metyrapone has been researched along with Alcohol Abuse in 6 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metyrapone treatment was not found to reduce alcohol consumption more than placebo." | 6.70 | No effect of the cortisol-synthesis inhibitor metyrapone on alcohol drinking: a pilot study. ( Balldin, J; Berggren, U; Eriksson, M; Fahlke, C; Hansen, S; Mårin, P, 2001) |
| "Metyrapone treatment was not found to reduce alcohol consumption more than placebo." | 2.70 | No effect of the cortisol-synthesis inhibitor metyrapone on alcohol drinking: a pilot study. ( Balldin, J; Berggren, U; Eriksson, M; Fahlke, C; Hansen, S; Mårin, P, 2001) |
| "Treatment with metyrapone or o,p'-DDD can always induce a clinical remission but not a cure, and neurotransmitter therapy may be effective in a minority of cases." | 2.37 | Cushing's syndrome. ( Besser, GM; Howlett, TA; Rees, LH, 1985) |
| "The impact of chronic alcohol abuse on the hypothalamic-pituitary-adrenal (HPA) axis was investigated in actively drinking, nondepressed alcoholics with no evidence of liver disease." | 1.28 | Alterations in the hypothalamic-pituitary-adrenal axis in actively drinking alcoholics. ( Dobs, AS; Wand, GS, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jenkins, RM | 1 |
| Page, MM | 1 |
| Eriksson, M | 1 |
| Fahlke, C | 1 |
| Hansen, S | 1 |
| Berggren, U | 1 |
| Mårin, P | 1 |
| Balldin, J | 1 |
| Wand, GS | 1 |
| Dobs, AS | 1 |
| von Bardeleben, U | 1 |
| Holsboer, F | 1 |
| Howlett, TA | 1 |
| Rees, LH | 1 |
| Besser, GM | 1 |
| Lundberg, PO | 1 |
| Osterman, PO | 1 |
| Wide, L | 1 |
2 reviews available for metyrapone and Alcohol Abuse
| Article | Year |
|---|---|
Human corticotropin releasing hormone: clinical studies in patients with affective disorders, alcoholism, panic disorder and in normal controls.
Topics: Adrenocorticotropic Hormone; Alcoholism; Aldosterone; Corticotropin-Releasing Hormone; Depression; D | 1988 |
Cushing's syndrome.
Topics: Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Alcoho | 1985 |
1 trial available for metyrapone and Alcohol Abuse
| Article | Year |
|---|---|
No effect of the cortisol-synthesis inhibitor metyrapone on alcohol drinking: a pilot study.
Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Analysis of Variance; Enzyme Inhibitors; Humans; Hydrocor | 2001 |
3 other studies available for metyrapone and Alcohol Abuse
| Article | Year |
|---|---|
Atypical case of alcohol-induced Cushingoid syndrome.
Topics: Alcoholism; Cushing Syndrome; Female; Humans; Metyrapone; Middle Aged | 1981 |
Alterations in the hypothalamic-pituitary-adrenal axis in actively drinking alcoholics.
Topics: Alcohol Drinking; Alcoholism; Corticotropin-Releasing Hormone; Cosyntropin; Hormones; Humans; Hypoth | 1991 |
Vasopressin test in cases of optic atrophy and optic neuritis.
Topics: Adolescent; Adult; Aged; Alcoholism; Amblyopia; Circadian Rhythm; Female; Humans; Hydrocortisone; Hy | 1971 |