desipramine has been researched along with Alcohol Abuse in 19 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Depression has been related to relapsed drinking in alcoholics striving to maintain sobriety." | 6.67 | Desipramine treatment of alcoholism. ( Kocsis, JH; Mason, BJ, 1991) |
| "Desipramine-treated depressed patients were more satisfied and were rated as more improved." | 2.68 | A double-blind, placebo-controlled trial of desipramine for primary alcohol dependence stratified on the presence or absence of major depression. ( Cutler, RB; Kocsis, JH; Mason, BJ; Ritvo, EC, 1996) |
| "Depression has been related to relapsed drinking in alcoholics striving to maintain sobriety." | 2.67 | Desipramine treatment of alcoholism. ( Kocsis, JH; Mason, BJ, 1991) |
| "Milnacipran was also tested for relapse after protracted abstinence and on ethanol-induced (1." | 1.37 | Fluoxetine, desipramine, and the dual antidepressant milnacipran reduce alcohol self-administration and/or relapse in dependent rats. ( Alaux-Cantin, S; André, E; Houchi, H; Legastelois, R; Naassila, M; Pierrefiche, O; Simon O'Brien, E; Vilpoux, C, 2011) |
| " Chronic administration of desipramine may have therapeutic efficacy in treating cocaine abuse only in subjects attempting to refrain from cocaine who are aided in their passage through a withdrawal phase by desipramine." | 1.28 | Schedule-induced oral self-administration of cocaine and ethanol solutions: lack of effect of chronic desipramine. ( Falk, JL; Tang, M, 1990) |
| "Desipramine clearance was affected to a lesser degree than imipramine, suggesting that from a pharmacokinetic standpoint it may be the preferred drug for the treatment of alcoholics with depression." | 1.27 | Clinical pharmacokinetics of imipramine and desipramine in alcoholics and normal volunteers. ( Barnhill, JG; Ciraulo, DA; Jaffe, JH, 1988) |
| " Tricyclic pharmacokinetic parameters, determined from plasma samples over 48 hours, indicated decreased total body clearance, increased elimination half-life, and higher peak plasma levels during disulfiram treatment." | 1.27 | Pharmacokinetic interaction of disulfiram and antidepressants. ( Barnhill, J; Boxenbaum, H; Ciraulo, DA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (36.84) | 18.7374 |
| 1990's | 10 (52.63) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davidson, J | 1 |
| Simon O'Brien, E | 1 |
| Legastelois, R | 1 |
| Houchi, H | 1 |
| Vilpoux, C | 1 |
| Alaux-Cantin, S | 1 |
| Pierrefiche, O | 1 |
| André, E | 1 |
| Naassila, M | 1 |
| Matussek, N | 1 |
| Wood, JM | 1 |
| Mason, BJ | 3 |
| Kocsis, JH | 3 |
| Ritvo, EC | 1 |
| Cutler, RB | 1 |
| Douglas, MB | 1 |
| Fleming, MF | 1 |
| Rowe, JB | 1 |
| Sullivan, PF | 1 |
| Mulder, RT | 1 |
| Joyce, PR | 1 |
| Amit, Z | 1 |
| Levitan, DE | 1 |
| Brown, ZE | 1 |
| Sutherland, EA | 1 |
| Meyer, RE | 1 |
| Gallant, D | 1 |
| Barnhill, JG | 2 |
| Balant-Gorgia, AE | 1 |
| Gay, M | 1 |
| Gex-Fabry, M | 1 |
| Balant, LP | 1 |
| Tang, M | 1 |
| Falk, JL | 1 |
| McBride, WJ | 1 |
| Murphy, JM | 1 |
| Lumeng, L | 1 |
| Li, TK | 1 |
| Ciraulo, DA | 2 |
| Jaffe, JH | 1 |
| Barnhill, J | 1 |
| Boxenbaum, H | 1 |
| Rockliff, BW | 1 |
2 reviews available for desipramine and Alcohol Abuse
| Article | Year |
|---|---|
Drugs as tools for exploring neuroendocrine functions.
Topics: Alcoholism; Clonidine; Depressive Disorder; Desipramine; Female; Growth Hormone; Humans; Insulin; Ma | 1984 |
New pharmacotherapies for cocaine dependence ... revisited.
Topics: Alcoholism; Cocaine; Desipramine; Disease Models, Animal; Double-Blind Method; Heroin Dependence; Hu | 1992 |
4 trials available for desipramine and Alcohol Abuse
| Article | Year |
|---|---|
A double-blind, placebo-controlled trial of desipramine for primary alcohol dependence stratified on the presence or absence of major depression.
Topics: Adrenergic Uptake Inhibitors; Adult; Alcoholism; Analysis of Variance; Antidepressive Agents, Tricyc | 1996 |
The effect of a history of conduct disorder in adult major depression.
Topics: Adolescent; Adult; Alcoholism; Antidepressive Agents, Tricyclic; Child; Child Behavior Disorders; Cl | 1996 |
Reduction of ethanol intake by pharmacologic agents--investigational problems.
Topics: Adult; Alcohol Drinking; Alcoholics Anonymous; Alcoholism; Combined Modality Therapy; Depressive Dis | 1992 |
Desipramine treatment of alcoholism.
Topics: Adult; Alcoholism; Depression; Desipramine; Double-Blind Method; Female; Humans; Male; Middle Aged; | 1991 |
13 other studies available for desipramine and Alcohol Abuse
| Article | Year |
|---|---|
Vintage treatments for PTSD: a reconsideration of tricyclic drugs.
Topics: Adrenergic Uptake Inhibitors; Alcoholism; Antidepressive Agents, Tricyclic; Desipramine; Diagnosis, | 2015 |
Fluoxetine, desipramine, and the dual antidepressant milnacipran reduce alcohol self-administration and/or relapse in dependent rats.
Topics: Alcoholism; Analysis of Variance; Animals; Antidepressive Agents; Central Nervous System Depressants | 2011 |
Effect of depletion of brain 5-hydroxytryptamine by 5,7-dihydroxytryptamine on ethanol tolerance and dependence in the rat.
Topics: 5,7-Dihydroxytryptamine; Alcoholism; Animals; Body Weight; Brain Chemistry; Desipramine; Dihydroxytr | 1980 |
Desipramine in the treatment of depressed alcoholics.
Topics: Alcoholism; Clinical Trials as Topic; Comorbidity; Depressive Disorder; Desipramine; Double-Blind Me | 1994 |
Treating depression in alcoholics.
Topics: Alcoholism; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Double-Blind Method; | 1996 |
Catecholaminergic involvement in alcohol's rewarding properties: implications for a treatment model for alcoholics.
Topics: Alcohol Drinking; Alcoholism; Alkaloids; Animals; Desipramine; Dopamine; Ethanol; Humans; Hydroxydop | 1977 |
Plasma desipramine levels and ECG changes in depressed young adults.
Topics: Adult; Alcoholism; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Electrocardio | 1992 |
Persistent impairment of clomipramine demethylation in recently detoxified alcoholic patients.
Topics: Adult; Alcoholism; Clomipramine; Dealkylation; Desipramine; Female; Humans; Hydroxylation; Imipramin | 1992 |
Schedule-induced oral self-administration of cocaine and ethanol solutions: lack of effect of chronic desipramine.
Topics: Alcohol Drinking; Alcoholism; Animals; Cocaine; Desipramine; Dose-Response Relationship, Drug; Drug | 1990 |
Effects of Ro 15-4513, fluoxetine and desipramine on the intake of ethanol, water and food by the alcohol-preferring (P) and -nonpreferring (NP) lines of rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Azides; Benzodiazepines; Desipramine; Drinking Behavior; Feed | 1988 |
Clinical pharmacokinetics of imipramine and desipramine in alcoholics and normal volunteers.
Topics: Administration, Oral; Adolescent; Adult; Aged; Alcoholism; Blood Proteins; Desipramine; Humans; Imip | 1988 |
Pharmacokinetic interaction of disulfiram and antidepressants.
Topics: Adult; Alcoholism; Desipramine; Disulfiram; Drug Interactions; Half-Life; Humans; Hydroxylation; Imi | 1985 |
A brief rating scale for antidepressant drug trials.
Topics: Alcoholism; Antidepressive Agents; Depression; Desipramine; Humans | 1971 |