Page last updated: 2024-10-18

glycine and Alcohol Abuse

glycine has been researched along with Alcohol Abuse in 27 studies

Research Excerpts

Excerpt	Relevance	Reference
"Alcohol dependence is a heterogeneous disorder where several signalling systems play important roles."	1.39	Ghrelin receptor (GHS-R1A) antagonism suppresses both alcohol consumption and the alcohol deprivation effect in rats following long-term voluntary alcohol consumption. ( Engel, JA; Fredriksson, I; Jerlhag, E; Steensland, P; Suchankova, P, 2013)
"The patient developed local swelling, bullae and exuding wounds."	1.39	Severe adverse effects related to dermal exposure to a glyphosate-surfactant herbicide. ( Ebbehøj, NE; Juhl, A; Madsen, PV; Mariager, TP; Schmidt, B, 2013)
"The mechanisms involved in alcohol use disorders are complex."	1.38	Ghrelin receptor (GHS-R1A) antagonism suppresses both operant alcohol self-administration and high alcohol consumption in rats. ( Bartlett, SE; Engel, JA; Hyytiä, P; Jerlhag, E; Landgren, S; Simms, JA, 2012)
"Treatment with sivelestat sodium hydrate also decreased serum neutrophil elastase activity."	1.33	[Survival by a young woman with malnutrition due to alcoholism and eating disorders and with acute respiratory distress syndrome due to severe pneumonia who showed increased serum neutrophil elastase activity]. ( Nakajima, H; Nakajima, S; Sawaguchi, H, 2006)

Research

Studies (27)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (22.22)	18.7374
1990's	4 (14.81)	18.2507
2000's	10 (37.04)	29.6817
2010's	7 (25.93)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Prisciandaro, JJ	1
Schacht, JP	1
Prescot, AP	1
Brenner, HM	1
Renshaw, PF	1
Brown, TR	1
Anton, RF	1
Suchankova, P	1
Steensland, P	1
Fredriksson, I	1
Engel, JA	2
Jerlhag, E	2
Harvey, RJ	1
Yee, BK	1
Gomez, JL	1
Cunningham, CL	1
Finn, DA	1
Young, EA	1
Helpenstell, LK	1
Schuette, LM	1
Fidler, TL	1
Kosten, TA	1
Ryabinin, AE	1
Alén, F	1
Santos, A	1
Moreno-Sanz, G	1
González-Cuevas, G	1
Giné, E	1
Franco-Ruiz, L	1
Navarro, M	1
López-Moreno, JA	1
Krystal, JH	1
Petrakis, IL	1
Limoncelli, D	1
Nappi, SK	1
Trevisan, L	1
Pittman, B	1
D'Souza, DC	1
Suckow, RF	1
Landgren, S	1
Simms, JA	1
Hyytiä, P	1
Bartlett, SE	1
Mariager, TP	1
Madsen, PV	1
Ebbehøj, NE	1
Schmidt, B	1
Juhl, A	1
SIEGEL, FL	1
ROACH, MK	1
POMEROY, LR	1
SPENCER, RP	1
BRODY, KR	1
LUTTERS, BM	1
Schumann, G	1
Rujescu, D	1
Kissling, C	1
Soyka, M	2
Dahmen, N	1
Preuss, UW	2
Wieman, S	1
Depner, M	1
Wellek, S	1
Lascorz, J	1
Bondy, B	2
Giegling, I	1
Anghelescu, I	1
Cowen, MS	1
Poustka, A	1
Spanagel, R	3
Mann, K	2
Henn, FA	1
Szegedi, A	1
Siggins, GR	1
Martin, G	1
Roberto, M	1
Nie, Z	1
Madamba, S	1
De Lecea, L	1
Koller, G	1
Zill, P	1
Ende, G	1
Welzel, H	1
Walter, S	1
Weber-Fahr, W	1
Diehl, A	1
Hermann, D	1
Heinz, A	1
Aliyev, NA	2
Aliyev, ZN	2
Nakajima, H	1
Sawaguchi, H	1
Nakajima, S	1
Vengeliene, V	1
Bilbao, A	1
Molander, A	1
Li, Z	1
Zharikova, A	1
Bastian, J	1
Esperon, L	1
Hebert, N	1
Mathes, C	1
Rowland, NE	1
Peris, J	1
Nath, R	1
Thind, SK	1
Murthy, MS	1
Talwar, HS	1
Farooqui, S	1
Aliguliyev, AR	1
Schofield, P	1
Darstein, M	1
Albrecht, C	1
López-Francos, L	1
Knörle, R	1
Hölter, SM	1
Feuerstein, TJ	1
Kharchenko, NK	2
Duplenko, PIu	1
Kovtun, TV	1
Stohniĭ, NA	1
Synyts'kyĭ, VM	1
Cooper, BR	1
Viik, K	1
Ferris, RM	1
White, HL	1
Mantero, O	1
Conti, F	1
Bertoli, L	1
Ball, GV	1
Sorensen, LB	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Glycine and Oral D-Cycloserine in Alcoholic Patients and Healthy Subjects[NCT00635102]				57 participants (Actual)	Interventional	1997-10-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 120 Minutes

Alcohol Craving Scale (ACS) Subscale: Desire to drink: Self-report rating scale used to measure desire to drink alcohol (0 No desire to drink alcohol - 100 Definitely desire to drink alcohol) (NCT00635102)
Timeframe: 120 minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	6.19	8	9.05	5.24
Healthy Subjects	1.30	1.667	2.08	2.08

Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	6.5	9	10.48	5.71
Healthy Subjects	1.82	2.17	1.67	2.08

Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes Prior to Glycine Infusion

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	7.27	8.5	6.67	4.76
Healthy Subjects	2.61	1.67	3.04	1.25

Alcohol Craving Scale (ACS) Subscale: Desire to Drink- Baseline

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	7.62	9.5	5	7.62
Healthy Subjects	3.04	2.5	1.67	0

Alcohol Craving Scale (ACS) Subscale: Desire to Drink: - 30 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	9.05	9	8	5.71
Healthy Subjects	1.82	2.17	2.5	2.08

Alcohol Craving Scale (ACS) Subscale: Discomfort - 120 Minutes

Alcohol Craving Scale (ACS) Subscale: Discomfort: Self-report rating scale - subscale reflecting expected alcohol-related relief from discomfort (0 Not at all - 100 Definitely) (NCT00635102)
Timeframe: 120 minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	8.57	9.5	9.05	6.19
Healthy Subjects	1.14	1.67	0.42	0.83

Alcohol Craving Scale (ACS) Subscale: Discomfort - 30 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	12.38	8.95	9.5	8.57
Healthy Subjects	1.82	1.74	0.42	0.42

Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	6.5	10.5	9.05	6.19
Healthy Subjects	1.36	1.74	0.42	0.83

Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes Prior to Glycine Infusion

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	6.36	8.95	7.14	10.48
Healthy Subjects	1.30	1.25	0.44	0.42

Alcohol Craving Scale (ACS) Subscale: Discomfort - Baseline

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	8.1	12.5	7.73	8.10
Healthy Subjects	2.61	1.67	0.42	0.42

Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 120 Minutes

Alcohol Craving Scale (ACS) Subscale: Mood improvement : Self-report rating scale used to measure expected alcohol-related mood improvement (0 Not at all - 100 Definitely) (NCT00635102)
Timeframe: 120 minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	6.19	7	8.57	7.62
Healthy Subjects	0.87	0.83	0.42	0.42

Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 30 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	11.43	8	10.5	6.67
Healthy Subjects	0.91	0.87	0.42	0.42

Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	5.5	8.5	8.1	6.67
Healthy Subjects	0.46	0.87	0.83	0.83

Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes Prior to Glycine Infusion

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	7.73	8	7.62	6.19
Healthy Subjects	0.87	0.83	1.30	0.42

Alcohol Craving Scale (ACS) Subscale: Mood Improvement - Baseline

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	6.67	10.5	6.82	8.10
Healthy Subjects	1.74	0.42	0.42	0

Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 120 Minutes

Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely) (NCT00635102)
Timeframe: 120 minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	34.29	33.5	30.48	36.67
Healthy Subjects	98.26	99.17	99.17	99.17

Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 30 Minutes

Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely) (NCT00635102)
Timeframe: 30 minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	32.86	36	36.5	36.67
Healthy Subjects	99.1	98.70	99.17	99.17

Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes

Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely) (NCT00635102)
Timeframe: 60 minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	34	39.5	25.71	37.14
Healthy Subjects	99.1	99.13	99.17	99.17

Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes Prior to Glycine Infusion

Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely) (NCT00635102)
Timeframe: 60 minutes prior to Glycine infusion

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	30.46	40.5	36.67	42.86
Healthy Subjects	98.26	95	99.13	99.17

Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - Baseline

Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely) (NCT00635102)
Timeframe: Baseline

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	29.05	35.5	42.27	41.43
Healthy Subjects	93.48	94.58	99.17	98.75

Biphasic Alcohol Effects Scale (BAES) - Subscale Sedation 60 Minutes Prior to Glycine Infusion

Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol (NCT00635102)
Timeframe: 60 minutes prior to Glycine infusion

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	6.23	6.6	7.24	4.57
Healthy Subjects	7.39	3.79	6.25	3.67

Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 120 Minutes

Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol (NCT00635102)
Timeframe: 120 minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	3.57	4.35	4	3.71
Healthy Subjects	4.13	1.67	3.04	1.25

Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 30 Minutes

Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol (NCT00635102)
Timeframe: 30 minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	7.14	5.8	5.2	4.62
Healthy Subjects	10.05	5.87	7.04	3.58

Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 60 Minutes

Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol (NCT00635102)
Timeframe: 60 minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	5.29	5.65	8.48	4.14
Healthy Subjects	9.64	5.83	8.54	2.54

Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - Baseline

Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol (NCT00635102)
Timeframe: Baseline

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	3.41	3.3	3.57	5
Healthy Subjects	1.91	2.75	1.83	1.88

Continuous Performance Task (CPT) - Distractibility A-Prime - 30 Minutes

gordon diagnostic system is a continuous performance task (CPT) to measure distractibility - (A-Prime score range 0 minimum - 1 maximum - the higher number the better the performance) (NCT00635102)
Timeframe: 30 minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.93	0.97	0.90	0.96
Healthy Subjects	0.1	0.1	0.1	0.1

Continuous Performance Task (CPT) - Vigilance - A-Prime Score 30 Minutes

gordon diagnostic system is a continuous performance task (CPT) to measure Vigilance - (A-Prime score range 0 minimum - 1 maximum - The higher number the better the performance) (NCT00635102)
Timeframe: 30 minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.98	0.1	0.1	0.99
Healthy Subjects	0.1	0.1	0.1	0.1

Hopkins Verbal Learning Task - Delay Recall - 90 Minutes

Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function. (delay recall - 30 minutes after Trials 1-3 were given) (0 No words recalled - 12 all words recalled) (NCT00635102)
Timeframe: 90 minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	5.1	7.75	6.29	8.25
Healthy Subjects	9.7	10.87	10.21	11.38

Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 1

Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function. (Three immediate recall trials) (0 No words recalled - 12 all words recalled) (NCT00635102)
Timeframe: 60 minutes - Trial 1

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	5.29	6.05	5.48	5.95
Healthy Subjects	7.09	8.52	7.75	8.2

Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 2

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	7.67	8.45	7.1	8.67
Healthy Subjects	10.09	11.09	10.5	10.96

Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 3

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	8	9.2	8.48	9.24
Healthy Subjects	10.57	11.48	11.17	11.67

Number of Drinks Felt Consumed at 120 Minutes

The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. (NCT00635102)
Timeframe: 120 minutes

Intervention	Number of Drinks Felt Consumed (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0	0.1	0.05	0
Healthy Subjects	0.13	0.21	0	0.04

Number of Drinks Felt Consumed at 30 Minutes

The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. (NCT00635102)
Timeframe: 30 minutes

Intervention	Number of Drinks Felt Consumed (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.38	0.20	0.38	0.24
Healthy Subjects	0.68	0.13	0.38	0.04

Number of Drinks Felt Consumed at 60 Minutes

The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. (NCT00635102)
Timeframe: 60 minutes

Intervention	Number of Drinks Felt Consumed (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.05	0.5	0.86	0.05
Healthy Subjects	1.24	0.4	0.83	0.2

Number of Drinks Felt Consumed at 60 Minutes Prior to Glycine Infusion

The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. (NCT00635102)
Timeframe: 60 minutes prior to Glycine infusion

Intervention	drinks felt consumed (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.50	0.30	0.24	0.05
Healthy Subjects	0.70	0.25	0.75	0.22

Visual Analog Scales (VAS) - 120 Minutes

Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely) (NCT00635102)
Timeframe: 120 minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.8	0.55	0.76	0.24
Healthy Subjects	0.35	0.21	0.29	0.25

Visual Analog Scales (VAS) - 30 Minutes

Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely) (NCT00635102)
Timeframe: 30 minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.48	0.65	0.48	0.52
Healthy Subjects	1.05	0.30	0.79	0.25

Visual Analog Scales (VAS) - 60 Minutes

Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely) (NCT00635102)
Timeframe: 60 minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.52	0.8	0.6	0.19
Healthy Subjects	0.91	0.22	0.71	0.17

Visual Analog Scales (VAS) - 60 Minutes Prior to Glycine Infusion

Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely) (NCT00635102)
Timeframe: 60 minutes prior to Glycine infusion

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.64	0.68	0.48	0.38
Healthy Subjects	0.82	0.33	0.96	0.61

Visual Analog Scales (VAS) - Baseline

Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely) (NCT00635102)
Timeframe: Baseline

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.32	0.5	0.76	0.48
Healthy Subjects	0.22	0.22	0.25	0.25

Visual Analog Scales of Similarity to Alcohol - Baseline

Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol (NCT00635102)
Timeframe: Baseline

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.18	0.25	0.10	0.24
Healthy Subjects	0.05	0.04	0.04	0

Visual Analog Scales of Similarity to Alcohol 120 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.43	0.3	0.57	0.10
Healthy Subjects	0.41	0.09	0.29	0.33

Visual Analog Scales of Similarity to Alcohol 30 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.57	0.60	1.05	0.43
Healthy Subjects	1.81	0.71	1.21	0.13

Visual Analog Scales of Similarity to Alcohol 60 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.67	0.75	0.81	0.24
Healthy Subjects	1.81	0.70	1.46	0.13

Visual Analog Scales of Similarity to Alcohol 60 Minutes Prior to Glycine Infusion

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.77	0.65	0.48	0.43
Healthy Subjects	1.41	0.67	1.17	.025

Reviews

4 reviews available for glycine and Alcohol Abuse

Article	Year
Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain. Nature reviews. Drug discovery, 2013, Volume: 12, Issue:11 Topics: Alcoholism; Animals; Drugs, Investigational; Glycine; Glycine Plasma Membrane Transport Proteins; Hu	2013
Glutamatergic transmission in opiate and alcohol dependence. Annals of the New York Academy of Sciences, 2003, Volume: 1003 Topics: Alcoholism; Amygdala; Animals; Ethanol; Glutamates; Glycine; Humans; Morphine Dependence; Neurons; N	2003
Neuropharmacology of alcohol addiction. British journal of pharmacology, 2008, Volume: 154, Issue:2 Topics: Alcoholism; Animals; Behavior, Addictive; Cannabinoids; Central Nervous System Agents; Corticotropin	2008
Molecular aspects of idiopathic urolithiasis. Molecular aspects of medicine, 1984, Volume: 7, Issue:1-2 Topics: Adult; Alcoholism; Animals; Calcium; Child; Child, Preschool; Dietary Carbohydrates; Dietary Fats; D	1984

Trials

3 trials available for glycine and Alcohol Abuse

Article	Year
Characterization of the interactive effects of glycine and D-cycloserine in men: further evidence for enhanced NMDA receptor function associated with human alcohol dependence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011, Volume: 36, Issue:3 Topics: Adult; Alcoholism; Amnesia; Antimetabolites; Arousal; Chromatography, Liquid; Cognition; Cycloserine	2011
Application of glycine in acute alcohol hallucinosis. Human psychopharmacology, 2005, Volume: 20, Issue:8 Topics: Administration, Sublingual; Adult; Alcoholism; Double-Blind Method; Drug Administration Schedule; Gl	2005
[The effect of medikhronal on the psychophysiological and metabolic processes in alcoholism]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2000, Volume: 46, Issue:2 Topics: Adult; Alcohol Deterrents; Alcoholism; Brain; Drug Combinations; Electroencephalography; Formates; G	2000

Other Studies

20 other studies available for glycine and Alcohol Abuse

Article	Year
Evidence for a unique association between fronto-cortical glycine levels and recent heavy drinking in treatment naïve individuals with alcohol use disorder. Neuroscience letters, 2019, 07-27, Volume: 706 Topics: Adult; Alcoholism; Binge Drinking; Female; Frontal Lobe; Glutamic Acid; Glycine; Humans; Male; Proto	2019
Ghrelin receptor (GHS-R1A) antagonism suppresses both alcohol consumption and the alcohol deprivation effect in rats following long-term voluntary alcohol consumption. PloS one, 2013, Volume: 8, Issue:8 Topics: Administration, Oral; Alcohol Drinking; Alcoholism; Animals; CpG Islands; DNA Methylation; Gene Expr	2013
Differential effects of ghrelin antagonists on alcohol drinking and reinforcement in mouse and rat models of alcohol dependence. Neuropharmacology, 2015, Volume: 97 Topics: Alcohol Drinking; Alcoholism; Animals; Central Nervous System Agents; Conditioning, Operant; Disease	2015
Cannabinoid-induced increase in relapse-like drinking is prevented by the blockade of the glycine-binding site of N-methyl-D-aspartate receptors. Neuroscience, 2009, Jan-23, Volume: 158, Issue:2 Topics: Alcohol Drinking; Alcoholism; Animals; Benzoxazines; Binding Sites; Cannabinoids; Conditioning, Oper	2009
Ghrelin receptor (GHS-R1A) antagonism suppresses both operant alcohol self-administration and high alcohol consumption in rats. Addiction biology, 2012, Volume: 17, Issue:1 Topics: Alcohol Drinking; Alcoholism; Analysis of Variance; Animals; Central Nervous System Depressants; Cho	2012
Severe adverse effects related to dermal exposure to a glyphosate-surfactant herbicide. Clinical toxicology (Philadelphia, Pa.), 2013, Volume: 51, Issue:2 Topics: Adrenal Cortex Hormones; Adult; Alcoholism; Alopecia; Analgesics; Blister; Burns, Chemical; Fingers;	2013
PLASMA AMINO ACID PATTERNS IN ALCOHOLISM: THE EFFECTS OF ETHANOL LOADING. Proceedings of the National Academy of Sciences of the United States of America, 1964, Volume: 51 Topics: Alanine; Alcoholism; Amino Acids; Autoanalysis; Biomedical Research; Blood; Ethanol; Genetics, Medic	1964
SOME EFFECTS OF ETHANOL ON THE GASTROINTESTINAL TRACT. The American journal of digestive diseases, 1964, Volume: 9 Topics: Alcohol Oxidoreductases; Alcoholism; Colon; Cricetinae; Ethanol; Gastrointestinal Tract; Glycine; Hi	1964
Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts. Biological psychiatry, 2003, Dec-15, Volume: 54, Issue:12 Topics: 5' Untranslated Regions; Adult; Alanine; Alcoholism; Case-Control Studies; Chi-Square Distribution;	2003
Alcoholism-related phenotypes and genetic variants of the CB1 receptor. European archives of psychiatry and clinical neuroscience, 2003, Volume: 253, Issue:6 Topics: Adult; Alanine; Alcoholism; Analysis of Variance; Case-Control Studies; Chitinases; Delirium; Drosop	2003
Monitoring the effects of chronic alcohol consumption and abstinence on brain metabolism: a longitudinal proton magnetic resonance spectroscopy study. Biological psychiatry, 2005, Dec-15, Volume: 58, Issue:12 Topics: Adult; Aged; Alcoholism; Aspartic Acid; Brain Chemistry; Creatine; Female; Functional Laterality; Gl	2005
[Survival by a young woman with malnutrition due to alcoholism and eating disorders and with acute respiratory distress syndrome due to severe pneumonia who showed increased serum neutrophil elastase activity]. Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 2006, Volume: 80, Issue:6 Topics: Adult; Alcoholism; Feeding and Eating Disorders; Female; Glycine; Humans; Leukocyte Elastase; Malnut	2006
High temporal resolution of amino acid levels in rat nucleus accumbens during operant ethanol self-administration: involvement of elevated glycine in anticipation. Journal of neurochemistry, 2008, Volume: 106, Issue:1 Topics: Alcohol-Induced Disorders, Nervous System; Alcoholism; Amino Acids; Animals; Central Nervous System	2008
Amino acid neurotransmitters in alcohol withdrawal. Alcohol and alcoholism (Oxford, Oxfordshire), 1994, Volume: 29, Issue:6 Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Amino Acids; Aspartic Acid; gamma-Aminobutyric Acid;	1994
Glycine: the other inhibitory neurotransmitter. Alcoholism, clinical and experimental research, 1996, Volume: 20, Issue:8 Suppl Topics: Alcoholism; Animals; DNA Mutational Analysis; Drug Synergism; Ethanol; Glycine; Humans; Mice; Mice,	1996
Release and accumulation of neurotransmitters in the rat brain: acute effects of ethanol in vitro and effects of long-term voluntary ethanol intake. Alcoholism, clinical and experimental research, 1998, Volume: 22, Issue:3 Topics: Acetylcholine; Alcoholism; Animals; Brain; Caudate Nucleus; Ethanol; gamma-Aminobutyric Acid; Glycin	1998
[The effect of medikhronal on the biogenic amine level in the brain structures and blood of animals with alcohol dependence]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 1999, Volume: 45, Issue:4 Topics: Alcohol Deterrents; Alcoholic Intoxication; Alcoholism; Animals; Biogenic Amines; Brain; Brain Chemi	1999
Antagonism of the enhanced susceptibility to audiogenic seizures during alcohol withdrawal in the rat by gamma-aminobutyric acid (GABA) and "GABA-mimetic" agents. The Journal of pharmacology and experimental therapeutics, 1979, Volume: 209, Issue:3 Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Alcoholism; Aminobutyrates; Animals; Binding, Co	1979
[Alpha-mercaptopropionylglycine (Thiola) in the treatment of chronic liver diseases with special reference to the effects of the drug on the index of prognosis in alcoholic cirrhosis]. Minerva medica, 1974, Feb-07, Volume: 65, Issue:9 Topics: Alcoholism; Amino Acids, Sulfur; Biopsy; Drug Evaluation; Glycine; Humans; Liver; Liver Cirrhosis; L	1974
Pathogenesis of hyperuricemia in saturnine gout. The New England journal of medicine, 1969, 05-29, Volume: 280, Issue:22 Topics: Adult; Alcoholic Beverages; Alcoholism; Carbon Isotopes; Creatinine; Diet; Food Contamination; Glyci	1969