chlorzoxazone has been researched along with Alcohol Abuse in 12 studies
Chlorzoxazone: A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
chlorzoxazone : A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pharmacokinetics of a single oral dose of 250 mg chlorzoxazone, a marker of the activity of CYP2E1, were measured in five healthy drug-free volunteers and in 16 patients with alcoholism receiving 1." | 7.70 | Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers. ( Besson, J; Buclin, T; Eap, CB; Savary, L; Schnyder, C, 1998) |
| "The pharmacokinetics of a single oral dose of 250 mg chlorzoxazone, a marker of the activity of CYP2E1, were measured in five healthy drug-free volunteers and in 16 patients with alcoholism receiving 1." | 3.70 | Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers. ( Besson, J; Buclin, T; Eap, CB; Savary, L; Schnyder, C, 1998) |
| "Chlormethiazole is a sedative and anticonvulsive drug used in the treatment of alcohol withdrawal." | 1.30 | Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans. ( Gebhardt, AC; Lucas, D; Ménez, JF; Seitz, HK, 1997) |
| "001) and other pharmacokinetic parameters." | 1.30 | Chlorzoxazone pharmacokinetics as a marker of hepatic cytochrome P4502E1 in humans. ( Basu, P; Kessova, I; Lieber, CS; Mishin, VM; Oneta, CM; Rosman, AS, 1998) |
| "Chlorzoxazone metabolism was used to assess CYP2E1 phenotype." | 1.29 | Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects. ( Bardou, LG; Berthou, F; Bodénez, P; Girre, C; Hispard, E; Joannet, I; Lucas, D; Ménez, C; Ménez, JF, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (83.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lucas, D | 7 |
| Ménez, C | 4 |
| Girre, C | 4 |
| Bodénez, P | 3 |
| Hispard, E | 3 |
| Ménez, JF | 5 |
| Dally, S | 1 |
| Berthou, F | 3 |
| Poitrenaud, F | 1 |
| Joannet, I | 1 |
| Bardou, LG | 1 |
| Nakanishi, S | 1 |
| Yamazaki, H | 1 |
| Gebhardt, AC | 1 |
| Seitz, HK | 1 |
| Dupont, I | 1 |
| Clot, P | 1 |
| Albano, E | 1 |
| Eap, CB | 1 |
| Schnyder, C | 1 |
| Besson, J | 1 |
| Savary, L | 1 |
| Buclin, T | 1 |
| Mishin, VM | 1 |
| Rosman, AS | 1 |
| Basu, P | 1 |
| Kessova, I | 1 |
| Oneta, CM | 1 |
| Lieber, CS | 1 |
| Raucy, JL | 1 |
| Schultz, ED | 1 |
| Kearins, MC | 1 |
| Arora, S | 1 |
| Johnston, DE | 1 |
| Omdahl, JL | 1 |
| Eckmann, L | 1 |
| Carpenter, SP | 1 |
| de la Maza, MP | 1 |
| Hirsch, S | 1 |
| Petermann, M | 1 |
| Suazo, M | 1 |
| Ugarte, G | 1 |
| Bunout, D | 1 |
| Plee-Gautier, E | 1 |
| Foresto, F | 1 |
| Ferrara, R | 1 |
| Simon, B | 1 |
| Manno, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacokinetic and Bioequivalence Comparison of Baclofen and Chlorzoxazone When Administered Individually or Concurrently[NCT05257447] | Phase 1 | 19 participants (Actual) | Interventional | 2022-04-27 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for chlorzoxazone and Alcohol Abuse
| Article | Year |
|---|---|
[Induction of cytochrome P-450 IIE1 after chronic ethanol administration in man and in animals].
Topics: Alcoholism; Animals; Biomarkers; Chlorzoxazone; Cytochrome P-450 CYP2E1; Enzyme Induction; Ethanol; | 1997 |
11 other studies available for chlorzoxazone and Alcohol Abuse
| Article | Year |
|---|---|
Decrease in cytochrome P4502E1 as assessed by the rate of chlorzoxazone hydroxylation in alcoholics during the withdrawal phase.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P | 1995 |
Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics.
Topics: Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Chlorzoxazone; Cytochrome P-45 | 1994 |
High-performance liquid chromatographic determination of chlorzoxazone and 6-hydroxychlorzoxazone in serum: a tool for indirect evaluation of cytochrome P4502E1 activity in humans.
Topics: Administration, Oral; Adult; Alcoholism; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytoch | 1993 |
Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects.
Topics: Adult; Alcoholism; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Deoxyribo | 1995 |
Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans.
Topics: Adult; Aged; Alcoholism; Chlormethiazole; Chlorzoxazone; Cytochrome P-450 CYP2E1 Inhibitors; Enzyme | 1997 |
Cytochrome P4502E1 inducibility and hydroxyethyl radical formation among alcoholics.
Topics: Adult; Alcoholism; Analysis of Variance; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 CYP2E | 1998 |
Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers.
Topics: Administration, Oral; Adult; Alcoholism; Anticonvulsants; Area Under Curve; Chlormethiazole; Chlorzo | 1998 |
Chlorzoxazone pharmacokinetics as a marker of hepatic cytochrome P4502E1 in humans.
Topics: Alcoholism; Biomarkers; Chlorzoxazone; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Liv | 1998 |
CYP2E1 expression in human lymphocytes from various ethnic populations.
Topics: Adult; Alcoholism; Alleles; Chlorzoxazone; Cytochrome P-450 CYP2E1; Female; Humans; Indians, North A | 1999 |
Changes in microsomal activity in alcoholism and obesity.
Topics: Adult; Alcoholism; Analysis of Variance; Chlorzoxazone; Cytochrome P-450 CYP2E1; Humans; Liver Cirrh | 2000 |
Genetic repeat polymorphism in the regulating region of CYP2E1: frequency and relationship with enzymatic activity in alcoholics.
Topics: Adult; Alcoholism; Chlorzoxazone; Cytochrome P-450 CYP2E1; Female; Gene Frequency; Genotype; Heteroz | 2001 |