mecamylamine has been researched along with Alcohol Abuse in 9 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Individuals had current alcohol dependence (n = 128), had an average age of 48." | 2.87 | Mecamylamine treatment for alcohol dependence: a randomized controlled trial. ( Arias, A; Gueorguieva, R; Jane, JS; Krystal, JH; O'Brien, E; O'Malley, SS; Petrakis, IL; Ralevski, E; Sevarino, KA, 2018) |
| "Mecamylamine is a nicotinic acetylcholine receptor (nAChR) antagonist that was recently used in a clinical trial to treat alcohol use disorder (AUD) in both smokers and non-smokers." | 2.87 | Tobacco use during a clinical trial of mecamylamine for alcohol dependence: Medication effects on smoking and associations with reductions in drinking. ( McKee, SA; Petrakis, IL; Ralevski, E; Roberts, W; Verplaetse, TL, 2018) |
| "Within the PTSD group, combat exposure was associated with increased drinking independent of the severity of PTSD symptoms." | 2.79 | Characteristics and drinking patterns of veterans with alcohol dependence with and without post-traumatic stress disorder. ( Arias, AJ; Fuehrlein, B; Jane, JS; O'Brien, E; Petrakis, IL; Ralevski, E, 2014) |
| "Alcohol dependence and other alcohol use disorders are major public health problems." | 2.48 | Cholinergic receptor system as a target for treating alcohol abuse and dependence. ( Prendergast, MA; Rahman, S, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Petrakis, IL | 3 |
| Ralevski, E | 3 |
| Gueorguieva, R | 1 |
| O'Malley, SS | 1 |
| Arias, A | 1 |
| Sevarino, KA | 1 |
| Jane, JS | 2 |
| O'Brien, E | 2 |
| Krystal, JH | 1 |
| Weera, MM | 1 |
| Agim, ZS | 1 |
| Cannon, JR | 1 |
| Chester, JA | 1 |
| Roberts, W | 1 |
| Verplaetse, TL | 1 |
| McKee, SA | 1 |
| Fuehrlein, B | 1 |
| Arias, AJ | 1 |
| Kuzmin, A | 1 |
| Jerlhag, E | 1 |
| Liljequist, S | 1 |
| Engel, J | 1 |
| Chatterjee, S | 1 |
| Bartlett, SE | 1 |
| Bhutada, P | 1 |
| Mundhada, Y | 1 |
| Ghodki, Y | 1 |
| Dixit, P | 1 |
| Umathe, S | 1 |
| Jain, K | 1 |
| Rahman, S | 1 |
| Prendergast, MA | 1 |
| Hodges, H | 1 |
| Allen, Y | 1 |
| Sinden, J | 1 |
| Mitchell, SN | 1 |
| Arendt, T | 1 |
| Lantos, PL | 1 |
| Gray, JA | 1 |
2 reviews available for mecamylamine and Alcohol Abuse
| Article | Year |
|---|---|
Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders.
Topics: Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Benzazepines; Brain; Humans; Mecamyl | 2010 |
Cholinergic receptor system as a target for treating alcohol abuse and dependence.
Topics: Alcohol Deterrents; Alcoholism; Animals; Disease Models, Animal; Humans; Mecamylamine; Molecular Tar | 2012 |
3 trials available for mecamylamine and Alcohol Abuse
| Article | Year |
|---|---|
Mecamylamine treatment for alcohol dependence: a randomized controlled trial.
Topics: Adult; Alcohol Drinking; Alcoholism; Ambulatory Care; Comorbidity; Craving; Double-Blind Method; Fem | 2018 |
Tobacco use during a clinical trial of mecamylamine for alcohol dependence: Medication effects on smoking and associations with reductions in drinking.
Topics: Adult; Alcohol Drinking; Alcoholism; Double-Blind Method; Female; Humans; Male; Mecamylamine; Middle | 2018 |
Characteristics and drinking patterns of veterans with alcohol dependence with and without post-traumatic stress disorder.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Alcohol Drinking; Alcoholism; Comorbidity; Co | 2014 |
4 other studies available for mecamylamine and Alcohol Abuse
| Article | Year |
|---|---|
Genetic correlations between nicotine reinforcement-related behaviors and propensity toward high or low alcohol preference in two replicate mouse lines.
Topics: Alcoholism; Animals; Biogenic Monoamines; Female; Genotype; Male; Mecamylamine; Mice; Nicotine; Nico | 2019 |
Effects of subunit selective nACh receptors on operant ethanol self-administration and relapse-like ethanol-drinking behavior.
Topics: Aconitine; Administration, Oral; Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Central Ne | 2009 |
Acquisition, expression, and reinstatement of ethanol-induced conditioned place preference in mice: effects of exposure to stress and modulation by mecamylamine.
Topics: Alcoholism; Animals; Conditioning, Psychological; Ethanol; Male; Mecamylamine; Mice; Motor Activity; | 2012 |
The effects of cholinergic drugs and cholinergic-rich foetal neural transplants on alcohol-induced deficits in radial maze performance in rats.
Topics: Acetylcholine; Alcohol Drinking; Alcoholism; Animals; Brain Mapping; Brain Tissue Transplantation; C | 1991 |