benphothiamine has been researched along with Alcohol Abuse in 5 studies
benfotiamine : A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.
Excerpt | Relevance | Reference |
---|---|---|
" Baclofen has been shown to promote abstinence, to reduce craving, and to reduce anxiety in alcohol-dependent individuals, and it promises to be a useful agent, although clinical data are limited at present." | 5.24 | Randomized open-label trial of baclofen for relapse prevention in alcohol dependence. ( Arora, S; Elwadhi, D; Gupta, M; Rastogi, R; Verma, P, 2017) |
"Severe alcoholism can be associated with significant nutritional and vitamin deficiency, especially vitamin B1 (thiamine) which is associated with neurological deficits impacting mood and cognition." | 5.20 | Change in psychiatric symptomatology after benfotiamine treatment in males is related to lifetime alcoholism severity. ( Butler, MG; Manzardo, AM; Pendleton, T; Penick, EC; Poje, A, 2015) |
"Alcohol dependence is associated with severe nutritional and vitamin deficiency." | 2.78 | Double-blind, randomized placebo-controlled clinical trial of benfotiamine for severe alcohol dependence. ( Butler, MG; Campbell, J; He, J; Manzardo, AM; Penick, EC; Poje, A, 2013) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (20.00) | 18.2507 |
2000's | 1 (20.00) | 29.6817 |
2010's | 3 (60.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Manzardo, AM | 2 |
He, J | 1 |
Poje, A | 2 |
Penick, EC | 2 |
Campbell, J | 1 |
Butler, MG | 2 |
Pendleton, T | 1 |
Gupta, M | 1 |
Verma, P | 1 |
Rastogi, R | 1 |
Arora, S | 1 |
Elwadhi, D | 1 |
Kretschmar, C | 1 |
Kaumeier, S | 1 |
Haase, W | 1 |
Ayazpoor, U | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
The Effectiveness of Benfotiamine in Reducing Abusive Drinking Among Family History Positive and Negative Alcoholics[NCT00680121] | Phase 4 | 120 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
The alcoholism severity scale measures the severity of a person's dependence to alcohol. The scale ranges from a score of 0 (least severe) to 33 (most severe). The higher the score the worse the dependence. (NCT00680121)
Timeframe: 6 Months
Intervention | scores on a scale (Mean) |
---|---|
Control Group | 14.0 |
Benfotiamine | 10.7 |
Scale measures impulsiveness. It includes 30 items that are scored to yield six first-order factors (attention, motor, self-control, cognitive complexity, perseverance, and cognitive instability impulsiveness) and three second-order factors (attentional, motor, and non-planning impulsiveness). Items are scored on a 4 point scale with 1 point equaling rarely/never up to 4 points equaling almost always/always. Total impulsivity score ranges from 30 (least impulsive) to 120 (most impulsive). The higher the score the higher the level of impulsiveness. (NCT00680121)
Timeframe: 6 Months
Intervention | scores on a scale (Mean) |
---|---|
Control Group | 65.0 |
Benfotiamine | 65.4 |
measured as standard drinks of alcohol per day (SD/day) (NCT00680121)
Timeframe: Change from Baseline to 6 Months
Intervention | alcoholic drinks per day (Mean) |
---|---|
Control Group | -3.4 |
Benfotiamine | -3.0 |
The SCL-90 is a brief multidimensional self-report inventory that screens for nine symptoms of psychopathology and provides three global distress indicators. It provides an overview of symptom severity and intensity. The outcome measures psychiatric symptoms using a 30-item scale reported as t-scores relative to a normative population. (NCT00680121)
Timeframe: 6 Months
Intervention | t-score (Mean) |
---|---|
Control Group | 1.02 |
Benfotiamine | 1.04 |
4 trials available for benphothiamine and Alcohol Abuse
Article | Year |
---|---|
Double-blind, randomized placebo-controlled clinical trial of benfotiamine for severe alcohol dependence.
Topics: Adult; Alcoholism; Algorithms; Diagnostic and Statistical Manual of Mental Disorders; Double-Blind M | 2013 |
Change in psychiatric symptomatology after benfotiamine treatment in males is related to lifetime alcoholism severity.
Topics: Adult; Alcoholism; Depression; Double-Blind Method; Humans; Male; Middle Aged; Psychiatric Status Ra | 2015 |
Randomized open-label trial of baclofen for relapse prevention in alcohol dependence.
Topics: Adult; Alcohol Abstinence; Alcohol Drinking; Alcoholism; Anxiety; Baclofen; Craving; GABA-B Receptor | 2017 |
[Medicamentous therapy of alcoholic polyneuropathy. Randomized double-blind study comparing 2 vitamin B preparations and a nucleotide preparation].
Topics: Adult; Alcoholism; Cytidine; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combin | 1996 |
1 other study available for benphothiamine and Alcohol Abuse
Article | Year |
---|---|
[Chronic alcohol abuse. Benfotiamine in alcohol damage is a must].
Topics: Alcoholic Neuropathy; Alcoholism; Humans; Thiamine; Treatment Outcome; Workplace | 2001 |