Compounds > viqualine

Page last updated: 2024-12-10

viqualine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID Source	ID
PubMed CID	3050111
CHEMBL ID	2104497
SCHEMBL ID	141644
MeSH ID	M0116857

Synonyms (18)

Synonym
viqualine
viqualine [inn]
4-[3-[(3r,4r)-3-ethenylpiperidin-4-yl]propyl]-6-methoxyquinoline
6-methoxy-4-(3-((3r,4r)-3-vinyl-4-piperidyl)propyl)quinoline
viqualinum [inn-latin]
unii-1y3a5e2l1j
viqualinum
viqualina [inn-spanish]
1y3a5e2l1j ,
72714-74-0
CHEMBL2104497
viqualine [mart.]
6-methoxy-4-(3-((3r,4r)-3-vinyl-4-piperidyl)propyl)quinoline.
SCHEMBL141644
(3r,4r)-4-[3-(6-methoxyquinolin-4-yl)propyl]-3-vinylpiperidine
XFXANHWIBFMEOY-JKSUJKDBSA-N
Q7933523
DTXSID601024516

Research Excerpts

Pharmacokinetics

Excerpt	Reference	Relevance
" The mean apparent half-life was 12."	( Pharmacokinetics and bioavailability of viqualine, a new antidepressant. Bouquet, S; Courtois, P; Fourtillan, JB; Girault, J; Lefebvre, MA; Maulet, C, )	0.4

Bioavailability

Excerpt	Reference	Relevance
" The bioavailability of oral viqualine averaged 80%."	( Pharmacokinetics and bioavailability of viqualine, a new antidepressant. Bouquet, S; Courtois, P; Fourtillan, JB; Girault, J; Lefebvre, MA; Maulet, C, )	0.69

Dosage Studied

Excerpt	Relevance	Reference
" The subjects were randomly assigned to receive ethanol dosed to maintain blood alcohol concentrations of 17-22 mmol."	( Kinetic and dynamic interactions of oral viqualine and ethanol in man. Kadlec, KE; Kaplan, HL; Naranjo, CA; Sellers, EM; Shaw, CA; Sullivan, JT, 1989)	0.54

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (83.33)	18.7374
1990's	1 (16.67)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	3 (42.86%)	5.53%
Reviews	1 (14.29%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	3 (42.86%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
acetaldehyde Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.. acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.. aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.. acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.	3.36	1	1	aldehyde	carcinogenic agent; EC 3.5.1.4 (amidase) inhibitor; electron acceptor; Escherichia coli metabolite; human metabolite; mouse metabolite; mutagen; oxidising agent; Saccharomyces cerevisiae metabolite; teratogenic agent
1-(3-chlorophenyl)piperazine 1-(3-chlorophenyl)piperazine: supposed metabolite of TRAZODONE; RN given refers to parent cpd; structure. 1-(3-chlorophenyl)piperazine : A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.	3.07	1	0	monochlorobenzenes; N-arylpiperazine	drug metabolite; environmental contaminant; serotonergic agonist; xenobiotic
p-chloroamphetamine p-Chloroamphetamine: Chlorinated analog of AMPHETAMINE. Potent neurotoxin that causes release and eventually depletion of serotonin in the CNS. It is used as a research tool.	1.96	1	0
lorazepam Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.	3.35	1	1	benzodiazepine

Condition	Indicated	Relationship Strength	Studies	Trials
Recrudescence [description not available]	0	2.89	1	0
Alcohol Abuse [description not available]	0	2.89	1	0
Alcohol Drinking Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.	0	4.68	2	1
Alcoholism A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)	0	2.89	1	0
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	0	3.36	1	1
Depression, Endogenous [description not available]	0	3.35	1	1
Depressive Disorder An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.	0	3.35	1	1