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3-hydroxybutyric acid and Alcohol Abuse

3-hydroxybutyric acid has been researched along with Alcohol Abuse in 29 studies

3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.

Research Excerpts

ExcerptRelevanceReference
" Alcoholism may cause hypoglycemia accompanying with AKA, due to a low carbohydrate intake, the inhibition of gluconeogenesis, and reduced hepaticglycogen storage as seen in this case."3.81Case of alcoholic ketoacidosis accompanied with severe hypoglycemia. ( Iwanaga, Y; Matsuzaki, T; Shiraishi, W; Yamamoto, A, 2015)
"Data from 191 post-mortem cases where post-mortem blood beta-hydroxybutyrate (βHB) and acetone concentrations and vitreous humor glucose concentrations (where available) had been measured were retrospectively investigated to determine the markers required to identify and distinguish between Alcoholic Ketoacidosis (AKA), Diabetic Ketoacidosis (DKA) and Hyperosmolar Hyperglycemic State (HHS)."3.78Investigation of markers to indicate and distinguish death due to alcoholic ketoacidosis, diabetic ketoacidosis and hyperosmolar hyperglycemic state using post-mortem samples. ( Andrews, R; Dhillo, W; Hockenhull, J; Paterson, S, 2012)
"Alcoholic ketoacidosis (AKA) is an important and probably underdiagnosed differential diagnosis for metabolic acidosis with an increased anion gap."2.38[Alcoholic ketoacidosis]. ( Caspar, CB; Iten, PX; Jost, R; Risti, B; Russi, EW; Speich, R, 1993)
"Originally described in diabetic ketoacidosis, renal vacuoles can be found in other ketogenic states such as alcoholic ketoacidosis (AKA), starvation, and hypothermia, underpinned by deranged fatty acid metabolism."1.91Subnuclear renal tubular vacuoles in alcohol use disorder. ( Auld, FM; Milroy, CM; Parai, JL, 2023)
"The main background of ketoacidosis was considered as alcohol abuse in 6 cases, diabetes in 5, malnutrition in 3, and hypothermia and infection in 1 case each."1.72Clinicopathologic Appearance of Advanced Ketoacidosis With Basal Vacuolation in Renal Tubules. ( Hata, Y; Ichimata, S; Nishida, N, 2022)
"Patients with alcohol use disorder (AUD) present with important emotional, cognitive, and social impairments."1.56Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder. ( Amadieu, C; Bindels, LB; Cani, PD; Colet, JM; Coste, V; de Timary, P; Delzenne, NM; Dricot, L; Furgiuele, S; Le Roy, T; Leclercq, S; Leyrolle, Q; Neyrinck, AM; Petit, G; Quoilin, C; Stärkel, P; Tagliatti, V; Verbeke, K, 2020)
"Fetal ketoacidosis with hypoxic-ischemic brain damage was determined to be the cause of death."1.48Detection of elevated ketone bodies by postmortem 1H-MRS in a case of fetal ketoacidosis. ( Fliss, B; Gascho, D; Heimer, J; Martinez, RM; Zoelch, N, 2018)
"Diabetes and alcohol abuse may cause severe metabolic disturbances that can be fatal."1.39Assessment of Traub formula and ketone bodies in cause of death investigations. ( Keltanen, T; Lindroos, K; Palo, JU; Partanen, T; Sajantila, A; Valonen, T, 2013)
"Alcohol ketoacidosis is a frequently missed diagnosis, but is well described in the literature."1.39Ketoacidosis and trace amounts of isopropanol in a chronic alcoholic patient. ( Dwyer, JB; Tamama, K, 2013)
"To examine the effect of ketoacidosis on renal cells in isolation, five cases of lethal alcoholic ketoacidosis without hyperglycemia were examined (vitreous humor β-hydroxybutyrate: 6."1.38Basal renal tubular epithelial cell vacuolization and alcoholic ketoacidosis. ( Byard, RW; Zhou, C, 2012)
"Vitreous BHB was a marker of diabetic ketoacidosis when above 6."1.38Postmortem vitreous beta-hydroxybutyrate: interpretation in a forensic setting. ( Heninger, M, 2012)
"In six further cases a diabetic ketoacidosis (DKA) was diagnosed as the cause of death."1.31Beta-hydroxybutyric acid--an indicator for an alcoholic ketoacidosis as cause of death in deceased alcohol abusers. ( Iten, PX; Meier, M, 2000)
"Alcoholic ketoacidosis is rare and must be considered in the differential diagnosis of any alcoholic patient with acidosis."1.29[Alcoholic ketoacidosis. Apropos of a case with coma]. ( Jobard, JM, 1993)
"Forensic pathologists are familiar with alcohol abusers, who are found dead and in whom the cause of death cannot be ascertained."1.29Alcoholic ketoacidosis as a cause of death in forensic cases. ( Felby, S; Nielsen, E; Theilade, P; Thomsen, JL, 1995)
" Male Sprague-Dawley rats were rendered physically dependent on ethanol by intragastric administration of ethanol at a dosage of 9 to 15 grams per kilogram per day over a 4-day period."1.27Suppression of an ethanol withdrawal syndrome in rats by butyrate, lactate and beta-hydroxybutyrate. ( Derr, M; Derr, RF; Draves, K, 1983)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19905 (17.24)18.7374
1990's8 (27.59)18.2507
2000's2 (6.90)29.6817
2010's10 (34.48)24.3611
2020's4 (13.79)2.80

Authors

AuthorsStudies
Ichimata, S1
Hata, Y1
Nishida, N1
Ahlström, S1
Ahlner, J1
Jönsson, AK1
Green, H1
Auld, FM1
Parai, JL1
Milroy, CM1
Leclercq, S1
Le Roy, T1
Furgiuele, S1
Coste, V1
Bindels, LB1
Leyrolle, Q1
Neyrinck, AM1
Quoilin, C1
Amadieu, C1
Petit, G1
Dricot, L1
Tagliatti, V1
Cani, PD1
Verbeke, K1
Colet, JM1
Stärkel, P1
de Timary, P1
Delzenne, NM1
Heimer, J1
Gascho, D1
Fliss, B1
Martinez, RM1
Zoelch, N1
Zhou, C2
Gilbert, JD1
Yool, A1
Byard, RW2
Palmiere, C1
Mangin, P1
Werner, D1
Keltanen, T1
Sajantila, A1
Palo, JU1
Partanen, T1
Valonen, T1
Lindroos, K1
Matsuzaki, T1
Shiraishi, W1
Iwanaga, Y1
Yamamoto, A1
Hassan, HM1
Cooper, GA1
Hockenhull, J1
Dhillo, W1
Andrews, R1
Paterson, S1
Rehman, HU1
Heninger, M1
Dwyer, JB1
Tamama, K1
Oster, JR1
Epstein, M1
Derr, RF1
Draves, K1
Derr, M1
Adner, N1
Nygren, A1
Davin, A1
Vion-Dury, J1
Viout, P1
Cozzone, PJ1
Hooper, RJ1
Jobard, JM1
Caspar, CB1
Risti, B1
Iten, PX2
Jost, R1
Russi, EW1
Speich, R1
Denmark, LN1
Thomsen, JL1
Felby, S1
Theilade, P1
Nielsen, E1
Hirsch, S1
De La Maza, MP1
Petermann, M1
Bunout, D1
Pounder, DJ1
Stevenson, RJ1
Taylor, KK1
Meier, M1
Testar, X1
Llobera, M1
Herrera, E1
Casazza, JP1
Veech, RL1

Reviews

2 reviews available for 3-hydroxybutyric acid and Alcohol Abuse

ArticleYear
Acid-base aspects of ketoacidosis.
    American journal of nephrology, 1984, Volume: 4, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acid-Base Equilibrium; Acidosis; Acidosis, Respiratory; Alcoholism; Alkalosis

1984
[Alcoholic ketoacidosis].
    Schweizerische medizinische Wochenschrift, 1993, Oct-16, Volume: 123, Issue:41

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Alcoholism; Diagnosis, Differential; Ethanol; Female

1993

Other Studies

27 other studies available for 3-hydroxybutyric acid and Alcohol Abuse

ArticleYear
Clinicopathologic Appearance of Advanced Ketoacidosis With Basal Vacuolation in Renal Tubules.
    Archives of pathology & laboratory medicine, 2022, 09-01, Volume: 146, Issue:9

    Topics: 3-Hydroxybutyric Acid; Alcoholism; Epithelial Cells; Glucose; Humans; Ketosis; Perilipin-2; Retrospe

2022
The Importance of BHB Testing on the Post-Mortem Diagnosis of Ketoacidosis.
    Biomolecules, 2021, 12-21, Volume: 12, Issue:1

    Topics: 3-Hydroxybutyric Acid; Alcoholism; Diabetic Ketoacidosis; Diagnosis; Humans; Hypothermia

2021
Subnuclear renal tubular vacuoles in alcohol use disorder.
    Journal of forensic sciences, 2023, Volume: 68, Issue:5

    Topics: 3-Hydroxybutyric Acid; Alcoholism; Diabetic Ketoacidosis; Epithelial Cells; Fatty Liver; Forensic Pa

2023
Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder.
    Cell reports, 2020, 10-13, Volume: 33, Issue:2

    Topics: 3-Hydroxybutyric Acid; Alcoholism; Animals; Anti-Bacterial Agents; Bacteria; Behavior, Animal; Brain

2020
Detection of elevated ketone bodies by postmortem 1H-MRS in a case of fetal ketoacidosis.
    Journal of forensic and legal medicine, 2018, Volume: 59

    Topics: 3-Hydroxybutyric Acid; Acetone; Acidosis, Lactic; Alcoholism; Cerebrum; Fasting; Female; Fetal Blood

2018
Basal epithelial formalin pigment deposition in the kidneys--a useful marker for ketoacidosis at autopsy.
    Journal of forensic and legal medicine, 2013, Volume: 20, Issue:4

    Topics: 3-Hydroxybutyric Acid; Adult; Aged; Aged, 80 and over; Alcoholism; Biomarkers; Case-Control Studies;

2013
Postmortem distribution of 3-beta-hydroxybutyrate.
    Journal of forensic sciences, 2014, Volume: 59, Issue:1

    Topics: 3-Hydroxybutyric Acid; Alcoholism; Case-Control Studies; Death, Sudden; Diabetic Ketoacidosis; Femal

2014
Assessment of Traub formula and ketone bodies in cause of death investigations.
    International journal of legal medicine, 2013, Volume: 127, Issue:6

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Alcoholism; Algorithms; Autopsy; Biomarkers; Blood Gl

2013
Case of alcoholic ketoacidosis accompanied with severe hypoglycemia.
    Journal of UOEH, 2015, Mar-01, Volume: 37, Issue:1

    Topics: 3-Hydroxybutyric Acid; Alcoholism; Coma; Dietary Carbohydrates; Fluid Therapy; Gluconeogenesis; Gluc

2015
Determination of beta-hydroxybutyrate in blood and urine using gas chromatography- mass spectrometry.
    Journal of analytical toxicology, 2009, Volume: 33, Issue:8

    Topics: 3-Hydroxybutyric Acid; Alcoholism; Biomarkers; Drug Stability; Gas Chromatography-Mass Spectrometry;

2009
Investigation of markers to indicate and distinguish death due to alcoholic ketoacidosis, diabetic ketoacidosis and hyperosmolar hyperglycemic state using post-mortem samples.
    Forensic science international, 2012, Jan-10, Volume: 214, Issue:1-3

    Topics: 3-Hydroxybutyric Acid; Acetone; Adult; Aged; Alcoholism; Biomarkers; Diabetic Ketoacidosis; Female;

2012
Basal renal tubular epithelial cell vacuolization and alcoholic ketoacidosis.
    Journal of forensic sciences, 2012, Volume: 57, Issue:1

    Topics: 3-Hydroxybutyric Acid; Adult; Aged; Alcoholism; Case-Control Studies; Epithelial Cells; Female; Fore

2012
A woman with ketoacidosis but not diabetes.
    BMJ (Clinical research ed.), 2012, Mar-01, Volume: 344

    Topics: 2-Propanol; 3-Hydroxybutyric Acid; Abdominal Pain; Acidosis; Adult; Alcoholism; Diabetic Ketoacidosi

2012
Postmortem vitreous beta-hydroxybutyrate: interpretation in a forensic setting.
    Journal of forensic sciences, 2012, Volume: 57, Issue:5

    Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholism; Biomarkers; Central N

2012
Ketoacidosis and trace amounts of isopropanol in a chronic alcoholic patient.
    Clinica chimica acta; international journal of clinical chemistry, 2013, Jan-16, Volume: 415

    Topics: 2-Propanol; 3-Hydroxybutyric Acid; Acetone; Adult; Alcoholism; Blood Glucose; Chronic Disease; Human

2013
Suppression of an ethanol withdrawal syndrome in rats by butyrate, lactate and beta-hydroxybutyrate.
    Life sciences, 1983, May-30, Volume: 32, Issue:22

    Topics: 3-Hydroxybutyric Acid; Alcoholism; Animals; Butyrates; Butyric Acid; Citric Acid Cycle; Humans; Hydr

1983
Insulin effect in chronic alcoholics during alcohol withdrawal.
    Diabetologia, 1982, Volume: 22, Issue:3

    Topics: 3-Hydroxybutyric Acid; Adult; Aged; Alcoholism; Blood Glucose; C-Peptide; Growth Hormone; Humans; Hy

1982
Rapid evaluation of ethanol content and metabolism in human plasma using quantitative proton magnetic resonance spectroscopy.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1994, Volume: 29, Issue:5

    Topics: 3-Hydroxybutyric Acid; Acetates; Acetone; Alcohol Drinking; Alcoholism; Biomarkers; Ethanol; Humans;

1994
Alcoholic ketoacidosis: the late presentation of acidosis in an alcoholic.
    Annals of clinical biochemistry, 1994, Volume: 31 ( Pt 6)

    Topics: 3-Hydroxybutyric Acid; Acidosis; Alcoholism; Analgesics; Antiemetics; Blood Chemical Analysis; Fluid

1994
[Alcoholic ketoacidosis. Apropos of a case with coma].
    Annales de gastroenterologie et d'hepatologie, 1993, Volume: 29, Issue:5

    Topics: 3-Hydroxybutyric Acid; Adult; Alcoholism; Diagnosis, Differential; Humans; Hydroxybutyrates; Ketosis

1993
The investigation of beta-hydroxybutyrate as a marker for sudden death due to hypoglycemia in alcoholics.
    Forensic science international, 1993, Volume: 62, Issue:3

    Topics: 3-Hydroxybutyric Acid; Adult; Aged; Aged, 80 and over; Alcoholism; Cause of Death; Death, Sudden; Ev

1993
Alcoholic ketoacidosis as a cause of death in forensic cases.
    Forensic science international, 1995, Oct-30, Volume: 75, Issue:2-3

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholis

1995
Lipid turnover in alcoholics before and after an ethanol load.
    Nutrition (Burbank, Los Angeles County, Calif.), 1998, Volume: 14, Issue:5

    Topics: 3-Hydroxybutyric Acid; Acetates; Acetoacetates; Adult; Alcoholism; Biopsy, Needle; Ethanol; Fatty Ac

1998
Alcoholic ketoacidosis at autopsy.
    Journal of forensic sciences, 1998, Volume: 43, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholis

1998
Beta-hydroxybutyric acid--an indicator for an alcoholic ketoacidosis as cause of death in deceased alcohol abusers.
    Journal of forensic sciences, 2000, Volume: 45, Issue:3

    Topics: 3-Hydroxybutyric Acid; Adult; Aged; Aged, 80 and over; Alcoholism; Cause of Death; Diabetic Ketoacid

2000
Comparative metabolic effects of chronic ethanol intake and undernutrition in pregnant rats and their fetuses.
    Alcoholism, clinical and experimental research, 1988, Volume: 12, Issue:2

    Topics: 3-Hydroxybutyric Acid; Alcoholism; Animals; Blood Proteins; Body Weight; Female; Fetal Alcohol Spect

1988
The production of 1,2-propanediol in ethanol treated rats.
    Biochemical and biophysical research communications, 1985, Jun-14, Volume: 129, Issue:2

    Topics: 3-Hydroxybutyric Acid; Alcoholism; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans

1985