pregnanolone has been researched along with Alcohol Abuse in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (15.38) | 18.2507 |
| 2000's | 11 (42.31) | 29.6817 |
| 2010's | 8 (30.77) | 24.3611 |
| 2020's | 3 (11.54) | 2.80 |
| Authors | Studies |
|---|---|
| Auta, J; Camussi, D; Gatta, E; Guidotti, A; Pandey, SC | 1 |
| Tomaselli, G; Vallée, M | 1 |
| Boero, G; Morrow, AL; Porcu, P | 1 |
| Aspesi, D; Gatta, E; Grayson, DR; Guidotti, A; Pandey, SC; Pinna, G; Saudagar, V | 1 |
| Crabbe, JC; Finn, DA; Ford, MM; Helms, ML; Jensen, JP; Nipper, MA; Rossi, DJ | 1 |
| Becker, HC; Cook, JB; Lopez, MF; Maldonado-Devincci, AM; McKinley, RE; Morrow, AL; Morrow, DH; O'Buckley, TK | 1 |
| Amato, RJ; Hulin, MW; Lawrence, MN; Weed, PF; Winsauer, PJ | 1 |
| Beattie, MC; Hasirci, AS; Maldonado-Devincci, AM; Morrow, AL; O'Buckley, TK | 1 |
| Finn, DA; Ford, MM; Fretwell, A; Strong, MN; Tanchuck, M; Yoneyama, N | 1 |
| Gurkovskaya, OV; Winsauer, PJ | 1 |
| Beckley, EH; Finn, DA; Ford, MM; Kaufman, KR | 1 |
| Crabbe, JC; Finn, DA; Ford, MM; Hashimoto, J; Long, SL; Roselli, CE; Tanchuck, MA; Wiren, KM | 1 |
| Alward, SE; Becker, HC; Biggio, G; Lopez, MF; Morrow, AL; O'Buckley, TK; Porcu, P; Serra, M | 1 |
| Ashenhurst, JR; Hutchison, KE; Morrow, AL; Ray, LA | 1 |
| Besheer, J; Hodge, CW; Lindsay, TG; Morrow, AL; O'Buckley, TK | 1 |
| Cerný, I; Havlíková, H; Hill, M; Kancheva, L; Kancheva, R; Popov, P; Pouzar, V; Stárka, L; Vrbíková, J | 1 |
| Cerny, I; Cibula, D; Havlikova, H; Hill, M; Kancheva, L; Kancheva, R; Meloun, M; Popov, P; Pouzar, V; Starka, L; Vrbikova, J | 1 |
| Bäckström, T; Biggio, G; Finn, DA; Janak, PH; Purdy, RH; Valenzuela, CF | 1 |
| Biggio, F; Biggio, G; Follesa, P; Murru, L; Sanna, E; Serra, M; Talani, G | 1 |
| Becker, HC; Besheer, J; Crissman, AM; Grant, KA; Hodge, CW; Platt, DM; Shannon, EE; Shelton, KL | 1 |
| Murphy, NP; Okabe, C; Sakoori, K | 1 |
| Devaud, LL; Morrow, AL; Paul, SM; Purdy, RH | 1 |
| Zimmerberg, B | 1 |
| Janak, PH; Redfern, JE; Samson, HH | 1 |
| Devaud, LL; Janis, GC; Mitsuyama, H; Morrow, AL | 1 |
| Fleming, R; Morrow, AL; Penland, S; VanDoren, MJ | 1 |
8 review(s) available for pregnanolone and Alcohol Abuse
| Article | Year |
|---|---|
Neurosteroids (allopregnanolone) and alcohol use disorder: From mechanisms to potential pharmacotherapy.
Topics: Alcoholism; Anxiety; Ethanol; Humans; Neurosteroids; Pregnanolone; Receptors, GABA-A | 2022 |
Stress and drug abuse-related disorders: The promising therapeutic value of neurosteroids focus on pregnenolone-progesterone-allopregnanolone pathway.
Topics: Alcoholism; Animals; Marijuana Use; Neurosteroids; Pregnanolone; Pregnenolone; Progesterone; Signal Transduction; Stress, Psychological | 2019 |
A Rationale for Allopregnanolone Treatment of Alcohol Use Disorders: Basic and Clinical Studies.
Topics: Alcoholism; Anesthetics; Animals; Brain; Clinical Trials as Topic; Corticotropin-Releasing Hormone; Humans; Pregnanolone; Receptors, GABA-B; Treatment Outcome | 2020 |
Manipulation of GABAergic steroids: Sex differences in the effects on alcohol drinking- and withdrawal-related behaviors.
Topics: Alcohol Drinking; Alcoholism; Animals; Disease Models, Animal; Female; GABA Agonists; GABA-A Receptor Agonists; Male; Mice; Pregnanolone; Rats; Receptors, GABA-A; Reinforcement, Psychology; Sex Characteristics; Sex Factors; Substance Withdrawal Syndrome | 2010 |
The role of neuroactive steroids in ethanol/stress interactions: proceedings of symposium VII at the Volterra conference on alcohol and stress, May 2008.
Topics: Adrenocorticotropic Hormone; Alcoholism; Animals; Corticosterone; Ethanol; Humans; Hypothalamo-Hypophyseal System; Mice; Pituitary-Adrenal System; Pregnanolone; Receptors, GABA-A; Social Isolation; Stress, Psychological | 2009 |
Neurosteroids, GABAA receptors, and ethanol dependence.
Topics: Alcoholism; Animals; Brain; Ethanol; Gene Expression Regulation; Humans; Neurons; Pregnanolone; Receptors, GABA-A; RNA, Messenger; Substance Withdrawal Syndrome | 2006 |
Neuroactive steroid modulators of the stress response.
Topics: Adrenalectomy; Alcoholism; Animals; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Estrus; Female; Flunitrazepam; Hypothalamo-Hypophyseal System; Male; Menstruation; Pregnancy; Pregnanolone; Pregnenolone; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Stress, Physiological | 1995 |
Ethanol and neurosteroid interactions in the brain.
Topics: Alcoholism; Animals; Brain Chemistry; Central Nervous System Depressants; Ethanol; Humans; Pregnanolone | 2001 |
1 trial(s) available for pregnanolone and Alcohol Abuse
| Article | Year |
|---|---|
Naltrexone selectively elevates GABAergic neuroactive steroid levels in heavy drinkers with the Asp40 allele of the OPRM1 gene: a pilot investigation.
Topics: Adult; Alcohol Drinking; Alcoholism; Alleles; Amino Acid Substitution; Aspartic Acid; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Naltrexone; Pilot Projects; Polymorphism, Single Nucleotide; Pregnanolone; Receptors, Opioid, mu; Young Adult | 2010 |
17 other study(ies) available for pregnanolone and Alcohol Abuse
| Article | Year |
|---|---|
Epigenetic Regulation of GABAergic Neurotransmission and Neurosteroid Biosynthesis in Alcohol Use Disorder.
Topics: Adult; Alcoholism; Autopsy; Cerebellum; Cohort Studies; DNA Methylation; Epigenesis, Genetic; gamma-Aminobutyric Acid; Humans; Male; Neurosteroids; Prefrontal Cortex; Pregnanolone; Protein Biosynthesis; Receptors, GABA-A; Synaptic Transmission | 2021 |
Ethanol withdrawal-induced dysregulation of neurosteroid levels in plasma, cortex, and hippocampus in genetic animal models of high and low withdrawal.
Topics: Administration, Inhalation; Alcoholism; Animals; Cerebral Cortex; Disease Models, Animal; Ethanol; Female; Hippocampus; Male; Mice; Mice, Inbred DBA; Mice, Transgenic; Neurotransmitter Agents; Pregnanolone; Substance Withdrawal Syndrome | 2017 |
Chronic intermittent ethanol exposure and withdrawal alters (3α,5α)-3-hydroxy-pregnan-20-one immunostaining in cortical and limbic brain regions of C57BL/6J mice.
Topics: Alcoholism; Animals; Anxiety; Central Amygdaloid Nucleus; Corpus Striatum; Dose-Response Relationship, Drug; Ethanol; Hippocampus; Male; Mice; Mice, Inbred C57BL; Models, Animal; Nucleus Accumbens; Prefrontal Cortex; Pregnanolone; Stress, Psychological; Time Factors; Withholding Treatment | 2014 |
Comparison of dehydroepiandrosterone (DHEA) and pregnanolone with existing pharmacotherapies for alcohol abuse on ethanol- and food-maintained responding in male rats.
Topics: Acamprosate; Alcohol Drinking; Alcoholism; Animals; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Eating; Ethanol; Male; Naltrexone; Pregnanolone; Rats; Rats, Long-Evans; Self Administration; Taurine | 2015 |
Cellular GABAergic Neuroactive Steroid (3α,5α)-3-Hydroxy-Pregnan-20-One (3α,5α-THP) Immunostaining Levels Are Increased in the Ventral Tegmental Area of Human Alcohol Use Disorder Patients: A Postmortem Study.
Topics: Alcohol-Related Disorders; Alcoholism; Autopsy; Female; gamma-Aminobutyric Acid; Hepatitis, Alcoholic; Humans; Immunohistochemistry; Male; Middle Aged; Pregnanolone; Sex Characteristics; Substantia Nigra; Ventral Tegmental Area | 2017 |
Inhibition of 5alpha-reduced steroid biosynthesis impedes acquisition of ethanol drinking in male C57BL/6J mice.
Topics: Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Cholestenone 5 alpha-Reductase; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Finasteride; Male; Mice; Mice, Inbred C57BL; Pregnanolone; Receptors, GABA-A; Time Factors | 2008 |
Discriminative stimulus effects of ethanol, pregnanolone, and dehydroepiandrosterone (DHEA) in rats administered ethanol or saline as adolescents.
Topics: Adolescent; Adult; Age Factors; Alcoholism; Animals; Dehydroepiandrosterone; Discrimination, Psychological; Ethanol; Humans; Male; Models, Animal; Pregnanolone; Psychology, Adolescent; Rats; Rats, Long-Evans | 2009 |
Selected line difference in the effects of ethanol dependence and withdrawal on allopregnanolone levels and 5alpha-reductase enzyme activity and expression.
Topics: Administration, Inhalation; Alcoholism; Animals; Brain; Brain Chemistry; Central Nervous System Depressants; Ethanol; Gene Expression Regulation, Enzymologic; Hippocampus; Hydrocortisone; Male; Mice; Mice, Inbred Strains; Oxidoreductases; Pregnanolone; Radioimmunoassay; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity; Substance Withdrawal Syndrome | 2009 |
Pregnenolone and ganaxolone reduce operant ethanol self-administration in alcohol-preferring p rats.
Topics: Alcoholism; Animals; Cerebral Cortex; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ethanol; Male; Motor Activity; Pregnanolone; Pregnenolone; Rats; Rats, Inbred Strains; Self Administration | 2010 |
Altered profiles of serum neuroactive steroids in premenopausal women treated for alcohol addiction.
Topics: Alcoholism; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydrocortisone; Pregnanolone; Pregnenolone; Premenopause; Progesterone; Radioimmunoassay; Stereoisomerism; Steroids; Time Factors | 2005 |
Reinstatement of serum pregnanolone isomers and progesterone during alcohol detoxification therapy in premenopausal women.
Topics: Adult; Alcoholism; Estradiol; Female; Gas Chromatography-Mass Spectrometry; Humans; Linear Models; Longitudinal Studies; Menstrual Cycle; Middle Aged; Pregnanolone; Premenopause; Progesterone; Radioimmunoassay; Regression Analysis; Treatment Outcome | 2005 |
Neuroactive steroids and ethanol.
Topics: Alcoholism; Animals; Brain; Dehydroepiandrosterone; Female; Fetal Alcohol Spectrum Disorders; Humans; Male; Menstrual Cycle; Mice; Mice, Inbred C57BL; Pregnancy; Pregnanolone; Receptors, GABA-A | 2005 |
Understanding how the brain perceives alcohol: neurobiological basis of ethanol discrimination.
Topics: Alcoholic Intoxication; Alcoholism; Animals; Brain; Discrimination Learning; Drug Tolerance; Ethanol; Female; Haplorhini; Humans; Male; Mice; Pregnanolone; Rats; Receptor, Metabotropic Glutamate 5; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Serotonin, 5-HT3 | 2006 |
Lack of evidence of a role for the neurosteroid allopregnanolone in ethanol-induced reward and c-fos expression in DBA/2 mice.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Brain; Central Nervous System Depressants; Conditioning, Psychological; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Ethanol; Finasteride; Male; Mice; Mice, Inbred DBA; Motor Activity; Pregnanolone; Progesterone; Proto-Oncogene Proteins c-fos; Reward; Ventral Tegmental Area | 2006 |
The role of neurosteroids in alcohol-related behaviors: new studies from the laboratory and clinic.
Topics: Affect; Alcoholism; Animals; Arousal; Behavior, Animal; Brain; Desoxycorticosterone; Female; Gas Chromatography-Mass Spectrometry; Gonadal Steroid Hormones; Hormones; Humans; Male; Neurotransmitter Agents; Pregnanolone; Receptors, GABA-A; Synaptic Transmission | 1996 |
The reinforcing effects of ethanol are altered by the endogenous neurosteroid, allopregnanolone.
Topics: Alcohol Drinking; Alcoholism; Animals; Conditioning, Operant; Male; Motivation; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA; Reinforcement Schedule; Self Administration | 1998 |
Effects of chronic ethanol consumption and withdrawal on the neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one in male and female rats.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Cerebral Cortex; Estrus; Female; Male; Pregnanolone; Rats; Rats, Sprague-Dawley; Sex Factors | 1998 |