oxazepam has been researched along with Alcohol Abuse in 39 studies
Oxazepam: A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.
oxazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The progression in severity of withdrawal symptoms (increase in CIWA-Ar above baseline) was also significantly greater in the placebo group (p < 0." | 2.70 | Divalproex sodium in alcohol withdrawal: a randomized double-blind placebo-controlled clinical trial. ( Baer, JS; Malte, CA; Reoux, JP; Saxon, AJ; Sloan, KL, 2001) |
| "Among patients who had withdrawal symptoms at baseline, vital signs became normal more rapidly in the patients receiving atenolol, and their abnormal behavioral characteristics also resolved more rapidly." | 2.66 | The efficacy of atenolol in the outpatient management of the alcohol withdrawal syndrome. Results of a randomized clinical trial. ( Gottlieb, LD; Horwitz, RI; Kraus, ML, 1989) |
| " Recent research suggests that this is due to metabolic and pharmacokinetic differences rather than an intrinsically more favourable toxic-to-therapeutic dosage ratio." | 2.64 | The clinical activity of oxazepam. ( Cardon, A; Fouks, L; Pinalie, B; Porcheron, JB, 1978) |
| "Oxazepam is an anxiolytic with established clinical efficacy." | 2.38 | Oxazepam: update 1989. ( Ayd, FJ, 1990) |
| "According to the guidelines, benzodiazepines with a short half-life are the reference medication to treat alcohol withdrawal syndrome." | 1.43 | Population Pharmacokinetics of High-Dose Oxazepam in Alcohol-Dependent Patients: Is There a Risk of Accumulation? ( Imbert, B; Liachenko, N; Marsot, A; Simon, N, 2016) |
| "Oxazepam is a safe, efficient and cheap drug for the treatment of alcohol withdrawal symptoms, but controlled studies are needed to compare its effectiveness with that of clomethiazol." | 1.36 | Oxazepam versus clomethiazol in alcohol withdrawal treatment. ( de Millas, W; Ganzer, F; Haasen, C; Kuhn, S, 2010) |
| "Despite similar intensity of alcohol withdrawal symptoms, ALC/COC subjects received less oxazepam to treat alcohol withdrawal symptoms compared to ALC subjects." | 1.31 | Concurrent cocaine withdrawal alters alcohol withdrawal symptoms. ( Insua, A; Kaempf, G; Kampman, KM; Lipkin, C; O'Brien, CP; Pettinati, H; Sparkman, T; Turk, E; Volpicelli, J, 2002) |
| " Drug was most often given on a fixed dosing schedule with additional medication "as needed" (52% of the programs)." | 1.29 | Alcohol withdrawal: a nationwide survey of inpatient treatment practices. ( Friedman, LS; Mayo-Smith, MF; Saitz, R, 1995) |
| " We report five cases of high-dose triazolam abuse in which the daily dosage ranged from 5 to 15 mg (100-300 mg diazepam equivalent) and the duration of use ranged from 3 months to 5 years." | 1.28 | Detoxification for triazolam physical dependence. ( Sellers, EM; Sullivan, JT, 1992) |
| "Seizures and delirium tremens were recorded among 292 randomly selected patients admitted to an in-patient alcoholism program." | 1.27 | Should alcohol withdrawal seizures be treated with anti-epileptic drugs? ( Hillbom, ME; Hjelm-Jäger, M, 1984) |
| " These findings and other results of pharmacokinetic research have clinical implications in terms of dosage schedules, drug accumulation during long-term therapy, antianxiety therapy in the elderly, drug interactions, pharmacotherapy in specific disease states, and the influence of route of administration on drug action." | 1.26 | Clinical implications of benzodiazepine pharmacokinetics. ( Greenblatt, DJ; Shader, RI, 1977) |
| "Oxazepam has no important active metabolites and its net disposition is minimally altered by disulfiram." | 1.26 | Interaction of disulfiram with benzodiazepines. ( Billings, BJ; Giles, HG; Greenblatt, DJ; MacLeod, SM; Marshman, JA; Martin, PR; Sellers, EM, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (46.15) | 18.7374 |
| 1990's | 9 (23.08) | 18.2507 |
| 2000's | 4 (10.26) | 29.6817 |
| 2010's | 8 (20.51) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Verthein, U | 1 |
| Kuhn, S | 2 |
| Gabriel, K | 1 |
| Mautsch, U | 1 |
| Reimer, J | 1 |
| Behrendt, K | 1 |
| Martinez, L | 1 |
| Vorspan, F | 1 |
| Declèves, X | 1 |
| Azuar, J | 1 |
| Fortias, M | 1 |
| Questel, F | 1 |
| Dereux, A | 1 |
| Grichy, L | 1 |
| Barreteau, H | 1 |
| Bellivier, F | 1 |
| Lépine, JP | 1 |
| Bloch, V | 1 |
| Melby, K | 1 |
| Gråwe, RW | 1 |
| Aamo, TO | 1 |
| Salvesen, Ø | 1 |
| Spigset, O | 1 |
| Caputo, F | 1 |
| Skala, K | 1 |
| Mirijello, A | 1 |
| Ferrulli, A | 1 |
| Walter, H | 1 |
| Lesch, O | 1 |
| Addolorato, G | 1 |
| Bråtveit, A | 1 |
| Imbert, B | 1 |
| Marsot, A | 1 |
| Liachenko, N | 1 |
| Simon, N | 1 |
| Nüstedt, V | 1 |
| de Millas, W | 1 |
| Ganzer, F | 1 |
| Haasen, C | 1 |
| Kampman, KM | 1 |
| Pettinati, H | 1 |
| Volpicelli, J | 1 |
| Kaempf, G | 1 |
| Turk, E | 1 |
| Insua, A | 1 |
| Lipkin, C | 1 |
| Sparkman, T | 1 |
| O'Brien, CP | 1 |
| Pavlic, M | 1 |
| Libiseller, K | 1 |
| Hermann, M | 1 |
| Hengster, P | 1 |
| Margreiter, R | 1 |
| Wurm, M | 1 |
| Hillbom, ME | 1 |
| Hjelm-Jäger, M | 1 |
| Hicks, R | 1 |
| Dysken, MW | 1 |
| Davis, JM | 1 |
| Lesser, J | 1 |
| Ripeckyj, A | 1 |
| Lazarus, L | 1 |
| Solomon, JG | 1 |
| Mayo-Smith, MF | 2 |
| Bernard, D | 1 |
| Cohen, SI | 1 |
| Saitz, R | 1 |
| Friedman, LS | 1 |
| Wartenberg, AA | 1 |
| Goldstein, MZ | 1 |
| Pataki, A | 1 |
| Webb, MT | 1 |
| Reoux, JP | 2 |
| Miller, K | 1 |
| Saxon, AJ | 1 |
| Malte, CA | 1 |
| Baer, JS | 1 |
| Sloan, KL | 1 |
| Shader, RI | 1 |
| Greenblatt, DJ | 3 |
| MacLeod, SM | 1 |
| Sellers, EM | 2 |
| Giles, HG | 1 |
| Billings, BJ | 1 |
| Martin, PR | 1 |
| Marshman, JA | 1 |
| Baekeland, F | 1 |
| Lundwall, LK | 1 |
| Bliding, A | 2 |
| Fouks, L | 1 |
| Pinalie, B | 1 |
| Porcheron, JB | 1 |
| Cardon, A | 1 |
| Woo, E | 1 |
| Guthy, H | 1 |
| Sullivan, JT | 1 |
| Gallant, DM | 1 |
| Stuppaeck, CH | 1 |
| Pycha, R | 1 |
| Miller, C | 1 |
| Whitworth, AB | 1 |
| Oberbauer, H | 1 |
| Fleischhacker, WW | 1 |
| Ayd, FJ | 1 |
| Horwitz, RI | 1 |
| Gottlieb, LD | 1 |
| Kraus, ML | 1 |
| Gillmer, RE | 1 |
| Pernhaupt, G | 1 |
| Malm, U | 1 |
| Bonuzzi, L | 1 |
| Roncari, G | 1 |
| Zuanazzi, GF | 1 |
| Bowman, EH | 1 |
| Thimann, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acute and Long-term Effects of Intranasal Oxytocin in Alcohol Withdrawal and Dependence: A Prospective Randomized Parallel Group Placebo-controlled Trial[NCT02903251] | Phase 3 | 40 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| The Gamma Hydroxybutyric Acid in Alcohol-dependence Treatment Efficacy (GATE) I Trial: a Comparative Study Versus Oxazepam in the Treatment of Alcohol Withdrawal Syndrome[NCT02090504] | Phase 4 | 127 participants (Actual) | Interventional | 2002-02-28 | Completed | ||
| Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit[NCT04156464] | Phase 4 | 142 participants (Anticipated) | Interventional | 2020-07-06 | Recruiting | ||
| Placebo Controlled Trial of Depakote ER in Alcohol Dependent Patients With Mood and/or Anxiety Symptoms[NCT00202514] | Phase 2/Phase 3 | 40 participants | Interventional | 2004-09-30 | Completed | ||
| Prospective Assessment of Valproate on Ethanol Withdrawal[NCT03235531] | Phase 4 | 210 participants (Anticipated) | Interventional | 2017-07-11 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for oxazepam and Alcohol Abuse
| Article | Year |
|---|---|
The pharmacokinetics of psychotropic medication in the elderly: a review.
Topics: Aged; Alcoholism; Analgesics; Antidepressive Agents, Tricyclic; Barbiturates; Biological Availabilit | 1981 |
Alcoholism among elderly persons.
Topics: Aged; Alcoholism; Benzodiazepines; Contraindications; Disulfiram; Humans; Incidence; Lorazepam; Ment | 1996 |
Oxazepam: update 1989.
Topics: Aged; Alcoholism; Alprazolam; Female; Humans; Oxazepam; Seizures; Substance Withdrawal Syndrome; Sub | 1990 |
12 trials available for oxazepam and Alcohol Abuse
| Article | Year |
|---|---|
Effect of intranasal oxytocin on alcohol withdrawal syndrome: A randomized placebo-controlled double-blind clinical trial.
Topics: Administration, Intranasal; Adult; Alcoholism; Benzodiazepines; Double-Blind Method; Female; Humans; | 2019 |
Sodium oxybate in the treatment of alcohol withdrawal syndrome: a randomized double-blind comparative study versus oxazepam. The GATE 1 trial.
Topics: Adult; Alcoholism; Anxiety; Craving; Double-Blind Method; Female; Humans; Male; Oxazepam; Severity o | 2014 |
Divalproex sodium in alcohol withdrawal: a randomized double-blind placebo-controlled clinical trial.
Topics: Adolescent; Adult; Aged; Alcoholism; Anticonvulsants; Anxiety; Depression; Double-Blind Method; Etha | 2001 |
Divalproex sodium in alcohol withdrawal: a randomized double-blind placebo-controlled clinical trial.
Topics: Adolescent; Adult; Aged; Alcoholism; Anticonvulsants; Anxiety; Depression; Double-Blind Method; Etha | 2001 |
Divalproex sodium in alcohol withdrawal: a randomized double-blind placebo-controlled clinical trial.
Topics: Adolescent; Adult; Aged; Alcoholism; Anticonvulsants; Anxiety; Depression; Double-Blind Method; Etha | 2001 |
Divalproex sodium in alcohol withdrawal: a randomized double-blind placebo-controlled clinical trial.
Topics: Adolescent; Adult; Aged; Alcoholism; Anticonvulsants; Anxiety; Depression; Double-Blind Method; Etha | 2001 |
Effects of discontinuity of medication on the results of a double-blind drug study in outpatient alcoholics.
Topics: Adult; Alcoholism; Ambulatory Care; Clinical Trials as Topic; Dibenzocycloheptenes; Drug Combination | 1975 |
The clinical activity of oxazepam.
Topics: Alcoholism; Anxiety Disorders; Clinical Trials as Topic; Depression; Drug Evaluation; Humans; Mental | 1978 |
[Therapy of inflammatory symptoms in chronic alcoholism with Adumbran].
Topics: Adult; Alcoholism; Clinical Trials as Topic; Humans; Inflammation; Male; Middle Aged; Oxazepam | 1976 |
One more look at carbamazepine in the treatment of alcohol withdrawal.
Topics: Adolescent; Adult; Aged; Alcohol Withdrawal Delirium; Alcoholism; Carbamazepine; Double-Blind Method | 1992 |
Carbamazepine versus oxazepam in the treatment of alcohol withdrawal: a double-blind study.
Topics: Adult; Alcoholism; Carbamazepine; Double-Blind Method; Humans; Middle Aged; Oxazepam; Randomized Con | 1992 |
The efficacy of atenolol in the outpatient management of the alcohol withdrawal syndrome. Results of a randomized clinical trial.
Topics: Adult; Alcoholism; Atenolol; Double-Blind Method; Female; Humans; Male; Middle Aged; Oxazepam; Progn | 1989 |
Benzoctamine and oxazepam in the management of alcohol withdrawal states. Comparison by double-blind trial.
Topics: Adult; Aggression; Alcoholism; Anger; Anthracenes; Anxiety; Clinical Trials as Topic; Drive; Drug Ev | 1973 |
[Psychopharmacologic treatment of alcohol dependent postintoxication immobility. A double blind study of chlorprothixene--oxazepam--placebo].
Topics: Alcoholism; Chlorprothixene; Humans; Oxazepam; Placebos | 1970 |
Treatment of alcoholism in the subacute stage. (A study of three active agents).
Topics: Adult; Aged; Alcoholism; Antidepressive Agents; Chlordiazepoxide; Humans; Male; Middle Aged; Oxazepa | 1966 |
24 other studies available for oxazepam and Alcohol Abuse
| Article | Year |
|---|---|
[Treatment of Alcohol Withdrawal Syndrome with Oxazepam or Clomethiazole - A Naturalistic Observational Study].
Topics: Alcoholism; Chlormethiazole; Female; Germany; Humans; Male; Middle Aged; Oxazepam; Substance Withdra | 2018 |
An observational study of benzodiazepine prescription during inpatient alcohol detoxification for patients with vs. without chronic pretreatment with high-dosage baclofen.
Topics: Administration, Oral; Adult; Alcohol Drinking; Alcoholism; Baclofen; Diazepam; Female; GABA Modulato | 2018 |
[Handwrestling or stethoscope?].
Topics: Alcoholism; Anti-Anxiety Agents; Humans; Life Style; Oxazepam; Physician-Patient Relations | 2014 |
Population Pharmacokinetics of High-Dose Oxazepam in Alcohol-Dependent Patients: Is There a Risk of Accumulation?
Topics: Administration, Oral; Adult; Aged; Alcoholism; Body Weight; Drug Monitoring; Ethanol; Female; Half-L | 2016 |
[Ambulant treatment of alcohol withdrawal].
Topics: Alcohol Withdrawal Delirium; Alcoholism; Ambulatory Care; Anticonvulsants; Chlormethiazole; Combined | 2016 |
Oxazepam versus clomethiazol in alcohol withdrawal treatment.
Topics: Adult; Alcoholism; Analysis of Variance; Chlormethiazole; Ethanol; Female; GABA Modulators; Humans; | 2010 |
Concurrent cocaine withdrawal alters alcohol withdrawal symptoms.
Topics: Adolescent; Adult; Alcoholism; Anti-Anxiety Agents; Cocaine; Cocaine-Related Disorders; Ethanol; Fem | 2002 |
Small human hepatocytes in rotary culture for treatment of alcohol addicts? A pilot study.
Topics: Alcoholism; Cell Count; Cell Culture Techniques; Cell Line; Culture Media; Cytochrome P-450 Enzyme S | 2007 |
[Therapeutic indications for high dosage of oxazepam].
Topics: Alcoholism; Amitriptyline; Dibenzazepines; Humans; Hypnotics and Sedatives; Mental Disorders; Methot | 1967 |
Should alcohol withdrawal seizures be treated with anti-epileptic drugs?
Topics: Adult; Aged; Alcohol Withdrawal Delirium; Alcoholism; Anticonvulsants; Carbamazepine; Chlormethiazol | 1984 |
Drug interactions on an alcohol unit.
Topics: Adult; Alcoholism; Ataxia; Diagnosis, Differential; Drug Interactions; Epilepsy; Humans; Male; Oxaze | 1982 |
Late-onset seizures in alcohol withdrawal.
Topics: Adult; Aged; Alcohol Withdrawal Delirium; Alcoholism; Anti-Anxiety Agents; Diagnosis, Differential; | 1995 |
Alcohol and benzodiazepines generate anxiety, panic and phobias.
Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Anti-Anxiety Agents; Anxiety Disorders; Diazepam; Female; | 1995 |
Alcohol withdrawal: a nationwide survey of inpatient treatment practices.
Topics: Adrenergic beta-Antagonists; Alcoholism; Barbiturates; Benzodiazepines; Chlordiazepoxide; Clonidine; | 1995 |
Alcohol withdrawal treatment practices.
Topics: Alcoholism; Anti-Anxiety Agents; Ethanol; Humans; Oxazepam; Substance Withdrawal Syndrome; Treatment | 1996 |
Routine hospital alcohol detoxification practice compared to symptom triggered management with an Objective Withdrawal Scale (CIWA-Ar).
Topics: Adult; Aged; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Female; Hospitalization; Hos | 2000 |
Clinical implications of benzodiazepine pharmacokinetics.
Topics: Administration, Oral; Adult; Age Factors; Aged; Alcoholism; Anti-Anxiety Agents; Chlordiazepoxide; C | 1977 |
Interaction of disulfiram with benzodiazepines.
Topics: Adult; Alcoholism; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Disulfiram; Drug Interactions; H | 1978 |
The abuse potential of benzodiazepines with special reference to oxazepam.
Topics: Adult; Alcoholism; Anxiety; Benzodiazepines; Female; Humans; Male; Neurotic Disorders; Oxazepam; Sub | 1978 |
Massive benzodiazepine requirements during acute alcohol withdrawal.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Diazepam; Dose-Response Relationship, Drug; Half-Lif | 1979 |
Detoxification for triazolam physical dependence.
Topics: Adult; Alcoholism; Diazepam; Dose-Response Relationship, Drug; Female; Half-Life; Hospitalization; H | 1992 |
[Oxazepam in the treatment of neurotic disorders as well as in ambulatory detoxication treatment for alcoholics and polytoxicomaniacs].
Topics: Adult; Alcoholism; Ambulatory Care; Austria; Female; Humans; Male; Methods; Neurotic Disorders; Oxaz | 1972 |
[Oxazepam in alcoholism, depression and anxiety neuroses. A preliminary trial].
Topics: Absenteeism; Adolescent; Adult; Aged; Alcoholism; Anxiety Disorders; Depression; Humans; Male; Middl | 1968 |
[Preliminary note on a new antianxiety agent: oxazepam].
Topics: Alcoholism; Epilepsy; Humans; Intracranial Arteriosclerosis; Mental Disorders; Oxazepam; Tranquilizi | 1966 |