sordarin: antifungal mold metabolite of Sordaria araneosa; sordarins A and B are stereoisomers [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
sordarin : An antifungal metabolite of Sordaria araneosa that inhibits protein synthesis. It has a tetracyclic diterpene glycoside structure. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
ID Source | ID |
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PubMed CID | 44582273 |
CHEMBL ID | 476273 |
MeSH ID | M0044362 |
Synonym |
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sordarin |
CHEMBL476273 |
The antifungal effect of GM 237354, a sordarin derivative, was studied in an in vitro pharmacokinetic (PK)-pharmacodynamic dynamic system (bioreactor) This reproduces PK profiles observed in a previously described model of drug efficacy against murine systemic candidiasis. Further investigation identified the 5'-i-Pr derivative 7b, which displays superior pharmacokinetics properties compared to other azasordarins.
Excerpt | Reference | Relevance |
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" In this study, the in vitro pharmacodynamic parameters of four sordarin derivatives (GM 191519, GM 237354, GM 193663, and GM 219771) have been evaluated by a new quantitative approach and compared with the commercially available drugs pentamidine, atovaquone, and trimethoprim-sulfamethoxazole (TMP-SMX)." | ( In vitro pharmacodynamic parameters of sordarin derivatives in comparison with those of marketed compounds against Pneumocystis carinii isolated from rats. Aliouat, EM; Aviles, P; Dei-Cas, E; Dujardin, L; Gargallo-Viola, D; Herreros, E; Martinez, A, 2000) | 0.31 |
" The present study investigates possible correlations between sordarin pharmacokinetic (PK) properties and therapeutic efficacy, based on a murine model of invasive systemic candidiasis, and provides a rationale for dose selection in the first study of efficacy in humans." | ( Pharmacokinetics-pharmacodynamics of a sordarin derivative (GM 237354) in a murine model of lethal candidiasis. Aviles, P; Falcoz, C; Gargallo-Viola, D; San Roman, R, 2000) | 0.31 |
"The antifungal effect of GM 237354, a sordarin derivative, was studied in an in vitro pharmacokinetic (PK)-pharmacodynamic dynamic system (bioreactor) which reproduces PK profiles observed in a previously described model of drug efficacy against murine systemic candidiasis." | ( Correlation between in vitro and in vivo activities of GM 237354, a new sordarin derivative, against Candida albicans in an in vitro pharmacokinetic-pharmacodynamic model and influence of protein binding. Aviles, P; Falcoz, C; Gargallo-Viola, D; Gómez De Las Heras, F; Guillén, MJ; San Roman, R, 2001) | 0.31 |
" After intravenous dosing in animals, both the area under the concentration-time curve and the elimination half-life were highest in Cynomolgus monkeys, followed by those in rats, mice, and rabbits." | ( Animal pharmacokinetics and interspecies scaling of sordarin derivatives following intravenous administration. Aviles, P; Gargallo-Viola, D; Gómez De Las Heras, F; Guillén, MJ; Pateman, A; San Roman, R, 2001) | 0.31 |
" Further investigation identified the 5'-i-Pr derivative 7b, which displays superior pharmacokinetic properties compared to other azasordarins." | ( Identification of a broad-spectrum azasordarin with improved pharmacokinetic properties. Balasubramanian, BN; Carroll, TM; Dodier, M; Gao, Q; Gill, P; Laurent, DR; Marinier, A; Mazzucco, CE; Quesnelle, C; Regueiro-Ren, A; Serrano-Wu, MH; Stickle, TM; Vyas, DM; Wu, D; Yang, H; Yang, Z; Zheng, M; Zoeckler, ME, 2003) | 0.32 |
Excerpt | Relevance | Reference |
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" When the amount of EF-2 exceeded that of ribosomes sordarin inhibited the GTPase activity following an inverted bell-shaped dose-response curve, whereas when EF-2 and ribosomes were in equimolar concentrations sordarin yielded a typical sigmoidal dose-dependent inhibition." | ( Sordarin inhibits fungal protein synthesis by blocking translocation differently to fusidic acid. Domínguez, JM; Gómez-Lorenzo, MG; Martín, JJ, 1999) | 0.3 |
" The in vitro maximum effect (E(max)), the drug concentrations to reach 50% of E(max) (EC(50)), and the slope of the dose-response curve were then estimated by the Hill equation (E(max) sigmoid model)." | ( In vitro pharmacodynamic parameters of sordarin derivatives in comparison with those of marketed compounds against Pneumocystis carinii isolated from rats. Aliouat, EM; Aviles, P; Dei-Cas, E; Dujardin, L; Gargallo-Viola, D; Herreros, E; Martinez, A, 2000) | 0.31 |
" A good correlation independent of the dosing interval was observed with AUC (but not C(max) or t > MIC) and both AUSTC and kidney burden." | ( Pharmacokinetics-pharmacodynamics of a sordarin derivative (GM 237354) in a murine model of lethal candidiasis. Aviles, P; Falcoz, C; Gargallo-Viola, D; San Roman, R, 2000) | 0.31 |
" After intravenous dosing in animals, both the area under the concentration-time curve and the elimination half-life were highest in Cynomolgus monkeys, followed by those in rats, mice, and rabbits." | ( Animal pharmacokinetics and interspecies scaling of sordarin derivatives following intravenous administration. Aviles, P; Gargallo-Viola, D; Gómez De Las Heras, F; Guillén, MJ; Pateman, A; San Roman, R, 2001) | 0.31 |
Assay ID | Title | Year | Journal | Article |
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AID528795 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPL21A YBR191W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID202693 | Antifungal activity against Saccharomyces cerevisiae (strain YPH98) | 1998 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 8, Issue:16 | Alkyl side-chain derivatives of sordaricin as potent antifungal agents against yeast. |
AID528668 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring FUN12 YAL035W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528660 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring GRR1 YJR090C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528813 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph4 gene at 300 to 500 ng/ml after 24 hrs by liquid growth assay | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531894 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YLR143W mutation in unknown gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID417558 | Antifungal activity against Candida albicans FP633 in po dosed ICR mouse candidiasis model treated after 1 hr post infection for 4 days | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | FR290581, a novel sordarin derivative: synthesis and antifungal activity. |
AID49966 | Minimum inhibitory concentration against Candida glabrata | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Oxime derivatives of sordaricin as potent antifungal agents. |
AID528629 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring QRI5 YLR204W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528622 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring IBD2 YNL164C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531876 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph1 gene at 300 to 500 ng/ml after 24 hrs by liquid growth assay | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531904 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YDR008C mutation by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID49986 | Minimum inhibitory concentration required to inhibit 90-100%growth of Candida glabrata | 2002 | Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19 | Sordarin oxazepine derivatives as potent antifungal agents. |
AID528800 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring JJJ3/DPH4 YJR097W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531875 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph2 gene at 300 to 500 ng/ml after 24 hrs by liquid growth assay | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID417551 | Antifungal activity against Candida glabrata ATCC 90030 | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | FR290581, a novel sordarin derivative: synthesis and antifungal activity. |
AID531912 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DAL7 YIR031C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531883 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YLR125W mutation in unknown gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531877 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph5 gene at 100 ng/ml by plate assay | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528656 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring UBX3 YDL091C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531901 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YER087W mutation in unknown gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID417556 | Cmax in mouse at 2 mg/kg, po | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | FR290581, a novel sordarin derivative: synthesis and antifungal activity. |
AID528643 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ARN1 YHL040C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528805 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring NOT5 YPR072W mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528803 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring CNM67 YNL225C mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528627 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DIA4 YHR011W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528808 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ATP12 YJL180C mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528638 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MIP6 YHR015W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531909 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MOH1 YBL049W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528657 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SEM1 YDR363W-A mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531911 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SUR2 YDR297W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528652 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring KTR7 YIL085C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID1129293 | Cytotoxicity against mouse RAW264.7 cells by Alamar Blue assay | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4 | Diterpene glycosides and polyketides from Xylotumulus gibbisporus. |
AID528666 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring PTP3 YER075C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531880 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph2 gene at 100 ng/ml by plate assay | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531890 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YOL079W mutation in unknown gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528632 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MGT1 YDL200C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528673 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRP20 YDR405W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528618 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MTF1 YMR228W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528631 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YBR099C mutation by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528814 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph5 gene at 300 to 500 ng/ml after 24 hrs by liquid growth assay | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528626 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RBS1 YDL189W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID417554 | Antifungal activity against Aspergillus fumigatus ATCC 204305 | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | FR290581, a novel sordarin derivative: synthesis and antifungal activity. |
AID417549 | Antifungal activity against Candida albicans ATCC 90028 | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | FR290581, a novel sordarin derivative: synthesis and antifungal activity. |
AID531898 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YSC83 YHR017W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528651 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ECM3 YOR092W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528644 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring LYS14 YDR034C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531902 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring FYV1 YDR024W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528662 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DOC1 YGL240W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531888 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YDL063C mutation in unknown gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528798 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPL12B YDR418W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531878 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph4 gene at 100 ng/ml by plate assay | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID417555 | Antifungal activity against Candida albicans FP290581 in ICR mouse serum drug administered po twice a day | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | FR290581, a novel sordarin derivative: synthesis and antifungal activity. |
AID1129292 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by spectrophotometric analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4 | Diterpene glycosides and polyketides from Xylotumulus gibbisporus. |
AID528621 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring CPR6 YLR216C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531897 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YHR151C mutation in unknown gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531910 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring COX11 YPL132W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528670 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRPL3 YMR024W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528810 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring AFG3 YER017C mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528653 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring BEM2 YER155C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531907 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YBR141C mutation in unknown gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528617 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring AMS1 YGL156W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528616 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring TOK1 YJL093C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528642 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ARN2 YHL047C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528639 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MIP1 YOR330C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528635 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MUP3 YHL036W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531886 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YDR042C mutation in unknown gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531891 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DLT1 YMR126C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528671 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRPL24 YMR193W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID45145 | Minimum inhibitory concentration against Candida albicans | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Oxime derivatives of sordaricin as potent antifungal agents. |
AID528663 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring NAT3 YPR131C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID48921 | Minimum inhibitory concentration required to inhibit 90-100%growth of Candida albicans | 2002 | Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19 | Sordarin oxazepine derivatives as potent antifungal agents. |
AID528676 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRP21 YBL090W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531879 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph3 gene at 100 ng/ml by plate assay | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528812 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph3 gene at 300 to 500 ng/ml after 24 hrs by liquid growth assay | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531899 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YHL041W mutation in unknown gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528797 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPL1B YGL135W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531896 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring FMP35 YIL157C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528669 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MSR1 YHR091C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID1129291 | Antifungal activity against Saccharomyces cerevisiae ATCC 2345 by NCCLS method | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4 | Diterpene glycosides and polyketides from Xylotumulus gibbisporus. |
AID528636 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DJP1 YIR004W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528628 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DHH1 YDL160C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID55181 | Minimum inhibitory concentration required to inhibit 90-100% growth of Cryptococcus neoformans | 2002 | Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19 | Sordarin oxazepine derivatives as potent antifungal agents. |
AID417552 | Antifungal activity against Candida tropicalis 21005 | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | FR290581, a novel sordarin derivative: synthesis and antifungal activity. |
AID528645 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring THI20 YOL055C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528667 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring STE1 YDR410C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531903 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YDR020C mutation in unknown gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531887 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring LDB17 YDL146W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID417557 | Half life in mouse at 2 mg/kg, po | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | FR290581, a novel sordarin derivative: synthesis and antifungal activity. |
AID528807 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ATP1 YBL099W mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID86205 | Cytotoxicity was evaluated against Hep-2 cells in vitro | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Oxime derivatives of sordaricin as potent antifungal agents. |
AID528620 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ADY3 YDL239C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528806 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YBL100C mutation assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528623 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring PRR2 YDL214C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528658 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring QRI7 YDL104C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528802 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DPH1 YIL103W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531908 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SCS22 YBL091C-A mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528640 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring HMI1 YOL095C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528665 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RAM1 YDL090C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531893 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YLR202C mutation in unknown gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528794 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPS18A YDR450W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID1129290 | Antifungal activity against Candida albicans ATCC MYA-2876 by NCCLS method | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4 | Diterpene glycosides and polyketides from Xylotumulus gibbisporus. |
AID528648 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SER1 YOR184W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528625 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SHE2 YKL130C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528646 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ADE4 YMR300C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528672 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRPL11 YDL202W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528654 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SBE2 YDR351W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528655 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring CUE1 YMR264W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528647 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ARO3 YDR035W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531882 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RMD9 YGL107C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528634 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RAD28 YDR030C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID1129289 | Antifungal activity against Candida albicans ATCC 18804 by NCCLS method | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4 | Diterpene glycosides and polyketides from Xylotumulus gibbisporus. |
AID49959 | Anti-fungal activity against Candida glabrata A28790 (WT) | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23 | Core-modified sordaricin derivatives: synthesis and antifungal activity. |
AID417553 | Antifungal activity against Candida parapsilosis ATCC 22019 | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | FR290581, a novel sordarin derivative: synthesis and antifungal activity. |
AID531900 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YGR228W mutation in unknown gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528796 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPL16B YNL069C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528815 | Antifungal activity against Saccharomyces cerevisiae BY4741 assessed as reduction in fungal growth up to 500 ng/ml for 72 hrs by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528675 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRPL36 YBR122C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528619 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring CTF3 YLR381W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID235609 | Therapeutic index (CC50/MIC) was determined | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Oxime derivatives of sordaricin as potent antifungal agents. |
AID528809 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SSQ1 YLR369W mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID417560 | Antifungal activity against Cryptococcus neoformans TIMM 0354 | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | FR290581, a novel sordarin derivative: synthesis and antifungal activity. |
AID528799 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DPH5 YLR172C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531881 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph1 gene at 100 ng/ml by plate assay | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528678 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPS11A YDR025W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528633 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SHU2 YDR078C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID44951 | Anti-fungal activity against Candida albicans A28660 (WT); No data | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23 | Core-modified sordaricin derivatives: synthesis and antifungal activity. |
AID528649 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring BUD9 YGR041W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528804 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SPS1 YDR523C mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528661 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring PRE9 YGR135W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528664 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring EAF3 YPR023C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528637 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring BAP2 YBR068C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528650 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MHP1 YJL042W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID47611 | Anti-fungal activity against Candida albicans A28235 (WT) | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23 | Core-modified sordaricin derivatives: synthesis and antifungal activity. |
AID531885 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YDL062W mutation in unknown gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531884 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YER184C mutation in unknown gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528677 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RSM19 YNR037C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528679 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPS4A YJR145C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528801 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DPH2 YKL191W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528811 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring HEM14 YER014W mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531895 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YKL098W mutation in unknown gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528641 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring GGC1 YDL198C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531892 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YMR141C mutation in unknown gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531906 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YBR255W mutation in unknown gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528674 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRPL37 YBR268W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID417550 | Antifungal activity against fluconazole-resistant Candida albicans 22009 | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | FR290581, a novel sordarin derivative: synthesis and antifungal activity. |
AID528659 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DSK2 YMR276W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531905 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YCL042W mutation by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528624 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring COQ1 YBR003W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID531889 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRH1 YDR033W mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
AID528630 | Antifungal activity against Saccharomyces cerevisiae BY4741 harboring PUF3 YLL013C mutant gene by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 1 (1.45) | 18.7374 |
1990's | 11 (15.94) | 18.2507 |
2000's | 39 (56.52) | 29.6817 |
2010's | 14 (20.29) | 24.3611 |
2020's | 4 (5.80) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 4 (5.71%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 66 (94.29%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |