saccharin has been researched along with Alcohol Abuse in 36 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Additional experiments assessed the influence of (i) adulteration with quinine of the alcohol solution (Experiment 2) and (ii) concurrent presentation of a saccharin solution (Experiment 3) on alcohol drinking under the CA10% and IA20% conditions." | 3.76 | Increase in alcohol intake, reduced flexibility of alcohol drinking, and evidence of signs of alcohol intoxication in Sardinian alcohol-preferring rats exposed to intermittent access to 20% alcohol. ( Carai, MA; Colombo, G; Fantini, N; Gessa, GL; Lobina, C; Loi, B; Maccioni, P, 2010) |
| "Although the serotonin (5-HT)1A receptor agonist ipsapirone reduces ethanol intake in a variety of animal models of alcoholism, such effects have only been reported in models based on nonoperant behavior (e." | 3.70 | Effects of the 5-HT1A receptor agonist ipsapirone on operant self-administration of ethanol in the rat. ( De Vry, J; Haussels, A; Manze, B; Schreiber, R, 1999) |
| "saccharin and sucrose) and drug abuse has been reported in both the human and other animal literature." | 2.44 | Selective breeding for differential saccharin intake as an animal model of drug abuse. ( Anker, JJ; Carroll, ME; Dess, NK; Morgan, AD; Perry, JL, 2008) |
| "Here we determine the effects of alcohol dependence on the choice between alcohol and a non-drug reward, saccharin, using the discrete choice model in food-restricted male rats." | 1.48 | Effects of alcohol dependence on discrete choice between alcohol and saccharin. ( Coen, K; Funk, D; Lê, AD; Loughlin, A; Russo, M, 2018) |
| "Comorbid chronic stress and alcohol dependence may lead to a complicated and potentially severe treatment profile." | 1.39 | Increased anxiety, voluntary alcohol consumption and ethanol-induced place preference in mice following chronic psychosocial stress. ( Bahi, A, 2013) |
| "Epidemiological studies suggest that alcohol abuse during the adolescent developmental period may result in long-term changes such as an increased susceptibility to alcohol-related problems in adulthood." | 1.34 | The effects of continuous and intermittent ethanol exposure in adolesence on the aversive properties of ethanol during adulthood. ( Diaz-Granados, JL; Graham, DL, 2007) |
| "It has been hypothesized that alcohol addiction is mediated, at least in part, by specific gamma-aminobutyric acid(A) (GABA(A)) receptors within the ventral pallidum (VP)." | 1.32 | The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum. ( Carroll, MR; Cook, JM; Cummings, R; Eiler, WJ; Foster, KL; Garcia, M; Grey, C; Harvey, SC; Jones, CM; June, HL; Ma, C; Mason, D; McCane, S; McKay, PF; Sarma, PV; Seyoum, R; Skolnick, P; Woods, JE; Yin, W, 2003) |
| " In this study, we subjected these rats to several long-term administration protocols suggested to favour the development of alcohol dependence, including multiple alcohol concentrations or sweetened alcohol solutions (ethanol 10% or 20%+saccharin), and deprivation periods." | 1.32 | The High-Ethanol Preferring rat as a model to study the shift between alcohol abuse and dependence. ( Jones, BC; Mormède, P; Terenina-Rigaldie, E, 2004) |
| "The study of alcohol abuse traditionally has placed great emphasis on the development of tolerance and dependence as key factors." | 1.29 | Effects of chronic ethanol exposure on oral self-administration of ethanol or saccharin by Wistar rats. ( Heinrichs, SC; Hyytiä, P; Koob, GF; Schulteis, G, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (22.22) | 18.7374 |
| 1990's | 3 (8.33) | 18.2507 |
| 2000's | 13 (36.11) | 29.6817 |
| 2010's | 7 (19.44) | 24.3611 |
| 2020's | 5 (13.89) | 2.80 |
| Authors | Studies |
|---|---|
| Bauer, MR | 1 |
| Hernández, M | 1 |
| Kasten, CR | 1 |
| Boehm, SL | 1 |
| Chandler, CM | 1 |
| Shaykin, JD | 1 |
| Peng, H | 1 |
| Pauly, JR | 1 |
| Nixon, K | 1 |
| Bardo, MT | 1 |
| Doyle, MR | 1 |
| Dirik, S | 1 |
| Martinez, AR | 1 |
| Hughes, TE | 1 |
| Iyer, MR | 2 |
| Sneddon, EA | 1 |
| Seo, H | 1 |
| Cohen, SM | 1 |
| de Guglielmo, G | 1 |
| Bezerra-Karounis, MA | 1 |
| Krahe, TE | 1 |
| Maisonnette, S | 1 |
| Landeira-Fernandez, J | 1 |
| Ezquer, F | 1 |
| Quintanilla, ME | 3 |
| Moya-Flores, F | 1 |
| Morales, P | 1 |
| Munita, JM | 1 |
| Olivares, B | 1 |
| Landskron, G | 1 |
| Hermoso, MA | 1 |
| Ezquer, M | 1 |
| Herrera-Marschitz, M | 1 |
| Israel, Y | 1 |
| He, AB | 1 |
| Chang, YC | 1 |
| Meng, AWY | 1 |
| Huang, ACW | 1 |
| Russo, M | 1 |
| Funk, D | 1 |
| Loughlin, A | 1 |
| Coen, K | 1 |
| Lê, AD | 1 |
| Augier, E | 1 |
| Barbier, E | 1 |
| Dulman, RS | 1 |
| Licheri, V | 1 |
| Augier, G | 1 |
| Domi, E | 1 |
| Barchiesi, R | 1 |
| Farris, S | 1 |
| Nätt, D | 1 |
| Mayfield, RD | 1 |
| Adermark, L | 1 |
| Heilig, M | 1 |
| Dess, NK | 2 |
| Madkins, CD | 1 |
| Geary, BA | 1 |
| Chapman, CD | 1 |
| Dyr, W | 2 |
| Wyszogrodzka, E | 1 |
| Paterak, J | 1 |
| Siwińska-Ziółkowska, A | 1 |
| Małkowska, A | 1 |
| Polak, P | 1 |
| Carroll, ME | 1 |
| Morgan, AD | 1 |
| Anker, JJ | 1 |
| Perry, JL | 1 |
| Lyons, AM | 1 |
| Lowery, EG | 1 |
| Sparta, DR | 1 |
| Thiele, TE | 2 |
| Sabino, V | 1 |
| Cottone, P | 1 |
| Zhao, Y | 1 |
| Steardo, L | 2 |
| Rice, KC | 1 |
| Conti, B | 1 |
| Koob, GF | 2 |
| Zorrilla, EP | 1 |
| Tampier, L | 2 |
| Navarro, M | 1 |
| Cubero, I | 1 |
| Ko, L | 1 |
| Loi, B | 1 |
| Lobina, C | 1 |
| Maccioni, P | 1 |
| Fantini, N | 1 |
| Carai, MA | 1 |
| Gessa, GL | 1 |
| Colombo, G | 1 |
| Bahi, A | 1 |
| Ingman, K | 1 |
| Honkanen, A | 1 |
| Hyytiä, P | 2 |
| Huttunen, MO | 1 |
| Korpi, ER | 1 |
| June, HL | 1 |
| Foster, KL | 1 |
| McKay, PF | 1 |
| Seyoum, R | 1 |
| Woods, JE | 1 |
| Harvey, SC | 1 |
| Eiler, WJ | 1 |
| Grey, C | 1 |
| Carroll, MR | 1 |
| McCane, S | 1 |
| Jones, CM | 1 |
| Yin, W | 1 |
| Mason, D | 1 |
| Cummings, R | 1 |
| Garcia, M | 1 |
| Ma, C | 1 |
| Sarma, PV | 1 |
| Cook, JM | 1 |
| Skolnick, P | 1 |
| LESTER, D | 2 |
| GREENBERG, LA | 1 |
| Terenina-Rigaldie, E | 1 |
| Jones, BC | 1 |
| Mormède, P | 1 |
| Diaz-Granados, JL | 1 |
| Graham, DL | 1 |
| Rodd, ZA | 1 |
| Kimpel, MW | 1 |
| Edenberg, HJ | 1 |
| Bell, RL | 1 |
| Strother, WN | 1 |
| McClintick, JN | 1 |
| Carr, LG | 1 |
| Liang, T | 1 |
| McBride, WJ | 1 |
| Perez, E | 1 |
| Le Magnen, J | 2 |
| Marfaing-Jallat, P | 2 |
| Miceli, D | 1 |
| Crawford, D | 1 |
| Baker, TB | 1 |
| Schulteis, G | 1 |
| Heinrichs, SC | 1 |
| Cohen, C | 1 |
| Perrault, G | 1 |
| Sanger, DJ | 1 |
| Schreiber, R | 1 |
| Manze, B | 1 |
| Haussels, A | 1 |
| De Vry, J | 1 |
| Kostowski, W | 1 |
| Rezvani, AH | 1 |
| Parsian, A | 1 |
| Overstreet, DH | 1 |
| Martin, JC | 1 |
| Martin, DC | 1 |
| Radow, B | 1 |
| Sigman, G | 1 |
| Froehlich, JC | 1 |
| Harts, J | 1 |
| Lumeng, L | 1 |
| Li, TK | 1 |
| Freed, EX | 1 |
| Cicero, TJ | 1 |
| Snider, SR | 1 |
| Perez, VJ | 1 |
| Swanson, LW | 1 |
2 reviews available for saccharin and Alcohol Abuse
| Article | Year |
|---|---|
Selective breeding for differential saccharin intake as an animal model of drug abuse.
Topics: Alcoholism; Animals; Arousal; Disease Models, Animal; Female; Genotype; Male; Mice; Mice, Inbred Str | 2008 |
The Fawn-Hooded (FH/Wjd) rat: a genetic animal model of comorbid depression and alcoholism.
Topics: Alcoholism; Animals; Depression; Disease Models, Animal; Maze Learning; Phenotype; Rats; Rats, Inbre | 2002 |
34 other studies available for saccharin and Alcohol Abuse
| Article | Year |
|---|---|
Systemic administration of racemic baclofen reduces both acquisition and maintenance of alcohol consumption in male and female mice.
Topics: Alcohol Drinking; Alcoholism; Animals; Baclofen; Ethanol; Female; GABA-B Receptor Agonists; Male; Mi | 2022 |
Effects of voluntary adolescent intermittent alcohol exposure and social isolation on adult alcohol intake in male rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Ethanol; Male; Rats; Saccharin; Social Isolation; Water | 2022 |
Catechol-O-Methyltransferase inhibition and alcohol use disorder: Evaluating the efficacy of tolcapone in ethanol-dependent rats.
Topics: Alcoholism; Animals; Benzophenones; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhib | 2024 |
Alcohol intake in Carioca High- and Low-conditioned Freezing rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Anxiety Disorders; Conditioning, Psychological; Disease Model | 2020 |
Innate gut microbiota predisposes to high alcohol consumption.
Topics: Alcoholism; Animals; Ethanol; Gastrointestinal Microbiome; Genotype; Male; Rats; Rats, Wistar; Sacch | 2021 |
Re-evaluation of the reward comparison hypothesis for alcohol abuse.
Topics: Alcoholism; Animals; Central Nervous System Depressants; Conditioning, Psychological; Disease Models | 2017 |
Effects of alcohol dependence on discrete choice between alcohol and saccharin.
Topics: Alcoholism; Animals; Central Nervous System Depressants; Choice Behavior; Ethanol; Male; Nicotine; N | 2018 |
A molecular mechanism for choosing alcohol over an alternative reward.
Topics: Alcoholism; Amygdala; Animals; Behavior, Addictive; Choice Behavior; Down-Regulation; Ethanol; GABA | 2018 |
"Jello® shots" and cocktails as ethanol vehicles: parametric studies with high- and low-saccharin-consuming rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Eating; Ethanol; Food Deprivation; Food Pre | 2013 |
Ethanol-induced conditioned taste aversion in Warsaw Alcohol High-Preferring (WHP) and Warsaw Alcohol Low-Preferring (WLP) rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Avoidance Learning; Choice Behavior; Conditioning, Classical; | 2016 |
Effects of food availability and administration of orexigenic and anorectic agents on elevated ethanol drinking associated with drinking in the dark procedures.
Topics: Alcohol Drinking; Alcoholism; Animals; Appetite Depressants; Appetite Stimulants; Darkness; Disease | 2008 |
The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking.
Topics: Alcohol Drinking; Alcoholism; Animals; Brain; Conditioning, Operant; Disease Models, Animal; Ethanol | 2009 |
Effect of concurrent saccharin intake on ethanol consumption by high-alcohol-drinking (UChB) rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Choice Behavior; Drinking; Female; Motivation; Rats; Rats, In | 2009 |
Deletion of agouti-related protein blunts ethanol self-administration and binge-like drinking in mice.
Topics: Agouti-Related Protein; Alcohol Drinking; Alcoholism; Animals; Central Nervous System Depressants; C | 2009 |
Increase in alcohol intake, reduced flexibility of alcohol drinking, and evidence of signs of alcohol intoxication in Sardinian alcohol-preferring rats exposed to intermittent access to 20% alcohol.
Topics: Alcohol Drinking; Alcoholic Intoxication; Alcoholism; Animals; Choice Behavior; Disease Models, Anim | 2010 |
Increased anxiety, voluntary alcohol consumption and ethanol-induced place preference in mice following chronic psychosocial stress.
Topics: Alcohol Drinking; Alcoholism; Animals; Anxiety; Behavior, Addictive; Choice Behavior; Conditioning, | 2013 |
Risperidone reduces limited access alcohol drinking in alcohol-preferring rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Antipsychotic Agents; Disease Models, Animal; Dopamine D2 Rec | 2003 |
The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum.
Topics: Alcoholism; Alcohols; Animals; Body Weight; Carbolines; Conditioning, Operant; Disease Models, Anima | 2003 |
Nutrition and the etiology of alcoholism; the effect of sucrose, saccharin and fat on the self-selection of ethyl alcohol by rats.
Topics: Alcoholism; Animals; Ethanol; Nutritional Physiological Phenomena; Nutritional Sciences; Nutritional | 1952 |
The High-Ethanol Preferring rat as a model to study the shift between alcohol abuse and dependence.
Topics: Alcohol Drinking; Alcoholism; Animals; Central Nervous System Depressants; Disease Models, Animal; E | 2004 |
The effects of continuous and intermittent ethanol exposure in adolesence on the aversive properties of ethanol during adulthood.
Topics: Administration, Inhalation; Age Factors; Alcohol Drinking; Alcoholism; Animals; Association Learning | 2007 |
Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats.
Topics: Alcoholism; Amygdala; Animals; Conditioning, Operant; Ethanol; Female; Gene Expression; Male; Models | 2008 |
Baclofen reduces ethanol intake in high-alcohol-drinking University of Chile bibulous rats.
Topics: Alcoholism; Animals; Baclofen; Behavior, Animal; Choice Behavior; Disease Models, Animal; Ethanol; L | 2008 |
A bioassay of ethanol-dependence in rats.
Topics: Alcoholism; Animals; Conditioning, Psychological; Humans; Male; Rats; Saccharin; Substance Withdrawa | 1980 |
Alcohol dependence and taste-mediated learning in the rat.
Topics: Alcoholism; Animals; Conditioning, Operant; Humans; Learning; Male; Rats; Saccharin; Stress, Psychol | 1982 |
Effects of chronic ethanol exposure on oral self-administration of ethanol or saccharin by Wistar rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Drug Tolerance; Ethanol; Male; Motivation; Rats; Rats, Wistar | 1996 |
Effects of D1 dopamine receptor agonists on oral ethanol self-administration in rats: comparison with their efficacy to produce grooming and hyperactivity.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Administration, Oral; Alcohol Drinking; | 1999 |
Effects of the 5-HT1A receptor agonist ipsapirone on operant self-administration of ethanol in the rat.
Topics: Alcoholism; Animals; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Dose-Response | 1999 |
Animal model of ethanol abuse: rats selectively bred for high and low voluntary alcohol intake.
Topics: Alcohol Drinking; Alcoholism; Animals; Disease Models, Animal; Rats; Rats, Wistar; Saccharin | 2000 |
Blood alcohol level and caloric intake in the gravid rat as a function of diurnal period, trimester, and vehicle.
Topics: Alcoholism; Animals; Body Weight; Circadian Rhythm; Diet; Energy Intake; Ethanol; Female; Fetus; Hum | 1978 |
Ethanol-induced taste aversion in ethanol-dependent and normal rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Avoidance Learning; Conditioning, Operant; Ethanol; Humans; M | 1979 |
Differences in response to the aversive properties of ethanol in rats selectively bred for oral ethanol preference.
Topics: Alcohol Drinking; Alcoholism; Animals; Conditioning, Psychological; Drinking Behavior; Ethanol; Fema | 1988 |
A rat model of alcoholism?
Topics: Acetone; Alcohol Drinking; Alcoholism; Animal Nutritional Physiological Phenomena; Animals; Conditio | 1972 |
Physical dependence on and tolerance to alcohol in the rat.
Topics: Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Disease Models, Animal; Drug Tolerance; Eth | 1971 |