ro 15-4513 has been researched along with Alcohol Abuse in 18 studies
Ro 15-4513: a partial inverse agonist of benzodiazepine receptors
| Excerpt | Relevance | Reference |
|---|---|---|
| " CIE is validated as a model for human alcohol withdrawal syndrome (AWS) by demonstrating increased level of anxiety; diazepam improved performance in the test." | 3.72 | Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors. ( Cagetti, E; Liang, J; Olsen, RW; Spigelman, I, 2003) |
| "Like acetaldehyde, alcohol has been widely considered a nonspecific drug, despite rather persuasive evidence implicating inhibitory GABA(A) receptors (GABA(A)Rs) in acute alcohol actions, for example, a GABA(A)R ligand, the imidazobenzodiazepine Ro15-4513 antagonizes many low-to-moderate dose alcohol actions in mammals." | 2.44 | Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development? ( Olsen, RW; Wallner, M, 2008) |
| "Intermittent chronic administration of ethanol to rats has been shown previously to produce a hyperexcitable, kindling-like state, accompanied by reduced inhibitory synaptic transmission in the hippocampus and changes in gamma-aminobutyric acid type A (GABAA) receptors." | 1.31 | Altered gabaa receptor subunit and splice variant expression in rats treated with chronic intermittent ethanol. ( Fanselow, M; Olsen, RW; Park, MK; Petrie, J; Sapp, DW; Tyndale, RF, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (16.67) | 18.7374 |
| 1990's | 8 (44.44) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 3 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lingford-Hughes, A | 2 |
| Myers, J | 2 |
| Watson, B | 1 |
| Reid, AG | 2 |
| Kalk, N | 1 |
| Feeney, A | 2 |
| Hammers, A | 2 |
| Riaño-Barros, DA | 1 |
| McGinnity, CJ | 1 |
| Taylor, LG | 2 |
| Rosso, L | 2 |
| Brooks, DJ | 2 |
| Turkheimer, F | 2 |
| Nutt, DJ | 2 |
| Grasby, P | 1 |
| Kontturi, LS | 1 |
| Aalto, AJ | 1 |
| Wallner, M | 2 |
| Uusi-Oukari, M | 3 |
| Cagetti, E | 2 |
| Liang, J | 2 |
| Spigelman, I | 2 |
| Olsen, RW | 4 |
| Mhatre, MC | 2 |
| Ticku, MK | 5 |
| Wu, WJ | 1 |
| Pruett, SB | 1 |
| Morrow, AL | 1 |
| Devaud, LL | 1 |
| Bucci, D | 1 |
| Smith, FD | 1 |
| Mehta, AK | 1 |
| Mäkelä, R | 1 |
| Oja, SS | 1 |
| Alho, H | 1 |
| Anghelescu, I | 1 |
| Klawe, C | 1 |
| Lüddens, H | 1 |
| Korpi, ER | 2 |
| Petrie, J | 1 |
| Sapp, DW | 1 |
| Tyndale, RF | 1 |
| Park, MK | 1 |
| Fanselow, M | 1 |
| Wegelius, K | 1 |
| Casanova, M | 1 |
| Zito, M | 1 |
| Kleinman, JE | 1 |
| Mhatre, M | 1 |
| McBride, WJ | 1 |
| Murphy, JM | 1 |
| Lumeng, L | 1 |
| Li, TK | 1 |
| Gallant, DM | 1 |
3 reviews available for ro 15-4513 and Alcohol Abuse
| Article | Year |
|---|---|
Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development?
Topics: Acetaldehyde; Alcoholism; Animals; Azides; Behavior, Addictive; Benzodiazepines; Binding, Competitiv | 2008 |
Alcohol: effects on GABAA receptor function and gene expression.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Cerebellum; Cerebral Cortex; Ethanol; Gene Expression; | 1993 |
Alcohol and GABA-benzodiazepine receptor function.
Topics: Alcoholism; Animals; Azides; Behavior; Benzodiazepines; Chlorides; Ethanol; Humans; Ion Channels; Re | 1990 |
15 other studies available for ro 15-4513 and Alcohol Abuse
| Article | Year |
|---|---|
Using [(11)C]Ro15 4513 PET to characterise GABA-benzodiazepine receptors in opiate addiction: Similarities and differences with alcoholism.
Topics: Adult; Affinity Labels; Alcoholism; Azides; Benzodiazepines; Brain; Carbon Radioisotopes; Hippocampu | 2016 |
A [11C]Ro15 4513 PET study suggests that alcohol dependence in man is associated with reduced α5 benzodiazepine receptors in limbic regions.
Topics: Adult; Alcoholism; Azides; Benzodiazepines; Carbon Radioisotopes; Case-Control Studies; Ethanol; Hum | 2012 |
The cerebellar GABAAR α6-R100Q polymorphism alters ligand binding in outbred Sprague-Dawley rats in a similar manner as in selectively bred AT and ANT rats.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Binding Sites; Cerebellum; Drug Tolerance; Ethanol; Ge | 2011 |
Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors.
Topics: Affinity Labels; Alcoholism; Allosteric Regulation; Anesthetics; Animals; Anxiety; Azides; Benzodiaz | 2003 |
Altered pharmacology of synaptic and extrasynaptic GABAA receptors on CA1 hippocampal neurons is consistent with subunit changes in a model of alcohol withdrawal and dependence.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Diazepam; Drug Interactions; Ethanol; GABA Agonists; H | 2004 |
Suppression of splenic natural killer cell activity in a mouse model for binge drinking. II. Role of the neuroendocrine system.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alcoholism; Animals; Azides; Benzodiazepi | 1996 |
GABAA and NMDA receptor subunit mRNA expression in ethanol dependent rats.
Topics: Alcoholism; Animals; Azides; Base Sequence; Benzodiazepines; Cerebellum; Cerebral Cortex; Dizocilpin | 1994 |
Prevalence of the GABAA receptor assemblies containing alpha1-subunit in the rat cerebellum and cerebral cortex as determined by immunoprecipitation: lack of modulation by chronic ethanol administration.
Topics: Affinity Labels; Alcoholism; Animals; Azides; Benzodiazepines; Brain Chemistry; Central Nervous Syst | 1999 |
Furosemide action on cerebellar GABA(A) receptors in alcohol-sensitive ANT rats.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Bicuculline; Bridged Bicyclo Compounds, Heterocyclic; | 1999 |
Altered gabaa receptor subunit and splice variant expression in rats treated with chronic intermittent ethanol.
Topics: Alcoholism; Alternative Splicing; Animals; Azides; Benzodiazepines; Cerebellum; Cerebral Cortex; Eth | 2001 |
Cerebellar and frontal cortical benzodiazepine receptors in human alcoholics and chronically alcohol-drinking rats.
Topics: Adult; Alcohol Drinking; Alcoholism; Animals; Azides; Benzodiazepines; Brain; Cerebellum; Diazepam; | 1992 |
Chronic ethanol administration alters gamma-aminobutyric acidA receptor gene expression.
Topics: Affinity Labels; Alcoholism; Animals; Azides; Base Sequence; Benzodiazepines; Binding Sites; Cerebel | 1992 |
Chronic ethanol treatment selectively increases the binding of inverse agonists for benzodiazepine binding sites in cultured spinal cord neurons.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Cells, Cultured; Female; Flumazenil; Flunitrazepam; Ma | 1989 |
Effects of Ro 15-4513, fluoxetine and desipramine on the intake of ethanol, water and food by the alcohol-preferring (P) and -nonpreferring (NP) lines of rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Azides; Benzodiazepines; Desipramine; Drinking Behavior; Feed | 1988 |
A specific antagonist of ethanol: clinical implications.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Ethanol; Rats | 1987 |