n-methyl-3,4-methylenedioxyamphetamine has been researched along with Alcohol Abuse in 39 studies
N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
3,4-methylenedioxymethamphetamine : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Post-traumatic stress disorder (PTSD) is commonly associated with alcohol and substance use disorders (ASUD)." | 3.11 | The effects of MDMA-assisted therapy on alcohol and substance use in a phase 3 trial for treatment of severe PTSD. ( Brown, RT; Coker, A; Doblin, R; Emerson, A; Klaire, SS; Mitchell, JM; Nicholas, CR; Wang, JB; Yazar-Klosinski, B, 2022) |
| "Given that alcohol use disorder is so often associated with early traumatic experiences, the author is proposing in a current on-going UK-based study that patients with alcohol use disorder who have undergone a medical detoxification from alcohol might benefit from a course of MDMA-assisted psychotherapy." | 2.58 | Why MDMA therapy for alcohol use disorder? And why now? ( Sessa, B, 2018) |
| "Oxytocin therefore has fascinating potential to reverse the corrosive effects of long-term drugs abuse on social behavior and to perhaps inoculate against future vulnerability to addictive disorders." | 2.48 | Breaking the loop: oxytocin as a potential treatment for drug addiction. ( Bowen, MT; McGregor, IS, 2012) |
| " Some studies have found a dose-response relationship, so that increasing levels of abuse are associated with greater risk of hemorrhage." | 2.42 | Cerebrovascular complications of alcohol and sympathomimetic drug abuse. ( Bruno, A, 2003) |
| "The greatest challenge facing the drug abuse prevention field is to get information out to practitioners and communities about the best prevention programs, approaches, and principles of effectiveness." | 2.41 | Prevention of alcohol and drug abuse: what works? ( Kumpfer, KL, 2002) |
| "Besides smoking, alcohol abuse has also been implicated as a renal risk factor." | 2.41 | [Adverse renal effects of legal and illicit drugs]. ( Orth, SR, 2002) |
| " No unexpected adverse events were observed." | 1.62 | First study of safety and tolerability of 3,4-methylenedioxymethamphetamine-assisted psychotherapy in patients with alcohol use disorder. ( Brew-Girard, E; Burrows, S; Durant, C; Higbed, L; Nutt, DJ; O'Brien, S; Rickard, J; Rose-Morris, A; Sakal, C; Sessa, B; Titheradge, D; Williams, TM; Wilson, S; Wiseman, C, 2021) |
| " There have been no serious adverse events related to MDMA, no unexpected physiological responses to the MDMA sessions or changes to blood results or electrocardiograms, measured before and after the 8-week course." | 1.51 | First study of safety and tolerability of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy in patients with alcohol use disorder: preliminary data on the first four participants. ( Nutt, D; O'Brien, S; Sakal, C; Sessa, B, 2019) |
| "Twenty-five had complaints related to substance use including ethanol (n = 18), "molly" or "ecstasy" (n = 13), and marijuana (n = 8)." | 1.48 | Emergency Department Patient Burden from an Electronic Dance Music Festival. ( Chhabra, N; Gimbar, RP; Thompson, TM; Walla, LM, 2018) |
| "Further research is needed to study substance use and related problem behavior among immigrant youth controlling for the impact of acculturation and other factors." | 1.34 | Former Soviet Union immigrant and native-born adolescents in Israel: substance use and related problem behavior. ( Isralowitz, RE; Reznik, A, 2007) |
| "Simultaneous polysubstance use (SPU) is a common phenomenon, yet little is known about how various substances are used with one another." | 1.33 | Patterns of simultaneous polysubstance use in drug using university students. ( Barrett, SP; Darredeau, C; Pihl, RO, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (7.69) | 18.2507 |
| 2000's | 20 (51.28) | 29.6817 |
| 2010's | 13 (33.33) | 24.3611 |
| 2020's | 3 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Sessa, B | 4 |
| Aday, JS | 1 |
| O'Brien, S | 3 |
| Curran, HV | 1 |
| Measham, F | 1 |
| Higbed, L | 2 |
| Nutt, DJ | 2 |
| Nicholas, CR | 1 |
| Wang, JB | 1 |
| Coker, A | 1 |
| Mitchell, JM | 1 |
| Klaire, SS | 1 |
| Yazar-Klosinski, B | 1 |
| Emerson, A | 1 |
| Brown, RT | 1 |
| Doblin, R | 1 |
| Durant, C | 1 |
| Sakal, C | 2 |
| Titheradge, D | 1 |
| Williams, TM | 1 |
| Rose-Morris, A | 1 |
| Brew-Girard, E | 1 |
| Burrows, S | 1 |
| Wiseman, C | 1 |
| Wilson, S | 1 |
| Rickard, J | 1 |
| Chhabra, N | 1 |
| Gimbar, RP | 1 |
| Walla, LM | 1 |
| Thompson, TM | 1 |
| He, L | 1 |
| Pan, X | 1 |
| Wang, N | 1 |
| Yang, J | 1 |
| Jiang, J | 1 |
| Luo, Y | 1 |
| Zhang, X | 1 |
| Li, X | 1 |
| Lake, S | 1 |
| Gaddis, A | 1 |
| Tupper, KW | 1 |
| Nosova, E | 1 |
| DeBeck, K | 1 |
| Nutt, D | 1 |
| O'Sullivan, EM | 1 |
| Kumpfer, KL | 1 |
| Keyes, KM | 1 |
| Martins, SS | 1 |
| Hasin, DS | 1 |
| Wilkins, C | 1 |
| Sweetsur, P | 1 |
| Krebs, TS | 1 |
| Johansen, PØ | 1 |
| Jerome, L | 1 |
| Halpern, JH | 1 |
| Fernández-Serrano, MJ | 1 |
| Lozano, O | 1 |
| Pérez-García, M | 3 |
| Verdejo-García, A | 2 |
| van Holst, RJ | 1 |
| Schilt, T | 1 |
| Kinner, SA | 1 |
| George, J | 1 |
| Johnston, J | 1 |
| Dunn, M | 1 |
| Degenhardt, L | 1 |
| McGregor, IS | 1 |
| Bowen, MT | 1 |
| Carmona-Perera, M | 1 |
| Young, L | 1 |
| Molina-Fernández, A | 1 |
| Burucker, J | 1 |
| Kropp, S | 1 |
| Chow, C | 1 |
| Vallance, K | 1 |
| Stockwell, T | 1 |
| Macdonald, S | 1 |
| Martin, G | 1 |
| Ivsins, A | 1 |
| Marsh, DC | 1 |
| Michelow, W | 1 |
| Roth, E | 1 |
| Duff, C | 1 |
| Bruno, A | 1 |
| Soto, O | 1 |
| Hedley-Whyte, ET | 1 |
| Wareing, M | 1 |
| Fisk, JE | 1 |
| Murphy, P | 1 |
| Montgomery, C | 1 |
| Verdejo-García, AJ | 1 |
| López-Torrecillas, F | 1 |
| Aguilar de Arcos, F | 1 |
| Johanson, CE | 1 |
| Kilbey, M | 1 |
| Gatchalian, K | 1 |
| Tancer, M | 1 |
| Reay, JL | 1 |
| Hamilton, C | 1 |
| Kennedy, DO | 1 |
| Scholey, AB | 1 |
| Hopper, JW | 1 |
| Su, Z | 1 |
| Looby, AR | 1 |
| Ryan, ET | 1 |
| Penetar, DM | 1 |
| Palmer, CM | 1 |
| Lukas, SE | 1 |
| Barrett, SP | 1 |
| Darredeau, C | 1 |
| Pihl, RO | 1 |
| Laurindo da Silva, L | 1 |
| Parrott, AC | 1 |
| Isralowitz, RE | 1 |
| Reznik, A | 1 |
| Izco, M | 1 |
| Marchant, I | 1 |
| Escobedo, I | 1 |
| Peraile, I | 1 |
| Delgado, M | 1 |
| Higuera-Matas, A | 1 |
| Olias, O | 1 |
| Ambrosio, E | 1 |
| O'Shea, E | 1 |
| Colado, MI | 1 |
| Richman, J | 1 |
| Ferber, A | 1 |
| Yücel, M | 1 |
| Lubman, DI | 1 |
| Solowij, N | 1 |
| Brewer, WJ | 1 |
| Hooft, PJ | 1 |
| van de Voorde, HP | 1 |
| Durst, R | 1 |
| Rebaudengo-Rosca, P | 1 |
| Pedersen, W | 1 |
| Skrondal, A | 1 |
| Birnbach, DJ | 1 |
| Orth, SR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| MDMA-Assisted Therapy 6 to 12 Months After Childbirth for People With Co-occurring Opioid Use and Post Traumatic Stress Disorders[NCT05219175] | Phase 2 | 15 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | ||
| Oxytocin in Alcohol Use Disorder: A Novel and Translational Approach[NCT02711189] | Phase 1 | 0 participants (Actual) | Interventional | 2016-03-08 | Withdrawn | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for n-methyl-3,4-methylenedioxyamphetamine and Alcohol Abuse
| Article | Year |
|---|---|
Why MDMA therapy for alcohol use disorder? And why now?
Topics: Alcoholism; Combined Modality Therapy; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine | 2018 |
Prevention of alcohol and drug abuse: what works?
Topics: Adolescent; Alcoholism; Amphetamine-Related Disorders; Binge Drinking; Cocaine-Related Disorders; Co | 2002 |
Drug-related decrease in neuropsychological functions of abstinent drug users.
Topics: Alcoholism; Amphetamine-Related Disorders; Cannabis; Central Nervous System Stimulants; Cocaine; Coc | 2011 |
Breaking the loop: oxytocin as a potential treatment for drug addiction.
Topics: Adaptation, Psychological; Alcoholism; Animals; Drug Tolerance; Hallucinogens; Humans; N-Methyl-3,4- | 2012 |
[Levels of evidence in drug therapy for alcohol use disorders and illicit drug use].
Topics: Alcohol Deterrents; Alcoholism; Amphetamine-Related Disorders; Cocaine-Related Disorders; Combined M | 2012 |
Cerebrovascular complications of alcohol and sympathomimetic drug abuse.
Topics: Alcohol Drinking; Alcoholism; Catecholamines; Cocaine; Humans; N-Methyl-3,4-methylenedioxyamphetamin | 2003 |
Severe aplastic anemia with hot pockets following daily Ecstasy ingestion.
Topics: Adult; Alcoholism; Anemia, Aplastic; Antilymphocyte Serum; Bone Marrow; Fatal Outcome; Hematopoiesis | 2008 |
Understanding drug addiction: a neuropsychological perspective.
Topics: Adolescent; Adult; Age Factors; Alcoholism; Analgesics, Opioid; Behavior, Addictive; Central Nervous | 2007 |
[Adverse renal effects of legal and illicit drugs].
Topics: Acute Kidney Injury; Adolescent; Adult; Alcoholism; Amphetamines; Anti-Anxiety Agents; Benzodiazepin | 2002 |
2 trials available for n-methyl-3,4-methylenedioxyamphetamine and Alcohol Abuse
| Article | Year |
|---|---|
The effects of MDMA-assisted therapy on alcohol and substance use in a phase 3 trial for treatment of severe PTSD.
Topics: Adult; Alcoholism; Combined Modality Therapy; Ethanol; Humans; N-Methyl-3,4-methylenedioxyamphetamin | 2022 |
Discriminative stimulus effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans trained to discriminate among d-amphetamine, meta-chlorophenylpiperazine and placebo.
Topics: Adult; Alcoholism; Amphetamine-Related Disorders; Arousal; Dextroamphetamine; Discrimination Learnin | 2006 |
28 other studies available for n-methyl-3,4-methylenedioxyamphetamine and Alcohol Abuse
| Article | Year |
|---|---|
Debunking the myth of 'Blue Mondays': No evidence of affect drop after taking clinical MDMA.
Topics: Affect; Alcohol Drinking; Alcoholism; Cognition; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxya | 2022 |
First study of safety and tolerability of 3,4-methylenedioxymethamphetamine-assisted psychotherapy in patients with alcohol use disorder.
Topics: Alcohol Drinking; Alcoholism; Combined Modality Therapy; Drug Monitoring; Female; Hallucinogens; Hum | 2021 |
Emergency Department Patient Burden from an Electronic Dance Music Festival.
Topics: Adolescent; Adult; Alcoholism; Chicago; Dancing; Drug Overdose; Emergency Medical Services; Emergenc | 2018 |
New types of drug use and risks of drug use among men who have sex with men: a cross-sectional study in Hangzhou, China.
Topics: Adolescent; Adult; Alcoholism; China; Cross-Sectional Studies; HIV Infections; Homosexuality, Male; | 2018 |
3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) use and transitions to injection drug use among street-involved youth.
Topics: Adolescent; Adult; Alcoholism; Amphetamine-Related Disorders; British Columbia; Cocaine-Related Diso | 2019 |
First study of safety and tolerability of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy in patients with alcohol use disorder: preliminary data on the first four participants.
Topics: Adult; Alcohol Deterrents; Alcoholism; Combined Modality Therapy; Drug Administration Schedule; Fema | 2019 |
Dental health of Irish alcohol/drug abuse treatment centre residents.
Topics: Adolescent; Adult; Age Factors; Aged; Alcoholism; Amphetamine-Related Disorders; Beer; Cocaine-Relat | 2012 |
Past 12-month and lifetime comorbidity and poly-drug use of ecstasy users among young adults in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions.
Topics: Adolescent; Adult; Age Factors; Alcoholism; Amphetamine-Related Disorders; Comorbidity; Diagnosis, D | 2008 |
Trends in population drug use in New Zealand: findings from national household surveying of drug use in 1998, 2001, 2003, and 2006.
Topics: Adult; Alcohol Drinking; Alcoholism; Amphetamine-Related Disorders; Cross-Sectional Studies; Female; | 2008 |
Importance of psychiatric confounding in non-randomized studies of heavy ecstasy users.
Topics: Alcohol Drinking; Alcoholism; Amphetamine-Related Disorders; Bias; Cognition Disorders; Comorbidity; | 2009 |
Impact of severity of drug use on discrete emotions recognition in polysubstance abusers.
Topics: Adolescent; Adult; Alcoholism; Cocaine-Related Disorders; Data Interpretation, Statistical; Educatio | 2010 |
Pills and pints: risky drinking and alcohol-related harms among regular ecstasy users in Australia.
Topics: Adolescent; Adult; Alcohol Drinking; Alcoholism; Amphetamine-Related Disorders; Australia; Cross-Sec | 2012 |
Moral decision-making in polysubstance dependent individuals.
Topics: Adult; Alcoholism; Case-Control Studies; Cocaine-Related Disorders; Decision Making; Heroin Dependen | 2012 |
Sexual identity and drug use harm among high-risk, active substance users.
Topics: Adolescent; Adult; Aged; Alcoholism; Bisexuality; British Columbia; Crack Cocaine; Cross-Sectional S | 2013 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2003. A 37-year-old man with a history of alcohol and drug abuse and sudden onset of leg weakness.
Topics: Adult; Alcoholism; Arthritis, Gouty; Biopsy; Colchicine; Diagnosis, Differential; Gout Suppressants; | 2003 |
Verbal working memory deficits in current and previous users of MDMA.
Topics: Adult; Alcoholism; Comprehension; Female; Hallucinogens; Humans; Male; Marijuana Abuse; Mathematics; | 2004 |
Differential effects of MDMA, cocaine, and cannabis use severity on distinctive components of the executive functions in polysubstance users: a multiple regression analysis.
Topics: Adult; Alcoholism; Cocaine-Related Disorders; Cognition Disorders; Female; Humans; Male; Marijuana A | 2005 |
MDMA polydrug users show process-specific central executive impairments coupled with impaired social and emotional judgement processes.
Topics: Adolescent; Adult; Alcoholism; Amphetamine-Related Disorders; Attention; Cocaine-Related Disorders; | 2006 |
Incidence and patterns of polydrug use and craving for ecstasy in regular ecstasy users: an ecological momentary assessment study.
Topics: Adult; Alcoholism; Comorbidity; Demography; Diagnostic and Statistical Manual of Mental Disorders; D | 2006 |
Patterns of simultaneous polysubstance use in drug using university students.
Topics: Adolescent; Adult; Alcoholism; Cocaine; Ethanol; Female; Humans; Male; Marijuana Abuse; N-Methyl-3,4 | 2006 |
[Modalities of drug consumption among male prostitutes].
Topics: Adult; Alcoholism; Amphetamine-Related Disorders; Attitude to Health; Cocaine-Related Disorders; Eth | 2006 |
Alcohol, ecstasy, Aldous Huxley's 'soma'.
Topics: Affect; Alcoholism; Amphetamine-Related Disorders; Central Nervous System Depressants; Drug and Narc | 2007 |
Former Soviet Union immigrant and native-born adolescents in Israel: substance use and related problem behavior.
Topics: Acculturation; Adolescent; Alcoholism; Amphetamine-Related Disorders; Child; Cross-Cultural Comparis | 2007 |
Mice with decreased cerebral dopamine function following a neurotoxic dose of MDMA (3,4-methylenedioxymethamphetamine, "Ecstasy") exhibit increased ethanol consumption and preference.
Topics: Alcohol Drinking; Alcoholism; Animals; Dopamine; Dopamine Antagonists; Ethanol; Male; Mice; Mice, In | 2007 |
Reckless behaviour related to the use of 3,4-methylenedioxymethamphetamine (ecstasy): apropos of a fatal accident during car-surfing.
Topics: Accidents, Traffic; Adult; Alcoholism; Brain Injuries; Dangerous Behavior; Fatal Outcome; Humans; Ma | 1994 |
[Attention deficit hyperactivity disorder, facilitating alcohol and drug abuse in an adult].
Topics: Adult; Alcoholism; Attention Deficit Disorder with Hyperactivity; Cannabis; Central Nervous System S | 1997 |
Ecstasy and new patterns of drug use: a normal population study.
Topics: Adolescent; Alcoholism; Amphetamines; Cannabis; Cohort Studies; Female; Hallucinogens; Heroin; Human | 1999 |
Interactions in anesthesia: anesthetic management of the drug abusing parturient.
Topics: Alcoholism; Amphetamine-Related Disorders; Anesthesia, Obstetrical; Cocaine-Related Disorders; Femal | 2001 |