modafinil has been researched along with Alcohol Abuse in 12 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Modafinil treated subjects were more likely to report very low levels of cocaine craving intensity and duration on the Brief Substance Craving Scale (OR=2." | 2.80 | A double blind, placebo controlled trial of modafinil for the treatment of cocaine dependence without co-morbid alcohol dependence. ( Dackis, C; Kampman, KM; Lynch, KG; O'Brien, CP; Pettinati, HM; Spratt, K; Wierzbicki, MR, 2015) |
| "Modafinil is a promising compound in this respect." | 2.78 | Effect of modafinil on cognitive functions in alcohol dependent patients: a randomized, placebo-controlled trial. ( Dom, G; Goudriaan, AE; Joos, L; Sabbe, BG; Schmaal, L; van den Brink, W, 2013) |
| "Chronic alcohol abuse is associated with deficits in cognitive control functions." | 2.78 | Modafinil modulates resting-state functional network connectivity and cognitive control in alcohol-dependent patients. ( Dom, G; Goudriaan, AE; Joos, L; Krüse, AM; Schmaal, L; van den Brink, W; Veltman, DJ, 2013) |
| "Modafinil was tested for efficacy in facilitating abstinence in cocaine-dependent patients, compared to placebo." | 2.74 | Modafinil for the treatment of cocaine dependence. ( Anderson, AL; Chiang, N; Ciraulo, D; Dackis, C; Elkashef, AM; Holmes, T; Kahn, R; Li, SH; Reid, MS; Roache, JD; Salloum, IM; Shemanski, L; Slee, A; Smith, EV; Somoza, E; Urschel, HC; Vocci, F, 2009) |
| "Modafinil (CRL 40476) is a vigilance-promoting, putative central alpha 1-adrenergic agonist with a pharmacological profile quite different from that of amphetamine." | 2.67 | Treatment of the alcoholic organic brain syndrome: double-blind, placebo-controlled clinical, psychometric and electroencephalographic mapping studies with modafinil. ( Anderer, P; Frey, R; Grünberger, J; Mader, R; Saletu, B; Saletu, M, 1993) |
| "Modafinil- and placebo-treated patients improved continously over the 6-week period." | 2.67 | On the treatment of the alcoholic organic brain syndrome with an alpha-adrenergic agonist modafinil: double-blind, placebo-controlled clinical, psychometric and neurophysiological studies. ( Frey, R; Grünberger, J; Mader, R; Saletu, B; Saletu, M; Zatschek, I, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Haney, M | 1 |
| Rubin, E | 1 |
| Denson, RK | 1 |
| Foltin, RW | 1 |
| Minzenberg, MJ | 1 |
| Joos, L | 5 |
| Goudriaan, AE | 5 |
| Schmaal, L | 5 |
| van den Brink, W | 5 |
| Sabbe, BG | 2 |
| Dom, G | 4 |
| Pattij, T | 1 |
| Veltman, DJ | 3 |
| Kampman, KM | 1 |
| Lynch, KG | 1 |
| Pettinati, HM | 1 |
| Spratt, K | 1 |
| Wierzbicki, MR | 1 |
| Dackis, C | 2 |
| O'Brien, CP | 1 |
| Anderson, AL | 1 |
| Reid, MS | 1 |
| Li, SH | 1 |
| Holmes, T | 1 |
| Shemanski, L | 1 |
| Slee, A | 1 |
| Smith, EV | 1 |
| Kahn, R | 1 |
| Chiang, N | 1 |
| Vocci, F | 1 |
| Ciraulo, D | 1 |
| Roache, JD | 1 |
| Salloum, IM | 1 |
| Somoza, E | 1 |
| Urschel, HC | 1 |
| Elkashef, AM | 1 |
| Koeleman, M | 1 |
| Fransen, E | 1 |
| Chamberlain, SR | 1 |
| Krüse, AM | 1 |
| Saletu, B | 2 |
| Saletu, M | 2 |
| Grünberger, J | 2 |
| Frey, R | 2 |
| Anderer, P | 1 |
| Mader, R | 2 |
| Zatschek, I | 1 |
9 trials available for modafinil and Alcohol Abuse
| Article | Year |
|---|---|
Effect of modafinil on cognitive functions in alcohol dependent patients: a randomized, placebo-controlled trial.
Topics: Adolescent; Adult; Alcoholism; Attention; Benzhydryl Compounds; Cognition; Cognition Disorders; Doub | 2013 |
Neural substrates of impulsive decision making modulated by modafinil in alcohol-dependent patients.
Topics: Adult; Alcoholism; Benzhydryl Compounds; Cerebral Cortex; Cross-Over Studies; Delay Discounting; Dou | 2014 |
A double blind, placebo controlled trial of modafinil for the treatment of cocaine dependence without co-morbid alcohol dependence.
Topics: Adolescent; Adult; Alcoholism; Benzhydryl Compounds; Cocaine; Cocaine-Related Disorders; Cognitive B | 2015 |
Modafinil for the treatment of cocaine dependence.
Topics: Adult; Alcoholism; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine-Related Disorder | 2009 |
Effects of modafinil on neural correlates of response inhibition in alcohol-dependent patients.
Topics: Adult; Alcoholism; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Cross-Over Studie | 2013 |
Effect of modafinil on impulsivity and relapse in alcohol dependent patients: a randomized, placebo-controlled trial.
Topics: Adult; Alcoholism; Benzhydryl Compounds; Central Nervous System Stimulants; Diagnostic and Statistic | 2013 |
Modafinil modulates resting-state functional network connectivity and cognitive control in alcohol-dependent patients.
Topics: Adult; Alcoholism; Benzhydryl Compounds; Cerebral Cortex; Cognition; Double-Blind Method; Functional | 2013 |
Treatment of the alcoholic organic brain syndrome: double-blind, placebo-controlled clinical, psychometric and electroencephalographic mapping studies with modafinil.
Topics: Adult; Alcoholism; Analysis of Variance; Benzhydryl Compounds; Brain; Brain Mapping; Central Nervous | 1993 |
On the treatment of the alcoholic organic brain syndrome with an alpha-adrenergic agonist modafinil: double-blind, placebo-controlled clinical, psychometric and neurophysiological studies.
Topics: Adrenergic alpha-Agonists; Adult; Alcoholism; Attention; Benzhydryl Compounds; Blood Pressure; Centr | 1990 |
3 other studies available for modafinil and Alcohol Abuse
| Article | Year |
|---|---|
Modafinil reduces smoked cocaine self-administration in humans: effects vary as a function of cocaine 'priming' and cost.
Topics: Adult; Alcoholism; Benzhydryl Compounds; Cocaine; Cocaine-Related Disorders; Cues; Double-Blind Meth | 2021 |
Gin and juice: modafinil tightens up the drinker's brain at rest.
Topics: Alcoholism; Benzhydryl Compounds; Cerebral Cortex; Cognition; Humans; Male; Modafinil; Nootropic Age | 2013 |
Modafinil, inhibitory control, and alcoholism.
Topics: Alcoholism; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Humans; Inhibition, Psyc | 2013 |