Compounds > rwj-333369
Page last updated: 2024-08-02 05:46:09

rwj-333369

Description

S-2-O-carbamoyl-1-o-chlorophenyl-ethanol: neuromodulator/Antiepileptic Agent; structure in first source [MeSH]

carisbamate : no description available [CHeBI]

Cross-References

ID SourceID
PubMed CID6918474
CHEMBL ID2087003
SCHEMBL ID729003
CHEBI ID135966
MeSH IDM0508880

Synonyms (39)

Synonym
jnj-10234094
ykp-509
comfyde
rwj-333369
carisbamate
D06573
carisbamate (usan)
194085-75-1
CHEBI:135966
[(2s)-2-(2-chlorophenyl)-2-hydroxyethyl] carbamate
rwj 333369
s-2-o-carbamoyl-1-o-chlorophenyl-ethanol
(+)-(2s)-2-(2-chlorophenyl)-2-hydroxyethyl carbamate
unii-p7725i9v3z
carisbamate [usan:inn]
1,2-ethanediol, 1-(2-chlorophenyl)-, 2-carbamate, (1s)-
p7725i9v3z ,
1,2-ethanediol,1-(2-chlorophenyl)-, 2-carbamate, (1s)-
rwj-333369-000
CHEMBL2087003
SCHEMBL729003
(2s)-2-(2-chlorophenyl)-2-hydroxyethyl carbamate
carisbamate [who-dd]
carisbamate [mi]
carisbamate [usan]
(s)-2-o-carbamoyl-1-o-chlorophenyl-ethanol
carisbamate [inn]
(s)-2-carbamoyloxy-1-o-chlorophenylethanol
OLBWFRRUHYQABZ-MRVPVSSYSA-N
(s)-carisbamate
DTXSID70426076
DB12338
EX-A7280
rwj 333369; ykp 509
(s)-2-(2-chlorophenyl)-2-hydroxyethyl carbamate
EN300-8659675
CS-0003652
HY-14948
AKOS040751033

Drug Classes (1)

ClassDescription
organochlorine compoundAn organochlorine compound is a compound containing at least one carbon-chlorine bond.

Bioassays (5)

Assay IDTitleYearJournalArticle
AID684345Anticonvulsant activity in po dosed Sprague-Dawley albino rat assessed as protection against subcutaneous metrazol-induced seizures2012Journal of medicinal chemistry, Mar-22, Volume: 55, Issue:6
ISSN: 1520-4804		Syntheses and evaluation of anticonvulsant activity of novel branched alkyl carbamates.
AID684127Neurotoxicity in po dosed Sprague-Dawley albino rat assessed as minimal motor impairment by rotarod test2012Journal of medicinal chemistry, Mar-22, Volume: 55, Issue:6
ISSN: 1520-4804		Syntheses and evaluation of anticonvulsant activity of novel branched alkyl carbamates.
AID684339Anticonvulsant activity in po dosed Sprague-Dawley albino rat assessed as protection against maximal electroshock-induced seizures2012Journal of medicinal chemistry, Mar-22, Volume: 55, Issue:6
ISSN: 1520-4804		Syntheses and evaluation of anticonvulsant activity of novel branched alkyl carbamates.
AID684348Protective index, ratio of TD50 for po dosed Sprague-Dawley albino rat by rotarod test to ED50 for po dosed Sprague-Dawley albino rat by subcutaneous metrazol seizures test2012Journal of medicinal chemistry, Mar-22, Volume: 55, Issue:6
ISSN: 1520-4804		Syntheses and evaluation of anticonvulsant activity of novel branched alkyl carbamates.
AID684342Protective index, ratio of TD50 for po dosed Sprague-Dawley albino rat by rotarod test to ED50 for po dosed Sprague-Dawley albino rat by maximal electroshock seizures test2012Journal of medicinal chemistry, Mar-22, Volume: 55, Issue:6
ISSN: 1520-4804		Syntheses and evaluation of anticonvulsant activity of novel branched alkyl carbamates.

Research

Studies (42)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's21 (50.00)29.6817
2010's19 (45.24)24.3611
2020's2 (4.76)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials12 (27.27%)5.53%
Reviews6 (13.64%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other26 (59.09%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
chloroacetaldehyde
0
organochlorine compound00low000000
3-chloroalanine
0
chloroalanine;
non-proteinogenic alpha-amino acid;
organochlorine compound		00low000000
quinacrine
0
acridines;
aromatic ether;
organochlorine compound;
tertiary amino compound		antimalarial;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor		00low000000
chlordecone
0
cyclic ketone;
organochlorine compound		insecticide;
persistent organic pollutant		00low000000
4-(2,4-dichlorophenoxy)butyric acid
0
aromatic ether;
monocarboxylic acid;
organochlorine compound		agrochemical;
phenoxy herbicide;
synthetic auxin		00low000000
2-hydroxysaclofen
0
organochlorine compound00low000000
3,4-dichloroisocoumarin
0
isocoumarins;
organochlorine compound		geroprotector;
serine protease inhibitor		00low000000
5-(n,n-hexamethylene)amiloride
0
aromatic amine;
azepanes;
guanidines;
monocarboxylic acid amide;
organochlorine compound;
pyrazines		antineoplastic agent;
apoptosis inducer;
odorant receptor antagonist;
sodium channel blocker		00low000000
ethylisopropylamiloride
0
aromatic amine;
guanidines;
monocarboxylic acid amide;
organochlorine compound;
pyrazines;
tertiary amino compound		anti-arrhythmia drug;
neuroprotective agent;
sodium channel blocker		00low000000
7-chlorokynurenic acid
0
organochlorine compound;
quinolinemonocarboxylic acid		neuroprotective agent;
NMDA receptor antagonist		00low000000
acetochlor
0
aromatic amide;
monocarboxylic acid amide;
organochlorine compound		environmental contaminant;
herbicide;
xenobiotic		00low000000
alachlor
0
aromatic amide;
monocarboxylic acid amide;
organochlorine compound		environmental contaminant;
herbicide;
xenobiotic		00low000000
alprazolam
0
organochlorine compound;
triazolobenzodiazepine		anticonvulsant;
anxiolytic drug;
GABA agonist;
muscle relaxant;
sedative;
xenobiotic		00low000000
amodiaquine
0
aminoquinoline;
organochlorine compound;
phenols;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
drug allergen;
EC 2.1.1.8 (histamine N-methyltransferase) inhibitor;
non-steroidal anti-inflammatory drug;
prodrug		00low000000
benzylhydrochlorothiazide
0
benzenes;
benzothiadiazine;
organochlorine compound;
secondary amino compound;
sulfonamide		00low000000
carmustine
0
N-nitrosoureas;
organochlorine compound		alkylating agent;
antineoplastic agent		00low000000
carprofen
0
carbazoles;
organochlorine compound		EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-steroidal anti-inflammatory drug;
photosensitizing agent		00low000000
cgs 15943
0
aromatic amine;
biaryl;
furans;
organochlorine compound;
primary amino compound;
quinazolines;
triazoloquinazoline		adenosine A1 receptor antagonist;
adenosine A2A receptor antagonist;
antineoplastic agent;
central nervous system stimulant		00low000000
chloral hydrate
0
aldehyde hydrate;
ethanediol;
organochlorine compound		general anaesthetic;
mouse metabolite;
sedative;
xenobiotic		00low000000
chlorambucil
0
aromatic amine;
monocarboxylic acid;
nitrogen mustard;
organochlorine compound;
tertiary amino compound		alkylating agent;
antineoplastic agent;
carcinogenic agent;
drug allergen;
immunosuppressive agent		00low000000
chloroquine
0
aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug		00low000000
chloroxine
0
monohydroxyquinoline;
organochlorine compound		antibacterial agent;
antifungal drug;
antiseborrheic		00low000000
chlorpromazine
0
organochlorine compound;
phenothiazines;
tertiary amine		anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug		00low000000
chlorzoxazone
0
1,3-benzoxazoles;
heteroaryl hydroxy compound;
organochlorine compound		muscle relaxant;
sedative		00low000000
ciprofibrate
0
cyclopropanes;
monocarboxylic acid;
organochlorine compound		antilipemic drug00low000000
clioquinol
0
monohydroxyquinoline;
organochlorine compound;
organoiodine compound		antibacterial agent;
antifungal agent;
antimicrobial agent;
antineoplastic agent;
antiprotozoal drug;
chelator;
copper chelator		00low000000
clobazam
0
1,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
GABA modulator		00low000000
clobenpropit
0
imidazoles;
imidothiocarbamic ester;
organochlorine compound		H3-receptor antagonist;
H4-receptor agonist		00low000000
cloxyquin
0
organochlorine compound;
quinolines		00low000000
coumaphos
0
organic thiophosphate;
organochlorine compound;
organothiophosphate insecticide		acaricide;
agrochemical;
antinematodal drug;
avicide;
EC 3.1.1.8 (cholinesterase) inhibitor		00low000000
cypermethrin
0
aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organochlorine compound		agrochemical;
molluscicide;
pyrethroid ester acaricide;
pyrethroid ester insecticide		00low000000
nordazepam
0
1,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
GABA modulator;
human metabolite;
sedative		00low000000
diazepam
0
1,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic		00low000000
diazoxide
0
benzothiadiazine;
organochlorine compound;
sulfone		antihypertensive agent;
beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
diuretic;
K-ATP channel agonist;
sodium channel blocker;
sympathomimetic agent;
vasodilator agent		00low000000
enflurane
0
ether;
organochlorine compound;
organofluorine compound		anaesthetic00low000000
fludiazepam
0
1,4-benzodiazepinone;
organochlorine compound;
organofluorine compound		anxiolytic drug00low000000
flurazepam
0
1,4-benzodiazepinone;
monofluorobenzenes;
organochlorine compound;
tertiary amino compound		anticonvulsant;
anxiolytic drug;
GABAA receptor agonist;
sedative		00low000000
glafenine
0
aminoquinoline;
carboxylic ester;
glycol;
organochlorine compound;
secondary amino compound		inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug		00low000000
halothane
0
haloalkane;
organobromine compound;
organochlorine compound;
organofluorine compound		inhalation anaesthetic00low000000
hydrochlorothiazide
0
benzothiadiazine;
organochlorine compound;
sulfonamide		antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic		00low000000
hydroxychloroquine
0
aminoquinoline;
organochlorine compound;
primary alcohol;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
dermatologic drug		00low000000
indapamide
0
indoles;
organochlorine compound;
sulfonamide		antihypertensive agent;
diuretic		00low000000
lomustine
0
N-nitrosoureas;
organochlorine compound		alkylating agent;
antineoplastic agent		00low000000
loratadine
0
benzocycloheptapyridine;
ethyl ester;
N-acylpiperidine;
organochlorine compound;
tertiary carboxamide		anti-allergic agent;
cholinergic antagonist;
geroprotector;
H1-receptor antagonist		00low000000
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
0
chromones;
morpholines;
organochlorine compound		autophagy inhibitor;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
geroprotector		00low000000
mechlorethamine
0
nitrogen mustard;
organochlorine compound		alkylating agent00low000000
meclofenamic acid
0
aminobenzoic acid;
organochlorine compound;
secondary amino compound		analgesic;
anticonvulsant;
antineoplastic agent;
antipyretic;
antirheumatic drug;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-steroidal anti-inflammatory drug		00low000000
methoxyflurane
0
ether;
organochlorine compound;
organofluorine compound		hepatotoxic agent;
inhalation anaesthetic;
nephrotoxic agent;
non-narcotic analgesic		00low000000
metolachlor
0
aromatic amide;
benzenes;
ether;
organochlorine compound		00low000000
metolazone
0
organochlorine compound;
quinazolines;
sulfonamide		antihypertensive agent;
diuretic;
ion transport inhibitor		00low000000
midazolam
0
imidazobenzodiazepine;
monofluorobenzenes;
organochlorine compound		anticonvulsant;
antineoplastic agent;
anxiolytic drug;
apoptosis inducer;
central nervous system depressant;
GABAA receptor agonist;
general anaesthetic;
muscle relaxant;
sedative		00low000000
mosapramine
0
azaspiro compound;
dibenzoazepine;
organochlorine compound;
tertiary amino compound		00low000000
n-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide
0
naphthalenes;
organochlorine compound;
primary amino compound;
sulfonamide		00low000000
naled
0
dialkyl phosphate;
organobromine compound;
organochlorine compound;
organophosphate insecticide		acaricide;
agrochemical;
antibacterial agent;
antifungal agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor		00low000000
oxazepam
0
1,4-benzodiazepinone;
organochlorine compound		anxiolytic drug;
environmental contaminant;
xenobiotic		00low000000
perphenazine
0
N-(2-hydroxyethyl)piperazine;
N-alkylpiperazine;
organochlorine compound;
phenothiazines		antiemetic;
dopaminergic antagonist;
phenothiazine antipsychotic drug		00low000000
prochlorperazine
0
N-alkylpiperazine;
N-methylpiperazine;
organochlorine compound;
phenothiazines		alpha-adrenergic antagonist;
antiemetic;
cholinergic antagonist;
dopamine receptor D2 antagonist;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
first generation antipsychotic		00low000000
propachlor
0
anilide;
monocarboxylic acid amide;
organochlorine compound		environmental contaminant;
herbicide;
xenobiotic		00low000000
7-chloro-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol
0
benzazepine;
organochlorine compound;
tertiary amino compound		dopaminergic antagonist00low000000
semustine
0
N-nitrosoureas;
organochlorine compound		alkylating agent;
antineoplastic agent;
carcinogenic agent		00low000000
sibutramine
0
organochlorine compound;
tertiary amino compound		anti-obesity agent;
serotonin uptake inhibitor		00low000000
tulobuterol
0
organochlorine compound00low000000
pirinixic acid
0
aryl sulfide;
organochlorine compound;
pyrimidines		00low000000
trichlorfon
0
organic phosphonate;
organochlorine compound;
phosphonic ester		agrochemical;
anthelminthic drug;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
insecticide		00low000000
chloramphenicol
0
C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor		00low000000
chlorquinaldol
0
monohydroxyquinoline;
organochlorine compound		antibacterial drug;
antiprotozoal drug;
antiseptic drug		00low000000
1,1-dichloroethane
0
organochlorine compound00low000000
trichloroacetaldehyde
0
aldehyde;
organochlorine compound		mouse metabolite00low000000
trichloroacetic acid
0
monocarboxylic acid;
organochlorine compound		carcinogenic agent;
metabolite;
mouse metabolite		00low000000
chloropicrin
0
C-nitro compound;
one-carbon compound;
organochlorine compound		antifungal agrochemical;
fumigant insecticide;
nematicide		00low000000
chloropentafluoroethane
0
organochlorine compound;
organofluorine compound		00low000000
dichloroacetaldehyde
0
organochlorine compound00low000000
dichloroacetic acid
0
monocarboxylic acid;
organochlorine compound		astringent;
marine metabolite		00low000000
sulfachlorpyridazine
0
organochlorine compound;
pyridazines;
sulfonamide		antibacterial drug;
drug allergen;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor		00low000000
thiopropazate
0
acetate ester;
N-alkylpiperazine;
organochlorine compound;
phenothiazines		dopaminergic antagonist;
phenothiazine antipsychotic drug		00low000000
hexachlorobutadiene
0
organochlorine compound00low000000
symclosene
0
1,3,5-triazinanes;
organochlorine compound		00low000000
3,3'-dichlorobenzidine
0
biphenyls;
monochlorobenzenes;
organochlorine compound		00low000000
1,2-dibromo-3-chloropropane
0
organochlorine compound00low000000
1,2,3-trichloropropane
0
organochlorine compound00low000000
1,3-dichloro-2-propanol
0
organochlorine compound;
secondary alcohol		cross-linking reagent;
protic solvent		00low000000
benzotrichloride
0
benzenes;
organochlorine compound;
volatile organic compound		carcinogenic agent00low000000
epichlorohydrin
0
epoxide;
organochlorine compound		00low000000
1-bromo-2-chloroethane
0
haloalkane;
organobromine compound;
organochlorine compound		mutagen00low000000
allyl chloride
0
organochlorine compound00low000000
cyanuric chloride
0
chloro-1,3,5-triazine;
organochlorine compound		cross-linking reagent00low000000
chlorendic acid
0
bridged compound;
dicarboxylic acid;
organochlorine compound		carcinogenic agent00low000000
tris(chloroethyl)phosphate
0
organochlorine compound;
trialkyl phosphate		00low000000
chloranil
0
1,4-benzoquinones;
organochlorine compound		EC 2.7.1.33 (pantothenate kinase) inhibitor;
metabolite		00low000000
captan
0
isoindoles;
organochlorine compound;
organosulfur compound;
phthalimide fungicide		antifungal agrochemical00low000000
folpet
0
organochlorine compound;
organosulfur compound;
phthalimide fungicide		antifungal agrochemical00low000000
trichloronate
0
organochlorine compound00low000000
bromochlorodifluoromethane
0
one-carbon compound;
organobromine compound;
organochlorine compound;
organofluorine compound		00low000000
metofenazate
0
N-alkylpiperazine;
organochlorine compound;
phenothiazines		00low000000
mustard gas
0
ethyl sulfide;
organochlorine compound		alkylating agent;
carcinogenic agent;
vesicant		00low000000
1-chloro-2-methylpropene
0
organochlorine compound00low000000
8-chlorotheophylline
0
organochlorine compound;
purines		central nervous system stimulant00low000000
1,3-dichloroacetone
0
ketone;
organochlorine compound		00low000000
bis(chloromethyl) ether
0
ether;
organochlorine compound		alkylating agent;
carcinogenic agent		00low000000
trichloroacetonitrile
0
aliphatic nitrile;
organochlorine compound		00low000000
3-chloro-2-methylprop-1-ene
0
organochlorine compound00low000000
2,6-dichlorobenzoquinone
0
1,4-benzoquinones;
organochlorine compound		carcinogenic agent;
poison		00low000000
n-dichlorofluoromethylthio-n',n'-dimethyl-n-p-tolylsulfamide
0
organochlorine compound;
organofluorine compound;
phenylsulfamide fungicide;
sulfamides		antifungal agrochemical;
genotoxin		00low000000
lormetazepam
0
1,4-benzodiazepinone;
organochlorine compound		sedative00low000000
2-chloro-1,4-naphthoquinone
0
1,4-naphthoquinones;
organochlorine compound		00low000000
chlordecone alcohol
0
organochlorine compound00low000000
dichlofluanid
0
organochlorine compound;
organofluorine compound;
phenylsulfamide fungicide;
sulfamides		acaricide;
antifungal agrochemical		00low000000
win 18446
0
organochlorine compound;
secondary carboxamide		EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor00low000000
pyrazon
0
benzenes;
organochlorine compound;
primary amino compound;
pyridazinone		environmental contaminant;
herbicide;
xenobiotic		00low000000
bromocyclen
0
organochlorine compound00low000000
5-chlorouracil
0
organochlorine compound00low000000
amiloride
0
aromatic amine;
guanidines;
organochlorine compound;
pyrazines		diuretic;
sodium channel blocker		00low000000
dienochlor
0
organochlorine compound00low000000
captafol
0
isoindoles;
organochlorine compound;
organosulfur compound;
phthalimide fungicide		antifungal agrochemical00low000000
etridiazol
0
aromatic ether;
organochlorine compound;
thiadiazole antifungal agent;
thiadiazoles		antifungal agrochemical;
nitrification inhibitor		00low000000
o-chlorobenzylidenemalonitrile
0
organochlorine compound00low000000
diloxanide furoate
0
carboxylic ester;
furans;
organochlorine compound;
tertiary carboxamide		antiamoebic agent;
prodrug		00low000000
cladribine
0
organochlorine compound;
purine 2'-deoxyribonucleoside		antineoplastic agent;
immunosuppressive agent		00low000000
dichloroacetylene
0
organochlorine compound00low000000
chloroethylene oxide
0
organochlorine compound00low000000
4-chloro-7-nitrobenzofurazan
0
benzoxadiazole;
C-nitro compound;
organochlorine compound		EC 1.4.3.4 (monoamine oxidase) inhibitor;
EC 3.6.1.3 (adenosinetriphosphatase) inhibitor;
fluorescent probe;
fluorochrome		00low000000
clodronic acid
0
1,1-bis(phosphonic acid);
one-carbon compound;
organochlorine compound		antineoplastic agent;
bone density conservation agent		00low000000
ornidazole
0
C-nitro compound;
imidazoles;
organochlorine compound;
secondary alcohol		antiamoebic agent;
antibacterial drug;
antiinfective agent;
antiprotozoal drug;
antitrichomonal drug;
epitope		00low000000
acridine half-mustard
0
aminoacridines;
aromatic ether;
organochlorine compound;
secondary amino compound		mutagen00low000000
didesethylflurazepam
0
1,4-benzodiazepinone;
monofluorobenzenes;
organochlorine compound;
primary amino compound		anticonvulsant;
anxiolytic drug;
drug metabolite;
GABAA receptor agonist;
sedative		00low000000
clonixin
0
aminopyridine;
organochlorine compound;
pyridinemonocarboxylic acid		antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
lipoxygenase inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
platelet aggregation inhibitor;
vasodilator agent		00low000000
chlorodibromomethane
0
organochlorine compound00low000000
1-chloro-2-propanol
0
organochlorine compound;
secondary alcohol		00low000000
butachlor
0
aromatic amide;
organochlorine compound;
tertiary carboxamide		environmental contaminant;
herbicide;
xenobiotic		00low000000
pyoluteorin
0
aromatic ketone;
beta-hydroxy ketone;
diol;
organochlorine compound;
organochlorine pesticide;
polyketide;
pyrroles;
resorcinols		antibacterial agent;
antifungal agent;
apoptosis inducer;
bacterial metabolite;
marine metabolite		00low000000
5-chloro-2-methyl-4-isothiazolin-3-one
0
1,2-thiazoles;
organochlorine compound		antimicrobial agent;
environmental contaminant;
xenobiotic		00low000000
triforine
0
amide fungicide;
formamides;
N-alkylpiperazine;
organochlorine compound		allergen;
antifungal agrochemical;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor		00low000000
oxamethacin
0
aromatic ether;
hydroxamic acid;
N-acylindole;
organochlorine compound		EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug		00low000000
norflurazone
0
(trifluoromethyl)benzenes;
organochlorine compound;
pyridazinone;
secondary amino compound		agrochemical;
carotenoid biosynthesis inhibitor;
herbicide		00low000000
octachlorostyrene
0
organochlorine compound00low000000
perfosfamide
0
nitrogen mustard;
organochlorine compound;
peroxol;
phosphorodiamide		alkylating agent;
antineoplastic agent;
drug allergen;
immunosuppressive agent;
metabolite		00low000000
nimustine
0
aminopyrimidine;
N-nitrosoureas;
organochlorine compound		alkylating agent;
antineoplastic agent		00low000000
tiamenidine
0
organochlorine compound00low000000
acifluorfen
0
aromatic ether;
benzoic acids;
C-nitro compound;
monocarboxylic acid;
organochlorine compound;
organofluorine compound		agrochemical;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide		00low000000
metazachlor
0
aromatic amide;
organochlorine compound;
pyrazoles		environmental contaminant;
herbicide;
xenobiotic		00low000000
4,5-amino-3,5-dichloro-6-fluoro-2-pyridinyloxyacetic acid
0
aminopyridine;
aromatic ether;
monocarboxylic acid;
organochlorine compound;
organofluorine compound		environmental contaminant;
herbicide;
xenobiotic		00low000000
haloxyfop
0
aromatic ether;
monocarboxylic acid;
organochlorine compound;
organofluorine compound;
pyridines		00low000000
quizalofop-ethyl
0
aromatic ether;
ethyl ester;
organochlorine compound;
quinoxaline derivative		00low000000
cicletanine
0
organochlorine compound00low000000
lonapalene
0
naphthalenes;
organochlorine compound		00low000000
sertindole
0
heteroarylpiperidine;
imidazolidinone;
organochlorine compound;
organofluorine compound;
phenylindole		alpha-adrenergic antagonist;
H1-receptor antagonist;
second generation antipsychotic;
serotonergic antagonist		00low000000
ziprasidone
0
1,2-benzisothiazole;
indolones;
organochlorine compound;
piperazines		antipsychotic agent;
dopaminergic antagonist;
histamine antagonist;
muscarinic antagonist;
psychotropic drug;
serotonergic antagonist		00low000000
tiludronic acid
0
organochlorine compound00low000000
r 29148
0
organochlorine compound;
oxazolidines;
tertiary carboxamide		herbicide safener00low000000
heptenophos
0
organochlorine compound;
organophosphate insecticide;
trialkyl phosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor		00low000000
efavirenz
0
acetylenic compound;
benzoxazine;
cyclopropanes;
organochlorine compound;
organofluorine compound		antiviral drug;
HIV-1 reverse transcriptase inhibitor		00low000000
ro 5-3335
0
1,4-benzodiazepinone;
organochlorine compound;
pyrroles		anti-HIV-1 agent;
antineoplastic agent;
HIV-1 Tat inhibitor;
RUNX1 inhibitor		00low000000
5-bromo-4-chloro-3-indolyl beta-galactoside
0
beta-D-galactoside;
D-aldohexose derivative;
indolyl carbohydrate;
organobromine compound;
organochlorine compound		chromogenic compound00low000000
5-bromo-4-chloro-3-indoxyl phosphate
0
aryl phosphate;
indoles;
organobromine compound;
organochlorine compound		chromogenic compound00low000000
z 424
0
organochlorine compound00low000000
tianeptine
0
dibenzothiazepine;
monocarboxylic acid;
organochlorine compound		00low000000
trichlorosucrose
0
disaccharide derivative;
organochlorine compound		environmental contaminant;
sweetening agent;
xenobiotic		00low000000
clobuzarit
0
biphenyls;
organochlorine compound		00low000000
eberconazole
0
dibenzannulene;
imidazoles;
organochlorine compound		00low000000
gr 117289
0
1-benzofurans;
biaryl;
imidazolyl carboxylic acid;
monocarboxylic acid;
organobromine compound;
organochlorine compound;
tetrazoles		angiotensin receptor antagonist;
antihypertensive agent		00low000000
rebeccamycin
0
indolocarbazole;
N-glycosyl compound;
organic heterohexacyclic compound;
organochlorine compound		00low000000
triasulfuron
0
1,3,5-triazines;
aromatic ether;
N-sulfonylurea;
organochlorine compound		agrochemical;
herbicide		00low000000
4,5,6,7-tetrachloro-2-trifluoromethylbenzimidazole
0
organochlorine compound00low000000
8-((4-chlorophenyl)thio)cyclic-3',5'-amp
0
3',5'-cyclic purine nucleotide;
adenyl ribonucleotide;
aryl sulfide;
organochlorine compound		protein kinase agonist00low000000
3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid
0
organochlorine compound00low000000
raiser
0
(trifluoromethyl)benzenes;
organochlorine compound;
pyrrolidines		agrochemical;
carotenoid biosynthesis inhibitor;
herbicide		00low000000
kathon 930
0
1,2-thiazoles;
organochlorine compound		environmental contaminant;
fungicide;
xenobiotic		00low000000
quinclorac
0
monocarboxylic acid;
organochlorine compound;
quinolinemonocarboxylic acid		agrochemical;
herbicide;
synthetic auxin		00low000000
dimethenamid
0
aromatic amide;
ether;
organochlorine compound;
thiophenes		00low000000
fluxofenim
0
organochlorine compound00low000000
clodinafop-propargyl
0
aromatic ether;
carboxylic ester;
organochlorine compound;
organofluorine compound;
propyzamide;
pyridines		agrochemical;
EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor;
herbicide		00low000000
3-chlorolactate
0
2-hydroxy monocarboxylic acid;
organochlorine compound		00low000000
cloquintocet-mexyl
0
aromatic ether;
carboxylic ester;
organochlorine compound;
quinolines		00low000000
2,6-dichloroisonicotinic acid
0
monocarboxylic acid;
organochlorine compound;
pyridines		EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor00low000000
sporidesmin
0
aromatic ether;
cyclic ketone;
diketone;
organic disulfide;
organic heteropentacyclic compound;
organochlorine compound;
secondary alcohol;
tertiary alcohol;
tertiary amino compound		mycotoxin;
Wnt signalling activator		00low000000
4-hydroxycyclophosphamide
0
nitrogen mustard;
organochlorine compound;
phosphorodiamide		alkylating agent;
metabolite		00low000000
fotemustine
0
N-nitrosoureas;
organic phosphonate;
organochlorine compound		00low000000
cyfluthrin
0
aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organochlorine compound;
organofluorine compound		agrochemical;
pyrethroid ester insecticide		00low000000
thiamethoxam
0
1,3-thiazoles;
2-nitroguanidine derivative;
organochlorine compound;
oxadiazane		antifeedant;
carcinogenic agent;
environmental contaminant;
neonicotinoid insectide;
xenobiotic		00low000000
1-hydroxymethylmidazolam
0
aromatic primary alcohol;
imidazobenzodiazepine;
monofluorobenzenes;
organochlorine compound		drug metabolite;
human blood serum metabolite;
human urinary metabolite		00low000000
s-chloromethylglutathione
0
organochlorine compound;
S-substituted glutathione		alkylating agent;
bacterial xenobiotic metabolite;
mouse metabolite		00low000000
exp3174
0
biphenylyltetrazole;
imidazoles;
organochlorine compound		metabolite00low000000
florfenicol
0
organochlorine compound;
organofluorine compound;
secondary alcohol;
secondary carboxamide;
sulfone		antimicrobial agent00low000000
monochlorobimane
0
organochlorine compound;
pyrazolopyrazole		fluorochrome00low000000
Prothioconazole-desthio
0
organochlorine compound00low000000
saclofen
0
organochlorine compound00low000000
piperaquine
0
aminoquinoline;
N-arylpiperazine;
organochlorine compound		antimalarial00low000000
mk 0663
0
bipyridines;
organochlorine compound;
sulfone		cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug		00low000000
norketamine
0
organochlorine compound00low000000
7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
0
isoquinolines;
organochlorine compound		00low000000
4-hydroxymidazolam
0
imidazobenzodiazepine;
monofluorobenzenes;
organic hydroxy compound;
organochlorine compound		drug metabolite;
human blood serum metabolite;
human urinary metabolite		00low000000
cki 7
0
isoquinolines;
organochlorine compound;
primary amino compound;
sulfonamide		EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor00low000000
6-bromo-3-(bromomethyl)-7-methyl-2,3,7-trichloro-1-octene
0
monoterpenoid;
organobromine compound;
organochlorine compound		algal metabolite;
antineoplastic agent;
marine metabolite		00low000000
pyrrolomycin a
0
antibiotic antifungal agent;
C-nitro compound;
organochlorine compound;
pyrroles		antibacterial agent;
bacterial metabolite		00low000000
sk&f 83959
0
benzazepine;
catechols;
organochlorine compound;
tertiary amino compound		dopamine agonist00low000000
1-hydroxymethylmidazolam glucuronide
0
beta-D-glucosiduronic acid;
imidazobenzodiazepine;
monofluorobenzenes;
monosaccharide derivative;
organochlorine compound		drug metabolite;
human blood serum metabolite;
human urinary metabolite		00low000000
cox 189
0
amino acid;
monocarboxylic acid;
organochlorine compound;
organofluorine compound;
secondary amino compound		cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug		00low000000
pannarin
0
aldehyde;
aromatic ether;
depsidones;
organic heterotricyclic compound;
organochlorine compound;
phenols		antimicrobial agent;
antineoplastic agent;
apoptosis inducer;
lichen metabolite		00low000000
5,6-dehydronorketamine
0
organochlorine compound00low000000
6-chloro-3,5-diaminopyrazine-3-carboxamide
0
organochlorine compound;
pyrazines		00low000000
quizalofop
0
aromatic ether;
monocarboxylic acid;
organochlorine compound;
quinoxaline derivative		00low000000
chloroorienticin b
0
cyclic ether;
glycopeptide;
heterodetic cyclic peptide;
monosaccharide derivative;
organochlorine compound;
polyphenol		antimicrobial agent;
bacterial metabolite		00low000000
lapatinib
0
furans;
organochlorine compound;
organofluorine compound;
quinazolines		antineoplastic agent;
tyrosine kinase inhibitor		00low000000
cimicoxib
0
aromatic ether;
imidazoles;
organochlorine compound;
organofluorine compound;
sulfonamide		cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug		00low000000
n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide
0
chloroindole;
organochlorine compound;
sulfonamide		antineoplastic agent;
EC 4.2.1.1 (carbonic anhydrase) inhibitor		00low000000
nsc-89199
0
carbamate ester;
organochlorine compound;
steroid phosphate		00low000000
estramustine
0
17beta-hydroxy steroid;
carbamate ester;
organochlorine compound		alkylating agent;
antineoplastic agent;
radiation protective agent		00low000000
acivicin
0
isoxazoles;
non-proteinogenic L-alpha-amino acid;
organochlorine compound		antileishmanial agent;
antimetabolite;
antimicrobial agent;
antineoplastic agent;
EC 2.3.2.2 (gamma-glutamyltransferase) inhibitor;
glutamine antagonist;
metabolite		00low000000
o-(chloroacetylcarbamoyl)fumagillol
0
carbamate ester;
organochlorine compound;
semisynthetic derivative;
sesquiterpenoid;
spiro-epoxide		angiogenesis inhibitor;
antineoplastic agent;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
methionine aminopeptidase 2 inhibitor;
retinoic acid receptor alpha antagonist		00low000000
griseofulvin
0
1-benzofurans;
antibiotic antifungal drug;
benzofuran antifungal drug;
organochlorine compound;
oxaspiro compound		antibacterial agent;
Penicillium metabolite		00low000000
mometasone furoate
0
11beta-hydroxy steroid;
2-furoate ester;
20-oxo steroid;
3-oxo-Delta(1),Delta(4)-steroid;
organochlorine compound;
steroid ester		anti-allergic agent;
anti-inflammatory drug		00low000000
ochratoxin a
0
isochromanes;
monocarboxylic acid amide;
N-acyl-L-phenylalanine;
organochlorine compound;
phenylalanine derivative		Aspergillus metabolite;
calcium channel blocker;
carcinogenic agent;
mycotoxin;
nephrotoxin;
Penicillium metabolite;
teratogenic agent		00low000000
chlorpromazine n-oxide
0
organochlorine compound;
phenothiazines;
tertiary amine oxide		metabolite00low000000
loteprednol etabonate
0
11beta-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
etabonate ester;
organochlorine compound;
steroid acid ester;
steroid ester		anti-inflammatory drug00low000000
melphalan
0
L-phenylalanine derivative;
nitrogen mustard;
non-proteinogenic L-alpha-amino acid;
organochlorine compound		alkylating agent;
antineoplastic agent;
carcinogenic agent;
drug allergen;
immunosuppressive agent		00low000000
bromochloroacetic acid
0
2-bromocarboxylic acid;
monocarboxylic acid;
organochlorine compound		00low000000
tolfenamic acid
0
aminobenzoic acid;
organochlorine compound;
secondary amino compound		EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug		00low000000
1,4-dichloro-2-butene
0
organochlorine compound00low000000
1-(4-chlorophenyl)-1-cyclohexyl-3-(4-morpholinyl)-1-propanol
0
organochlorine compound00low000000
2-[(3-chlorophenyl)-(3-oxo-5-propyl-1,2-dihydropyrazol-4-yl)methyl]propanedinitrile
0
organochlorine compound00low000000
1-piperidinecarboxylic acid (5-chloro-8-quinolinyl) ester
0
organochlorine compound;
quinolines		00low000000
transfluthrin
0
carboxylic ester;
cyclopropanes;
organochlorine compound;
organofluorine compound		pyrethroid ester insecticide00low000000
tram 34
0
organochlorine compound00low000000
N-(2-chlorophenyl)hydrazine-1-carbothioamide
0
organochlorine compound00low000000
3-pyridinecarboxylic acid (5-chloro-8-quinolinyl) ester
0
organochlorine compound;
quinolines		00low000000
CHIC-35
0
aromatic compound;
organic heterotricyclic compound;
organochlorine compound;
primary carboxamide		EC 3.5.1.98 (histone deacetylase) inhibitor00low000000
dieldrin
0
epoxide;
organochlorine compound;
organochlorine insecticide		carcinogenic agent;
xenobiotic		00low000000
3-(2-chlorophenyl)-5-methyl-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)-4-isoxazolecarboxamide
0
organochlorine compound00low000000
4-chloro-N-(4-chloro-2-methylphenyl)-5-dithiazolimine
0
organochlorine compound00low000000
1-[(7-chloro-4-quinolinyl)amino]-3-(2,4-dichlorophenyl)thiourea
0
organochlorine compound;
quinolines		00low000000
2-chloro-N-[3-[(2-chlorophenyl)methyl]-2-thiazolylidene]acetamide
0
organochlorine compound00low000000
2-(4-chlorophenyl)guanidine
0
organochlorine compound00low000000
2-(4-chlorophenyl)-6-(methylthio)-4-oxo-2,3-dihydro-1,3-thiazine-5-carbonitrile
0
organochlorine compound00low000000
N-(4-chlorophenethyl)-N'-(4-chlorophenyl)urea
0
organochlorine compound00low000000
6-amino-4-(3-chlorophenyl)-3-methyl-1-(phenylmethyl)-4H-pyrano[2,3-c]pyrazole-5-carbonitrile
0
organochlorine compound;
pyranopyrazole		00low000000
5-chloro-7-[3-pyridinyl-(2-pyridinylamino)methyl]-8-quinolinol
0
organochlorine compound;
quinolines		00low000000
cb 7969312
0
organochlorine compound;
quinolines		00low000000
toremifene
0
aromatic ether;
organochlorine compound;
tertiary amine		antineoplastic agent;
bone density conservation agent;
estrogen antagonist;
estrogen receptor modulator		00low000000
ospemifene
0
aromatic ether;
organochlorine compound;
primary alcohol		anti-inflammatory agent;
antineoplastic agent;
estrogen receptor modulator		00low000000
dasatinib
0
1,3-thiazoles;
aminopyrimidine;
monocarboxylic acid amide;
N-(2-hydroxyethyl)piperazine;
N-arylpiperazine;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antineoplastic agent;
tyrosine kinase inhibitor		00low000000
N-[(4-chlorophenyl)methyl]-3-(1-ethyl-5-methyl-4-pyrazolyl)-4,5-dihydroisoxazole-5-carboxamide
0
organochlorine compound00low000000
4-butyl-3-(4-chloro-1,5-dimethyl-3-pyrazolyl)-1H-1,2,4-triazole-5-thione
0
organochlorine compound00low000000
quinoxyfen
0
aromatic ether;
monofluorobenzenes;
organochlorine compound;
quinolines		antifungal agrochemical00low000000
5-chloro-7-[1-piperidinyl(2-pyridinyl)methyl]-8-quinolinol
0
organochlorine compound;
quinolines		00low000000
5-chloro-7-[(4-ethyl-1-piperazinyl)-(3-pyridinyl)methyl]-8-quinolinol
0
organochlorine compound;
quinolines		00low000000
ML162
0
monochlorobenzenes;
monomethoxybenzene;
organochlorine compound;
secondary carboxamide;
tertiary carboxamide;
thiophenes		EC 1.11.1.9 (glutathione peroxidase) inhibitor;
ferroptosis inducer		00low000000
epi 001
0
diether;
organochlorine compound		androgen antagonist00low000000
3-[(3-chlorophenyl)methylthio]-N-cyclopentylpropanamide
0
organochlorine compound00low000000
5-[3-(2-chloro-6-methoxy-3-quinolinyl)-5-(2-furanyl)-3,4-dihydropyrazol-2-yl]-5-oxopentanoic acid
0
organochlorine compound;
quinolines		00low000000
[3-(2-chloro-6-ethoxy-3-quinolinyl)-5-phenyl-3,4-dihydropyrazol-2-yl]-thiophen-2-ylmethanone
0
organochlorine compound;
quinolines		00low000000
4-chloro-N-(1,3,4-thiadiazol-2-yl)-5-dithiazolimine
0
organochlorine compound00low000000
[4-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]-(2-oxiranyl)methanone
0
organochlorine compound00low000000
clodronic acid
0
organochlorine compound00low000000
ex 527
0
carbazoles;
monocarboxylic acid amide;
organochlorine compound		00low000000
ro 60-0175
0
indoles;
organochlorine compound;
organofluorine compound;
primary amino compound		00low000000
maytansine
0
alpha-amino acid ester;
carbamate ester;
epoxide;
maytansinoid;
organic heterotetracyclic compound;
organochlorine compound		antimicrobial agent;
antimitotic;
antineoplastic agent;
plant metabolite;
tubulin modulator		00low000000
cyhalothrin
0
aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organochlorine compound;
organofluorine compound		agrochemical;
pyrethroid ester acaricide;
pyrethroid ester insecticide		00low000000
arachidonyl-2-chloroethylamide
0
fatty amide;
organochlorine compound;
secondary carboxamide;
synthetic cannabinoid		CB1 receptor agonist;
CB2 receptor agonist;
neuroprotective agent		00low000000
nostocarboline
0
alkaloid;
beta-carbolines;
organic cation;
organochlorine compound		antimalarial;
EC 3.1.1.8 (cholinesterase) inhibitor;
metabolite		00low000000
su 11652
0
olefinic compound;
organochlorine compound;
oxindoles;
pyrrolecarboxamide;
tertiary amino compound		EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor		00low000000
chlorferron
0
organochlorine compound00low000000
2-amino-6-chloropurine
0
2-aminopurines;
organochlorine compound		00low000000
clodinafop
0
aromatic ether;
monocarboxylic acid;
organochlorine compound;
organofluorine compound;
pyridines		EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor;
phenoxy herbicide		00low000000
salubrinal
0
aminal;
organochlorine compound;
quinolines;
secondary carboxamide;
thioureas		00low000000
picloxydine
0
organochlorine compound00low000000
ma-1
0
carboxamidine;
organochlorine compound;
pyrimidone;
pyrrolidines		antineoplastic agent;
EC 2.4.2.4 (thymidine phosphorylase) inhibitor		00low000000
bifenthrin
0
carboxylic ester;
cyclopropanecarboxylate ester;
cyclopropanes;
organochlorine compound;
organofluorine compound		pyrethroid ester acaricide;
pyrethroid ester insecticide		00low000000
chaetoviridin a
0
azaphilone;
beta-hydroxy ketone;
enone;
gamma-lactone;
organic heterotricyclic compound;
organochlorine compound;
secondary alcohol		antifungal agent;
Chaetomium metabolite		00low000000
su 5614
0
organochlorine compound;
oxindoles;
pyrroles		vascular endothelial growth factor receptor antagonist00low000000
bay 12-9566
0
biphenyls;
organochlorine compound		00low000000
2-[3-(3-chlorophenyl)-5-isoxazolyl]-1-hydroxy-4H-1,2,4-benzotriazin-3-one
0
organochlorine compound00low000000
nsc 716970
0
aromatic amine;
aromatic ether;
indolecarboxamide;
organochlorine compound		antineoplastic agent00low000000
lonafarnib
0
benzocycloheptapyridine;
heteroarylpiperidine;
N-acylpiperidine;
organobromine compound;
organochlorine compound;
ureas		00low000000
cangrelor
0
adenosine 5'-phosphate;
aryl sulfide;
nucleoside triphosphate analogue;
organochlorine compound;
organofluorine compound;
secondary amino compound		P2Y12 receptor antagonist;
platelet aggregation inhibitor		00low000000
cyazofamid
0
imidazole fungicide;
imidazoles;
nitrile;
organochlorine compound;
sulfamides;
sulfonamide fungicide		antifungal agrochemical;
mitochondrial cytochrome-bc1 complex inhibitor		00low000000
avanafil
0
aromatic amide;
monocarboxylic acid amide;
organochlorine compound;
prolinols;
pyrimidines		EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
vasodilator agent		00low000000
rivaroxaban
0
aromatic amide;
lactam;
monocarboxylic acid amide;
morpholines;
organochlorine compound;
oxazolidinone;
thiophenes		anticoagulant;
EC 3.4.21.6 (coagulation factor Xa) inhibitor		00low000000
estin
0
1-benzofurans;
ether;
methyl ester;
organochlorine compound;
oxaspiro compound;
phenols		Aspergillus metabolite;
Penicillium metabolite		00low000000
pitolisant
0
organochlorine compound00low000000
dysidenin
0
1,3-thiazoles;
organochlorine compound;
secondary carboxamide;
tertiary carboxamide		animal metabolite;
marine metabolite;
toxin		00low000000
6-chlorotryptophan
0
L-alpha-amino acid zwitterion;
L-tryptophan derivative;
non-proteinogenic L-alpha-amino acid;
organochlorine compound		00low000000
tolfenpyrad
0
aromatic amide;
aromatic ether;
organochlorine compound;
pyrazole insecticide		agrochemical;
antifungal agent;
EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor;
mitochondrial NADH:ubiquinone reductase inhibitor		00low000000
saracatinib
0
aromatic ether;
benzodioxoles;
diether;
N-methylpiperazine;
organochlorine compound;
oxanes;
quinazolines;
secondary amino compound		anticoronaviral agent;
antineoplastic agent;
apoptosis inducer;
autophagy inducer;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
radiosensitizing agent		00low000000
marizomib
0
beta-lactone;
gamma-lactam;
organic heterobicyclic compound;
organochlorine compound;
salinosporamide		antineoplastic agent;
proteasome inhibitor		00low000000
cyantraniliprole
0
nitrile;
organobromine compound;
organochlorine compound;
pyrazole insecticide;
pyridines;
secondary carboxamide		ryanodine receptor agonist00low000000
lorcaserin
0
benzazepine;
organochlorine compound		anti-obesity agent;
appetite depressant		00low000000
3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide
0
organochlorine compound00low000000
N-[(2-chlorophenyl)methyl]-2-(4-ethyl-1-oxo-2-pyrrolo[1,2-d][1,2,4]triazinyl)acetamide
0
organochlorine compound00low000000
complestatin
0
cyclic ether;
heterodetic cyclic peptide;
indoles;
organic heterobicyclic compound;
organochlorine compound;
peptide antibiotic;
polyphenol		anti-HIV-1 agent;
antimicrobial agent;
HIV-1 integrase inhibitor;
metabolite		00low000000
neuroprotectin a
0
cyclic ether;
heterodetic cyclic peptide;
indoles;
organochlorine compound;
polyphenol		HIV-1 integrase inhibitor;
metabolite		00low000000
cnf 2024
0
2-aminopurines;
aromatic ether;
organochlorine compound;
pyridines		antineoplastic agent;
Hsp90 inhibitor		00low000000
4'-epichaetoviridin A
0
azaphilone;
beta-hydroxy ketone;
enone;
gamma-lactone;
organic heterotricyclic compound;
organochlorine compound;
secondary alcohol		Chaetomium metabolite00low000000
plx 4720
0
aromatic ketone;
difluorobenzene;
organochlorine compound;
pyrrolopyridine;
sulfonamide		antineoplastic agent;
B-Raf inhibitor		00low000000
N-[3-(3-chlorophenyl)phenyl]-1-(3-isoxazolylmethyl)-4-piperidinecarboxamide
0
biphenyls;
organochlorine compound		00low000000
N-[3-(3-chlorophenyl)phenyl]-1-(3-oxolanylmethyl)-4-piperidinecarboxamide
0
biphenyls;
organochlorine compound		00low000000
marinopyrrole a
0
aromatic ketone;
organochlorine compound;
phenols;
pyrroles		antibacterial agent;
antimicrobial agent;
antineoplastic agent;
bacterial metabolite;
marine metabolite		00low000000
suvorexant
0
1,3-benzoxazoles;
aromatic amide;
diazepine;
organochlorine compound;
triazoles		central nervous system depressant;
orexin receptor antagonist		00low000000
chaetoviridin E
0
azaphilone;
enone;
gamma-lactone;
organic heterotricyclic compound;
organochlorine compound		Chaetomium metabolite00low000000
pexidartinib
0
aminopyridine;
organochlorine compound;
organofluorine compound;
pyrrolopyridine;
secondary amino compound		antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor		00low000000
4-chloro-N-(5-methyl-1,3,4-oxadiazol-2-yl)-5-dithiazolimine
0
organochlorine compound00low000000
thiopental sodium
0
organochlorine compound;
piperazines;
pyrimidines		antineoplastic agent;
tyrosine kinase inhibitor		00low000000
jq1 compound
0
carboxylic ester;
organochlorine compound;
tert-butyl ester;
thienotriazolodiazepine		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
bromodomain-containing protein 4 inhibitor;
cardioprotective agent;
ferroptosis inducer		00low000000
N-[9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methylpyrazole-4-carboxamide
0
aromatic amide;
bridged compound;
olefinic compound;
organochlorine compound;
organofluorine compound;
pyrazoles		00low000000
lornoxicam
0
heteroaryl hydroxy compound;
monocarboxylic acid amide;
organochlorine compound;
pyridines;
thienothiazine		antipyretic;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug		00low000000
AZD3463
0
aminopiperidine;
aminopyrimidine;
indoles;
monomethoxybenzene;
organochlorine compound;
secondary amino compound;
tertiary amino compound		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor		00low000000
ceritinib
0
aminopyrimidine;
aromatic ether;
organochlorine compound;
piperidines;
secondary amino compound;
sulfone		antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor		00low000000
HG-10-102-01
0
aminopyrimidine;
aromatic ether;
monocarboxylic acid amide;
morpholines;
organochlorine compound;
secondary amino compound		EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor00low000000
opt 80
0
carboxylic ester;
glycoside;
macrolide antibiotic;
organochlorine compound;
phenols		antibacterial drug;
bacterial metabolite;
EC 2.7.7.6 (RNA polymerase) inhibitor		00low000000
acarbose
0
chondramide;
indoles;
organochlorine compound;
phenols		antineoplastic agent;
bacterial metabolite		00low000000
clothianidin
0
1,3-thiazoles;
2-nitroguanidine derivative;
clothianidin;
organochlorine compound		environmental contaminant;
neonicotinoid insectide;
nicotinic acetylcholine receptor agonist;
xenobiotic		00low000000
THZ531
0
aminopyrimidine;
enamide;
indoles;
N-acylpiperidine;
organochlorine compound;
secondary amino compound;
secondary carboxamide		antineoplastic agent;
apoptosis inducer;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor		00low000000
clozapine
0
benzodiazepine;
N-arylpiperazine;
N-methylpiperazine;
organochlorine compound		adrenergic antagonist;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
GABA antagonist;
histamine antagonist;
muscarinic antagonist;
second generation antipsychotic;
serotonergic antagonist;
xenobiotic		00low000000
norclozapine
0
dibenzodiazepine;
organochlorine compound;
piperazines		delta-opioid receptor agonist;
metabolite;
serotonergic antagonist		00low000000
5-[1-[(2-chlorophenyl)methyl]-2,5-dimethyl-3-pyrrolyl]-N-(1-methoxypropan-2-yl)-6H-1,3,4-thiadiazin-2-amine
0
organochlorine compound00low000000
8-((4-chlorophenyl)thio)cyclic-3',5'-gmp
0
3',5'-cyclic purine nucleotide;
aryl sulfide;
organochlorine compound;
ribonucleotide		protein kinase agonist00low000000
XL413
0
benzofuropyrimidine;
organochlorine compound;
pyrrolidines		antineoplastic agent;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor		00low000000
clothianidin
0
1,3-thiazoles;
2-nitroguanidine derivative;
clothianidin;
organochlorine compound		environmental contaminant;
neonicotinoid insectide;
nicotinic acetylcholine receptor agonist;
xenobiotic		00low000000
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
carbamazepine
1
dibenzoazepine;
ureas		analgesic;
anticonvulsant;
antimanic drug;
drug allergen;
EC 3.5.1.98 (histone deacetylase) inhibitor;
environmental contaminant;
glutamate transporter activator;
mitogen;
non-narcotic analgesic;
sodium channel blocker;
xenobiotic		2012201212.0low000010
valproic acid
1
branched-chain fatty acid;
branched-chain saturated fatty acid		anticonvulsant;
antimanic drug;
EC 3.5.1.98 (histone deacetylase) inhibitor;
GABA agent;
neuroprotective agent;
psychotropic drug;
teratogenic agent		2012201212.0low000010
felbamate
1
carbamate esteranticonvulsant;
neuroprotective agent		2012201212.0low000010
sec-butyl-propylacetamide
1
2012201212.0low000010
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
carbamates
40
amino-acid anion2007202113.7high120023161
2-amino-5-phosphonovalerate
1
non-proteinogenic alpha-amino acidNMDA receptor antagonist2011201113.0low000010
phenytoin
3
imidazolidine-2,4-dioneanticonvulsant;
drug allergen;
sodium channel blocker;
teratogenic agent		2008201114.7low000210
valproic acid
1
branched-chain fatty acid;
branched-chain saturated fatty acid		anticonvulsant;
antimanic drug;
EC 3.5.1.98 (histone deacetylase) inhibitor;
GABA agent;
neuroprotective agent;
psychotropic drug;
teratogenic agent		2007200717.0low000100
ethosuximide
1
dicarboximide;
pyrrolidinone		anticonvulsant;
geroprotector;
T-type calcium channel blocker		2008200816.0low000100
lidocaine
1
benzenes;
monocarboxylic acid amide;
tertiary amino compound		anti-arrhythmia drug;
drug allergen;
environmental contaminant;
local anaesthetic;
xenobiotic		2009200915.0low000100
labetalol
1
benzamides;
benzenes;
phenols;
primary carboxamide;
salicylamides;
secondary alcohol;
secondary amino compound		201720177.0low000010
lamotrigine
2
1,2,4-triazines;
dichlorobenzene;
primary arylamine		anticonvulsant;
antidepressant;
antimanic drug;
calcium channel blocker;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
excitatory amino acid antagonist;
geroprotector;
non-narcotic analgesic;
xenobiotic		2007201314.0low000110
nevirapine
1
cyclopropanes;
dipyridodiazepine		antiviral drug;
HIV-1 reverse transcriptase inhibitor		201720177.0low000010
phenobarbital
1
barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative		2008200816.0low000100
ropinirole
1
indolones;
tertiary amine		antidyskinesia agent;
antiparkinson drug;
central nervous system drug;
dopamine agonist		201720177.0low000010
urethane
1
carbamate esterfungal metabolite;
mutagen		2008200816.0low000100
pilocarpine
2
pilocarpineantiglaucoma drug2013201410.5low000020
pyrroles
2
pyrrole;
secondary amine		2009201711.0low000110
kainic acid
1
dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid		antinematodal drug;
excitatory amino acid agonist		2008200816.0low000100
lithium carbonate
1
carbonate salt;
lithium salt		antimanic drug2014201410.0low000010
uridine diphosphate glucuronic acid
1
UDP-D-glucuronic acidEscherichia coli metabolite;
human metabolite;
mouse metabolite		2007200717.0low100100
cephapirin
1
cephalosporinantibacterial drug201720177.0low000010
alkenes
1
2008200816.0low000100
glutamic acid
1
glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical		2011201113.0low000010
cyclindole
1
201720177.0medium000010
4-aminopyrimidine
1
aminopyrimidine2009200915.0low000100
chlorosulfonyl isocyanate
1
2008200816.0low000100
voriconazole
1
conazole antifungal drug;
difluorobenzene;
pyrimidines;
tertiary alcohol;
triazole antifungal drug		P450 inhibitor201720177.0low000010
cyanates
1
2008200816.0low000100
lacosamide
1
N-acyl-amino acid2009200915.0low000100
cannabidiol
1
olefinic compound;
phytocannabinoid;
resorcinols		antimicrobial agent;
plant metabolite		202220222.0low000001
D-fructopyranose
3
cyclic hemiketal;
D-fructose;
fructopyranose		sweetening agent2008200915.7low000300
lithium
1
alkali metal atom2013201311.0low000010
6-cyano-7-nitroquinoxaline-2,3-dione
1
quinoxaline derivative2011201113.0low000010
topiramate
3
cyclic ketal;
ketohexose derivative;
sulfamate ester		anticonvulsant;
sodium channel blocker		2008200915.7low000300
ucb 34714
1
gamma-lactam;
non-proteinogenic amino acid derivative		anticonvulsant2009200915.0low000100
tofacitinib
1
N-acylpiperidine;
nitrile;
pyrrolopyrimidine;
tertiary amino compound		antirheumatic drug;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor		201720177.0low000010
losartan potassium
1
201520159.0low000010
sazetidine-a
1
2012201212.0low000010
picrotoxin
1
2011201113.0low000010
piperidines
2
201220179.5low000020
warfarin
1
benzenes;
hydroxycoumarin;
methyl ketone		2012201212.0low100010
olanzapine
1
benzodiazepine;
N-arylpiperazine;
N-methylpiperazine		antiemetic;
dopaminergic antagonist;
histamine antagonist;
muscarinic antagonist;
second generation antipsychotic;
serotonergic antagonist;
serotonin uptake inhibitor		201720177.0low000010
spd 502
1
2009200915.0medium000100
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Abdominal Epilepsy0
6
200820229.5low300222
Abdominal Migraine0
1
2009200915.0low100100
Absence Seizure0
3
2008201214.7low000210
Absence Seizure Disorder0
1
2008200816.0low000100
Absence Status0
5
2008201412.8low000230
Acute Brain Injuries0
1
2007200717.0low000100
Adenoma Sebaceum0
1
202220222.0low000001
Aging0
1
2008200816.0low100100
Alcohol Abuse0
1
2012201212.0low000010
Alcohol Drinking0
1
2009200915.0low000100
Alcoholism1
1
2012201212.0low000010
Asymmetric Diabetic Proximal Motor Neuropathy0
1
2014201410.0low100010
Audiogenic Epilepsy0
2
2007200816.5low100200
Aura0
5
2007202213.6low000401
Benign Essential Tremor0
1
2010201014.0low100100
Benign Psychomotor Epilepsy, Childhood0
2
201420159.5low000020
Body Weight0
1
2008200816.0low100100
Brain Edema0
1
2007200717.0low000100
Brain Injuries0
1
2007200717.0low000100
Brain Swelling0
1
2007200717.0low000100
Cirrhosis, Liver0
1
2012201212.0low100010
Cognition Disorders0
1
2011201113.0low100010
Complex Partial Epilepsy0
1
2014201410.0low000010
Concussive Convulsion0
1
2011201113.0low000010
Convulsive Generalized Seizure Disorder0
1
2008200816.0low000100
Craniocerebral Injuries0
1
2011201113.0low000010
Craniocerebral Trauma0
1
2011201113.0low000010
Cryptogenic Infantile Spasms0
2
201120227.5low000011
Deficiency, Magnesium0
1
2008200816.0low000100
Depression0
1
2007200717.0low100100
Diabetic Neuropathies1
1
2014201410.0low100010
Disease Models, Animal0
10
2007201513.4low000550
Dizziness0
1
2010201014.0low100100
Dizzyness0
1
2010201014.0low100100
Drug Refractory Epilepsy0
1
202120213.0low000001
Encephalopathy, Toxic0
1
2012201212.0low000010
Epilepsies, Partial0
6
200820229.5low300222
Epilepsy1
5
2007202213.6low000401
Epilepsy, Absence0
1
2008200816.0low000100
Epilepsy, Complex Partial1
1
2014201410.0low000010
Epilepsy, Reflex0
2
2007200816.5low100200
Epilepsy, Temporal Lobe0
2
201420159.5low000020
Essential Tremor0
1
2010201014.0low100100
Lennox Gastaut Syndrome0
1
202220222.0low000001
Lennox-Gastaut Syndrome0
1
202220222.0low000001
Liver Cirrhosis0
1
2012201212.0low100010
Magnesium Deficiency0
1
2008200816.0low000100
Migraine Disorders1
1
2009200915.0low100100
Muscle Spasm0
1
2011201113.0low000010
Neuralgia, Postherpetic0
1
2014201410.0low100010
Postherpetic Neuralgia0
1
2014201410.0low100010
Pregnancy0
2
2009201114.0low000110
Seizures1
3
2008201214.7low000210
Sensitivity and Specificity0
1
2013201311.0low000010
Spasm0
1
2011201113.0low000010
Spasms, Infantile0
2
201120227.5low000011
Status Epilepticus0
5
2008201412.8low000230
Tuberous Sclerosis0
1
202220222.0low000001

Safety/Toxicity (3)

ArticleYear
Efficacy and safety of carisbamate in patients with diabetic neuropathy or postherpetic neuralgia: results from 3 randomized, double-blind placebo-controlled trials.
Pain practice : the official journal of World Institute of Pain, , Volume: 14, Issue:4		2014
A randomized, double-blind, placebo-controlled study of the efficacy, safety, and tolerability of adjunctive carisbamate treatment in patients with partial-onset seizures.
Epilepsia, , Volume: 52, Issue:4		2011
Pharmacokinetics, safety, and tolerability of the new antiepileptic carisbamate in the elderly.
Epilepsy research, , Volume: 79, Issue:1		2008

Long-term Use (1)

ArticleYear
Carisbamate, a novel antiepileptic candidate compound, attenuates alcohol intake in alcohol-preferring rats.
Alcoholism, clinical and experimental research, , Volume: 33, Issue:8		2009

Pharmacokinetics (4)

ArticleYear
Effect of carisbamate on the pharmacokinetics and pharmacodynamics of warfarin in healthy participants.
Journal of clinical pharmacology, , Volume: 52, Issue:9		2012
Effect of mild and moderate hepatic impairment on the pharmacokinetics and safety of carisbamate.
Journal of clinical pharmacology, , Volume: 52, Issue:5		2012
Pharmacokinetics of carisbamate (RWJ-333369) in healthy Japanese and Western subjects.
Epilepsia, , Volume: 50, Issue:8		2009
Pharmacokinetics, safety, and tolerability of the new antiepileptic carisbamate in the elderly.
Epilepsy research, , Volume: 79, Issue:1		2008

Dosage (7)

ArticleYear
Cognitive effects of carisbamate in randomized, placebo-controlled, healthy-volunteer, multidose studies.
Epilepsy & behavior : E&B, , Volume: 22, Issue:2		2011
Pharmacokinetics of carisbamate (RWJ-333369) in healthy Japanese and Western subjects.
Epilepsia, , Volume: 50, Issue:8		2009
Evaluation of carisbamate for the treatment of migraine in a randomized, double-blind trial.
Headache, , Volume: 49, Issue:2		2009
Pharmacokinetics, safety, and tolerability of the new antiepileptic carisbamate in the elderly.
Epilepsy research, , Volume: 79, Issue:1		2008
An interaction study between the new antiepileptic and CNS drug carisbamate (RWJ-333369) and lamotrigine and valproic acid.
Epilepsia, , Volume: 48, Issue:7		2007
Metabolism and excretion of RWJ-333369 [1,2-ethanediol, 1-(2-chlorophenyl)-, 2-carbamate, (S)-] in mice, rats, rabbits, and dogs.
Drug metabolism and disposition: the biological fate of chemicals, , Volume: 35, Issue:4		2007
The absorption, metabolism, and excretion of the novel neuromodulator RWJ-333369 (1,2-ethanediol, [1-2-chlorophenyl]-, 2-carbamate, [S]-) in humans.
Drug metabolism and disposition: the biological fate of chemicals, , Volume: 35, Issue:4		2007