flunitrazepam has been researched along with Alcohol Abuse in 24 studies
Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An analysis of kinetic parameters (Kd and Bmax) of [3H]flunitrazepam and [3H]PK-11195 binding with synaptosomal and mitochondrial membranes in the human brain showed that BDR was decreased and capacity increased in different human brain areas under the influence of alcohol abuse." | 3.80 | [Brain benzodiazepine receptors in humans and rats with alcohol addiction]. ( Bokhan, NA; Semke, VIa; Shushpanova, TB; Solonskiĭ, AV; Udut, VV, 2014) |
| "Long-term alcohol abuse is known to target specific areas of the brain such as the superior frontal cortex (SFC), resulting in neuronal cell loss." | 1.31 | Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex. ( Buckley, ST; Dodd, PR; Eckert, AL, 2000) |
| "Seizures were detected in 25% of the animals during withdrawal episode 10-13." | 1.29 | Glutamate and benzodiazepine receptor autoradiography in rat brain after repetition of alcohol dependence. ( Allerup, P; Bech, B; Diemer, NH; Ebert, B; Hemmingsen, R; Ulrichsen, J, 1996) |
| "Whereas cases with concomitant Wernicke encephalopathy may also have had greater numbers of superior frontal [3H]muscimol binding sites than controls, alcoholics with cirrhosis of the liver showed more muted differences." | 1.29 | GABAA receptors in damaged cerebral cortex areas in human chronic alcoholics. ( Dodd, PR, 1994) |
| "The effect of alcohol dependence induced by ethanol inhalation on GABA-dependent 36Cl- influx into membrane vesicles prepared from the mouse brain has been examined." | 1.28 | Functional alterations in cerebral GABAA receptor complex associated with formation of alcohol dependence: analysis using GABA-dependent 36Cl- influx into neuronal membrane vesicles. ( Kuriyama, K; Ueha, T, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (25.00) | 18.7374 |
| 1990's | 11 (45.83) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 3 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shushpanova, TV | 1 |
| Solonskii, AV | 2 |
| Novozheeva, TP | 1 |
| Udut, VV | 2 |
| Shushpanova, TB | 1 |
| Semke, VIa | 1 |
| Bokhan, NA | 1 |
| Laqueille, X | 1 |
| Launay, C | 1 |
| Dervaux, A | 1 |
| Kanit, M | 1 |
| Laukkanen, V | 1 |
| Storvik, M | 1 |
| Häkkinen, M | 1 |
| Akamine, Y | 1 |
| Tupala, E | 1 |
| Virkkunen, M | 1 |
| Tiihonen, J | 1 |
| Kumar, S | 1 |
| Kralic, JE | 1 |
| O'Buckley, TK | 1 |
| Grobin, AC | 1 |
| Morrow, AL | 2 |
| Mehta, AK | 2 |
| Ticku, MK | 3 |
| Hemmingsen, R | 2 |
| Braestrup, C | 1 |
| Nielsen, M | 1 |
| Barry, DI | 1 |
| Harro, J | 1 |
| Wahlström, G | 1 |
| Oreland, L | 1 |
| Katsura, M | 1 |
| Ohkuma, S | 1 |
| Kuriyama, K | 2 |
| Klein, RL | 1 |
| Mascia, MP | 1 |
| Whiting, PJ | 1 |
| Harris, RA | 1 |
| Devaud, LL | 1 |
| Purdy, RH | 1 |
| Paul, SM | 1 |
| Dodd, PR | 6 |
| Thomas, GJ | 2 |
| McCloskey, A | 1 |
| Crane, DI | 2 |
| Smith, ID | 1 |
| Ulrichsen, J | 1 |
| Bech, B | 1 |
| Ebert, B | 1 |
| Diemer, NH | 1 |
| Allerup, P | 1 |
| Kril, JJ | 2 |
| Watson, WE | 2 |
| Johnston, GA | 2 |
| Harper, CG | 2 |
| Lewohl, JM | 1 |
| Buckley, ST | 1 |
| Eckert, AL | 1 |
| Gisselmann, A | 1 |
| Ueha, T | 1 |
| Freund, G | 2 |
| Ballinger, WE | 2 |
| Mhatre, M | 1 |
| Gundlach, AL | 1 |
| Davies, N | 1 |
3 reviews available for flunitrazepam and Alcohol Abuse
| Article | Year |
|---|---|
[Abuse of alcohol and benzodiazepine during substitution therapy in heroin addicts: a review of the literature].
Topics: Adolescent; Adult; Alcoholism; Benzodiazepines; Buprenorphine; Clonazepam; Clorazepate Dipotassium; | 2009 |
[Functional significance of diazepam binding inhibitor (DBI) in establishment of alcohol dependence].
Topics: Alcoholism; Animals; Brain; Carrier Proteins; Diazepam Binding Inhibitor; Ethanol; Flunitrazepam; GA | 1995 |
Neuroactive steroid modulators of the stress response.
Topics: Adrenalectomy; Alcoholism; Animals; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; E | 1995 |
21 other studies available for flunitrazepam and Alcohol Abuse
| Article | Year |
|---|---|
Effect of meta-chlorobenzhydryl urea (m-ClBHU) on benzodiazepine receptor system in rat brain during experimental alcoholism.
Topics: Alcoholism; Animals; Anticonvulsants; Benzodiazepinones; Brain; Flunitrazepam; gamma-Aminobutyric Ac | 2014 |
[Brain benzodiazepine receptors in humans and rats with alcohol addiction].
Topics: Alcoholism; Animals; Cerebral Cortex; Ethanol; Flunitrazepam; Humans; Male; Mitochondria; Rats; Rats | 2014 |
Decreased GABA(A) benzodiazepine binding site densities in postmortem brains of Cloninger type 1 and 2 alcoholics.
Topics: Adult; Alcoholism; Anxiety; Autopsy; Autoradiography; Brain Chemistry; Dentate Gyrus; Female; Flunit | 2013 |
Chronic ethanol consumption enhances internalization of alpha1 subunit-containing GABAA receptors in cerebral cortex.
Topics: Administration, Oral; Alcoholism; Animals; Binding, Competitive; Blotting, Western; Cerebral Cortex; | 2003 |
Effect of chronic administration of ethanol on GABAA receptor assemblies derived from alpha2-, alpha3-, beta2- and gamma2-subunits in the rat cerebral cortex.
Topics: Alcoholism; Animals; Central Nervous System Depressants; Cerebral Cortex; Ethanol; Flunitrazepam; GA | 2005 |
The benzodiazepine/GABA receptor complex during severe ethanol intoxication and withdrawal in the rat.
Topics: Alcoholic Intoxication; Alcoholism; Animals; Diazepam; Ethanol; Flunitrazepam; Humans; Male; Rats; R | 1982 |
Cholecystokinin receptor binding after long-term ethanol treatment in rats.
Topics: Alcoholism; Animals; Binding, Competitive; Brain; Corpus Striatum; Dose-Response Relationship, Drug; | 1994 |
GABAA receptor function and binding in stably transfected cells: chronic ethanol treatment.
Topics: Alcoholism; Animals; Cattle; Cell Line; Dose-Response Relationship, Drug; Ethanol; Flunitrazepam; Ge | 1995 |
The neurochemical pathology of thiamine deficiency: GABAA and glutamateNMDA receptor binding sites in a goat model.
Topics: Alcoholism; Amprolium; Animals; Brain Chemistry; Diazepam; Disease Models, Animal; Dizocilpine Malea | 1996 |
Glutamate and benzodiazepine receptor autoradiography in rat brain after repetition of alcohol dependence.
Topics: Alcoholism; Animals; Autoradiography; Brain; Dizocilpine Maleate; Down-Regulation; Ethanol; Excitato | 1996 |
Receptor binding sites and uptake activities mediating GABA neurotransmission in chronic alcoholics with Wernicke encephalopathy.
Topics: Adult; Aged; Aged, 80 and over; Alcoholism; Binding Sites; Diazepam; Female; Fibrosis; Flunitrazepam | 1996 |
GABAA receptors in damaged cerebral cortex areas in human chronic alcoholics.
Topics: Adult; Aged; Alcoholism; Binding Sites; Case-Control Studies; Cerebral Cortex; Diazepam; Flunitrazep | 1994 |
Zolpidem binding sites on the GABA(A) receptor in brain from human cirrhotic and non-cirrhotic alcoholics.
Topics: Adult; Aged; Aged, 80 and over; Alcoholism; Binding Sites; Brain; Female; Flunitrazepam; Frontal Lob | 1997 |
Prevalence of the GABAA receptor assemblies containing alpha1-subunit in the rat cerebellum and cerebral cortex as determined by immunoprecipitation: lack of modulation by chronic ethanol administration.
Topics: Affinity Labels; Alcoholism; Animals; Azides; Benzodiazepines; Brain Chemistry; Central Nervous Syst | 1999 |
Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex.
Topics: Alcoholism; Autoradiography; Blotting, Northern; Cerebral Cortex; Flunitrazepam; GABA Agonists; GABA | 2000 |
[Insomnia in alcoholics recently detoxified: treatment with flunitrazepam].
Topics: Adult; Alcoholism; Anti-Anxiety Agents; Dose-Response Relationship, Drug; Drug Tolerance; Female; Fl | 1979 |
Functional alterations in cerebral GABAA receptor complex associated with formation of alcohol dependence: analysis using GABA-dependent 36Cl- influx into neuronal membrane vesicles.
Topics: Administration, Inhalation; Alcohol Withdrawal Delirium; Alcoholism; Animals; Brain; Bridged Bicyclo | 1992 |
Neuroreceptor changes in the putamen of alcohol abusers.
Topics: Adult; Aging; Alcoholism; Binding, Competitive; Flunitrazepam; Humans; Hypoxia; Putamen; Quinuclidin | 1989 |
Loss of muscarinic cholinergic receptors from the temporal cortex of alcohol abusers.
Topics: Aged; Alcoholism; Flunitrazepam; Humans; Middle Aged; Postmortem Changes; Quinuclidinyl Benzilate; R | 1989 |
Chronic ethanol treatment selectively increases the binding of inverse agonists for benzodiazepine binding sites in cultured spinal cord neurons.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Cells, Cultured; Female; Flumazenil; Flunitrazepam; Ma | 1989 |
Necropsy study of GABA/benzodiazepine receptor binding sites in brain tissue from chronic alcoholic patients.
Topics: Alcoholism; Brain; Diazepam; Flunitrazepam; Humans; Receptors, GABA-A | 1988 |