phenobarbital has been researched along with Alcohol Abuse in 82 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In severely jaundiced patients (serum bilirubin concentrations greater than 140 mumol/l) a markedly decreased or absent uptake of 99mTc-EHIDA was observed." | 3.66 | The influence of bilirubin, alcohol and certain drugs on the kinetics of 99mTc-Diethyl IDA (EHIDA) in humans. ( Coenegracht, JM; Oei, TL; van Breda Vriesman, PJ, 1983) |
| "The effect of phenobarbital (PB) pretreatment and of chronic alcoholism on blood ethanol elimination rate (BEER) was investigated in man." | 3.66 | Alcohol metabolism in man: effect of intravenous fructose infusion on blood ethanol elimination rate following stimulation by phenobarbital treatment or chronic alcohol consumption. ( Bode, C; Bode, JC; Thiele, D, 1979) |
| "Phenobarbital (PB) has been acknowledged among clinicians as a potential alternative to benzodiazepines (BZD) to decrease the need for hospital length of stay and complications associated with alcohol withdrawal syndrome (AWS)." | 3.01 | Current evidence and clinical utility of phenobarbital for alcohol withdrawal syndrome. ( Choi, H; Colgan, B; Kistler, H; Mercado, F; Nishimura, Y, 2023) |
| "Secondary outcomes such as rates of seizures, hospital, and ICU length of stay (LOS), also were included." | 3.01 | Evaluation of phenobarbital based approach in treating patient with alcohol withdrawal syndrome: A systematic review and meta-analysis. ( AlRemeithi, R; Bronstein, D; Kartiko, S; Pourmand, A; Tran, QK, 2023) |
| "Propofol is a viable alternative for patients refractory to benzodiazepines; however, the role of other agents remains unclear." | 2.53 | Treatment of Severe Alcohol Withdrawal. ( Cadiz, M; Doshi, MR; Holzhausen, JM; Natavio, A; Schmidt, KJ; Winegardner, JE, 2016) |
| "The acquired immunodeficiency syndrome (AIDS) has recently emerged as a serious medical complication of parenteral substance abuse." | 2.37 | Major medical problems and detoxification treatment of parenteral drug-abusing alcoholics. ( Novick, DM, 1984) |
| " Further research is needed to identify an optimal dosing strategy for TSCU patients at high risk for severe AWS." | 1.91 | Phenobarbital for the Management of Alcohol Withdrawal Syndrome in Critically Ill, Surgical-Trauma Patients. ( Chau, T; Chuang, L; Goldenberg-Sandau, A; Igneri, L; Pham, C; Sensenig, R; Solomon, D, 2023) |
| "There was no incidence of delirium tremens or seizures and no difference in intubation rates ( p = 0." | 1.91 | Evaluation of phenobarbital for prevention of alcohol withdrawal in trauma patients. ( Dorfman, JD; Forni, A; Kip, LM; Li, I, 2023) |
| "Treatment with phenobarbital, alone or in combination with benzodiazepines, was associated with significantly lower odds of a return ED visit within three days compared with benzodiazepines alone [AOR 0." | 1.72 | Return Encounters in Emergency Department Patients Treated with Phenobarbital Versus Benzodiazepines for Alcohol Withdrawal. ( Lebin, JA; Mudan, A; Murphy, CE; Smollin, CG; Wang, RC, 2022) |
| " The purpose of this study was to compare the incidence of mechanical ventilation in patients with benzodiazepine-resistant alcohol withdrawal between front-loaded and low-intermittent phenobarbital dosing strategies." | 1.72 | Front-Loaded Versus Low-Intermittent Phenobarbital Dosing for Benzodiazepine-Resistant Severe Alcohol Withdrawal Syndrome. ( Dodd, KW; Hanif, T; Rachid, M; Shah, P; Stegner-Smith, KL, 2022) |
| "Phenobarbital has been shown to be an effective adjunctive therapy for AWS, reducing benzodiazepine use, in the emergency department." | 1.56 | Phenobarbital and symptom-triggered lorazepam versus lorazepam alone for severe alcohol withdrawal in the intensive care unit. ( Lam, SW; Nguyen, TA, 2020) |
| "Phenobarbital treatment was associated with decreased mortality, which might be confounded by somatic comorbidity among patients receiving chlordiazepoxide." | 1.43 | Phenobarbital compared to benzodiazepines in alcohol withdrawal treatment: A register-based cohort study of subsequent benzodiazepine use, alcohol recidivism and mortality. ( Askgaard, G; Fink-Jensen, A; Hallas, J; Madsen, KG; Molander, AC; Pottegård, A, 2016) |
| "Pyrazole treatment produced an identical 3- to 4-fold increase in content and catalytic activity of P450 2E1 in the two lines." | 1.28 | The content and activity of cytochrome P450 2E1 in liver microsomes from alcohol-preferring and non-preferring rats. ( Cederbaum, AI; Winters, DK, 1992) |
| "The development of withdrawal seizures depended on repeated episodes of withdrawal, whereas repeated alcohol intoxication per se did not explain the development of seizures." | 1.28 | Convulsive behaviour during alcohol dependence: discrimination between the role of intoxication and withdrawal. ( Clemmesen, L; Hemmingsen, R; Ulrichsen, J, 1992) |
| "Baclofen was largely ineffective in reducing withdrawal-induced tremors, although it was capable of producing sedation of a different type than that produced by phenobarbitol and ethanol." | 1.26 | The effects of ethanol, phenobarbital, and baclofen on ethanol withdrawal in the rhesus monkey. ( Tarika, JS; Winger, G, 1980) |
| "The effects of acute and chronic administration of D-Galactosamine (GalN), Ethanol and Phenobarbital were investigated on the activities of lysosomal enzymes, i." | 1.26 | [Clinical and experimental histochemical studies on the activities of liver lysosomal enzymes and gamma-glutamyl transpeptidase (gamma-GTP) (author's transl)]. ( Sato, R, 1978) |
| " The results do not support the hypothesis, at least not in the case of dopamine, that a postjunctional supersensitivity to neurotransmitters is important for withdrawal symptoms after chronic administration of drugs inducing physical dependence." | 1.26 | Dopamine-sensitive adenylate cyclase in homogenates of rat striata during ethanol and barbiturate withdrawal. ( Kuschinsky, K; Seeber, U, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 49 (59.76) | 18.7374 |
| 1990's | 12 (14.63) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (8.54) | 24.3611 |
| 2020's | 14 (17.07) | 2.80 |
| Authors | Studies |
|---|---|
| Lebin, JA | 1 |
| Mudan, A | 1 |
| Murphy, CE | 1 |
| Wang, RC | 1 |
| Smollin, CG | 1 |
| Staidle, A | 1 |
| Geier, C | 1 |
| Pistore, A | 1 |
| Penney, S | 1 |
| Bryce, R | 1 |
| Meyer, C | 1 |
| Bouchard, B | 1 |
| Shah, P | 1 |
| Stegner-Smith, KL | 1 |
| Rachid, M | 1 |
| Hanif, T | 1 |
| Dodd, KW | 1 |
| Bosch, NA | 2 |
| Law, AC | 1 |
| Walkey, AJ | 2 |
| Ware, LR | 1 |
| Schuler, BR | 1 |
| Goodberlet, MZ | 1 |
| Marino, KK | 1 |
| Lupi, KE | 1 |
| DeGrado, JR | 1 |
| Pham, C | 1 |
| Goldenberg-Sandau, A | 1 |
| Sensenig, R | 1 |
| Chau, T | 1 |
| Igneri, L | 1 |
| Solomon, D | 1 |
| Chuang, L | 1 |
| Nishimura, Y | 1 |
| Choi, H | 1 |
| Colgan, B | 1 |
| Kistler, H | 1 |
| Mercado, F | 1 |
| Terasaki, D | 1 |
| Kulick, B | 1 |
| Calcaterra, S | 1 |
| Ray, L | 1 |
| Pourmand, A | 1 |
| AlRemeithi, R | 1 |
| Kartiko, S | 1 |
| Bronstein, D | 1 |
| Tran, QK | 1 |
| Kip, LM | 1 |
| Forni, A | 1 |
| Dorfman, JD | 1 |
| Li, I | 1 |
| Murphy, JA | 1 |
| Curran, BM | 1 |
| Gibbons, WA | 1 |
| Harnica, HM | 1 |
| Crable, EL | 1 |
| Ackerbauer, KA | 1 |
| Clark, K | 1 |
| Drainoni, ML | 1 |
| Grim, V | 1 |
| Ieong, MH | 1 |
| Murphy, J | 1 |
| Nelson, AC | 1 |
| Kaucher, KA | 1 |
| Sankoff, J | 1 |
| Mintzer, D | 1 |
| Taub, J | 1 |
| Kehoe, J | 1 |
| Lee, JA | 1 |
| Duby, JJ | 1 |
| Cocanour, CS | 1 |
| Fenves, AZ | 1 |
| Mojtahed, A | 1 |
| Nisavic, M | 1 |
| Massoth, LR | 1 |
| Nguyen, TA | 1 |
| Lam, SW | 1 |
| Schmidt, KJ | 1 |
| Doshi, MR | 1 |
| Holzhausen, JM | 1 |
| Natavio, A | 1 |
| Cadiz, M | 1 |
| Winegardner, JE | 1 |
| Askgaard, G | 1 |
| Hallas, J | 1 |
| Fink-Jensen, A | 1 |
| Molander, AC | 1 |
| Madsen, KG | 1 |
| Pottegård, A | 1 |
| Riggan, MA | 1 |
| Hayman, K | 1 |
| Chen, BC | 1 |
| Hoffman, RS | 1 |
| Long, D | 1 |
| Long, B | 1 |
| Koyfman, A | 1 |
| JOYCE, CR | 1 |
| EDGECOMBE, PC | 1 |
| KENNARD, DA | 1 |
| WEATHERALL, M | 1 |
| WOODS, DP | 1 |
| WARIN, EM | 1 |
| LEVY, HA | 1 |
| BODI, T | 1 |
| SIEGLER, PE | 1 |
| SLAP, J | 1 |
| NODINE, JH | 1 |
| Olesen, OV | 1 |
| Ishii, H | 2 |
| Okuno, F | 1 |
| Shigeta, Y | 1 |
| Yasuraoka, S | 1 |
| Ebihara, Y | 1 |
| Takagi, T | 1 |
| Tsuchiya, M | 1 |
| Novick, DM | 1 |
| Ohnishi, K | 1 |
| Mishima, A | 1 |
| Hatano, H | 1 |
| Saito, M | 1 |
| Nakayama, T | 1 |
| Hiyama, Y | 1 |
| Tsuchiya, S | 1 |
| Nomura, F | 1 |
| Kono, K | 1 |
| Ohtsuki, T | 1 |
| Hirayama, C | 1 |
| Horie, Y | 1 |
| Tarika, JS | 1 |
| Winger, G | 1 |
| Coenegracht, JM | 1 |
| Oei, TL | 1 |
| van Breda Vriesman, PJ | 1 |
| Linder, M | 1 |
| Schwarz, E | 1 |
| Kielholz, P | 1 |
| Hobi, V | 1 |
| Goldberg, L | 2 |
| Hofstetter, M | 1 |
| Ladewig, D | 2 |
| Goldberg, DM | 1 |
| Cohen, MS | 1 |
| Mackenzie, TB | 1 |
| Collins, NM | 1 |
| Popkin, ME | 1 |
| Tampier, L | 1 |
| Quintanilla, ME | 1 |
| Mardones, J | 1 |
| Lau, CE | 1 |
| Tang, M | 1 |
| Falk, JL | 1 |
| Rodríguez-Martos, A | 1 |
| Binder, D | 1 |
| Jost, R | 1 |
| Flury, R | 1 |
| Salomon, F | 1 |
| Bhagwat, SV | 1 |
| Boyd, MR | 1 |
| Ravindranath, V | 1 |
| Rosenthal, RN | 1 |
| Perkel, C | 1 |
| Singh, P | 1 |
| Anand, O | 1 |
| Miner, CR | 1 |
| Joly, JG | 1 |
| Feinman, L | 1 |
| Lieber, CS | 4 |
| Rodgers, JE | 1 |
| Crouch, MA | 1 |
| Sato, R | 1 |
| Nambara, K | 1 |
| Bode, JC | 2 |
| Bode, C | 2 |
| Thiele, D | 2 |
| Seixas, FA | 1 |
| Yanaura, S | 1 |
| Suzuki, T | 1 |
| Teijeiro, J | 2 |
| Seeber, U | 1 |
| Kuschinsky, K | 1 |
| Rodin, EA | 1 |
| Lucas, D | 2 |
| Ménez, JF | 2 |
| Berthou, F | 2 |
| Cauvin, JM | 1 |
| Deitrich, RA | 2 |
| Piepho, R | 1 |
| Whelton, A | 1 |
| Mayor, G | 1 |
| Neu, H | 1 |
| Laddu, A | 1 |
| Winters, DK | 1 |
| Cederbaum, AI | 1 |
| Ulrichsen, J | 1 |
| Clemmesen, L | 1 |
| Hemmingsen, R | 1 |
| Stibler, H | 1 |
| Beaugé, F | 1 |
| Leguicher, A | 1 |
| Borg, S | 1 |
| Winston, GW | 1 |
| Narayan, S | 1 |
| Bounds, PL | 1 |
| Dreano, Y | 1 |
| Floch, HH | 1 |
| Schwarz-Ottersbach, E | 1 |
| Lé, CT | 1 |
| Igra, J | 1 |
| Rubin, E | 3 |
| Haschen, RJ | 1 |
| Wesson, DR | 1 |
| Smith, DE | 1 |
| Lerner, SE | 1 |
| Kettner, VR | 1 |
| De Matteis, F | 1 |
| Porta, EA | 1 |
| Koch, OR | 1 |
| Hartroft, WS | 1 |
| Altman, H | 1 |
| Evenson, RC | 1 |
| Sletten, IW | 1 |
| Cho, DW | 1 |
| Hepner, GW | 1 |
| Vesell, ES | 1 |
| Smith, SE | 1 |
| Freund, G | 1 |
| Miletto, G | 1 |
| Pelkonen, O | 1 |
| Jouppila, P | 1 |
| Kärki, NT | 1 |
| Carroll, BJ | 1 |
| Descloux, A | 1 |
| Knott, DH | 1 |
| Beard, JD | 1 |
| Bruncsák, A | 1 |
| Timár, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit[NCT04156464] | Phase 4 | 142 participants (Anticipated) | Interventional | 2020-07-06 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 reviews available for phenobarbital and Alcohol Abuse
| Article | Year |
|---|---|
Current evidence and clinical utility of phenobarbital for alcohol withdrawal syndrome.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Humans; Phenobarbital; Prospective Studies | 2023 |
Evaluation of phenobarbital based approach in treating patient with alcohol withdrawal syndrome: A systematic review and meta-analysis.
Topics: Adult; Alcoholism; Benzodiazepines; Humans; Phenobarbital; Prospective Studies; Retrospective Studie | 2023 |
Adjunctive Phenobarbital for Alcohol Withdrawal Syndrome: A Focused Literature Review.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Humans; Hypnotics and Sedatives; Phenobarbital; Substance W | 2021 |
Treatment of Severe Alcohol Withdrawal.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Critical Care; Dexmedetomidine; Drug Thera | 2016 |
The emergency medicine management of severe alcohol withdrawal.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Critical Care; Dose-Response Relationship, | 2017 |
Major medical problems and detoxification treatment of parenteral drug-abusing alcoholics.
Topics: Acquired Immunodeficiency Syndrome; Alcoholism; Homosexuality; Humans; Hypnotics and Sedatives; Infe | 1984 |
[Disorders of calcium and phosphorus metabolism in biliary tract diseases].
Topics: Adrenal Cortex Hormones; Alcoholism; Biliary Tract Diseases; Calcium; Calcium Metabolism Disorders; | 1982 |
The expanding role of microsomal enzyme induction, and its implications for clinical chemistry.
Topics: Acetaminophen; Alcoholism; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Electron Transport; E | 1980 |
Drug abuse in pregnancy: fetal ad neonatal effects.
Topics: Alcoholism; Birth Weight; Chlorpromazine; Diazepam; Female; Fetus; Humans; Infant, Newborn; Infant, | 1982 |
Phenobarbital for alcohol withdrawal syndrome.
Topics: Alcoholism; Humans; Hypnotics and Sedatives; Phenobarbital; Substance Withdrawal Syndrome | 1999 |
Ethanol metabolism in the liver.
Topics: Alcohol Oxidoreductases; Alcoholism; Animals; Biological Transport; Catalase; Depression, Chemical; | 1972 |
[Progress in diagnostic enzymology].
Topics: Alcoholism; Aminopeptidases; Amylases; Aspartate Aminotransferases; Cholinesterases; Creatine Kinase | 1973 |
Toxic hepatic porphyrias.
Topics: Alcoholism; Antifungal Agents; Chemical and Drug Induced Liver Injury; Chlorpropamide; Hexachlorocyc | 1968 |
Recent advances in molecular pathology: a review of the effects of alcohol on the liver.
Topics: Acute Disease; Alcoholic Intoxication; Alcoholism; Animals; Butyrates; Chemical and Drug Induced Liv | 1970 |
5 trials available for phenobarbital and Alcohol Abuse
| Article | Year |
|---|---|
Changes in EEG, blood levels, mood scales and performance scores during long term treatment with diazepam, phenobarbital or placebo in patients.
Topics: Adult; Alcoholism; Arousal; Diazepam; Electroencephalography; Emotions; Humans; Middle Aged; Phenoba | 1982 |
A pilot open randomized trial of valproate and phenobarbital in the treatment of acute alcohol withdrawal.
Topics: Adult; Affect; Alcohol Withdrawal Delirium; Alcoholism; Anticonvulsants; Dose-Response Relationship, | 1998 |
[A double blind comparative study of atrium 300 and heminiurine in chronic alcoholics].
Topics: Alcoholism; Barbiturates; Chlormethiazole; Chronic Disease; Clinical Trials as Topic; Drug Combinati | 1975 |
[A comparative double-blind study of atrium 300 and hemineurine in chronic alcoholics (author's transl)].
Topics: Alcoholism; Barbiturates; Chlormethiazole; Drug Combinations; Humans; Phenobarbital; Psychotropic Dr | 1976 |
Treatment- and task-induced changes in interhemispheric EEG.
Topics: Alcoholism; Brain; Diazepam; Electroencephalography; Functional Laterality; Humans; Male; Phenobarbi | 1989 |
63 other studies available for phenobarbital and Alcohol Abuse
| Article | Year |
|---|---|
Return Encounters in Emergency Department Patients Treated with Phenobarbital Versus Benzodiazepines for Alcohol Withdrawal.
Topics: Alcoholism; Benzodiazepines; Emergency Service, Hospital; Humans; Phenobarbital; Retrospective Studi | 2022 |
Phenobarbital and/or benzodiazepines for recurrent alcohol withdrawal: A self-controlled, retrospective cohort study.
Topics: Alcoholism; Benzodiazepines; Humans; Hypotension; Phenobarbital; Retrospective Studies; Substance Wi | 2022 |
A retrospective evaluation of phenobarbital versus benzodiazepines for treatment of alcohol withdrawal in a regional Canadian emergency department.
Topics: Adult; Alcoholism; Benzodiazepines; Canada; Emergency Service, Hospital; Humans; Length of Stay; Phe | 2022 |
Front-Loaded Versus Low-Intermittent Phenobarbital Dosing for Benzodiazepine-Resistant Severe Alcohol Withdrawal Syndrome.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Ethanol; Humans; Hypnotics and Sedatives; | 2022 |
Phenobarbital for Severe Alcohol Withdrawal Syndrome: A Multicenter Retrospective Cohort Study.
Topics: Alcoholism; Humans; Hypnotics and Sedatives; Phenobarbital; Retrospective Studies; Substance Withdra | 2022 |
Evaluation of Dexmedetomidine as an Adjunct to Phenobarbital for Alcohol Withdrawal in Critically Ill Patients.
Topics: Adult; Alcoholism; Benzodiazepines; Critical Illness; Delirium; Dexmedetomidine; Humans; Hypnotics a | 2023 |
Phenobarbital for the Management of Alcohol Withdrawal Syndrome in Critically Ill, Surgical-Trauma Patients.
Topics: Alcoholism; Benzodiazepines; Critical Illness; Humans; Phenobarbital; Retrospective Studies; Substan | 2023 |
Phenobarbital for alcohol withdrawal in the context of the opioid epidemic: a neglected caveat.
Topics: Alcoholism; Analgesics, Opioid; Buprenorphine; Humans; Methadone; Opiate Substitution Treatment; Opi | 2023 |
Evaluation of phenobarbital for prevention of alcohol withdrawal in trauma patients.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Humans; Phenobarbital; Retrospectiv | 2023 |
Implementation of a Phenobarbital-based Pathway for Severe Alcohol Withdrawal: A Mixed-Method Study.
Topics: Alcoholism; Humans; Length of Stay; Phenobarbital; Retrospective Studies; Substance Withdrawal Syndr | 2021 |
Incorporating phenobarbital into your symptom-based benzodiazepine alcohol withdrawal protocol in the emergency department.
Topics: Alcoholism; Benzodiazepines; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Phenoba | 2018 |
Effect of early and focused benzodiazepine therapy on length of stay in severe alcohol withdrawal syndrome.
Topics: Academic Medical Centers; Adult; Alcoholism; Benzodiazepines; Cohort Studies; Diazepam; Female; Huma | 2019 |
Case 13-2019: A 54-Year-Old Man with Alcohol Withdrawal and Altered Mental Status.
Topics: 2-Propanol; Acetone; Acid-Base Equilibrium; Acidosis; Alcohol Withdrawal Delirium; Alcoholism; Diagn | 2019 |
Phenobarbital and symptom-triggered lorazepam versus lorazepam alone for severe alcohol withdrawal in the intensive care unit.
Topics: Adult; Aged; Alcoholism; Central Nervous System Agents; Drug Therapy, Combination; Ethanol; Female; | 2020 |
Phenobarbital compared to benzodiazepines in alcohol withdrawal treatment: A register-based cohort study of subsequent benzodiazepine use, alcohol recidivism and mortality.
Topics: Adult; Alcoholism; Benzodiazepines; Chlordiazepoxide; Cohort Studies; Ethanol; Female; GABA Modulato | 2016 |
Regarding "Phenobarbital for Acute Alcohol Withdrawal: A Prospective Randomized Double-Blind Placebo-Controlled Study".
Topics: Alcoholism; Double-Blind Method; Humans; Phenobarbital; Prospective Studies; Substance Withdrawal Sy | 2016 |
Potentiation by phenobarbitone of effects of ethyl alcohol on human behaviour.
Topics: Alcoholism; Behavior; Ethanol; Humans; Pharmacology; Phenobarbital | 1959 |
WERNICKE'S ENCEPHALOPATHY AND ALCOHOLISM. THE COURSE AND TREATMENT OF AN UNUSUAL CASE.
Topics: Alcoholism; Chlorpromazine; Humans; Korsakoff Syndrome; Nursing; Occupational Therapy; Penicillins; | 1963 |
CHLORPROTHIXENE: A NEW NON-PHENOTHIAZINE ATARACTIC AGENT: SPECTRUM IN THE OUTPATIENT THERAPY OF PSYCHONEUROSIS.
Topics: Alcoholism; Anxiety; Anxiety Disorders; Chlorprothixene; Fluphenazine; Humans; Neurotic Disorders; O | 1963 |
The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin. Excretion of HPPH in the urine.
Topics: Acetazolamide; Adult; Aged; Alcoholism; Amitriptyline; Chlordiazepoxide; Chlorpromazine; Chromatogra | 1967 |
Significance of serum gamma glutamyl transpeptidase as a marker of alcoholism.
Topics: Alcoholism; Animals; Cytochrome P-450 Enzyme System; Female; gamma-Glutamyltransferase; Humans; Memb | 1980 |
[Effect of chronic ethanol feeding on the amount of phenobarbital inducible form of cytochrome P-450 and its localization in the hepatic lobule of the rat].
Topics: Alcoholism; Animals; Cytochrome P-450 Enzyme System; Histocytochemistry; Humans; Liver; Male; Phenob | 1983 |
The effects of ethanol, phenobarbital, and baclofen on ethanol withdrawal in the rhesus monkey.
Topics: Alcoholism; Animals; Ataxia; Baclofen; Behavior, Animal; Drug Interactions; Ethanol; Humans; Macaca | 1980 |
The influence of bilirubin, alcohol and certain drugs on the kinetics of 99mTc-Diethyl IDA (EHIDA) in humans.
Topics: Alcoholism; Bilirubin; Epilepsy; Ethanol; Humans; Imino Acids; Jaundice; Kinetics; Phenobarbital; Ph | 1983 |
[Epileptic seizures in chronic alcoholism].
Topics: Alcoholism; Epilepsy; Humans; Phenobarbital; Substance Withdrawal Syndrome | 1983 |
A case of fetal abuse?
Topics: Adult; Alcoholism; Child Abuse; Chlorthalidone; Female; Fetus; Humans; Maternal-Fetal Relations; Mor | 1982 |
Genetic differences in tolerance to ethanol: a study in UChA and UChB rats.
Topics: Alcoholism; Animals; Drug Tolerance; Ethanol; Female; Humans; Latency Period, Psychological; Male; P | 1981 |
Cross-tolerance to phenobarbital following chronic ethanol polydipsia.
Topics: Alcoholism; Animals; Discrimination Learning; Drug Tolerance; Ethanol; Humans; Male; Phenobarbital; | 1981 |
[The medical treatment of the alcoholic--it's value and importance, shown with Atrium (author's transl)].
Topics: Adult; Alcoholism; Ambulatory Care; Barbiturates; Drug Combinations; Female; Humans; Male; Middle Ag | 1980 |
[Anxiolytic agents in alcoholism].
Topics: Alcoholism; Anti-Anxiety Agents; Anxiety; Barbiturates; Drug Combinations; Humans; Phenobarbital; Ps | 1994 |
[Acute liver failure following tetrabamate].
Topics: Adult; Alcoholism; Barbiturates; Drug Combinations; Female; Humans; Liver; Liver Failure, Acute; Liv | 1995 |
Brain mitochondrial cytochromes P450: xenobiotic metabolism, presence of multiple forms and their selective inducibility.
Topics: 7-Alkoxycoumarin O-Dealkylase; Alcoholism; Aminopyrine N-Demethylase; Animals; Brain; Cytochrome P-4 | 1995 |
Effect of chronic ethanol feeding on hepatic microsomal glycerophosphate acyltransferase activity.
Topics: Alcoholism; Animals; Dietary Fats; Fatty Liver, Alcoholic; Female; Glycerol-3-Phosphate O-Acyltransf | 1973 |
[Clinical and experimental histochemical studies on the activities of liver lysosomal enzymes and gamma-glutamyl transpeptidase (gamma-GTP) (author's transl)].
Topics: Acetylglucosaminidase; Acid Phosphatase; Adenosine Triphosphatases; Alcoholism; Animals; Anticonvuls | 1978 |
[Clinical and experimental studies on the enzymes of liver, small intestinal mucosa and pancreas after chronic ethanol ingestion and anti-epileptic drugs (author's transl)].
Topics: Alcoholism; Animals; Glucaric Acid; Humans; Intestinal Mucosa; Intestine, Small; Liver; Male; NADPH- | 1979 |
Alcohol metabolism in man: effect of intravenous fructose infusion on blood ethanol elimination rate following stimulation by phenobarbital treatment or chronic alcohol consumption.
Topics: Adult; Aged; Alcoholism; Blood Glucose; Ethanol; Fructose; Humans; Infusions, Parenteral; Lactates; | 1979 |
Drug/alcohol interactions: avert potential dangers.
Topics: Aged; Aging; Alcohol Drinking; Alcoholism; Antidepressive Agents, Tricyclic; Aspirin; California; Di | 1979 |
Cross-dependence between phenobarbital and alcohol in rats.
Topics: Alcoholism; Animals; Body Weight; Humans; Male; Phenobarbital; Rats; Substance Withdrawal Syndrome; | 1977 |
Dopamine-sensitive adenylate cyclase in homogenates of rat striata during ethanol and barbiturate withdrawal.
Topics: Adenylyl Cyclases; Alcoholism; Animals; Corpus Striatum; Dopamine; Humans; Male; Phenobarbital; Rats | 1976 |
Psychosocial management of patients with complex partial seizures.
Topics: Adult; Alcoholism; Carbamazepine; Delivery of Health Care; Drug Administration Schedule; Epilepsy; E | 1975 |
Differences in hepatic microsomal cytochrome P-450 isoenzyme induction by pyrazole, chronic ethanol, 3-methylcholanthrene, and phenobarbital in high alcohol sensitivity (HAS) and low alcohol sensitivity (LAS) rats.
Topics: Alcoholism; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Isoenzymes; Male; Me | 1992 |
Grand mal status epilepticus.
Topics: Alcoholism; Anticonvulsants; Diazepam; Epilepsy, Tonic-Clonic; Ethanol; Humans; Lorazepam; Male; Mid | 1992 |
The content and activity of cytochrome P450 2E1 in liver microsomes from alcohol-preferring and non-preferring rats.
Topics: Alcoholism; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Fomepizole; Immunoblotting; M | 1992 |
Convulsive behaviour during alcohol dependence: discrimination between the role of intoxication and withdrawal.
Topics: Alcoholism; Analysis of Variance; Animals; Behavior, Animal; Male; Phenobarbital; Rats; Rats, Inbred | 1992 |
Biophysical and biochemical alterations in erythrocyte membranes from chronic alcoholics.
Topics: Adult; Alcoholism; Biophysical Phenomena; Biophysics; Drug Tolerance; Erythrocyte Membrane; Ethanol; | 1991 |
Profiles of ethanol-induced microsomal alkoxyresorufin (alkoxyphenoxazone) O-dealkylation: comparison with phenobarbital- and Aroclor 1254-induced systems.
Topics: Alcoholism; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP2B1; Cytochrome P- | 1990 |
Ethanol-inducible cytochrome P-450: assessment of substrates' specific chemical probes in rat liver microsomes.
Topics: Acetone; Alcoholism; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Isoenzymes; | 1990 |
Shifting CNS symptoms in a chronic alcoholic.
Topics: Adult; Alcoholism; Central Nervous System Diseases; Cysticercosis; Dexamethasone; Humans; Male; Phen | 1985 |
Treatment of polydrug users in San Francisco.
Topics: Adult; Aftercare; Alcoholism; Ambulatory Care; Anti-Anxiety Agents; California; Crisis Intervention; | 1974 |
Patterns of psychotropic drug prescription in four midwestern state hospitals.
Topics: Alcoholism; Antidepressive Agents; Antipsychotic Agents; Chlorpromazine; Computers; Drug Utilization | 1972 |
Assessment of aminopyrine metabolism in man by breath analysis after oral administration of 14C-aminopyrine. Effects of phenobarbital, disulfiram and portal cirrhosis.
Topics: Administration, Oral; Adult; Aged; Alcoholism; Aminopyrine; Breath Tests; Carbon Dioxide; Carbon Rad | 1974 |
[Changes in the speed of alcohol catabolism in man due to phenobarbital, chronic alcohol consumption and fasting].
Topics: Alcoholism; Chronic Disease; Ethanol; Fasting; Humans; Liver; Phenobarbital; Time Factors | 1974 |
Genetic basis of phenobarbital-induced increase in aldehyde dehydrogenase: implications for alcohol research.
Topics: Alcohol Drinking; Alcoholism; Aldehydes; Animals; Enzyme Induction; Genotype; Humans; Inbreeding; Li | 1972 |
Taste thresholds in drug addicts and alcoholics.
Topics: Adult; Alcoholism; Amphetamine; Female; Humans; Male; Nicotiana; Phenobarbital; Plants, Toxic; Quini | 1972 |
Alcohol, barbiturate, and bromide withdrawal syndromes in mice.
Topics: Alcohol Drinking; Alcoholism; Animals; Barbiturates; Body Weight; Bromides; Diet; Disease Models, An | 1973 |
[A very special drug in acute or chronic alcoholism].
Topics: Administration, Oral; Alcoholism; Barbiturates; Chronic Disease; Drug Combinations; Humans; Phenobar | 1972 |
Attempts to induce drug metabolism in human fetal liver and placenta by the administration of phenobarbital to mothers.
Topics: Adult; Alcoholism; Aniline Compounds; Benzoates; Benzopyrenes; Chlorpromazine; Female; Humans; Liver | 1973 |
Barbiturate overdosage: presentation with focal neurological signs.
Topics: Adult; Alcoholism; Amobarbital; Barbiturates; Basilar Artery; Bromides; Cerebral Hemorrhage; Coma; C | 1969 |
[Treatment of the psychosyndrome of alcoholic withdrawal using Atrium].
Topics: Aggression; Alcoholism; Anxiety; Barbiturates; Depression; Drug Combinations; Drug Evaluation; Human | 1971 |
Diagnosis and therapy of acute withdrawal from alcohol.
Topics: Acute Disease; Adult; Alcoholism; Anti-Bacterial Agents; Anticonvulsants; Carbohydrate Metabolism; C | 1970 |
Alcoholism, alcohol, and drugs.
Topics: Alcoholism; Animals; Calorimetry; Chemical and Drug Induced Liver Injury; Diet; Drug Antagonism; Dru | 1971 |
[On acute isoniazid poisoning on the basis of 2 successfully treated cases].
Topics: Adult; Alcoholism; Blood Transfusion; Brain; Brain Edema; Gastric Lavage; Glucose; Glutamates; Human | 1967 |
Alcohol, other drugs, and the liver.
Topics: Alcoholism; Animals; Central Nervous System; Chemical and Drug Induced Liver Injury; Ethanol; Humans | 1968 |