muscimol has been researched along with Alcohol Abuse in 22 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Long-term alcohol abuse is known to target specific areas of the brain such as the superior frontal cortex (SFC), resulting in neuronal cell loss." | 1.31 | Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex. ( Buckley, ST; Dodd, PR; Eckert, AL, 2000) |
| "Sleep-wake states were studied following withdrawal in 36 adult male wistar alcohol-dependent rats, after chronic administration of ethanol (10 g/kg/24 h) for 13 days." | 1.30 | Effects of muscimol or homotaurine on sleep-wake states in alcohol-dependent rats during withdrawal. ( Bajenaru, O; Dall'Ava-Santucci, J; Dinh-Xuan, AT; Emmanouilidis, E; Manicom, R; Poenaru, S; Rouhani, S; Tran, G, 1998) |
| "Whereas cases with concomitant Wernicke encephalopathy may also have had greater numbers of superior frontal [3H]muscimol binding sites than controls, alcoholics with cirrhosis of the liver showed more muted differences." | 1.29 | GABAA receptors in damaged cerebral cortex areas in human chronic alcoholics. ( Dodd, PR, 1994) |
| "The effect of alcohol dependence induced by ethanol inhalation on GABA-dependent 36Cl- influx into membrane vesicles prepared from the mouse brain has been examined." | 1.28 | Functional alterations in cerebral GABAA receptor complex associated with formation of alcohol dependence: analysis using GABA-dependent 36Cl- influx into neuronal membrane vesicles. ( Kuriyama, K; Ueha, T, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (22.73) | 18.7374 |
| 1990's | 10 (45.45) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bianchi, PC | 1 |
| Carneiro de Oliveira, PE | 1 |
| Palombo, P | 1 |
| Leão, RM | 1 |
| Cogo-Moreira, H | 1 |
| Planeta, CDS | 1 |
| Cruz, FC | 1 |
| Mehta, AK | 3 |
| Ticku, MK | 3 |
| Warnault, V | 1 |
| Houchi, H | 1 |
| Barbier, E | 1 |
| Pierrefiche, O | 1 |
| Vilpoux, C | 1 |
| Ledent, C | 1 |
| Daoust, M | 1 |
| Naassila, M | 1 |
| Moore, EM | 1 |
| Serio, KM | 1 |
| Goldfarb, KJ | 1 |
| Stepanovska, S | 1 |
| Linsenbardt, DN | 1 |
| Boehm, SL | 1 |
| Marutha Ravindran, CR | 1 |
| Lê, AD | 1 |
| Lê Dzung, A | 1 |
| Funk, D | 1 |
| Harding, S | 1 |
| Juzytsch, W | 1 |
| Li, Z | 1 |
| Fletcher, PJ | 1 |
| DeFeudis, FV | 1 |
| Unwin, JW | 1 |
| Taberner, PV | 1 |
| Gonzalez, LP | 1 |
| Hettinger, MK | 1 |
| Klein, RL | 1 |
| Mascia, MP | 1 |
| Whiting, PJ | 1 |
| Harris, RA | 1 |
| Hodge, CW | 1 |
| Chappelle, AM | 1 |
| Samson, HH | 1 |
| Dodd, PR | 4 |
| Thomas, GJ | 2 |
| McCloskey, A | 1 |
| Crane, DI | 1 |
| Smith, ID | 1 |
| Roberts, AJ | 1 |
| Cole, M | 1 |
| Koob, GF | 1 |
| Kril, JJ | 1 |
| Watson, WE | 1 |
| Johnston, GA | 1 |
| Harper, CG | 1 |
| Rouhani, S | 2 |
| Dall'Ava-Santucci, J | 1 |
| Bajenaru, O | 1 |
| Emmanouilidis, E | 2 |
| Tran, G | 2 |
| Manicom, R | 1 |
| Dinh-Xuan, AT | 1 |
| Poenaru, S | 2 |
| Buckley, ST | 1 |
| Eckert, AL | 1 |
| Kuriyama, K | 1 |
| Ueha, T | 1 |
| Payan, C | 1 |
| Castresana, A | 1 |
| Soulairac, A | 1 |
| Ulrichsen, J | 1 |
| Clemmesen, L | 1 |
| Barry, D | 1 |
| Hemmingsen, R | 1 |
| Korpi, ER | 1 |
| Lindroos, F | 1 |
| Pyykkö, I | 1 |
| Malminen, O | 1 |
| Kaheinen, P | 1 |
| Ignatius, J | 1 |
| Mäntysalo, S | 1 |
1 review available for muscimol and Alcohol Abuse
| Article | Year |
|---|---|
Psychoactive agents and GABA-receptors.
Topics: Alcoholism; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Barbiturates; Benzodiazepines; Ethan | 1983 |
21 other studies available for muscimol and Alcohol Abuse
| Article | Year |
|---|---|
Functional inactivation of the orbitofrontal cortex disrupts context-induced reinstatement of alcohol seeking in rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Baclofen; Conditioning, Operant; Drug-Seeking Behavior; Femal | 2018 |
Effect of chronic administration of ethanol on GABAA receptor assemblies derived from alpha2-, alpha3-, beta2- and gamma2-subunits in the rat cerebral cortex.
Topics: Alcoholism; Animals; Central Nervous System Depressants; Cerebral Cortex; Ethanol; Flunitrazepam; GA | 2005 |
The lack of CB1 receptors prevents neuroadapatations of both NMDA and GABA(A) receptors after chronic ethanol exposure.
Topics: Adaptation, Physiological; Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Binding S | 2007 |
GABAergic modulation of binge-like ethanol intake in C57BL/6J mice.
Topics: Alcoholism; Animals; Baclofen; Central Nervous System Depressants; Darkness; Dose-Response Relations | 2007 |
Effect of chronic administration of ethanol on the regulation of the delta-subunit of GABA(A) receptors in the rat brain.
Topics: Alcoholism; Animals; Central Nervous System Depressants; Cerebellum; Ethanol; GABA Agonists; Male; M | 2007 |
Intra-median raphe nucleus (MRN) infusions of muscimol, a GABA-A receptor agonist, reinstate alcohol seeking in rats: role of impulsivity and reward.
Topics: 5,7-Dihydroxytryptamine; Alcoholism; Animals; Attention; Choice Behavior; Conditioning, Classical; E | 2008 |
Sex and strain differences in GABA receptor binding after chronic ethanol drinking in mice.
Topics: Alcoholism; Animals; Behavior, Animal; Brain Chemistry; Female; Humans; Kinetics; Male; Mice; Muscim | 1980 |
Intranigral muscimol suppresses ethanol withdrawal seizures.
Topics: Acoustic Stimulation; Alcoholism; Animals; gamma-Aminobutyric Acid; Humans; Male; Muscimol; Oxazoles | 1984 |
GABAA receptor function and binding in stably transfected cells: chronic ethanol treatment.
Topics: Alcoholism; Animals; Cattle; Cell Line; Dose-Response Relationship, Drug; Ethanol; Flunitrazepam; Ge | 1995 |
GABAergic transmission in the nucleus accumbens is involved in the termination of ethanol self-administration in rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Bicuculline; Dose-Response Relationship, Drug; gamma-Aminobut | 1995 |
The neurochemical pathology of thiamine deficiency: GABAA and glutamateNMDA receptor binding sites in a goat model.
Topics: Alcoholism; Amprolium; Animals; Brain Chemistry; Diazepam; Disease Models, Animal; Dizocilpine Malea | 1996 |
Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats.
Topics: Alcoholism; Amygdala; Animals; Brain Mapping; Conditioning, Operant; gamma-Aminobutyric Acid; Male; | 1996 |
Receptor binding sites and uptake activities mediating GABA neurotransmission in chronic alcoholics with Wernicke encephalopathy.
Topics: Adult; Aged; Aged, 80 and over; Alcoholism; Binding Sites; Diazepam; Female; Fibrosis; Flunitrazepam | 1996 |
GABAA receptors in damaged cerebral cortex areas in human chronic alcoholics.
Topics: Adult; Aged; Alcoholism; Binding Sites; Case-Control Studies; Cerebral Cortex; Diazepam; Flunitrazep | 1994 |
Effects of muscimol or homotaurine on sleep-wake states in alcohol-dependent rats during withdrawal.
Topics: Alcoholic Intoxication; Alcoholism; Animals; Behavior, Animal; Body Weight; Central Nervous System D | 1998 |
Prevalence of the GABAA receptor assemblies containing alpha1-subunit in the rat cerebellum and cerebral cortex as determined by immunoprecipitation: lack of modulation by chronic ethanol administration.
Topics: Affinity Labels; Alcoholism; Animals; Azides; Benzodiazepines; Brain Chemistry; Central Nervous Syst | 1999 |
Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex.
Topics: Alcoholism; Autoradiography; Blotting, Northern; Cerebral Cortex; Flunitrazepam; GABA Agonists; GABA | 2000 |
Functional alterations in cerebral GABAA receptor complex associated with formation of alcohol dependence: analysis using GABA-dependent 36Cl- influx into neuronal membrane vesicles.
Topics: Administration, Inhalation; Alcohol Withdrawal Delirium; Alcoholism; Animals; Brain; Bridged Bicyclo | 1992 |
Effects of alcohol dependence on shock-induced fighting: action of muscimol and homotaurine.
Topics: Aggression; Alcoholism; Animals; Body Weight; Electroshock; Ethanol; gamma-Aminobutyric Acid; Male; | 1992 |
The GABA/benzodiazepine receptor chloride channel complex during repeated episodes of physical ethanol dependence in the rat.
Topics: Alcoholism; Animals; Chlorides; Diazepam; Ion Channels; Male; Muscimol; Radioligand Assay; Rats; Rat | 1988 |
Ethanol-induced modulation of hippocampal EEG and cerebral 2-deoxyglucose accumulation in rat lines with differing alcohol sensitivities.
Topics: Alcoholism; Animals; Brain Chemistry; Cerebellum; Deoxy Sugars; Deoxyglucose; Drug Tolerance; Electr | 1987 |