Compounds > sordarin
Page last updated: 2024-12-08

sordarin

Description

sordarin: antifungal mold metabolite of Sordaria araneosa; sordarins A and B are stereoisomers [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

sordarin : An antifungal metabolite of Sordaria araneosa that inhibits protein synthesis. It has a tetracyclic diterpene glycoside structure. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID44582273
CHEMBL ID476273
MeSH IDM0044362

Synonyms (2)

Synonym
sordarin
CHEMBL476273

Research Excerpts

Pharmacokinetics

The antifungal effect of GM 237354, a sordarin derivative, was studied in an in vitro pharmacokinetic (PK)-pharmacodynamic dynamic system (bioreactor) This reproduces PK profiles observed in a previously described model of drug efficacy against murine systemic candidiasis. Further investigation identified the 5'-i-Pr derivative 7b, which displays superior pharmacokinetics properties compared to other azasordarins.

ExcerptReferenceRelevance
" In this study, the in vitro pharmacodynamic parameters of four sordarin derivatives (GM 191519, GM 237354, GM 193663, and GM 219771) have been evaluated by a new quantitative approach and compared with the commercially available drugs pentamidine, atovaquone, and trimethoprim-sulfamethoxazole (TMP-SMX)."( In vitro pharmacodynamic parameters of sordarin derivatives in comparison with those of marketed compounds against Pneumocystis carinii isolated from rats.
Aliouat, EM; Aviles, P; Dei-Cas, E; Dujardin, L; Gargallo-Viola, D; Herreros, E; Martinez, A, 2000)		0.31
" The present study investigates possible correlations between sordarin pharmacokinetic (PK) properties and therapeutic efficacy, based on a murine model of invasive systemic candidiasis, and provides a rationale for dose selection in the first study of efficacy in humans."( Pharmacokinetics-pharmacodynamics of a sordarin derivative (GM 237354) in a murine model of lethal candidiasis.
Aviles, P; Falcoz, C; Gargallo-Viola, D; San Roman, R, 2000)		0.31
"The antifungal effect of GM 237354, a sordarin derivative, was studied in an in vitro pharmacokinetic (PK)-pharmacodynamic dynamic system (bioreactor) which reproduces PK profiles observed in a previously described model of drug efficacy against murine systemic candidiasis."( Correlation between in vitro and in vivo activities of GM 237354, a new sordarin derivative, against Candida albicans in an in vitro pharmacokinetic-pharmacodynamic model and influence of protein binding.
Aviles, P; Falcoz, C; Gargallo-Viola, D; Gómez De Las Heras, F; Guillén, MJ; San Roman, R, 2001)		0.31
" After intravenous dosing in animals, both the area under the concentration-time curve and the elimination half-life were highest in Cynomolgus monkeys, followed by those in rats, mice, and rabbits."( Animal pharmacokinetics and interspecies scaling of sordarin derivatives following intravenous administration.
Aviles, P; Gargallo-Viola, D; Gómez De Las Heras, F; Guillén, MJ; Pateman, A; San Roman, R, 2001)		0.31
" Further investigation identified the 5'-i-Pr derivative 7b, which displays superior pharmacokinetic properties compared to other azasordarins."( Identification of a broad-spectrum azasordarin with improved pharmacokinetic properties.
Balasubramanian, BN; Carroll, TM; Dodier, M; Gao, Q; Gill, P; Laurent, DR; Marinier, A; Mazzucco, CE; Quesnelle, C; Regueiro-Ren, A; Serrano-Wu, MH; Stickle, TM; Vyas, DM; Wu, D; Yang, H; Yang, Z; Zheng, M; Zoeckler, ME, 2003)		0.32

Dosage Studied

ExcerptRelevanceReference
" When the amount of EF-2 exceeded that of ribosomes sordarin inhibited the GTPase activity following an inverted bell-shaped dose-response curve, whereas when EF-2 and ribosomes were in equimolar concentrations sordarin yielded a typical sigmoidal dose-dependent inhibition."( Sordarin inhibits fungal protein synthesis by blocking translocation differently to fusidic acid.
Domínguez, JM; Gómez-Lorenzo, MG; Martín, JJ, 1999)		0.3
" The in vitro maximum effect (E(max)), the drug concentrations to reach 50% of E(max) (EC(50)), and the slope of the dose-response curve were then estimated by the Hill equation (E(max) sigmoid model)."( In vitro pharmacodynamic parameters of sordarin derivatives in comparison with those of marketed compounds against Pneumocystis carinii isolated from rats.
Aliouat, EM; Aviles, P; Dei-Cas, E; Dujardin, L; Gargallo-Viola, D; Herreros, E; Martinez, A, 2000)		0.31
" A good correlation independent of the dosing interval was observed with AUC (but not C(max) or t > MIC) and both AUSTC and kidney burden."( Pharmacokinetics-pharmacodynamics of a sordarin derivative (GM 237354) in a murine model of lethal candidiasis.
Aviles, P; Falcoz, C; Gargallo-Viola, D; San Roman, R, 2000)		0.31
" After intravenous dosing in animals, both the area under the concentration-time curve and the elimination half-life were highest in Cynomolgus monkeys, followed by those in rats, mice, and rabbits."( Animal pharmacokinetics and interspecies scaling of sordarin derivatives following intravenous administration.
Aviles, P; Gargallo-Viola, D; Gómez De Las Heras, F; Guillén, MJ; Pateman, A; San Roman, R, 2001)		0.31
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (151)

Assay IDTitleYearJournalArticle
AID528795Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPL21A YBR191W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID202693Antifungal activity against Saccharomyces cerevisiae (strain YPH98)1998Bioorganic & medicinal chemistry letters, Aug-18, Volume: 8, Issue:16
Alkyl side-chain derivatives of sordaricin as potent antifungal agents against yeast.
AID528668Antifungal activity against Saccharomyces cerevisiae BY4741 harboring FUN12 YAL035W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528660Antifungal activity against Saccharomyces cerevisiae BY4741 harboring GRR1 YJR090C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528813Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph4 gene at 300 to 500 ng/ml after 24 hrs by liquid growth assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531894Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YLR143W mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID417558Antifungal activity against Candida albicans FP633 in po dosed ICR mouse candidiasis model treated after 1 hr post infection for 4 days2009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID49966Minimum inhibitory concentration against Candida glabrata2002Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6
Oxime derivatives of sordaricin as potent antifungal agents.
AID528629Antifungal activity against Saccharomyces cerevisiae BY4741 harboring QRI5 YLR204W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528622Antifungal activity against Saccharomyces cerevisiae BY4741 harboring IBD2 YNL164C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531876Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph1 gene at 300 to 500 ng/ml after 24 hrs by liquid growth assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531904Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YDR008C mutation by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID49986Minimum inhibitory concentration required to inhibit 90-100%growth of Candida glabrata2002Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19
Sordarin oxazepine derivatives as potent antifungal agents.
AID528800Antifungal activity against Saccharomyces cerevisiae BY4741 harboring JJJ3/DPH4 YJR097W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531875Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph2 gene at 300 to 500 ng/ml after 24 hrs by liquid growth assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID417551Antifungal activity against Candida glabrata ATCC 900302009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID531912Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DAL7 YIR031C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531883Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YLR125W mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531877Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph5 gene at 100 ng/ml by plate assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528656Antifungal activity against Saccharomyces cerevisiae BY4741 harboring UBX3 YDL091C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531901Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YER087W mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID417556Cmax in mouse at 2 mg/kg, po2009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID528643Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ARN1 YHL040C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528805Antifungal activity against Saccharomyces cerevisiae BY4741 harboring NOT5 YPR072W mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528803Antifungal activity against Saccharomyces cerevisiae BY4741 harboring CNM67 YNL225C mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528627Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DIA4 YHR011W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528808Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ATP12 YJL180C mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528638Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MIP6 YHR015W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531909Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MOH1 YBL049W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528657Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SEM1 YDR363W-A mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531911Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SUR2 YDR297W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528652Antifungal activity against Saccharomyces cerevisiae BY4741 harboring KTR7 YIL085C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID1129293Cytotoxicity against mouse RAW264.7 cells by Alamar Blue assay2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Diterpene glycosides and polyketides from Xylotumulus gibbisporus.
AID528666Antifungal activity against Saccharomyces cerevisiae BY4741 harboring PTP3 YER075C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531880Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph2 gene at 100 ng/ml by plate assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531890Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YOL079W mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528632Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MGT1 YDL200C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528673Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRP20 YDR405W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528618Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MTF1 YMR228W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528631Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YBR099C mutation by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528814Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph5 gene at 300 to 500 ng/ml after 24 hrs by liquid growth assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528626Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RBS1 YDL189W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID417554Antifungal activity against Aspergillus fumigatus ATCC 2043052009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID417549Antifungal activity against Candida albicans ATCC 900282009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID531898Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YSC83 YHR017W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528651Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ECM3 YOR092W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528644Antifungal activity against Saccharomyces cerevisiae BY4741 harboring LYS14 YDR034C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531902Antifungal activity against Saccharomyces cerevisiae BY4741 harboring FYV1 YDR024W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528662Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DOC1 YGL240W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531888Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YDL063C mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528798Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPL12B YDR418W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531878Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph4 gene at 100 ng/ml by plate assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID417555Antifungal activity against Candida albicans FP290581 in ICR mouse serum drug administered po twice a day2009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID1129292Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by spectrophotometric analysis2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Diterpene glycosides and polyketides from Xylotumulus gibbisporus.
AID528621Antifungal activity against Saccharomyces cerevisiae BY4741 harboring CPR6 YLR216C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531897Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YHR151C mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531910Antifungal activity against Saccharomyces cerevisiae BY4741 harboring COX11 YPL132W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528670Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRPL3 YMR024W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528810Antifungal activity against Saccharomyces cerevisiae BY4741 harboring AFG3 YER017C mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528653Antifungal activity against Saccharomyces cerevisiae BY4741 harboring BEM2 YER155C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531907Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YBR141C mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528617Antifungal activity against Saccharomyces cerevisiae BY4741 harboring AMS1 YGL156W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528616Antifungal activity against Saccharomyces cerevisiae BY4741 harboring TOK1 YJL093C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528642Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ARN2 YHL047C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528639Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MIP1 YOR330C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528635Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MUP3 YHL036W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531886Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YDR042C mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531891Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DLT1 YMR126C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528671Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRPL24 YMR193W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID45145Minimum inhibitory concentration against Candida albicans2002Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6
Oxime derivatives of sordaricin as potent antifungal agents.
AID528663Antifungal activity against Saccharomyces cerevisiae BY4741 harboring NAT3 YPR131C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID48921Minimum inhibitory concentration required to inhibit 90-100%growth of Candida albicans2002Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19
Sordarin oxazepine derivatives as potent antifungal agents.
AID528676Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRP21 YBL090W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531879Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph3 gene at 100 ng/ml by plate assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528812Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph3 gene at 300 to 500 ng/ml after 24 hrs by liquid growth assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531899Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YHL041W mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528797Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPL1B YGL135W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531896Antifungal activity against Saccharomyces cerevisiae BY4741 harboring FMP35 YIL157C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528669Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MSR1 YHR091C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID1129291Antifungal activity against Saccharomyces cerevisiae ATCC 2345 by NCCLS method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Diterpene glycosides and polyketides from Xylotumulus gibbisporus.
AID528636Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DJP1 YIR004W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528628Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DHH1 YDL160C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID55181Minimum inhibitory concentration required to inhibit 90-100% growth of Cryptococcus neoformans2002Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19
Sordarin oxazepine derivatives as potent antifungal agents.
AID417552Antifungal activity against Candida tropicalis 210052009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID528645Antifungal activity against Saccharomyces cerevisiae BY4741 harboring THI20 YOL055C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528667Antifungal activity against Saccharomyces cerevisiae BY4741 harboring STE1 YDR410C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531903Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YDR020C mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531887Antifungal activity against Saccharomyces cerevisiae BY4741 harboring LDB17 YDL146W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID417557Half life in mouse at 2 mg/kg, po2009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID528807Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ATP1 YBL099W mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID86205Cytotoxicity was evaluated against Hep-2 cells in vitro2002Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6
Oxime derivatives of sordaricin as potent antifungal agents.
AID528620Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ADY3 YDL239C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528806Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YBL100C mutation assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528623Antifungal activity against Saccharomyces cerevisiae BY4741 harboring PRR2 YDL214C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528658Antifungal activity against Saccharomyces cerevisiae BY4741 harboring QRI7 YDL104C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528802Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DPH1 YIL103W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531908Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SCS22 YBL091C-A mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528640Antifungal activity against Saccharomyces cerevisiae BY4741 harboring HMI1 YOL095C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528665Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RAM1 YDL090C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531893Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YLR202C mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528794Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPS18A YDR450W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID1129290Antifungal activity against Candida albicans ATCC MYA-2876 by NCCLS method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Diterpene glycosides and polyketides from Xylotumulus gibbisporus.
AID528648Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SER1 YOR184W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528625Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SHE2 YKL130C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528646Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ADE4 YMR300C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528672Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRPL11 YDL202W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528654Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SBE2 YDR351W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528655Antifungal activity against Saccharomyces cerevisiae BY4741 harboring CUE1 YMR264W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528647Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ARO3 YDR035W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531882Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RMD9 YGL107C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528634Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RAD28 YDR030C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID1129289Antifungal activity against Candida albicans ATCC 18804 by NCCLS method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Diterpene glycosides and polyketides from Xylotumulus gibbisporus.
AID49959Anti-fungal activity against Candida glabrata A28790 (WT)2002Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23
Core-modified sordaricin derivatives: synthesis and antifungal activity.
AID417553Antifungal activity against Candida parapsilosis ATCC 220192009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID531900Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YGR228W mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528796Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPL16B YNL069C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528815Antifungal activity against Saccharomyces cerevisiae BY4741 assessed as reduction in fungal growth up to 500 ng/ml for 72 hrs by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528675Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRPL36 YBR122C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528619Antifungal activity against Saccharomyces cerevisiae BY4741 harboring CTF3 YLR381W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID235609Therapeutic index (CC50/MIC) was determined2002Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6
Oxime derivatives of sordaricin as potent antifungal agents.
AID528809Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SSQ1 YLR369W mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID417560Antifungal activity against Cryptococcus neoformans TIMM 03542009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID528799Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DPH5 YLR172C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531881Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph1 gene at 100 ng/ml by plate assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528678Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPS11A YDR025W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528633Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SHU2 YDR078C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID44951Anti-fungal activity against Candida albicans A28660 (WT); No data2002Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23
Core-modified sordaricin derivatives: synthesis and antifungal activity.
AID528649Antifungal activity against Saccharomyces cerevisiae BY4741 harboring BUD9 YGR041W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528804Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SPS1 YDR523C mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528661Antifungal activity against Saccharomyces cerevisiae BY4741 harboring PRE9 YGR135W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528664Antifungal activity against Saccharomyces cerevisiae BY4741 harboring EAF3 YPR023C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528637Antifungal activity against Saccharomyces cerevisiae BY4741 harboring BAP2 YBR068C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528650Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MHP1 YJL042W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID47611Anti-fungal activity against Candida albicans A28235 (WT)2002Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23
Core-modified sordaricin derivatives: synthesis and antifungal activity.
AID531885Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YDL062W mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531884Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YER184C mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528677Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RSM19 YNR037C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528679Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPS4A YJR145C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528801Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DPH2 YKL191W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528811Antifungal activity against Saccharomyces cerevisiae BY4741 harboring HEM14 YER014W mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531895Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YKL098W mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528641Antifungal activity against Saccharomyces cerevisiae BY4741 harboring GGC1 YDL198C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531892Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YMR141C mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531906Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YBR255W mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528674Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRPL37 YBR268W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID417550Antifungal activity against fluconazole-resistant Candida albicans 220092009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID528659Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DSK2 YMR276W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531905Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YCL042W mutation by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528624Antifungal activity against Saccharomyces cerevisiae BY4741 harboring COQ1 YBR003W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531889Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRH1 YDR033W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528630Antifungal activity against Saccharomyces cerevisiae BY4741 harboring PUF3 YLL013C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (69)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (1.45)18.7374
1990's11 (15.94)18.2507
2000's39 (56.52)29.6817
2010's14 (20.29)24.3611
2020's4 (5.80)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews4 (5.71%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other66 (94.29%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pimagedine
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure. aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.		2.110guanidines;
one-carbon compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 1.4.3.4 (monoamine oxidase) inhibitor
fluconazole
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.		2.9340conazole antifungal drug;
difluorobenzene;
tertiary alcohol;
triazole antifungal drug		environmental contaminant;
P450 inhibitor;
xenobiotic
hydroxyurea
[no description available]		2.1510one-carbon compound;
ureas		antimetabolite;
antimitotic;
antineoplastic agent;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
genotoxin;
immunomodulator;
radical scavenger;
teratogenic agent
methyl methanesulfonate
[no description available]		2.1510methanesulfonate esteralkylating agent;
apoptosis inducer;
carcinogenic agent;
genotoxin;
mutagen
metyrapone
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.. metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.		2.2510aromatic ketoneantimetabolite;
diagnostic agent;
EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor
lysine
Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.		2.0510aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
adenosine diphosphate
Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.		2.0310adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		fundamental metabolite;
human metabolite
cycloheximide
Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.		2.0810antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
histidine
Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.		2.7730amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
ethylene oxide
Ethylene Oxide: A colorless and flammable gas at room temperature and pressure. Ethylene oxide is a bactericidal, fungicidal, and sporicidal disinfectant. It is effective against most micro-organisms, including viruses. It is used as a fumigant for foodstuffs and textiles and as an agent for the gaseous sterilization of heat-labile pharmaceutical and surgical materials. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p794). oxirane : A saturated organic heteromonocyclic parent that is a three-membered heterocycle of two carbon atoms and one oxygen atom.		2.0110gas molecular entity;
oxacycle;
saturated organic heteromonocyclic parent		allergen;
mouse metabolite;
mutagen
tetrahydrofuran
oxolane : A cyclic ether that is butane in which one hydrogen from each methyl group is substituted by an oxygen.		7.0110cyclic ether;
oxolanes;
saturated organic heteromonocyclic parent;
volatile organic compound		polar aprotic solvent
cyclopentane
Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.		2.0510cycloalkane;
cyclopentanes;
volatile organic compound		non-polar solvent
formal glycol
[no description available]		2.0110cyclic acetal;
dioxolane
2-piperidone
2-piperidone: structure given in first source. piperidin-2-one : A delta-lactam that is piperidine which is substituted by an oxo group at position 2.		2.0810delta-lactam;
piperidones		EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor
rhamnose
[no description available]		2.0210L-rhamnose
alkenes
[no description available]		2.2110
adenosine diphosphate ribose
Adenosine Diphosphate Ribose: An ester formed between the aldehydic carbon of RIBOSE and the terminal phosphate of ADENOSINE DIPHOSPHATE. It is produced by the hydrolysis of nicotinamide-adenine dinucleotide (NAD) by a variety of enzymes, some of which transfer an ADP-ribosyl group to target proteins.		2.0210ADP-sugarEscherichia coli metabolite;
mouse metabolite
hypusine
hypusine: N-terminal amino alcohol deriv of Lys occurring in bovine brain & in the urine of children with familial hyperlysinemia; minor descriptor (75-82); online & Index Medicus search LYSINE/AA (75-82). hypusine : An L-lysine derivative that is L-lysine bearing a (2R)-4-amino-2-hydroxybutyl substituent at position N(6).		2.0510
methotrexate
[no description available]		2.0710dicarboxylic acid;
monocarboxylic acid amide;
pteridines		abortifacient;
antimetabolite;
antineoplastic agent;
antirheumatic drug;
dermatologic drug;
DNA synthesis inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
immunosuppressive agent
peptide elongation factor 2
Peptide Elongation Factor 2: Peptide Elongation Factor 2 catalyzes the translocation of peptidyl-tRNA from the A site to the P site of eukaryotic ribosomes by a process linked to the hydrolysis of GTP to GDP.		4.1150
paromomycin
Paromomycin: An aminoglycoside antibacterial and antiprotozoal agent produced by species of STREPTOMYCES.. paromomycin : An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.		2.0810amino cyclitol glycoside;
aminoglycoside antibiotic		anthelminthic drug;
antibacterial drug;
antiparasitic agent;
antiprotozoal drug
gm237354
GM237354: a sordarin derivative		7.9240
puromycin
[no description available]		210puromycinsantiinfective agent;
antimicrobial agent;
antineoplastic agent;
EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor;
EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor;
nucleoside antibiotic;
protein synthesis inhibitor
nitroarginine
Nitroarginine: An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6). N(gamma)-nitro-L-arginine : An L-arginine derivative that is L-arginine in which the terminal nitrogen of the guanidyl group is replaced by a nitro group.		2.110guanidines;
L-arginine derivative;
N-nitro compound;
non-proteinogenic L-alpha-amino acid
trichostatin a
trichostatin A: chelates zinc ion in the active site of histone deacetylases, resulting in preventing histone unpacking so DNA is less available for transcription; do not confuse with TRICHOSANTHIN which is a protein; found in STREPTOMYCES		2.0710antibiotic antifungal agent;
hydroxamic acid;
trichostatin		bacterial metabolite;
EC 3.5.1.98 (histone deacetylase) inhibitor;
geroprotector
sordaricin
sordaricin : A tetracyclic diterpenoid that is produced by several fungi including Sordaria araneosa.		2.95403-oxo monocarboxylic acid;
aldehyde;
bridged compound;
primary alcohol;
tetracyclic diterpenoid		antifungal agent;
fungal metabolite
glycosides
[no description available]		7.7730
fusidic acid
Fusidic Acid: An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.. fusidic acid : A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.		7.723011alpha-hydroxy steroid;
3alpha-hydroxy steroid;
alpha,beta-unsaturated monocarboxylic acid;
steroid acid;
steroid antibiotic;
sterol ester		EC 2.7.1.33 (pantothenate kinase) inhibitor;
Escherichia coli metabolite;
protein synthesis inhibitor
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.4120antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
monorden
monorden: inhibits HSP90 Heat-Shock Proteins, DNA topoisomerase VI and human Topoisomerase II		2.0710cyclic ketone;
enone;
epoxide;
macrolide antibiotic;
monochlorobenzenes;
phenols		antifungal agent;
metabolite;
tyrosine kinase inhibitor
lactimidomycin
lactimidomycin: a glutarimide antibiotic isolated from Streptomyces amphibiosporus		2.0810macrolide
diphthamide
[no description available]		2.7730quaternary ammonium ion
echinocandin b
echinocandin B: a cyclic hexapeptide echinocandin antibiotic isolated from Aspergillus nidulans var. echinulatus with specific anti-yeast activity; inhibits beta-1,3-glucan synthesis. echinocandin B : A cyclic hexapeptide echinocandin antibiotic isolated from Aspergillus nidulans var. echinulatus with specific anti-yeast activity.		3.1110
guanosine diphosphate
Guanosine Diphosphate: A guanine nucleotide containing two phosphate groups esterified to the sugar moiety.		2.0210guanosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor
guanosine triphosphate
Guanosine Triphosphate: Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.		2.4720guanosine 5'-phosphate;
purine ribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Candida Infection
[description not available]		04.0350
Candidiasis
Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)		04.0350
C gattii Infection
[description not available]		02.0110
Cryptococcosis
Fungal infection caused by genus CRYPTOCOCCUS.		02.0110
Fungemia
The presence of fungi circulating in the blood. Opportunistic fungal sepsis is seen most often in immunosuppressed patients with severe neutropenia or in postoperative patients with intravenous catheters and usually follows prolonged antibiotic therapy.		02.0210
Esophageal Diseases
Pathological processes in the ESOPHAGUS.		02.0210
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		01.9910
Histoplasma capsulatum Infection
[description not available]		0210
Histoplasmosis
Infection resulting from exposure to the fungus HISTOPLASMA. It is worldwide in distribution and particularly common in the central and eastern states, especially areas around the Ohio and Mississippi River valleys.		0710
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		03.150
P carinii Pneumonia
[description not available]		02.4120
Pneumonia, Pneumocystis
A pulmonary disease in humans occurring in immunodeficient or malnourished patients or infants, characterized by DYSPNEA, tachypnea, and HYPOXEMIA. Pneumocystis pneumonia is a frequently seen opportunistic infection in AIDS. It is caused by the fungus PNEUMOCYSTIS JIROVECII. The disease is also found in other MAMMALS where it is caused by related species of Pneumocystis.		02.4120
Coccidioides immitis Infection
[description not available]		0210
Coccidioidomycosis
Infection with a fungus of the genus COCCIDIOIDES, endemic to the SOUTHWESTERN UNITED STATES. It is sometimes called valley fever but should not be confused with RIFT VALLEY FEVER. Infection is caused by inhalation of airborne, fungal particles known as arthroconidia, a form of FUNGAL SPORES. A primary form is an acute, benign, self-limited respiratory infection. A secondary form is a virulent, severe, chronic, progressive granulomatous disease with systemic involvement. It can be detected by use of COCCIDIOIDIN.		0710
Aspergillus Infection
[description not available]		0210
Aspergillosis
Infections with fungi of the genus ASPERGILLUS.		0710
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