nimodipine has been researched along with Alcohol Abuse in 8 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty three patients with chronic alcoholism of stage II with secondary affective disorders (anxiety, subdepression) and actualization of pathological drive for alcohol in remission period were divided into 3 groups: patients were treated with nimodipine (90 mg/day during 10 days), patients were treated with nifedipine (45 mg/day during 10 days) and patients of control group (they received a placebo for 10 days)." | 5.11 | [The efficacy of calcium channel blockers in the treatment of affective disorders and pathologic drive for alcohol in patients with alcoholism in the remission period]. ( Burakov, AM; Grinenko, AIa; Karandashova, GF; Krupitskiĭ, EM; Priputina, LS; Romanova, TN; Slavina, TIu; Vostrikov, VV, 2004) |
| "Nimodipine pretreatment attenuated the perceived similarity of ketamine effects to ethanol as well as ketamine-induced euphoria and sedation." | 2.70 | Attenuation of ketamine effects by nimodipine pretreatment in recovering ethanol dependent men: psychopharmacologic implications of the interaction of NMDA and L-type calcium channel antagonists. ( Burakov, AM; Fletcher, J; Grinenko, AY; Grinenko, NI; Krupitsky, EM; Krystal, JH; Petrakis, IL; Romanova, TN, 2001) |
| " Chronic nimodipine dosing in cocaine-dependent individuals is now needed to confirm its efficacy in the treatment of cocaine dependence." | 2.68 | The effects of nimodipine on the EEG of substance abusers. ( Guo, X; Herning, RI; Lange, WR, 1995) |
| " Chronic administration of nimodipine may alleviate the cognitive deficits observed in substance abusers during abstinence and prevent treatment relapse." | 2.68 | Nimodipine improves information processing in substance abusers. ( Guo, X; Herning, RI; Lange, WR, 1995) |
| "When nimodipine was given before the motor task learning and ethanol after the practice sessions, the tolerance to the ataxic effect of ethanol was increased." | 1.31 | Differential effects of a dihydropyridine calcium channel antagonist on the components of ethanol tolerance. ( Little, HJ; Smith, JW, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krupitskiĭ, EM | 1 |
| Burakov, AM | 2 |
| Priputina, LS | 1 |
| Vostrikov, VV | 1 |
| Romanova, TN | 2 |
| Karandashova, GF | 1 |
| Slavina, TIu | 1 |
| Grinenko, AIa | 1 |
| Herning, RI | 2 |
| Guo, X | 2 |
| Lange, WR | 2 |
| Rossetti, ZL | 1 |
| Isola, D | 1 |
| De Vry, J | 1 |
| Fadda, F | 1 |
| Smith, JW | 1 |
| Little, HJ | 3 |
| Holt, JD | 1 |
| Watson, WP | 1 |
| Krupitsky, EM | 1 |
| Grinenko, NI | 1 |
| Grinenko, AY | 1 |
| Fletcher, J | 1 |
| Petrakis, IL | 1 |
| Krystal, JH | 1 |
| Dolin, SJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Initiating Ketamine in Acutely Suicidal Patients in the Emergency Department[NCT04260607] | Phase 3 | 2 participants (Actual) | Interventional | 2020-01-14 | Terminated (stopped due to As a busy MTF we were unable to retain a health care provider with the appropriate expertise to buy-in to this study once the initiating PI left military service.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for nimodipine and Alcohol Abuse
| Article | Year |
|---|---|
[The efficacy of calcium channel blockers in the treatment of affective disorders and pathologic drive for alcohol in patients with alcoholism in the remission period].
Topics: Adult; Alcoholism; Calcium Channel Blockers; Double-Blind Method; Drive; Humans; Mood Disorders; Nif | 2004 |
The effects of nimodipine on the EEG of substance abusers.
Topics: Adult; Alcoholism; Analysis of Variance; Cocaine; Double-Blind Method; Electroencephalography; Heroi | 1995 |
Nimodipine improves information processing in substance abusers.
Topics: Adult; Alcoholism; Analysis of Variance; Cocaine; Double-Blind Method; Electroencephalography; Evoke | 1995 |
Attenuation of ketamine effects by nimodipine pretreatment in recovering ethanol dependent men: psychopharmacologic implications of the interaction of NMDA and L-type calcium channel antagonists.
Topics: Adult; Affect; Alcoholism; Anxiety; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Ty | 2001 |
4 other studies available for nimodipine and Alcohol Abuse
| Article | Year |
|---|---|
Effects of nimodipine on extracellular dopamine levels in the rat nucleus accumbens in ethanol withdrawal.
Topics: Alcoholism; Analysis of Variance; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dopam | 1999 |
Differential effects of a dihydropyridine calcium channel antagonist on the components of ethanol tolerance.
Topics: 2-Amino-5-phosphonovalerate; Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Ataxia; | 2000 |
Studies on a model of long term alcohol drinking.
Topics: Alcohol Drinking; Alcohol Withdrawal Delirium; Alcoholism; Animals; Brain; Calcium; Calcium Channel | 2001 |
Are changes in neuronal calcium channels involved in ethanol tolerance?
Topics: Alcoholism; Animals; Behavior, Animal; Brain; Calcium Channels; Dose-Response Relationship, Drug; Dr | 1989 |