Page last updated: 2024-12-08

carboxysalsolinol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

carboxysalsolinol: condensate of L-dopa & acetaldehyde; potentiates ethanol narcosis; RN given refers to parent cpd without isomeric designation; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID162692
CHEMBL ID1328080
SCHEMBL ID5131200
MeSH IDM0058219

Synonyms (18)

Synonym
6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
52618-26-5
nsc-157943
nsc157943 ,
nu 9611-29
carboxysalsolinol
NCI60_001153
1-methyl-3-carboxy-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
3-carboxysalsolinol
MB69132
1,2,3,4-tetrahydro-6,7-dihydroxy-1-methyl-3-isoquinolinecarboxylic acid
SCHEMBL5131200
CHEMBL1328080
cid_162692
1-methyl-6,7-bis(oxidanyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
bdbm41959
(-)-1-methyl-3-carboxy-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
DTXSID40904134

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
"A biphasic dose-response pattern is generated by the isoquinoline, 3-carboxysalsolinol, in analgesia tests conducted in mice."( Analgesic effects of 3-carboxysalsolinol alone and in combination with morphine.
Blum, K; Hirst, M; Marshall, A, 1977
)
0.8
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
mothers against decapentaplegic homolog 3 isoform 1Homo sapiens (human)IC50 (µMol)50.00000.03803.277210.2000AID1058
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19909 (90.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.74

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.74 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.74)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]