Page last updated: 2024-10-15

formycin b

Description

formycin B: RN given refers to (beta-D)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID135449281
CHEMBL ID1232777
CHEBI ID42654
SCHEMBL ID9222475
MeSH IDM0106480

Synonyms (32)

Synonym
CHEMBL1232777
7h-pyrazolo(4,3-d)pyrimidin-7-one, 1,4-dihydro-3-beta-d-ribofuranosyl-
3-(beta-d-ribofuranosyl)pyrazolo(4,3-d)6(h)-7-ketopyrimidine
brn 1021587
nsc 106486
7h-pyrazolo(4,3-d)pyrimidin-7-one, 1,6-dihydro-3-beta-d-ribofuranosyl-
7h-pyrazolo[4,3-d]pyrimidin-7-one, 1,4-dihydro-3-.beta.-d-ribofuranosyl-
3-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,4-dihydropyrazolo[4,3-d]pyrimidin-7-one
formycin b
13877-76-4
nsc-106486
ohyamycin
laurusin
fmb ,
DB04198
1PR1
1A69
CHEBI:42654 ,
(1s)-1,4-anhydro-1-(7-oxo-4,7-dihydro-1h-pyrazolo[4,3-d]pyrimidin-3-yl)-d-ribitol
3-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dihydropyrazolo[4,3-d]pyrimidin-7-one
unii-796vmv3yml
796vmv3yml ,
3-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1h,4h,7h-pyrazolo[4,3-d]pyrimidin-7-one
gtpl4737
MTCJZZBQNCXKAP-KSYZLYKTSA-N
TCMDC-143083
SCHEMBL9222475
(1s)-1,4-anhydro-1-(7-oxo-6,7-dihydro-1h-pyrazolo[4,3-d]pyrimidin-3-yl)-d-ribitol
3-((2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,6-dihydro-7h-pyrazolo[4,3-d]pyrimidin-7-one
Q27077702
3-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,6-dihydropyrazolo[4,3-d]pyrimidin-7-one
AKOS040751848

Research Excerpts

Overview

Formycin B is a structural analog of inosine that is a potent inhibitor of Leishmania multiplication.

ExcerptReference
"Formycin B is a structural analog of inosine that is a potent inhibitor of Leishmania multiplication. "( The effect of formycin B on mRNA translation and uptake of purine precursors in Leishmania mexicana.
Berman, JD; Giri, L; Nolan, LL, 1984
)

Effects

ExcerptReference
"Formycin B has a remarkable capacity for inhibiting the in vitro intracellular replication of T."( In vitro and in vivo activities of formycin B against Trypanosoma cruzi.
Araujo, FG; McCabe, RE; Remington, JS, 1985
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
formycin
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (6)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Purine Nucleoside PhosphorylaseEscherichia coliKi5.00005.00005.00005.0000AID977610
Chain C, Purine Nucleoside PhosphorylaseEscherichia coliKi5.00005.00005.00005.0000AID977610
Chain A, Purine nucleoside phosphorylaseEscherichia coliKi5.00005.000062.5000120.0000AID977610
Chain A, Purine nucleoside phosphorylase DeoD-typeEscherichia coli O157:H7Ki5.00005.000062.5000120.0000AID977610
Sterol 14-alpha demethylaseTrypanosoma cruzi strain CL BrenerIC50 (µMol)100.00000.00101.707010.0000AID1207588
Carnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)IC50 (µMol)100.00000.12594.244010.0000AID1207588
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (6)

Processvia Protein(s)Taxonomy
fatty acid metabolic processCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
fatty acid beta-oxidationCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
carnitine shuttleCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
carnitine metabolic processCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
response to blue lightCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
long-chain fatty acid transportCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
carnitine O-palmitoyltransferase activityCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
protein bindingCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (2)

Processvia Protein(s)Taxonomy
mitochondrionCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
mitochondrial outer membraneCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
mitochondrionCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1878800Cytotoxicity against dog MDCK cells assessed as reduction in cell viability incubated for 48 hrs by CellTiter96 Aqueous one solution assay2022Bioorganic & medicinal chemistry, 03-01, Volume: 57Synthesis and antiviral activity of formycin derivatives with anti-influenza virus activity.
AID1878799Antiviral activity against Influenza A virus A/WSN/33(H1N1) infected in dog MDCK cells assessed as reduction in viral titer in supernatants incubated for 24 hrs by plaque assay2022Bioorganic & medicinal chemistry, 03-01, Volume: 57Synthesis and antiviral activity of formycin derivatives with anti-influenza virus activity.
AID1811Experimentally measured binding affinity data derived from PDB1998Journal of molecular biology, Jul-03, Volume: 280, Issue:1
Crystal structure of the ternary complex of E. coli purine nucleoside phosphorylase with formycin B, a structural analogue of the substrate inosine, and phosphate (Sulphate) at 2.1 A resolution.
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB1998Journal of molecular biology, Jul-03, Volume: 280, Issue:1
Crystal structure of the ternary complex of E. coli purine nucleoside phosphorylase with formycin B, a structural analogue of the substrate inosine, and phosphate (Sulphate) at 2.1 A resolution.
AID1159562Trypanosoma brucei growth inhibition luminescent assay2015Scientific reports, Mar-05, Volume: 5New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.
AID1159564Intra-macrophage L. donovani assay2015Scientific reports, Mar-05, Volume: 5New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.
AID1159559Trypanosoma cruzi. Primary growth inhibition assay2015Scientific reports, Mar-05, Volume: 5New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.
AID1159563HepG2 cytotoxicity assay2015Scientific reports, Mar-05, Volume: 5New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.
AID1159557Trypanosoma brucei. Primary growth inhibition assay2015Scientific reports, Mar-05, Volume: 5New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.
AID1159560Leishmania donovani. Primary growth inhibition assay2015Scientific reports, Mar-05, Volume: 5New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.
AID1159565Trypanosoma cruzi intracellular imaging assay2015Scientific reports, Mar-05, Volume: 5New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.
AID1159561NIH-3T3 cytotoxicity2015Scientific reports, Mar-05, Volume: 5New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.
AID1159558TcCYP51 enzymatic inhibition2015Scientific reports, Mar-05, Volume: 5New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB2003The Journal of biological chemistry, Nov-21, Volume: 278, Issue:47
Structural basis for substrate specificity of Escherichia coli purine nucleoside phosphorylase.
AID1811Experimentally measured binding affinity data derived from PDB2003The Journal of biological chemistry, Nov-21, Volume: 278, Issue:47
Structural basis for substrate specificity of Escherichia coli purine nucleoside phosphorylase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (86)

TimeframeStudies, This Drug (%)All Drugs %
pre-199036 (41.86)18.7374
1990's33 (38.37)18.2507
2000's14 (16.28)29.6817
2010's2 (2.33)24.3611
2020's1 (1.16)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other86 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]