lactic acid and Alcohol Abuse studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

Excerpt	Relevance	Reference
"Lactic acidosis is common in critical care; by contrast, a subtype called alcohol-associated lactic acidosis (AALA) is rarely encountered."	7.83	Prognosis of alcohol-associated lactic acidosis in critically ill patients: an 8-year study. ( Chan, KS; Tseng, KL; Weng, SF; Yang, CC, 2016)
" Initial investigations demonstrated a severe lactic acidosis."	7.72	Severe lactic acidosis following alcohol related generalised seizures. ( Hulme, J; Sherwood, N, 2004)
"Lactic acidosis is common in critical care; by contrast, a subtype called alcohol-associated lactic acidosis (AALA) is rarely encountered."	3.83	Prognosis of alcohol-associated lactic acidosis in critically ill patients: an 8-year study. ( Chan, KS; Tseng, KL; Weng, SF; Yang, CC, 2016)
" Initial investigations demonstrated a severe lactic acidosis."	3.72	Severe lactic acidosis following alcohol related generalised seizures. ( Hulme, J; Sherwood, N, 2004)
" The authors present three patients with alcoholism in whom diagnosis of panic was facilitated by intravenous lactate infusion, and whose symptoms were alleviated by clonazepam."	3.68	The diagnosis and treatment of panic disorder in alcoholics: three cases. ( Baron, DH; Ciraulo, DA; Sands, BF; Shader, RI, 1990)
"Alcohol dependence is a common disorder associated with significant morbidity and mortality."	2.71	Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial. ( Ehrich, EW; Garbutt, JC; Gastfriend, DR; Kranzler, HR; Loewy, JW; O'Malley, SS; Pettinati, HM; Silverman, BL, 2005)
"Alcoholic ketoacidosis (AKA) is a complex syndrome that results from disrupted metabolism in the setting of excessive alcohol use and poor oral intake."	1.43	A Patient With Alcoholic Ketoacidosis and Profound Lactemia. ( Gerrity, RS; Katz, KD; King, AM; Menke, NB; Pizon, AF, 2016)
"Diabetes and alcohol abuse may cause severe metabolic disturbances that can be fatal."	1.39	Assessment of Traub formula and ketone bodies in cause of death investigations. ( Keltanen, T; Lindroos, K; Palo, JU; Partanen, T; Sajantila, A; Valonen, T, 2013)
"Alcohol ketoacidosis is a frequently missed diagnosis, but is well described in the literature."	1.39	Ketoacidosis and trace amounts of isopropanol in a chronic alcoholic patient. ( Dwyer, JB; Tamama, K, 2013)
"Diabetic ketoacidosis (DKA) and alcoholic ketoacidosis (AKA) are two medical emergencies characterized by elevated total ketone body concentration."	1.31	Differences in metabolic and hormonal milieu in diabetic- and alcohol-induced ketoacidosis. ( Bhoola, SM; DiGirolamo, M; Isaacs, SD; Kokko, JP; Tuvlin, JA; Umpierrez, GE, 2000)
" Male Sprague-Dawley rats were rendered physically dependent on ethanol by intragastric administration of ethanol at a dosage of 9 to 15 grams per kilogram per day over a 4-day period."	1.27	Suppression of an ethanol withdrawal syndrome in rats by butyrate, lactate and beta-hydroxybutyrate. ( Derr, M; Derr, RF; Draves, K, 1983)
"Metabolic acidosis is due to lactic acidosis, ketoacidosis and acetic acidosis but the degree of each varies from patient to patient."	1.27	Metabolic acidosis in the alcoholic: a pathophysiologic approach. ( Halperin, ML; Hammeke, M; Josse, RG; Jungas, RL, 1983)

Research

Studies (35)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Number of Participants Reporting at Least 1 Treatment-emergent Adverse Event (TEAE)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (34.29)	18.7374
1990's	5 (14.29)	18.2507
2000's	8 (22.86)	29.6817
2010's	9 (25.71)	24.3611
2020's	1 (2.86)	2.80

Authors	Studies
Yoshida, H	1
Harada, K	1
Sakamoto, Y	1
Yoshimura, J	1
Shimazu, T	1
Matsumoto, H	1
Kettritz, R	1
Ritter, T	1
Rudolph, B	1
Luft, FC	1
Jiawan, A	1
Tandjung, K	1
Pagar, KP	1
Vavia, PR	1
Keltanen, T	1
Sajantila, A	1
Palo, JU	1
Partanen, T	1
Valonen, T	1
Lindroos, K	1
Gerrity, RS	1
Pizon, AF	1
King, AM	1
Katz, KD	1
Menke, NB	1
Yang, CC	1
Chan, KS	1
Tseng, KL	1
Weng, SF	1
Akala, EO	1
Wiriyacoonkasem, P	1
Pan, G	1
Maturu, P	1
Varadacharyulu, N	1
Dwyer, JB	1
Tamama, K	1
LINDE, S	1
Hulme, J	1
Sherwood, N	1
Lang, W	1
Garbutt, JC	1
Kranzler, HR	1
O'Malley, SS	1
Gastfriend, DR	1
Pettinati, HM	1
Silverman, BL	1
Loewy, JW	1
Ehrich, EW	1
Siegel, S	1
Pavlic, M	1
Libiseller, K	1
Hermann, M	1
Hengster, P	1
Margreiter, R	1
Wurm, M	1
Coiro, V	1
Casti, A	1
Jotti, GS	1
Rubino, P	1
Manfredi, G	1
Maffei, ML	1
Melani, A	1
Volta, E	1
Chiodera, P	1
Lieber, CS	2
Nuutinen, HU	1
Salaspuro, MP	1
Valle, M	1
Lindros, KO	1
Hoberg, B	1
Delank, HW	1
Derr, RF	1
Draves, K	1
Derr, M	1
Baraona, E	1
Jauhonen, P	1
Miyakawa, H	1
Halperin, ML	1
Hammeke, M	1
Josse, RG	1
Jungas, RL	1
Palmer, KR	1
Jenkins, WJ	1
McDonough, KH	1
Causey, KM	1
Wassif, WS	1
Sherman, D	1
Salisbury, JR	1
Peters, TJ	1
George, DT	3
Lindquist, T	1
Ragan, PW	2
Alim, T	1
Eckardt, MJ	1
Linnoila, M	2
Hibbeln, JR	1
Umhau, JC	1
Phillips, MJ	1
Doty, L	1
Hommer, D	1
Rawlings, RR	1
Umpierrez, GE	1
DiGirolamo, M	1
Tuvlin, JA	1
Isaacs, SD	1
Bhoola, SM	1
Kokko, JP	1
Johnson, RD	1
Bahnisch, J	1
Stewart, B	1
Shearman, DJ	1
Edwards, JB	1
Baron, DH	1
Sands, BF	1
Ciraulo, DA	1
Shader, RI	1
Nutt, DJ	1
Waxman, RP	1
Cowley, DS	1
Jensen, CF	1
Johannessen, D	1
Parker, L	1
Dager, SR	1
Walker, RD	1
Nuzhnyĭ, VP	1
Tezikov, EB	1
Savitskaia, EV	1
Ugriumov, AI	1
Teschke, R	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Bridging ED to Outpatient AUD Therapy With Naltrexone[NCT05228418]	Phase 4	20 participants (Anticipated)	Interventional	2022-03-31	Not yet recruiting
In Hospital Administration of Extended-Release Naltrexone for Alcohol Use Disorder: A Pilot Study of Feasibility and Acceptability[NCT05087771]	Phase 4	0 participants (Actual)	Interventional	2022-03-31	Withdrawn (stopped due to no longer randomized, drug being offered to all patients)
A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Medisorb® Naltrexone in Alcohol-Dependent Adults[NCT01218958]	Phase 3	624 participants (Actual)	Interventional	2002-02-28	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

A TEAE is any adverse event, whether or not considered drug-related, that develops or worsens in severity after study drug administration begins (ie, from the first administration through the end of the follow-up period). (NCT01218958)
Timeframe: 24 weeks (Baseline to Week 24)

Percentage of Heavy Drinking Days Over the Treatment Period

Intervention	Participants (Number)
Medisorb Naltrexone 190 mg	190
Medisorb Naltrexone 380 mg	187
Placebo Groups (Pooled)	181

Drinking rates were assessed from participants' self-reports using the validated Timeline Follow-Back (TLFB) method. Using a TLFB calendar, participants reported the number of days they had consumed alcohol along with the amount they consumed on each day. A heavy drinking day was defined as ≥5 drinks/day for men and ≥4 drinks/day for women. (NCT01218958)
Timeframe: Baseline through Week 24 (168 days)

Article	Year
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial. JAMA, 2005, Apr-06, Volume: 293, Issue:13 Topics: Adult; Alcoholism; Double-Blind Method; Drug Carriers; Female; Humans; Injections, Intramuscular; La	2005
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial. JAMA, 2005, Apr-06, Volume: 293, Issue:13 Topics: Adult; Alcoholism; Double-Blind Method; Drug Carriers; Female; Humans; Injections, Intramuscular; La	2005
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial. JAMA, 2005, Apr-06, Volume: 293, Issue:13 Topics: Adult; Alcoholism; Double-Blind Method; Drug Carriers; Female; Humans; Injections, Intramuscular; La	2005
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial. JAMA, 2005, Apr-06, Volume: 293, Issue:13 Topics: Adult; Alcoholism; Double-Blind Method; Drug Carriers; Female; Humans; Injections, Intramuscular; La	2005
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial. JAMA, 2005, Apr-06, Volume: 293, Issue:13 Topics: Adult; Alcoholism; Double-Blind Method; Drug Carriers; Female; Humans; Injections, Intramuscular; La	2005
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial. JAMA, 2005, Apr-06, Volume: 293, Issue:13 Topics: Adult; Alcoholism; Double-Blind Method; Drug Carriers; Female; Humans; Injections, Intramuscular; La	2005
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial. JAMA, 2005, Apr-06, Volume: 293, Issue:13 Topics: Adult; Alcoholism; Double-Blind Method; Drug Carriers; Female; Humans; Injections, Intramuscular; La	2005
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial. JAMA, 2005, Apr-06, Volume: 293, Issue:13 Topics: Adult; Alcoholism; Double-Blind Method; Drug Carriers; Female; Humans; Injections, Intramuscular; La	2005
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial. JAMA, 2005, Apr-06, Volume: 293, Issue:13 Topics: Adult; Alcoholism; Double-Blind Method; Drug Carriers; Female; Humans; Injections, Intramuscular; La	2005
Use of dynamic tests of muscle function and histomorphometry of quadriceps muscle biopsies in the investigation of patients with chronic alcohol misuse and chronic fatigue syndrome. Annals of clinical biochemistry, 1994, Volume: 31 ( Pt 5) Topics: Adult; Alcoholism; Ammonia; AMP Deaminase; Analysis of Variance; Biopsy, Needle; Creatine Kinase; Di	1994
Effect of alcoholism on the incidence of lactate-induced panic attacks. Biological psychiatry, 1997, Dec-01, Volume: 42, Issue:11 Topics: Adult; Alcoholism; Female; Hemodynamics; Hormones; Humans; Lactic Acid; Male; Panic Disorder; Psychi	1997
Lactate-induced rage and panic in a select group of subjects who perpetrate acts of domestic violence. Biological psychiatry, 2000, May-01, Volume: 47, Issue:9 Topics: Adult; Alcoholism; Blood Pressure; Domestic Violence; Double-Blind Method; Female; Heart Rate; Human	2000

Article	Year
Comparison of Quantitative Values of Headspace Gas Chromatography--Mass Spectrometry and a Formate Quantification Kit in Blood Formate Quantification. Journal of analytical toxicology, 2023, Apr-14, Volume: 47, Issue:4 Topics: Alcoholism; Formates; Gas Chromatography-Mass Spectrometry; Humans; Lactic Acid; Methanol	2023
The Case \| Acid-base diagnoses in the 21st century. Kidney international, 2017, Volume: 92, Issue:5 Topics: Acidosis; Acute Kidney Injury; Alcoholic Intoxication; Alcoholism; Antidotes; Creatinine; Ethylene G	2017
New-Onset Heart Failure. JAMA cardiology, 2019, 06-01, Volume: 4, Issue:6 Topics: Acidosis; Adult; Alcoholism; Beriberi; Dyspnea; Echocardiography; Edema; Electrocardiography; Heart	2019
Naltrexone-loaded poly[La-(Glc-Leu)] polymeric microspheres for the treatment of alcohol dependence: in vitro characterization and in vivo biocompatibility assessment. Pharmaceutical development and technology, 2014, Volume: 19, Issue:4 Topics: Alcoholism; Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Drug Del	2014
Assessment of Traub formula and ketone bodies in cause of death investigations. International journal of legal medicine, 2013, Volume: 127, Issue:6 Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Alcoholism; Algorithms; Autopsy; Biomarkers; Blood Gl	2013
A Patient With Alcoholic Ketoacidosis and Profound Lactemia. The Journal of emergency medicine, 2016, Volume: 51, Issue:4 Topics: Acid-Base Equilibrium; Alcoholism; Fluid Therapy; Glucose; Humans; Hyperlactatemia; Ketosis; Lactic	2016
Prognosis of alcohol-associated lactic acidosis in critically ill patients: an 8-year study. Scientific reports, 2016, 10-17, Volume: 6 Topics: Acidosis, Lactic; Adult; Aged; Alcoholism; Critical Care; Critical Illness; Female; Hospital Mortali	2016
Studies on in vitro availability, degradation, and thermal properties of naltrexone-loaded biodegradable microspheres. Drug development and industrial pharmacy, 2011, Volume: 37, Issue:6 Topics: Alcoholism; Chromatography, Gel; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems;	2011
Adaptive changes in fatty acid profile of erythrocyte membrane in relation to plasma and red cell metabolic changes in chronic alcoholic men. Human & experimental toxicology, 2012, Volume: 31, Issue:7 Topics: Adult; Alcoholism; Amino Acids; Blood Glucose; Case-Control Studies; Erythrocyte Membrane; Erythrocy	2012
Ketoacidosis and trace amounts of isopropanol in a chronic alcoholic patient. Clinica chimica acta; international journal of clinical chemistry, 2013, Jan-16, Volume: 415 Topics: 2-Propanol; 3-Hydroxybutyric Acid; Acetone; Adult; Alcoholism; Blood Glucose; Chronic Disease; Human	2013
[Enzymatic activity (glutamic oxalacetic transaminase, glutamic pyruvic transaminase & lactic acid dehydrogenase, in alcoholism]. Svenska lakartidningen, 1959, Jan-02, Volume: 56, Issue:1 Topics: Alanine Transaminase; Alcoholic Intoxication; Alcoholism; L-Lactate Dehydrogenase; Lactic Acid; Oxid	1959
Severe lactic acidosis following alcohol related generalised seizures. Anaesthesia, 2004, Volume: 59, Issue:12 Topics: Acidosis, Lactic; Alcoholism; Epilepsy, Tonic-Clonic; Humans; Lactic Acid; Male; Middle Aged	2004
A response to 'Severe lactic acidosis following alcohol related generalised seizures'. Anaesthesia, 2005, Volume: 60, Issue:3 Topics: Acidosis, Lactic; Alcoholism; Epilepsy, Tonic-Clonic; Humans; Lactic Acid	2005
Extended-release intramuscular naltrexone: a viewpoint by Steven Siegel. Drugs, 2006, Volume: 66, Issue:13 Topics: Alcoholism; Delayed-Action Preparations; Humans; Injections, Intramuscular; Lactic Acid; Microsphere	2006
Small human hepatocytes in rotary culture for treatment of alcohol addicts? A pilot study. Alcoholism, clinical and experimental research, 2007, Volume: 31, Issue:5 Topics: Alcoholism; Cell Count; Cell Culture Techniques; Cell Line; Culture Media; Cytochrome P-450 Enzyme S	2007
Adrenocorticotropic hormone/cortisol response to physical exercise in abstinent alcoholic patients. Alcoholism, clinical and experimental research, 2007, Volume: 31, Issue:5 Topics: Adrenocorticotropic Hormone; Adult; Alcoholism; Blood Glucose; Carbon Dioxide; Exercise; Fatty Acids	2007
Alcohol and the liver. Recent developments in preclinical and clinical research. Overview. Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism, 1984, Volume: 2 Topics: Adenosine Triphosphatases; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Alcoholism; Animals; Etha	1984
Blood acetaldehyde concentration gradient between hepatic and antecubital venous blood in ethanol-intoxicated alcoholics and controls. European journal of clinical investigation, 1984, Volume: 14, Issue:4 Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Alcoholism; Ethanol; Humans; Kinetics; Lactates; Lactic	1984
[Cerebrospinal fluid findings in brain atrophies detected by computer tomography]. Der Nervenarzt, 1984, Volume: 55, Issue:6 Topics: Alcoholism; Atrophy; Brain; Brain Damage, Chronic; Brain Ischemia; Cerebrospinal Fluid Proteins; Enc	1984
Suppression of an ethanol withdrawal syndrome in rats by butyrate, lactate and beta-hydroxybutyrate. Life sciences, 1983, May-30, Volume: 32, Issue:22 Topics: 3-Hydroxybutyric Acid; Alcoholism; Animals; Butyrates; Butyric Acid; Citric Acid Cycle; Humans; Hydr	1983
Zonal redox changes as a cause of selective perivenular hepatotoxicity of alcohol. Pharmacology, biochemistry, and behavior, 1983, Volume: 18 Suppl 1 Topics: Alcoholism; Animals; Ethanol; Fatty Liver, Alcoholic; Hepatic Veins; Humans; Lactates; Lactic Acid;	1983
Metabolic acidosis in the alcoholic: a pathophysiologic approach. Metabolism: clinical and experimental, 1983, Volume: 32, Issue:3 Topics: Acetates; Acid-Base Equilibrium; Acidosis; Adenosine Triphosphate; Alcoholism; Ethanol; Glucose; Hum	1983
Impaired acetaldehyde oxidation in alcoholics. Gut, 1982, Volume: 23, Issue:9 Topics: Acetaldehyde; Adult; Alcoholism; Aldehyde Oxidoreductases; Ethanol; Humans; Lactates; Lactic Acid; L	1982
Effects of sepsis on recovery of the heart from 50 min ischemia. Shock (Augusta, Ga.), 1994, Volume: 1, Issue:6 Topics: Adenosine Triphosphate; Alcoholism; Animals; Catalase; Escherichia coli; Lactates; Lactic Acid; Male	1994
Differences in metabolic and hormonal milieu in diabetic- and alcohol-induced ketoacidosis. Journal of critical care, 2000, Volume: 15, Issue:2 Topics: Adult; Alcoholism; Blood Glucose; Diabetic Ketoacidosis; Diagnosis, Differential; Epinephrine; Femal	2000
Optimized spectrophotometric determination of aldehyde dehydrogenase activity in erythrocytes. Clinical chemistry, 1992, Volume: 38, Issue:4 Topics: Acetaldehyde; Alcoholism; Aldehyde Dehydrogenase; Aldehydes; Drug Stability; Erythrocytes; Humans; K	1992
The diagnosis and treatment of panic disorder in alcoholics: three cases. The American journal of drug and alcohol abuse, 1990, Volume: 16, Issue:3-4 Topics: Adult; Alcohol Drinking; Alcoholism; Anxiety Disorders; Clonazepam; Diazepam; Follow-Up Studies; Hum	1990
Panic response to lactate administration in alcoholic and nonalcoholic patients with panic disorder. The American journal of psychiatry, 1989, Volume: 146, Issue:9 Topics: Adult; Alcoholism; Anxiety Disorders; Blood Glucose; Blood Pressure; Calcium; Chlorides; Fear; Femal	1989
Response to sodium lactate infusion in alcoholics with panic attacks. The American journal of psychiatry, 1989, Volume: 146, Issue:11 Topics: Adult; Alcoholism; Anxiety Disorders; Fear; Heart Rate; Humans; Lactates; Lactic Acid; Male; Middle	1989
[Contractile function, glucose consumption and lactate release by the isolated rat heart during different regimens of alcohol administration and after discontinuation of ethanol]. Biulleten' eksperimental'noi biologii i meditsiny, 1986, Volume: 101, Issue:5 Topics: Alcoholic Intoxication; Alcoholism; Animals; Ethanol; Glucose; Glycogen; Lactates; Lactic Acid; Myoc	1986
[Alcohol and metabolism]. Der Internist, 1985, Volume: 26, Issue:7 Topics: Acetaldehyde; Alcohol Drinking; Alcoholism; Amino Acids; Blood Glucose; Cholesterol; Energy Metaboli	1985

Intervention	Percentage of days (Median)
Medisorb Naltrexone 190 mg	14.75
Medisorb Naltrexone 380 mg	10.23
Placebo Groups (Pooled)	19.77

lactic acid and Alcohol Abuse