fenfluramine has been researched along with Alcohol Abuse in 24 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Smokers had a blunted prolactin response to fenfluramine compared with nonsmokers without any alcoholism or antisocial personality effects." | 5.09 | Cigarette smoking decreases the prolactin response to serotonergic stimulation in subgroups of alcoholics and controls. ( Anthenelli, RM; Maxwell, RA, 2000) |
| " The prolactin response to fenfluramine (PRF) is generally believed to reflect the activity of the 5HT system and has been previously used to investigate 5HT activity in a variety of conditions, including alcoholism." | 3.74 | Prolactin response to fenfluramine in abstinent, alcohol-dependent patients. ( Davies, J; Frampton, C; Joyce, PR; Porter, RJ; Sellman, D, 2008) |
| "Alcohol dependence has been associated with long-lasting alterations in limbic-hypothalamic-pituitary-adrenal (LHPA) axis and serotonin (5-hydroxytryptamine [5-HT]) function." | 2.70 | Stress hormone dysregulation at rest and after serotonergic stimulation among alcohol-dependent men with extended abstinence and controls. ( Anthenelli, RM; Geracioti, TD; Hauger, R; Maxwell, RA, 2001) |
| " The hypothesis is proposed that this treatment is successful because of the dual and balanced increase in the bioavailability of the neurotransmitters, dopamine and serotonin, in the nucleus accumbens." | 1.29 | Combined dopamine and serotonin agonists: a synergistic approach to alcoholism and other addictive behaviors. ( Hitzig, P, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (20.83) | 18.7374 |
| 1990's | 8 (33.33) | 18.2507 |
| 2000's | 11 (45.83) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anthenelli, RM | 3 |
| Maxwell, RA | 3 |
| Berggren, U | 5 |
| Fahlke, C | 4 |
| Eriksson, M | 5 |
| Balldin, J | 5 |
| Schweitzer, I | 1 |
| Morris, P | 1 |
| Hopwood, M | 1 |
| Maguire, K | 1 |
| Norman, T | 1 |
| Berglund, K | 1 |
| Andersson, M | 1 |
| Engel, J | 2 |
| Sher, L | 1 |
| Milak, MS | 1 |
| Parsey, RV | 1 |
| Carballo, JJ | 1 |
| Cooper, TB | 2 |
| Malone, KM | 1 |
| Oquendo, MA | 1 |
| Mann, JJ | 1 |
| Porter, RJ | 1 |
| Sellman, D | 1 |
| Joyce, PR | 1 |
| Davies, J | 1 |
| Frampton, C | 1 |
| Hitzig, P | 1 |
| Coccaro, EF | 2 |
| Silverman, JM | 1 |
| Klar, HM | 2 |
| Horvath, TB | 1 |
| Siever, LJ | 2 |
| Sellers, EM | 2 |
| Farren, CK | 1 |
| Ziedonis, D | 1 |
| Clare, AW | 1 |
| Hammeedi, FA | 1 |
| Dinan, TG | 1 |
| Schulz, KP | 1 |
| McKay, KE | 1 |
| Newcorn, JH | 1 |
| Sharma, V | 1 |
| Gabriel, S | 1 |
| Halperin, JM | 1 |
| Buydens-Branchey, L | 1 |
| Branchey, M | 1 |
| Hudson, J | 1 |
| Rothman, M | 1 |
| Fergeson, P | 1 |
| McKernin, C | 1 |
| Geracioti, TD | 1 |
| Hauger, R | 1 |
| Weijers, HG | 1 |
| Wiesbeck, GA | 1 |
| Jakob, F | 1 |
| Böning, J | 1 |
| Krasner, N | 2 |
| Moore, MR | 2 |
| Goldberg, A | 2 |
| Booth, JC | 1 |
| Frame, AH | 1 |
| McLaren, AD | 1 |
| Higgins, GA | 1 |
| Tompkins, DM | 1 |
| Romach, MK | 1 |
| Maurer, G | 1 |
| Cochrane, K | 1 |
| Mohs, RC | 1 |
| Davis, KL | 1 |
| Liskow, BI | 1 |
| Goodwin, DW | 1 |
| Levin, A | 1 |
| Dow, J | 1 |
| MacDonald, CM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Pimavanserin on Aggression and Social Cognition.[NCT05895513] | Phase 2 | 35 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| Acamprosate for Central Nervous System Hyperexcitability and Neuroadaptation in Alcohol Withdrawal[NCT00106106] | Phase 2 | 56 participants (Actual) | Interventional | 2005-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The ratio of glutamate to creatine was determined using magnetic resonance spectroscopy (MRS), a technique that complements magnetic resonance imaging (MRI). MRS is used to determine the concentration of brain metabolites, such as glutamate, in brain tissue. MRS utilizes a magnetic field to look at magnetic nuclei, which absorb and re-emit electromagnetic energy in the presence of the magnetic field. By looking at the peaks in the resultant spectra the structure and concentration of metabolites can be determined. (NCT00106106)
Timeframe: Day 25
| Intervention | Ratio of glutamate to creatine (Mean) |
|---|---|
| Placebo | 1.350375 |
| Acamprosate | 1.166667 |
The ratio of glutamate to creatine was determined using magnetic resonance spectroscopy (MRS), a technique that complements magnetic resonance imaging (MRI). MRS is used to determine the concentration of brain metabolites, such as glutamate, in brain tissue. MRS utilizes a magnetic field to look at magnetic nuclei, which absorb and re-emit electromagnetic energy in the presence of the magnetic field. By looking at the peaks in the resultant spectra the structure and concentration of metabolites can be determined. (NCT00106106)
Timeframe: Day 4
| Intervention | Ratio of glutamate to creatine (Mean) |
|---|---|
| Placebo | 1.256772 |
| Acamprosate | 1.294178 |
1 review available for fenfluramine and Alcohol Abuse
| Article | Year |
|---|---|
Pharmacological treatment of alcohol intoxication, withdrawal and dependence: a critical review.
Topics: Alcohol Deterrents; Alcoholic Intoxication; Alcoholism; Antidepressive Agents, Tricyclic; Bromocript | 1987 |
8 trials available for fenfluramine and Alcohol Abuse
| Article | Year |
|---|---|
Independent alcohol and tobacco effects on stress axis function.
Topics: Adrenocorticotropic Hormone; Alcoholism; Double-Blind Method; Female; Fenfluramine; Humans; Hydrocor | 2002 |
Neuroendocrine evidence for reduced serotonergic neurotransmission during heavy drinking.
Topics: Adult; Alcoholic Intoxication; Alcoholism; Body Temperature Regulation; Citalopram; Cross-Over Studi | 1994 |
Serotonin function and risk for alcoholism in boys with attention-deficit hyperactivity disorder.
Topics: Alcoholism; Attention Deficit Disorder with Hyperactivity; Child; Fenfluramine; Humans; Hydrocortiso | 1998 |
Serotonergic function in cocaine addicts: prolactin responses to sequential D,L-fenfluramine challenges.
Topics: Administration, Oral; Adult; Alcoholism; Child of Impaired Parents; Cocaine-Related Disorders; Fathe | 1999 |
Cigarette smoking decreases the prolactin response to serotonergic stimulation in subgroups of alcoholics and controls.
Topics: Adolescent; Adult; Alcoholism; Analysis of Variance; Chi-Square Distribution; Fenfluramine; Humans; | 2000 |
Stress hormone dysregulation at rest and after serotonergic stimulation among alcohol-dependent men with extended abstinence and controls.
Topics: Adrenocorticotropic Hormone; Adult; Alcoholism; Analysis of Variance; Antisocial Personality Disorde | 2001 |
A trial of fenfluramine in the treatment of the chronic alcoholic patient.
Topics: Administration, Oral; Alcoholism; Chronic Disease; Clinical Trials as Topic; Dose-Response Relations | 1976 |
Serotonin and alcohol drinking.
Topics: 1-Naphthylamine; Adult; Alcohol Drinking; Alcoholism; Animals; Double-Blind Method; Fenfluramine; Hu | 1992 |
15 other studies available for fenfluramine and Alcohol Abuse
| Article | Year |
|---|---|
Tobacco use is associated with reduced central serotonergic neurotransmission in type 1 alcohol-dependent individuals.
Topics: Adult; Aged; Alcoholism; Analysis of Variance; Fenfluramine; Humans; Male; Middle Aged; Prolactin; S | 2003 |
Prolactin response to d-fenfluramine in combat-related post-traumatic stress disorder.
Topics: Adult; Alcoholism; Area Under Curve; Combat Disorders; Female; Fenfluramine; Humans; Male; Middle Ag | 2004 |
Personality profile in type I alcoholism: long duration of alcohol intake and low serotonergic activity are predictive factors of anxiety proneness.
Topics: Adult; Aged; Aggression; Alcoholism; Anxiety; Fenfluramine; Humans; Male; Middle Aged; Personality; | 2006 |
Inverse relationship between central serotonergic neurotransmission and blood pressure in alcohol-dependent male subjects.
Topics: Adult; Alcoholism; Blood Pressure; Brain; Fenfluramine; Humans; Male; Middle Aged; Prolactin; Seroto | 2006 |
Positron emission tomography study of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without comorbid lifetime alcohol dependence.
Topics: Adult; Alcoholism; Brain; Brain Mapping; Depressive Disorder, Major; Female; Fenfluramine; Fluorodeo | 2007 |
Prolactin response to fenfluramine in abstinent, alcohol-dependent patients.
Topics: Adult; Alcoholism; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders | 2008 |
Combined dopamine and serotonin agonists: a synergistic approach to alcoholism and other addictive behaviors.
Topics: Adult; Alcohol Deterrents; Alcoholism; Dopamine Agents; Drug Synergism; Female; Fenfluramine; Humans | 1993 |
Familial correlates of reduced central serotonergic system function in patients with personality disorders.
Topics: Aggression; Alcoholism; Family; Fenfluramine; Humans; Impulsive Behavior; Male; Personality Disorder | 1994 |
Medications to treat alcoholism?
Topics: Alcohol Deterrents; Alcoholism; Drug Synergism; Fenfluramine; Humans; Phentermine | 1993 |
D-fenfluramine-induced prolactin responses in postwithdrawal alcoholics and controls.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Fenfluramine; Genotype; Humans; Male; Middle Aged; P | 1995 |
Neuroendocrine responses to fenfluramine and its relationship to personality in alcoholism.
Topics: Adult; Alcohol-Induced Disorders, Nervous System; Alcoholism; Anxiety; Brain; Extraversion, Psycholo | 2001 |
Is long-term heavy alcohol consumption toxic for brain serotonergic neurons? Relationship between years of excessive alcohol consumption and serotonergic neurotransmission.
Topics: Alcoholism; Brain; Ethanol; Fenfluramine; Humans; Male; Middle Aged; Receptors, Serotonin; Selective | 2002 |
Serotonergic studies in patients with affective and personality disorders. Correlates with suicidal and impulsive aggressive behavior.
Topics: Adult; Aggression; Alcoholism; Depressive Disorder; Fenfluramine; Humans; Impulsive Behavior; Male; | 1989 |
The pattern of drug-taking among drug-dependent South African national servicemen.
Topics: Adolescent; Adult; Age Factors; Alcoholism; Amphetamine; Barbiturates; Cannabis; Cocaine; Datura str | 1972 |
Clinical and experimental studies on alcoholism.
Topics: Alcohol Deterrents; Alcoholism; Animals; Disulfiram; Ethanol; Fenfluramine; Humans; Liver Diseases; | 1973 |