| Assay ID | Title | Year | Journal | Article |
|---|
| AID329924 | Induction of histone H4 hyperacetylation in human U937 cells at 5 uM | 2008 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 18, Issue:8
| Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities. |
| AID1454706 | Inhibition of HDAC8 (unknown origin) preincubated for 2 hrs followed by Fluor-de-Lys substrate addition measured after 30 mins by fluorescence assay | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Class I HDAC Inhibitors: Potential New Epigenetic Therapeutics for Alcohol Use Disorder (AUD). |
| AID503674 | Increase in FXN mRNA expression in lymphocytes isolated from patient with Friedreich's ataxia at 5 uM after 48 hrs by qRT-PCR analysis | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID503677 | Increase in FXN mRNA expression in lymphocytes isolated from patient with Friedreich's ataxia at 5 uM after 48 hrs by qRT-PCR analysis relative to mRNA level in healthy human lymphocytes | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID329923 | Induction of histone H3 hyperacetylation in human U937 cells at 5 uM | 2008 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 18, Issue:8
| Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities. |
| AID329926 | Induction of granulocytic differentiation in human U937 cells assessed as CD11c expression at 5 uM after 30 hrs | 2008 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 18, Issue:8
| Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities. |
| AID1454705 | Inhibition of human recombinant N-terminal GST-tagged HDAC7 expressed in baculovirus infected insect cells preincubated for 2 hrs followed by Fluor-de-Lys substrate addition measured after 30 mins by fluorescence assay | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Class I HDAC Inhibitors: Potential New Epigenetic Therapeutics for Alcohol Use Disorder (AUD). |
| AID503668 | Cytotoxicity against human GM15850 cells at 5 uM after 96 hrs by trypan blue exclusion assay | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID503680 | Inhibition of HDAC in human GM15850 cells assessed as increase in histone H3 lysine 14 acetylation of FXN gene at 5 uM after 96 hrs by chromatin immunoprecipitation assay | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID1602214 | Inhibition of HDAC3 (unknown origin) | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Histone deacetylase 3 inhibitors in learning and memory processes with special emphasis on benzamides. |
| AID503675 | Increase in FXN mRNA expression in lymphocytes isolated from patient with Friedreich's ataxia at 5 uM after 48 hrs by qRT-PCR analysis relative to control | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID1454707 | Selectivity ratio of IC50 for human full length C-terminal His/FLAG-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells to IC50 for human full length C-terminal His-tagged HDAC3/N-terminal GST-tagged human NCOR2 co-expressed in baculovirus inf | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Class I HDAC Inhibitors: Potential New Epigenetic Therapeutics for Alcohol Use Disorder (AUD). |
| AID503673 | Cytotoxicity against lymphocytes isolated from patient with Friedreich's ataxia at 2.5 to 5 uM after 48 hrs by trypan blue exclusion assay | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID1454701 | Inhibition of human full length C-terminal FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 insect cells preincubated for 2 hrs followed by Fluor-de-Lys substrate addition measured after 30 mins by fluorescence assay | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Class I HDAC Inhibitors: Potential New Epigenetic Therapeutics for Alcohol Use Disorder (AUD). |
| AID503524 | Increase in FXN mRNA expression in lymphocytes isolated from patient with Friedreich's ataxia at 2.5 to 7.5 uM after 48 hrs by qRT-PCR analysis | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID503670 | Increase in frataxin protein level in human GM15850 cells at 2.5 uM after 4 days by SDS-PAGE relative to control | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID503672 | Effect on FXN mRNA expression in healthy human lymphocytes at 2.5 uM after 48 hrs by qRT-PCR analysis | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID1454702 | Inhibition of human full length C-terminal His-tagged HDAC3/N-terminal GST-tagged human NCOR2 co-expressed in baculovirus infected Sf9 insect cells preincubated for 2 hrs followed by Fluor-de-Lys substrate addition measured after 30 mins by fluorescence a | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Class I HDAC Inhibitors: Potential New Epigenetic Therapeutics for Alcohol Use Disorder (AUD). |
| AID1602216 | Inhibition of HDAC5 (unknown origin) | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Histone deacetylase 3 inhibitors in learning and memory processes with special emphasis on benzamides. |
| AID503683 | Inhibition of HDAC in human GM15850 cells assessed as increase in histone H4 lysine 12 acetylation of FXN gene at 5 uM after 96 hrs by chromatin immunoprecipitation assay | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID1602213 | Inhibition of HDAC2 (unknown origin) | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Histone deacetylase 3 inhibitors in learning and memory processes with special emphasis on benzamides. |
| AID503665 | Inhibition of HDAC in human HeLa cell extract by fluorescence plate reader assay | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID1454704 | Inhibition of human recombinant C-terminal His-tagged HDAC5 expressed in baculovirus infected insect cells preincubated for 2 hrs followed by Fluor-de-Lys substrate addition measured after 30 mins by fluorescence assay | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Class I HDAC Inhibitors: Potential New Epigenetic Therapeutics for Alcohol Use Disorder (AUD). |
| AID1454703 | Inhibition of human recombinant N-terminal GST-tagged/C-terminal His-tagged HDAC4 expressed in baculovirus infected insect cells preincubated for 2 hrs followed by Fluor-de-Lys substrate addition measured after 30 mins by fluorescence assay | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Class I HDAC Inhibitors: Potential New Epigenetic Therapeutics for Alcohol Use Disorder (AUD). |
| AID329922 | Inhibition of human HDAC4 in U937 cells at 5 uM | 2008 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 18, Issue:8
| Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities. |
| AID503686 | Inhibition of HDAC in human GM15850 cells assessed as increase in histone H4 lysine 16 acetylation of FXN gene at 5 uM after 96 hrs by chromatin immunoprecipitation assay | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID503684 | Inhibition of HDAC in human GM15850 cells assessed as increase in histone H3 lysine 9 acetylation of FXN gene at 5 uM after 96 hrs by chromatin immunoprecipitation assay | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID503671 | Increase in FXN mRNA expression in lymphocytes isolated from patient with Friedreich's ataxia at 2.5 uM after 48 hrs by qRT-PCR analysis | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID503666 | Increase in FXN mRNA expression in human GM15850 cells at 5 uM after 96 hrs by qRT-PCR analysis relative to control | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID503678 | Increase in FXN mRNA expression in lymphocytes isolated from patient with Friedreich's ataxia at 10 uM after 48 hrs by qRT-PCR analysis relative to mRNA level in healthy human lymphocytes | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID329921 | Inhibition of human HDAC1 in U937 cells at 5 uM | 2008 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 18, Issue:8
| Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities. |
| AID503676 | Increase in FXN mRNA expression in healthy human lymphocytes at 5 uM after 48 hrs by qRT-PCR analysis | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID1454700 | Inhibition of human full length C-terminal His/FLAG-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells preincubated for 2 hrs followed by Fluor-de-Lys substrate addition measured after 30 mins by fluorescence assay | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Class I HDAC Inhibitors: Potential New Epigenetic Therapeutics for Alcohol Use Disorder (AUD). |
| AID1602212 | Inhibition of HDAC1 (unknown origin) | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Histone deacetylase 3 inhibitors in learning and memory processes with special emphasis on benzamides. |
| AID503681 | Inhibition of HDAC in human GM15850 cells assessed as increase in histone H4 lysine 5 acetylation of FXN gene at 5 uM after 96 hrs by chromatin immunoprecipitation assay | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID503685 | Inhibition of HDAC in human GM15850 cells assessed as increase in histone H4 lysine 8 acetylation of FXN gene at 5 uM after 96 hrs by chromatin immunoprecipitation assay | 2006 | Nature chemical biology, Oct, Volume: 2, Issue:10
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
| AID1602218 | Inhibition of HDAC8 (unknown origin) | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Histone deacetylase 3 inhibitors in learning and memory processes with special emphasis on benzamides. |
| AID1602215 | Inhibition of HDAC4 (unknown origin) | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Histone deacetylase 3 inhibitors in learning and memory processes with special emphasis on benzamides. |
| AID329925 | Induction of alpha tubulin hyperacetylation in human U937 cells at 5 uM | 2008 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 18, Issue:8
| Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities. |
| AID1602217 | Inhibition of HDAC7 (unknown origin) | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Histone deacetylase 3 inhibitors in learning and memory processes with special emphasis on benzamides. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |