Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 42.5603 | 0.0060 | 38.0041 | 19,952.5996 | AID1159521; AID1159523 |
SMAD family member 2 | Homo sapiens (human) | Potency | 54.9410 | 0.1737 | 34.3047 | 61.8120 | AID1346859 |
SMAD family member 3 | Homo sapiens (human) | Potency | 54.9410 | 0.1737 | 34.3047 | 61.8120 | AID1346859 |
GLI family zinc finger 3 | Homo sapiens (human) | Potency | 45.8415 | 0.0007 | 14.5928 | 83.7951 | AID1259392 |
AR protein | Homo sapiens (human) | Potency | 25.9704 | 0.0002 | 21.2231 | 8,912.5098 | AID1259243; AID1259247; AID743035; AID743042; AID743053; AID743054; AID743063 |
estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 4.3277 | 0.0006 | 57.9133 | 22,387.1992 | AID1259378 |
nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 22.1142 | 0.0010 | 22.6508 | 76.6163 | AID1224838; AID1224893 |
progesterone receptor | Homo sapiens (human) | Potency | 3.4376 | 0.0004 | 17.9460 | 75.1148 | AID1346795 |
glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 9.7700 | 0.0002 | 14.3764 | 60.0339 | AID720692 |
retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 36.4471 | 0.0030 | 41.6115 | 22,387.1992 | AID1159552; AID1159555 |
retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 27.9414 | 0.0008 | 17.5051 | 59.3239 | AID1159527; AID1159531 |
estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 4.0402 | 0.0015 | 30.6073 | 15,848.9004 | AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403 |
farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 30.5076 | 0.3758 | 27.4851 | 61.6524 | AID743217; AID743220 |
pregnane X nuclear receptor | Homo sapiens (human) | Potency | 48.5577 | 0.0054 | 28.0263 | 1,258.9301 | AID1346982 |
estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 33.3661 | 0.0002 | 29.3054 | 16,493.5996 | AID743069; AID743075; AID743078; AID743079; AID743080; AID743091 |
peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 20.6831 | 0.0010 | 24.5048 | 61.6448 | AID743212; AID743215 |
peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 4.1901 | 0.0010 | 19.4141 | 70.9645 | AID743094; AID743140; AID743191 |
vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 29.7563 | 0.0237 | 23.2282 | 63.5986 | AID743222; AID743223; AID743241 |
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 68.5896 | 0.0017 | 23.8393 | 78.1014 | AID743083 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 0.9770 | 19.7391 | 45.9784 | 64.9432 | AID1159509 |
thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 6.9190 | 0.0003 | 23.4451 | 159.6830 | AID743065; AID743066; AID743067 |
nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 9.3362 | 0.0006 | 27.2152 | 1,122.0200 | AID743202; AID743219 |
Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 24.3365 | 0.0023 | 19.5956 | 74.0614 | AID651631 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Process | via Protein(s) | Taxonomy |
negative regulation of cell population proliferation | Cellular tumor antigen p53 | Homo sapiens (human) |
regulation of cell cycle | Cellular tumor antigen p53 | Homo sapiens (human) |
regulation of cell cycle G2/M phase transition | Cellular tumor antigen p53 | Homo sapiens (human) |
DNA damage response | Cellular tumor antigen p53 | Homo sapiens (human) |
ER overload response | Cellular tumor antigen p53 | Homo sapiens (human) |
cellular response to glucose starvation | Cellular tumor antigen p53 | Homo sapiens (human) |
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | Cellular tumor antigen p53 | Homo sapiens (human) |
regulation of apoptotic process | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of transcription by RNA polymerase II | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of miRNA transcription | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of transcription by RNA polymerase II | Cellular tumor antigen p53 | Homo sapiens (human) |
mitophagy | Cellular tumor antigen p53 | Homo sapiens (human) |
in utero embryonic development | Cellular tumor antigen p53 | Homo sapiens (human) |
somitogenesis | Cellular tumor antigen p53 | Homo sapiens (human) |
release of cytochrome c from mitochondria | Cellular tumor antigen p53 | Homo sapiens (human) |
hematopoietic progenitor cell differentiation | Cellular tumor antigen p53 | Homo sapiens (human) |
T cell proliferation involved in immune response | Cellular tumor antigen p53 | Homo sapiens (human) |
B cell lineage commitment | Cellular tumor antigen p53 | Homo sapiens (human) |
T cell lineage commitment | Cellular tumor antigen p53 | Homo sapiens (human) |
response to ischemia | Cellular tumor antigen p53 | Homo sapiens (human) |
nucleotide-excision repair | Cellular tumor antigen p53 | Homo sapiens (human) |
double-strand break repair | Cellular tumor antigen p53 | Homo sapiens (human) |
regulation of DNA-templated transcription | Cellular tumor antigen p53 | Homo sapiens (human) |
regulation of transcription by RNA polymerase II | Cellular tumor antigen p53 | Homo sapiens (human) |
protein import into nucleus | Cellular tumor antigen p53 | Homo sapiens (human) |
autophagy | Cellular tumor antigen p53 | Homo sapiens (human) |
DNA damage response | Cellular tumor antigen p53 | Homo sapiens (human) |
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | Cellular tumor antigen p53 | Homo sapiens (human) |
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | Cellular tumor antigen p53 | Homo sapiens (human) |
transforming growth factor beta receptor signaling pathway | Cellular tumor antigen p53 | Homo sapiens (human) |
Ras protein signal transduction | Cellular tumor antigen p53 | Homo sapiens (human) |
gastrulation | Cellular tumor antigen p53 | Homo sapiens (human) |
neuroblast proliferation | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of neuroblast proliferation | Cellular tumor antigen p53 | Homo sapiens (human) |
protein localization | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of DNA replication | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of cell population proliferation | Cellular tumor antigen p53 | Homo sapiens (human) |
determination of adult lifespan | Cellular tumor antigen p53 | Homo sapiens (human) |
mRNA transcription | Cellular tumor antigen p53 | Homo sapiens (human) |
rRNA transcription | Cellular tumor antigen p53 | Homo sapiens (human) |
response to salt stress | Cellular tumor antigen p53 | Homo sapiens (human) |
response to inorganic substance | Cellular tumor antigen p53 | Homo sapiens (human) |
response to X-ray | Cellular tumor antigen p53 | Homo sapiens (human) |
response to gamma radiation | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of gene expression | Cellular tumor antigen p53 | Homo sapiens (human) |
cardiac muscle cell apoptotic process | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of cardiac muscle cell apoptotic process | Cellular tumor antigen p53 | Homo sapiens (human) |
glial cell proliferation | Cellular tumor antigen p53 | Homo sapiens (human) |
viral process | Cellular tumor antigen p53 | Homo sapiens (human) |
glucose catabolic process to lactate via pyruvate | Cellular tumor antigen p53 | Homo sapiens (human) |
cerebellum development | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of cell growth | Cellular tumor antigen p53 | Homo sapiens (human) |
DNA damage response, signal transduction by p53 class mediator | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of transforming growth factor beta receptor signaling pathway | Cellular tumor antigen p53 | Homo sapiens (human) |
mitotic G1 DNA damage checkpoint signaling | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of telomere maintenance via telomerase | Cellular tumor antigen p53 | Homo sapiens (human) |
T cell differentiation in thymus | Cellular tumor antigen p53 | Homo sapiens (human) |
tumor necrosis factor-mediated signaling pathway | Cellular tumor antigen p53 | Homo sapiens (human) |
regulation of tissue remodeling | Cellular tumor antigen p53 | Homo sapiens (human) |
cellular response to UV | Cellular tumor antigen p53 | Homo sapiens (human) |
multicellular organism growth | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of mitochondrial membrane permeability | Cellular tumor antigen p53 | Homo sapiens (human) |
cellular response to glucose starvation | Cellular tumor antigen p53 | Homo sapiens (human) |
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of apoptotic process | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of apoptotic process | Cellular tumor antigen p53 | Homo sapiens (human) |
entrainment of circadian clock by photoperiod | Cellular tumor antigen p53 | Homo sapiens (human) |
mitochondrial DNA repair | Cellular tumor antigen p53 | Homo sapiens (human) |
regulation of DNA damage response, signal transduction by p53 class mediator | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of neuron apoptotic process | Cellular tumor antigen p53 | Homo sapiens (human) |
transcription initiation-coupled chromatin remodeling | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of proteolysis | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of DNA-templated transcription | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of DNA-templated transcription | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of RNA polymerase II transcription preinitiation complex assembly | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of transcription by RNA polymerase II | Cellular tumor antigen p53 | Homo sapiens (human) |
response to antibiotic | Cellular tumor antigen p53 | Homo sapiens (human) |
fibroblast proliferation | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of fibroblast proliferation | Cellular tumor antigen p53 | Homo sapiens (human) |
circadian behavior | Cellular tumor antigen p53 | Homo sapiens (human) |
bone marrow development | Cellular tumor antigen p53 | Homo sapiens (human) |
embryonic organ development | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of peptidyl-tyrosine phosphorylation | Cellular tumor antigen p53 | Homo sapiens (human) |
protein stabilization | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of helicase activity | Cellular tumor antigen p53 | Homo sapiens (human) |
protein tetramerization | Cellular tumor antigen p53 | Homo sapiens (human) |
chromosome organization | Cellular tumor antigen p53 | Homo sapiens (human) |
neuron apoptotic process | Cellular tumor antigen p53 | Homo sapiens (human) |
regulation of cell cycle | Cellular tumor antigen p53 | Homo sapiens (human) |
hematopoietic stem cell differentiation | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of glial cell proliferation | Cellular tumor antigen p53 | Homo sapiens (human) |
type II interferon-mediated signaling pathway | Cellular tumor antigen p53 | Homo sapiens (human) |
cardiac septum morphogenesis | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of programmed necrotic cell death | Cellular tumor antigen p53 | Homo sapiens (human) |
protein-containing complex assembly | Cellular tumor antigen p53 | Homo sapiens (human) |
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | Cellular tumor antigen p53 | Homo sapiens (human) |
thymocyte apoptotic process | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of thymocyte apoptotic process | Cellular tumor antigen p53 | Homo sapiens (human) |
necroptotic process | Cellular tumor antigen p53 | Homo sapiens (human) |
cellular response to hypoxia | Cellular tumor antigen p53 | Homo sapiens (human) |
cellular response to xenobiotic stimulus | Cellular tumor antigen p53 | Homo sapiens (human) |
cellular response to ionizing radiation | Cellular tumor antigen p53 | Homo sapiens (human) |
cellular response to gamma radiation | Cellular tumor antigen p53 | Homo sapiens (human) |
cellular response to UV-C | Cellular tumor antigen p53 | Homo sapiens (human) |
stem cell proliferation | Cellular tumor antigen p53 | Homo sapiens (human) |
signal transduction by p53 class mediator | Cellular tumor antigen p53 | Homo sapiens (human) |
intrinsic apoptotic signaling pathway by p53 class mediator | Cellular tumor antigen p53 | Homo sapiens (human) |
reactive oxygen species metabolic process | Cellular tumor antigen p53 | Homo sapiens (human) |
cellular response to actinomycin D | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of release of cytochrome c from mitochondria | Cellular tumor antigen p53 | Homo sapiens (human) |
cellular senescence | Cellular tumor antigen p53 | Homo sapiens (human) |
replicative senescence | Cellular tumor antigen p53 | Homo sapiens (human) |
oxidative stress-induced premature senescence | Cellular tumor antigen p53 | Homo sapiens (human) |
intrinsic apoptotic signaling pathway | Cellular tumor antigen p53 | Homo sapiens (human) |
oligodendrocyte apoptotic process | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of execution phase of apoptosis | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of mitophagy | Cellular tumor antigen p53 | Homo sapiens (human) |
regulation of mitochondrial membrane permeability involved in apoptotic process | Cellular tumor antigen p53 | Homo sapiens (human) |
regulation of intrinsic apoptotic signaling pathway by p53 class mediator | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of miRNA transcription | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of G1 to G0 transition | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of miRNA processing | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of glucose catabolic process to lactate via pyruvate | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of pentose-phosphate shunt | Cellular tumor antigen p53 | Homo sapiens (human) |
intrinsic apoptotic signaling pathway in response to hypoxia | Cellular tumor antigen p53 | Homo sapiens (human) |
regulation of fibroblast apoptotic process | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of reactive oxygen species metabolic process | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of reactive oxygen species metabolic process | Cellular tumor antigen p53 | Homo sapiens (human) |
negative regulation of stem cell proliferation | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of cellular senescence | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of intrinsic apoptotic signaling pathway | Cellular tumor antigen p53 | Homo sapiens (human) |
positive regulation of acute inflammatory response to antigenic stimulus | Cannabinoid receptor 1 | Homo sapiens (human) |
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | Cannabinoid receptor 1 | Homo sapiens (human) |
adenylate cyclase-modulating G protein-coupled receptor signaling pathway | Cannabinoid receptor 1 | Homo sapiens (human) |
spermatogenesis | Cannabinoid receptor 1 | Homo sapiens (human) |
axonal fasciculation | Cannabinoid receptor 1 | Homo sapiens (human) |
response to nutrient | Cannabinoid receptor 1 | Homo sapiens (human) |
memory | Cannabinoid receptor 1 | Homo sapiens (human) |
positive regulation of neuron projection development | Cannabinoid receptor 1 | Homo sapiens (human) |
negative regulation of serotonin secretion | Cannabinoid receptor 1 | Homo sapiens (human) |
positive regulation of fever generation | Cannabinoid receptor 1 | Homo sapiens (human) |
negative regulation of fatty acid beta-oxidation | Cannabinoid receptor 1 | Homo sapiens (human) |
regulation of synaptic transmission, GABAergic | Cannabinoid receptor 1 | Homo sapiens (human) |
response to lipopolysaccharide | Cannabinoid receptor 1 | Homo sapiens (human) |
negative regulation of mast cell activation | Cannabinoid receptor 1 | Homo sapiens (human) |
negative regulation of dopamine secretion | Cannabinoid receptor 1 | Homo sapiens (human) |
response to nicotine | Cannabinoid receptor 1 | Homo sapiens (human) |
cannabinoid signaling pathway | Cannabinoid receptor 1 | Homo sapiens (human) |
response to cocaine | Cannabinoid receptor 1 | Homo sapiens (human) |
glucose homeostasis | Cannabinoid receptor 1 | Homo sapiens (human) |
positive regulation of apoptotic process | Cannabinoid receptor 1 | Homo sapiens (human) |
response to ethanol | Cannabinoid receptor 1 | Homo sapiens (human) |
negative regulation of action potential | Cannabinoid receptor 1 | Homo sapiens (human) |
negative regulation of blood pressure | Cannabinoid receptor 1 | Homo sapiens (human) |
positive regulation of blood pressure | Cannabinoid receptor 1 | Homo sapiens (human) |
regulation of insulin secretion | Cannabinoid receptor 1 | Homo sapiens (human) |
regulation of synaptic transmission, glutamatergic | Cannabinoid receptor 1 | Homo sapiens (human) |
maternal process involved in female pregnancy | Cannabinoid receptor 1 | Homo sapiens (human) |
regulation of feeding behavior | Cannabinoid receptor 1 | Homo sapiens (human) |
regulation of penile erection | Cannabinoid receptor 1 | Homo sapiens (human) |
retrograde trans-synaptic signaling by endocannabinoid | Cannabinoid receptor 1 | Homo sapiens (human) |
regulation of presynaptic cytosolic calcium ion concentration | Cannabinoid receptor 1 | Homo sapiens (human) |
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission | Cannabinoid receptor 1 | Homo sapiens (human) |
adenylate cyclase-activating G protein-coupled receptor signaling pathway | Cannabinoid receptor 1 | Homo sapiens (human) |
regulation of metabolic process | Cannabinoid receptor 1 | Homo sapiens (human) |
response to amphetamine | Cannabinoid receptor 2 | Homo sapiens (human) |
inflammatory response | Cannabinoid receptor 2 | Homo sapiens (human) |
immune response | Cannabinoid receptor 2 | Homo sapiens (human) |
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | Cannabinoid receptor 2 | Homo sapiens (human) |
leukocyte chemotaxis | Cannabinoid receptor 2 | Homo sapiens (human) |
negative regulation of synaptic transmission, GABAergic | Cannabinoid receptor 2 | Homo sapiens (human) |
response to lipopolysaccharide | Cannabinoid receptor 2 | Homo sapiens (human) |
negative regulation of mast cell activation | Cannabinoid receptor 2 | Homo sapiens (human) |
cannabinoid signaling pathway | Cannabinoid receptor 2 | Homo sapiens (human) |
negative regulation of action potential | Cannabinoid receptor 2 | Homo sapiens (human) |
regulation of metabolic process | Cannabinoid receptor 2 | Homo sapiens (human) |
adenylate cyclase-activating G protein-coupled receptor signaling pathway | Cannabinoid receptor 2 | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |