pyrazole has been researched along with Alcohol Abuse in 8 studies
1H-pyrazole : The 1H-tautomer of pyrazole.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Alternating intraperitoneal injections of metabolically stable tert-butanol and ethanol for 4 consecutive days resulted in a physical dependence on alcohol, which was quantified by the latency and ED50 of picrotoxin-induced CNS hyperexcitability--myoclonic and tonic seizures and mortality--during the withdrawal period." | 3.67 | Increased sensitivity to picrotoxin as an index of physical dependence on alcohol in the mouse. ( Kovács, GL; Szabó, G; Telegdy, G, 1984) |
| "Pyrazole treatment produced an identical 3- to 4-fold increase in content and catalytic activity of P450 2E1 in the two lines." | 1.28 | The content and activity of cytochrome P450 2E1 in liver microsomes from alcohol-preferring and non-preferring rats. ( Cederbaum, AI; Winters, DK, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 5 (62.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Szabó, G | 1 |
| Kovács, GL | 1 |
| Telegdy, G | 1 |
| Poldrugo, F | 1 |
| Snead, OC | 1 |
| Crabbe, JC | 2 |
| Young, ER | 1 |
| Kosobud, A | 1 |
| Crawshaw, LI | 1 |
| O'Connor, CS | 1 |
| Hayteas, DL | 1 |
| Lucas, D | 1 |
| Ménez, JF | 1 |
| Berthou, F | 1 |
| Cauvin, JM | 1 |
| Deitrich, RA | 1 |
| Winters, DK | 1 |
| Cederbaum, AI | 1 |
| Lin, RC | 2 |
| Lumeng, L | 2 |
8 other studies available for pyrazole and Alcohol Abuse
| Article | Year |
|---|---|
Increased sensitivity to picrotoxin as an index of physical dependence on alcohol in the mouse.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Dose-Response Relationship, Drug; Humans; Lethal D | 1984 |
Effect of ethanol and acetaldehyde on gamma-hydroxybutyric acid in rat brain and liver.
Topics: Acetaldehyde; Alcoholism; Animals; Brain; Ethanol; Humans; Hydroxybutyrates; Liver; Male; Pyrazoles; | 1984 |
Genetic correlations with ethanol withdrawal severity.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Body Temperature Regulation; Drug Tolerance; Ethan | 1983 |
Temperature regulation in mice during withdrawal from ethanol dependence.
Topics: Alcoholism; Analysis of Variance; Animals; Body Temperature; Body Temperature Regulation; Male; Mice | 1994 |
Differences in hepatic microsomal cytochrome P-450 isoenzyme induction by pyrazole, chronic ethanol, 3-methylcholanthrene, and phenobarbital in high alcohol sensitivity (HAS) and low alcohol sensitivity (LAS) rats.
Topics: Alcoholism; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Isoenzymes; Male; Me | 1992 |
The content and activity of cytochrome P450 2E1 in liver microsomes from alcohol-preferring and non-preferring rats.
Topics: Alcoholism; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Fomepizole; Immunoblotting; M | 1992 |
Formation of a protein-acetaldehyde adduct in liver during chronic alcohol exposure.
Topics: Acetaldehyde; Alcoholism; Animals; Cyanamide; In Vitro Techniques; Liver; Male; Molecular Weight; Pr | 1991 |
Formation of the 37KD protein-acetaldehyde adduct in liver during alcohol treatment is dependent on alcohol dehydrogenase activity.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Alcoholism; Animals; Cells, Cultured; | 1990 |