spiperone has been researched along with Alcohol Abuse in 9 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both lisuride-treated (AL) and untreated ethanol-addicted rats (A) displayed a significant (P < ." | 1.29 | Striatal dopamine receptors and adenylyl cyclase activity in a rat model of alcohol addiction: effects of ethanol and lisuride treatment. ( May, T; Wolf, U; Wolffgramm, J, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barbaccia, ML | 1 |
| Bosio, A | 1 |
| Lucchi, L | 1 |
| Spano, PF | 1 |
| Trabucchi, M | 1 |
| Ng, GY | 1 |
| O'Dowd, BF | 1 |
| George, SR | 1 |
| May, T | 1 |
| Wolf, U | 1 |
| Wolffgramm, J | 1 |
| Tajuddin, NF | 1 |
| Druse, MJ | 2 |
| Tabakoff, B | 1 |
| Hoffman, PL | 1 |
| Pellegrino, SM | 1 |
| Noble, EP | 1 |
| Blum, K | 1 |
| Ritchie, T | 1 |
| Montgomery, A | 1 |
| Sheridan, PJ | 1 |
| Syvälahti, EK | 1 |
| Hietala, J | 1 |
| Röyttä, M | 1 |
| Grönroos, J | 1 |
| Korpi, ER | 1 |
| Sinclair, JD | 1 |
| Malminen, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Gut-brain Axis: a Novel Target for Treating Behavioral Alterations in Obesity[NCT01976156] | 100 participants (Actual) | Interventional | 2013-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for spiperone and Alcohol Abuse
| Article | Year |
|---|---|
Neuronal mechanisms regulating ethanol effects on the dopaminergic system.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alcoholism; Animals; Dopamine; Ethanol; Haloperidol; Humans; Male; M | 1982 |
Genotypic differences in brain dopamine receptor function in the DBA/2J and C57BL/6J inbred mouse strains.
Topics: Adenylyl Cyclases; Alcoholism; Animals; Base Sequence; Benzazepines; Blotting, Northern; Brain; Dise | 1994 |
Striatal dopamine receptors and adenylyl cyclase activity in a rat model of alcohol addiction: effects of ethanol and lisuride treatment.
Topics: Adenylyl Cyclases; Alcoholism; Animals; Benzazepines; Corpus Striatum; Dopamine Agonists; Dopamine A | 1995 |
Effects of chronic alcohol consumption and aging on dopamine D2 receptors in Fischer 344 rats.
Topics: Age Factors; Alcoholism; Animals; Brain; Brain Mapping; Cerebral Cortex; Corpus Striatum; Ethanol; F | 1996 |
Development of functional dependence on ethanol in dopaminergic systems.
Topics: Adenylyl Cyclases; Alcoholism; Animals; Corpus Striatum; Dopamine; Drug Tolerance; Ethanol; Humans; | 1979 |
The effects of chronic ethanol consumption on the mesolimbic and nigrostriatal dopamine systems.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alcoholism; Animals; Benzazepines; Brain Mapping; Corpus Striatum; D | 1992 |
Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism.
Topics: Alcoholism; Alleles; Caudate Nucleus; DNA Probes; Female; Humans; Male; Middle Aged; Protein Binding | 1991 |
Decrease in the number of rat brain dopamine and muscarinic receptors after chronic alcohol intake.
Topics: Alcoholism; Animals; Corpus Striatum; Ethanol; Male; Quinuclidinyl Benzilate; Rats; Rats, Inbred Str | 1988 |
Dopamine D2 receptor binding in striatal membranes of rat lines selected for differences in alcohol-related behaviours.
Topics: Alcoholism; Animals; Corpus Striatum; Kinetics; Male; Radioligand Assay; Receptors, Dopamine; Spiper | 1987 |