fluconazole and omeprazole

fluconazole has been researched along with omeprazole in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.78)	18.7374
1990's	2 (5.56)	18.2507
2000's	13 (36.11)	29.6817
2010's	19 (52.78)	24.3611
2020's	1 (2.78)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Doman, TN; McGovern, SL; Seidler, J; Shoichet, BK	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Pratim Roy, P; Roy, K	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bharate, SS; Vishwakarma, RA	1
Kheylik, Y; Kondratov, I; Krasavin, M; Naumchyk, V; Platonov, M; Zahanich, I; Zozulya, S	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Kovalenko, A; Krasavin, M; Lukin, A; Moore, D; Tikhonova, IG; Zahanich, I; Zhurilo, N; Zozulya, S	1
Chen, F; Chen, W; Lan, L; Li, B; Li, J; Liu, Y; Mao, F; Ni, S; Wei, H; Zhu, J	1
Hendel, L; Kieffer, M; Stenderup, A; Svejgaard, E; Walsøe, I	1
Lach, P; Laufen, H; Riedel, KD; Yeates, RA; Zimmermann, T	1
Bergemer, AM; Dupuy, P; Lesur, G; Parlier, H; Paupard, T; Turner, L	1
Cho, HK; Kang, BC; Shin, WG; Suh, OK; Yang, CQ	1
Pérez Prim, FJ; Vila, I	1
Pashankar, DS; Rahhal, RM; Ramkumar, DP	1
Al-Sahafi, A; Hasosah, MY; Jacobson, K; Satti, M; Showail, M	1
Kekulé, AS; Kreft, B; Lübbert, C; Marsch, WC; Oehme, A	1
Ammori, BJ; Ashcroft, DM; Darwich, AS; Jamei, M; Pade, D; Rostami-Hodjegan, A	1
Buchbjerg, JK; Chen, G; Højer, AM; Lee, R; Serenko, M; Zhao, Z	1
Namiki, N; Tanaka, S; Uchida, S	1
Fukazawa, H; Inoue, M; Kaneko, Y; Miyazaki, Y; Niki, M; Ohno, H; Tanabe, K; Umeyama, T; Urai, M	1
Köhler, JR; Liu, NN	1
Bae, SH; Han, S; Park, GJ; Park, MH; Park, WS; Shin, SH; Shin, YG; Yim, DS	1
Chiang, CW; Li, L; Ning, X; Quinney, SK; Shen, L; Wang, L; Wang, X; Zhang, P; Zhang, S	1
Jianping, C; Juan, D; Liang, M; Liwen, Z; Yanbo, D; Yun, Z	1
Blank, A; Burhenne, J; Elbe, A; Foerster, KI; Haefeli, WE; Mikus, G; Rose, P	1

Reviews

1 review(s) available for fluconazole and omeprazole

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

4 trial(s) available for fluconazole and omeprazole

Article	Year
The influence of gastric pH on the pharmacokinetics of fluconazole: the effect of omeprazole. International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:9 Topics: Administration, Oral; Adult; Analysis of Variance; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Drug Interactions; Female; Fluconazole; Gastric Acid; Gastric Emptying; Gastrins; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Omeprazole; Stomach	1994
Influence of fluconazole on the pharmacokinetics of omeprazole in healthy volunteers. Biopharmaceutics & drug disposition, 2002, Volume: 23, Issue:2 Topics: Adult; Anti-Ulcer Agents; Antifungal Agents; Area Under Curve; Chromatography, High Pressure Liquid; Drug Interactions; Fluconazole; Humans; Male; Omeprazole; Spectrophotometry, Ultraviolet	2002
Pharmacokinetic drug interactions involving vortioxetine (Lu AA21004), a multimodal antidepressant. Clinical drug investigation, 2013, Volume: 33, Issue:10 Topics: Adolescent; Adult; Antidepressive Agents; Antifungal Agents; Bupropion; Cohort Studies; Contraceptives, Oral, Hormonal; Cross-Over Studies; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Female; Fluconazole; Humans; Ketoconazole; Male; Middle Aged; Omeprazole; Piperazines; Rifampin; Single-Blind Method; Sulfides; Vortioxetine; Young Adult	2013
Drug-drug interaction of microdose and regular-dose omeprazole with a CYP2C19 inhibitor and inducer. Drug design, development and therapy, 2017, Volume: 11 Topics: Adult; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Fluconazole; Healthy Volunteers; Humans; Male; Middle Aged; Omeprazole; Rifampin; Young Adult	2017

Other Studies

31 other study(ies) available for fluconazole and omeprazole

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Identification and prediction of promiscuous aggregating inhibitors among known drugs. Journal of medicinal chemistry, 2003, Oct-09, Volume: 46, Issue:21 Topics: Antifungal Agents; beta-Lactamase Inhibitors; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Molecular; Molecular Conformation; Scattering, Radiation; Structure-Activity Relationship	2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques. European journal of medicinal chemistry, 2009, Volume: 44, Issue:7 Topics: Algorithms; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Factor Analysis, Statistical; Least-Squares Analysis; Linear Models; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. Bioorganic & medicinal chemistry letters, 2015, Apr-01, Volume: 25, Issue:7 Topics: Drug Discovery; Pharmaceutical Preparations; Solubility; Thermodynamics	2015
Phenoxymethyl 1,3-oxazoles and 1,2,4-oxadiazoles as potent and selective agonists of free fatty acid receptor 1 (GPR40). Bioorganic & medicinal chemistry letters, 2015, Aug-15, Volume: 25, Issue:16 Topics: Animals; Binding Sites; Caco-2 Cells; Cytochrome P-450 Enzyme System; Half-Life; Humans; Methylamines; Mice; Molecular Docking Simulation; Oxadiazoles; Oxazoles; Propionates; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Receptors, G-Protein-Coupled; Structure-Activity Relationship	2015
Novel free fatty acid receptor 1 (GPR40) agonists based on 1,3,4-thiadiazole-2-carboxamide scaffold. Bioorganic & medicinal chemistry, 2016, 07-01, Volume: 24, Issue:13 Topics: Amides; Animals; Drug Delivery Systems; Humans; Hypoglycemic Agents; Mice; Microsomes, Liver; Molecular Docking Simulation; Protein Binding; Receptors, G-Protein-Coupled; Thiadiazoles	2016
Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. Journal of medicinal chemistry, 2018, 01-11, Volume: 61, Issue:1 Topics: Animals; Drug Design; Enzyme Inhibitors; ERG1 Potassium Channel; HEK293 Cells; Hep G2 Cells; Humans; Inhibitory Concentration 50; Methicillin-Resistant Staphylococcus aureus; Mice; Oxidoreductases; Rats; Safety; Solubility; Structure-Activity Relationship; Water	2018
Esophageal candidosis in progressive systemic sclerosis: occurrence, significance, and treatment with fluconazole. Scandinavian journal of gastroenterology, 1988, Volume: 23, Issue:10 Topics: Adult; Aged; Antifungal Agents; Candidiasis; Esophageal Diseases; Esophagoscopy; Female; Fluconazole; Humans; Male; Middle Aged; Omeprazole; Ranitidine; Scleroderma, Systemic; Triazoles	1988
[Esophageal mycosis during treatment with omeprazole]. Gastroenterologie clinique et biologique, 1993, Volume: 17, Issue:8-9 Topics: Esophageal Diseases; Fluconazole; Humans; Male; Middle Aged; Mycoses; Omeprazole; Stomach Ulcer	1993
[Ongoing treatment with omeprazole and appearance of oropharyngeal candidiasis]. Atencion primaria, 2002, Volume: 30, Issue:10 Topics: Aged; Anti-Ulcer Agents; Antifungal Agents; Candida albicans; Candidiasis, Oral; Female; Fluconazole; Gastroesophageal Reflux; Humans; Nystatin; Omeprazole; Treatment Failure	2002
Simultaneous herpetic and candidal esophagitis in an immunocompetent teenager. Journal of pediatric gastroenterology and nutrition, 2005, Volume: 40, Issue:3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acyclovir; Adolescent; Antifungal Agents; Antiviral Agents; Candidiasis; Esophagitis; Fluconazole; Herpes Simplex; Humans; Immunocompetence; Lansoprazole; Male; Omeprazole; Treatment Outcome	2005
Esophageal candidiasis in an immunocompetent girl. World journal of pediatrics : WJP, 2009, Volume: 5, Issue:2 Topics: Adrenal Cortex Hormones; Anti-Ulcer Agents; Antifungal Agents; Asthma; Candidiasis; Drug Therapy, Combination; Esophagitis, Peptic; Female; Fluconazole; Humans; Immunocompetence; Infant; Omeprazole; Treatment Outcome	2009
[37-year old patient with fever, diarrhea and lymphadenopathy]. Der Internist, 2010, Volume: 51, Issue:8 Topics: Adult; AIDS Serodiagnosis; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Antifungal Agents; Antiretroviral Therapy, Highly Active; Candidiasis, Oral; Ciprofloxacin; Clarithromycin; Diagnosis, Differential; Diarrhea; Drug Therapy, Combination; Fever of Unknown Origin; Fluconazole; Giardia lamblia; Giardiasis; HIV Seropositivity; HIV-1; Homosexuality, Male; Humans; Immunoblotting; Lymphatic Diseases; Male; Metronidazole; Omeprazole	2010
A mechanistic pharmacokinetic model to assess modified oral drug bioavailability post bariatric surgery in morbidly obese patients: interplay between CYP3A gut wall metabolism, permeability and dissolution. The Journal of pharmacy and pharmacology, 2012, Volume: 64, Issue:7 Topics: Administration, Oral; Bariatric Surgery; Biological Availability; Chemistry, Pharmaceutical; Ciprofloxacin; Computer Simulation; Cytochrome P-450 CYP3A; Diclofenac; Fluconazole; Humans; Intestinal Mucosa; Models, Biological; Obesity, Morbid; Omeprazole; Permeability; Pharmaceutical Preparations; Simvastatin; Solubility	2012
Simultaneous and comprehensive in vivo analysis of cytochrome P450 activity by using a cocktail approach in rats. Biopharmaceutics & drug disposition, 2014, Volume: 35, Issue:4 Topics: Animals; Caffeine; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dextromethorphan; Drug Interactions; Fluconazole; Fluvoxamine; Ketoconazole; Losartan; Male; Midazolam; Omeprazole; Rats, Sprague-Dawley	2014
Potent drugs that attenuate anti-Candida albicans activity of fluconazole and their possible mechanisms of action. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2014, Volume: 20, Issue:10 Topics: Antifungal Agents; ATP-Binding Cassette Transporters; Candida albicans; Candidiasis; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Fluconazole; Fungal Proteins; Gene Expression; Ibuprofen; Membrane Transport Proteins; Microbial Sensitivity Tests; Omeprazole; Phenylpropionates; Proton Pump Inhibitors	2014
Antagonism of Fluconazole and a Proton Pump Inhibitor against Candida albicans. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:2 Topics: Antifungal Agents; Candida albicans; Cytosol; Drug Antagonism; Fluconazole; Hydrogen-Ion Concentration; Omeprazole; Proton Pump Inhibitors	2016
Translational High-Dimensional Drug Interaction Discovery and Validation Using Health Record Databases and Pharmacokinetics Models. Clinical pharmacology and therapeutics, 2018, Volume: 103, Issue:2 Topics: Adverse Drug Reaction Reporting Systems; Clonidine; Cytochrome P-450 CYP2C19 Inhibitors; Cytochrome P-450 CYP3A Inhibitors; Data Mining; Databases, Factual; Drug Development; Drug Discovery; Drug Interactions; Electronic Health Records; Evidence-Based Medicine; Fluconazole; Humans; Models, Biological; Muscular Diseases; Omeprazole; Patient Safety; Polypharmacy; Reproducibility of Results; Risk Assessment; Translational Research, Biomedical; United States	2018
A rare case report of fungal esophagitis combined with giant gastric ulcer in an immunocompetent patient. Medicine, 2019, Volume: 98, Issue:3 Topics: Aged; Anti-Ulcer Agents; Antifungal Agents; Endoscopy, Gastrointestinal; Esophagitis; Fluconazole; Humans; Immunocompetence; Male; Mycoses; Omeprazole; Stomach; Stomach Ulcer	2019
Evaluation of CYP2C19 activity using microdosed oral omeprazole in humans. European journal of clinical pharmacology, 2022, Volume: 78, Issue:6 Topics: Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Interactions; Fluconazole; Humans; Midazolam; Omeprazole; Rifampin; Sodium Bicarbonate; Yohimbine	2022