Page last updated: 2024-12-04

tartronic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Tartronic acid, also known as hydroxymalonic acid, is a dicarboxylic acid with the formula HOOCCH(OH)COOH. It is a white, crystalline solid that is soluble in water. Tartronic acid is found in some fruits and vegetables, and it is also a product of the metabolism of tartaric acid. It is an important intermediate in the biosynthesis of several natural products, including the antibiotic penicillin. Tartronic acid is also a potential precursor to other important chemicals, such as malic acid and oxaloacetic acid. Research on tartronic acid is ongoing, with interest in its potential applications in various fields such as pharmaceuticals, food, and biofuels. Tartronic acid is also being studied for its potential therapeutic effects, such as its ability to inhibit the growth of cancer cells and its potential use in the treatment of diabetes. '

hydroxymalonic acid : A dicarboxylic acid that is malonic acid substituted by a hydroxy group at position 2. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID45
CHEMBL ID1794676
CHEBI ID16513
SCHEMBL ID15060
MeSH IDM0102531

Synonyms (48)

Synonym
AKOS001115605
c3h4o5
CHEBI:16513 ,
hydroxypropanedioic acid
propanedioic acid, hydroxy-
nsc36171
nsc-36171
2-hydroxypropanedioic acid
malonic acid, hydroxy-
2-hydroxymalonate
2-hydroxymalonic acid
80-69-3
2-tartronic acid
tartronic acid
C02287
hydroxymalonic acid
F3F5D7E2-8FF8-4206-8F30-077B0F85979B
unii-34t0025e0l
34t0025e0l ,
einecs 201-301-1
nsc 36171
FT-0600419
.alpha.-hydroxymalonic acid
tartronic acid [mi]
tartronicacid
SCHEMBL15060
ROBFUDYVXSDBQM-UHFFFAOYSA-N
CHEMBL1794676 ,
DTXSID6075358
4M6U
bdbm50038354
J-524313
tartronic acid, >=97.0%
mfcd00004237
hydroxy-malonic acid
propanedioic acid, hydroxy- (9ci)
tartronic acid, 8ci
triadimenol metabolite p06
Q425473
AS-14777
AMY6179
hydroxymalonic'acid
H10518
hydroxymalonsa currencyure
2-hydroxymalonicacid
CS-W013581
EN300-18772
Z90123595
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
dicarboxylic acidAny carboxylic acid containing two carboxy groups.
dicarboxylic fatty acid
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (2)

PathwayProteinsCompounds
Secondary Metabolites: Glyoxylate Cycle715
L-serine biosynthesis II317

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1174256Inhibition of mouse serine racemase using L-serine substrate by reversed-phase HPLC analysis2015European journal of medicinal chemistry, Jan-07, Volume: 89Malonate-based inhibitors of mammalian serine racemase: kinetic characterization and structure-based computational study.
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB2014Biochemistry, Feb-25, Volume: 53, Issue:7
Potent inhibition of mandelate racemase by a fluorinated substrate-product analogue with a novel binding mode.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (36)

TimeframeStudies, This Drug (%)All Drugs %
pre-199015 (41.67)18.7374
1990's8 (22.22)18.2507
2000's4 (11.11)29.6817
2010's8 (22.22)24.3611
2020's1 (2.78)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 36.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index36.47 (24.57)
Research Supply Index3.61 (2.92)
Research Growth Index4.47 (4.65)
Search Engine Demand Index48.73 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (36.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other36 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]