1.99	1	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite
acetaminophen Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.. paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.	2.11	1	acetamides; phenols	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; cyclooxygenase 3 inhibitor; environmental contaminant; ferroptosis inducer; geroprotector; hepatotoxic agent; human blood serum metabolite; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic
amitriptyline Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.. amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.	2.11	1	carbotricyclic compound; tertiary amine	adrenergic uptake inhibitor; antidepressant; environmental contaminant; tropomyosin-related kinase B receptor agonist; xenobiotic
naloxone Naloxone: A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.. naloxone : A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.	2.11	1	morphinane alkaloid; organic heteropentacyclic compound; tertiary alcohol	antidote to opioid poisoning; central nervous system depressant; mu-opioid receptor antagonist

Condition	Relationship Strength	Studies	Trials
Amentia [description not available]	2.11	1	0
Acute Post-operative Pain [description not available]	2.11	1	0
Dementia An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.	2.11	1	0
Pain, Postoperative Pain during the period after surgery.	2.11	1	0
Alcohol Abuse [description not available]	2.05	1	0
Behavior Disorders [description not available]	2.05	1	0
Acute Post-Traumatic Stress Disorder [description not available]	2.05	1	0
Combat Disorders Neurotic reactions to unusual, severe, or overwhelming military stress.	2.05	1	0
Alcoholism A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)	2.05	1	0
Mental Disorders Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.	2.05	1	0
Stress Disorders, Post-Traumatic A class of traumatic stress disorders with symptoms that last more than one month.	2.05	1	0
Lymphocytopenia [description not available]	3.39	1	1
Lymphopenia Reduction in the number of lymphocytes.	3.39	1	1

dexamethasone-21-sulfobenzoate

Description

Cross-References

Synonyms (16)

Research Excerpts

Toxicity

Research

Studies (6)

Market Indicators

Research Demand Index: 12.31

Study Types