Page last updated: 2024-12-08

sordarin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

sordarin: antifungal mold metabolite of Sordaria araneosa; sordarins A and B are stereoisomers [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

sordarin : An antifungal metabolite of Sordaria araneosa that inhibits protein synthesis. It has a tetracyclic diterpene glycoside structure. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID44582273
CHEMBL ID476273
MeSH IDM0044362

Synonyms (2)

Synonym
sordarin
CHEMBL476273

Research Excerpts

Pharmacokinetics

The antifungal effect of GM 237354, a sordarin derivative, was studied in an in vitro pharmacokinetic (PK)-pharmacodynamic dynamic system (bioreactor) This reproduces PK profiles observed in a previously described model of drug efficacy against murine systemic candidiasis. Further investigation identified the 5'-i-Pr derivative 7b, which displays superior pharmacokinetics properties compared to other azasordarins.

ExcerptReferenceRelevance
" In this study, the in vitro pharmacodynamic parameters of four sordarin derivatives (GM 191519, GM 237354, GM 193663, and GM 219771) have been evaluated by a new quantitative approach and compared with the commercially available drugs pentamidine, atovaquone, and trimethoprim-sulfamethoxazole (TMP-SMX)."( In vitro pharmacodynamic parameters of sordarin derivatives in comparison with those of marketed compounds against Pneumocystis carinii isolated from rats.
Aliouat, EM; Aviles, P; Dei-Cas, E; Dujardin, L; Gargallo-Viola, D; Herreros, E; Martinez, A, 2000
)
0.31
" The present study investigates possible correlations between sordarin pharmacokinetic (PK) properties and therapeutic efficacy, based on a murine model of invasive systemic candidiasis, and provides a rationale for dose selection in the first study of efficacy in humans."( Pharmacokinetics-pharmacodynamics of a sordarin derivative (GM 237354) in a murine model of lethal candidiasis.
Aviles, P; Falcoz, C; Gargallo-Viola, D; San Roman, R, 2000
)
0.31
"The antifungal effect of GM 237354, a sordarin derivative, was studied in an in vitro pharmacokinetic (PK)-pharmacodynamic dynamic system (bioreactor) which reproduces PK profiles observed in a previously described model of drug efficacy against murine systemic candidiasis."( Correlation between in vitro and in vivo activities of GM 237354, a new sordarin derivative, against Candida albicans in an in vitro pharmacokinetic-pharmacodynamic model and influence of protein binding.
Aviles, P; Falcoz, C; Gargallo-Viola, D; Gómez De Las Heras, F; Guillén, MJ; San Roman, R, 2001
)
0.31
" After intravenous dosing in animals, both the area under the concentration-time curve and the elimination half-life were highest in Cynomolgus monkeys, followed by those in rats, mice, and rabbits."( Animal pharmacokinetics and interspecies scaling of sordarin derivatives following intravenous administration.
Aviles, P; Gargallo-Viola, D; Gómez De Las Heras, F; Guillén, MJ; Pateman, A; San Roman, R, 2001
)
0.31
" Further investigation identified the 5'-i-Pr derivative 7b, which displays superior pharmacokinetic properties compared to other azasordarins."( Identification of a broad-spectrum azasordarin with improved pharmacokinetic properties.
Balasubramanian, BN; Carroll, TM; Dodier, M; Gao, Q; Gill, P; Laurent, DR; Marinier, A; Mazzucco, CE; Quesnelle, C; Regueiro-Ren, A; Serrano-Wu, MH; Stickle, TM; Vyas, DM; Wu, D; Yang, H; Yang, Z; Zheng, M; Zoeckler, ME, 2003
)
0.32

Dosage Studied

ExcerptRelevanceReference
" When the amount of EF-2 exceeded that of ribosomes sordarin inhibited the GTPase activity following an inverted bell-shaped dose-response curve, whereas when EF-2 and ribosomes were in equimolar concentrations sordarin yielded a typical sigmoidal dose-dependent inhibition."( Sordarin inhibits fungal protein synthesis by blocking translocation differently to fusidic acid.
Domínguez, JM; Gómez-Lorenzo, MG; Martín, JJ, 1999
)
0.3
" The in vitro maximum effect (E(max)), the drug concentrations to reach 50% of E(max) (EC(50)), and the slope of the dose-response curve were then estimated by the Hill equation (E(max) sigmoid model)."( In vitro pharmacodynamic parameters of sordarin derivatives in comparison with those of marketed compounds against Pneumocystis carinii isolated from rats.
Aliouat, EM; Aviles, P; Dei-Cas, E; Dujardin, L; Gargallo-Viola, D; Herreros, E; Martinez, A, 2000
)
0.31
" A good correlation independent of the dosing interval was observed with AUC (but not C(max) or t > MIC) and both AUSTC and kidney burden."( Pharmacokinetics-pharmacodynamics of a sordarin derivative (GM 237354) in a murine model of lethal candidiasis.
Aviles, P; Falcoz, C; Gargallo-Viola, D; San Roman, R, 2000
)
0.31
" After intravenous dosing in animals, both the area under the concentration-time curve and the elimination half-life were highest in Cynomolgus monkeys, followed by those in rats, mice, and rabbits."( Animal pharmacokinetics and interspecies scaling of sordarin derivatives following intravenous administration.
Aviles, P; Gargallo-Viola, D; Gómez De Las Heras, F; Guillén, MJ; Pateman, A; San Roman, R, 2001
)
0.31
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (151)

Assay IDTitleYearJournalArticle
AID528795Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPL21A YBR191W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID202693Antifungal activity against Saccharomyces cerevisiae (strain YPH98)1998Bioorganic & medicinal chemistry letters, Aug-18, Volume: 8, Issue:16
Alkyl side-chain derivatives of sordaricin as potent antifungal agents against yeast.
AID528668Antifungal activity against Saccharomyces cerevisiae BY4741 harboring FUN12 YAL035W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528660Antifungal activity against Saccharomyces cerevisiae BY4741 harboring GRR1 YJR090C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528813Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph4 gene at 300 to 500 ng/ml after 24 hrs by liquid growth assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531894Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YLR143W mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID417558Antifungal activity against Candida albicans FP633 in po dosed ICR mouse candidiasis model treated after 1 hr post infection for 4 days2009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID49966Minimum inhibitory concentration against Candida glabrata2002Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6
Oxime derivatives of sordaricin as potent antifungal agents.
AID528629Antifungal activity against Saccharomyces cerevisiae BY4741 harboring QRI5 YLR204W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528622Antifungal activity against Saccharomyces cerevisiae BY4741 harboring IBD2 YNL164C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531876Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph1 gene at 300 to 500 ng/ml after 24 hrs by liquid growth assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531904Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YDR008C mutation by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID49986Minimum inhibitory concentration required to inhibit 90-100%growth of Candida glabrata2002Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19
Sordarin oxazepine derivatives as potent antifungal agents.
AID528800Antifungal activity against Saccharomyces cerevisiae BY4741 harboring JJJ3/DPH4 YJR097W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531875Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph2 gene at 300 to 500 ng/ml after 24 hrs by liquid growth assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID417551Antifungal activity against Candida glabrata ATCC 900302009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID531912Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DAL7 YIR031C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531883Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YLR125W mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531877Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph5 gene at 100 ng/ml by plate assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528656Antifungal activity against Saccharomyces cerevisiae BY4741 harboring UBX3 YDL091C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531901Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YER087W mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID417556Cmax in mouse at 2 mg/kg, po2009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID528643Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ARN1 YHL040C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528805Antifungal activity against Saccharomyces cerevisiae BY4741 harboring NOT5 YPR072W mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528803Antifungal activity against Saccharomyces cerevisiae BY4741 harboring CNM67 YNL225C mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528627Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DIA4 YHR011W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528808Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ATP12 YJL180C mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528638Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MIP6 YHR015W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531909Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MOH1 YBL049W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528657Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SEM1 YDR363W-A mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531911Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SUR2 YDR297W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528652Antifungal activity against Saccharomyces cerevisiae BY4741 harboring KTR7 YIL085C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID1129293Cytotoxicity against mouse RAW264.7 cells by Alamar Blue assay2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Diterpene glycosides and polyketides from Xylotumulus gibbisporus.
AID528666Antifungal activity against Saccharomyces cerevisiae BY4741 harboring PTP3 YER075C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531880Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph2 gene at 100 ng/ml by plate assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531890Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YOL079W mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528632Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MGT1 YDL200C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528673Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRP20 YDR405W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528618Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MTF1 YMR228W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528631Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YBR099C mutation by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528814Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph5 gene at 300 to 500 ng/ml after 24 hrs by liquid growth assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528626Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RBS1 YDL189W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID417554Antifungal activity against Aspergillus fumigatus ATCC 2043052009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID417549Antifungal activity against Candida albicans ATCC 900282009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID531898Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YSC83 YHR017W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528651Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ECM3 YOR092W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528644Antifungal activity against Saccharomyces cerevisiae BY4741 harboring LYS14 YDR034C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531902Antifungal activity against Saccharomyces cerevisiae BY4741 harboring FYV1 YDR024W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528662Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DOC1 YGL240W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531888Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YDL063C mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528798Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPL12B YDR418W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531878Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph4 gene at 100 ng/ml by plate assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID417555Antifungal activity against Candida albicans FP290581 in ICR mouse serum drug administered po twice a day2009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID1129292Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by spectrophotometric analysis2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Diterpene glycosides and polyketides from Xylotumulus gibbisporus.
AID528621Antifungal activity against Saccharomyces cerevisiae BY4741 harboring CPR6 YLR216C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531897Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YHR151C mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531910Antifungal activity against Saccharomyces cerevisiae BY4741 harboring COX11 YPL132W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528670Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRPL3 YMR024W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528810Antifungal activity against Saccharomyces cerevisiae BY4741 harboring AFG3 YER017C mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528653Antifungal activity against Saccharomyces cerevisiae BY4741 harboring BEM2 YER155C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531907Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YBR141C mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528617Antifungal activity against Saccharomyces cerevisiae BY4741 harboring AMS1 YGL156W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528616Antifungal activity against Saccharomyces cerevisiae BY4741 harboring TOK1 YJL093C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528642Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ARN2 YHL047C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528639Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MIP1 YOR330C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528635Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MUP3 YHL036W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531886Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YDR042C mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531891Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DLT1 YMR126C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528671Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRPL24 YMR193W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID45145Minimum inhibitory concentration against Candida albicans2002Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6
Oxime derivatives of sordaricin as potent antifungal agents.
AID528663Antifungal activity against Saccharomyces cerevisiae BY4741 harboring NAT3 YPR131C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID48921Minimum inhibitory concentration required to inhibit 90-100%growth of Candida albicans2002Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19
Sordarin oxazepine derivatives as potent antifungal agents.
AID528676Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRP21 YBL090W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531879Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph3 gene at 100 ng/ml by plate assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528812Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph3 gene at 300 to 500 ng/ml after 24 hrs by liquid growth assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531899Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YHL041W mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528797Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPL1B YGL135W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531896Antifungal activity against Saccharomyces cerevisiae BY4741 harboring FMP35 YIL157C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528669Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MSR1 YHR091C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID1129291Antifungal activity against Saccharomyces cerevisiae ATCC 2345 by NCCLS method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Diterpene glycosides and polyketides from Xylotumulus gibbisporus.
AID528636Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DJP1 YIR004W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528628Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DHH1 YDL160C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID55181Minimum inhibitory concentration required to inhibit 90-100% growth of Cryptococcus neoformans2002Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19
Sordarin oxazepine derivatives as potent antifungal agents.
AID417552Antifungal activity against Candida tropicalis 210052009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID528645Antifungal activity against Saccharomyces cerevisiae BY4741 harboring THI20 YOL055C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528667Antifungal activity against Saccharomyces cerevisiae BY4741 harboring STE1 YDR410C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531903Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YDR020C mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531887Antifungal activity against Saccharomyces cerevisiae BY4741 harboring LDB17 YDL146W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID417557Half life in mouse at 2 mg/kg, po2009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID528807Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ATP1 YBL099W mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID86205Cytotoxicity was evaluated against Hep-2 cells in vitro2002Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6
Oxime derivatives of sordaricin as potent antifungal agents.
AID528620Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ADY3 YDL239C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528806Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YBL100C mutation assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528623Antifungal activity against Saccharomyces cerevisiae BY4741 harboring PRR2 YDL214C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528658Antifungal activity against Saccharomyces cerevisiae BY4741 harboring QRI7 YDL104C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528802Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DPH1 YIL103W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531908Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SCS22 YBL091C-A mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528640Antifungal activity against Saccharomyces cerevisiae BY4741 harboring HMI1 YOL095C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528665Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RAM1 YDL090C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531893Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YLR202C mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528794Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPS18A YDR450W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID1129290Antifungal activity against Candida albicans ATCC MYA-2876 by NCCLS method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Diterpene glycosides and polyketides from Xylotumulus gibbisporus.
AID528648Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SER1 YOR184W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528625Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SHE2 YKL130C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528646Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ADE4 YMR300C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528672Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRPL11 YDL202W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528654Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SBE2 YDR351W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528655Antifungal activity against Saccharomyces cerevisiae BY4741 harboring CUE1 YMR264W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528647Antifungal activity against Saccharomyces cerevisiae BY4741 harboring ARO3 YDR035W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531882Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RMD9 YGL107C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528634Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RAD28 YDR030C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID1129289Antifungal activity against Candida albicans ATCC 18804 by NCCLS method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Diterpene glycosides and polyketides from Xylotumulus gibbisporus.
AID49959Anti-fungal activity against Candida glabrata A28790 (WT)2002Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23
Core-modified sordaricin derivatives: synthesis and antifungal activity.
AID417553Antifungal activity against Candida parapsilosis ATCC 220192009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID531900Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YGR228W mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528796Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPL16B YNL069C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528815Antifungal activity against Saccharomyces cerevisiae BY4741 assessed as reduction in fungal growth up to 500 ng/ml for 72 hrs by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528675Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRPL36 YBR122C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528619Antifungal activity against Saccharomyces cerevisiae BY4741 harboring CTF3 YLR381W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID235609Therapeutic index (CC50/MIC) was determined2002Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6
Oxime derivatives of sordaricin as potent antifungal agents.
AID528809Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SSQ1 YLR369W mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID417560Antifungal activity against Cryptococcus neoformans TIMM 03542009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID528799Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DPH5 YLR172C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531881Antifungal activity against Saccharomyces cerevisiae BY4741 harboring deletion mutation in dph1 gene at 100 ng/ml by plate assay2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528678Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPS11A YDR025W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528633Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SHU2 YDR078C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID44951Anti-fungal activity against Candida albicans A28660 (WT); No data2002Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23
Core-modified sordaricin derivatives: synthesis and antifungal activity.
AID528649Antifungal activity against Saccharomyces cerevisiae BY4741 harboring BUD9 YGR041W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528804Antifungal activity against Saccharomyces cerevisiae BY4741 harboring SPS1 YDR523C mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528661Antifungal activity against Saccharomyces cerevisiae BY4741 harboring PRE9 YGR135W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528664Antifungal activity against Saccharomyces cerevisiae BY4741 harboring EAF3 YPR023C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528637Antifungal activity against Saccharomyces cerevisiae BY4741 harboring BAP2 YBR068C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528650Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MHP1 YJL042W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID47611Anti-fungal activity against Candida albicans A28235 (WT)2002Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23
Core-modified sordaricin derivatives: synthesis and antifungal activity.
AID531885Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YDL062W mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531884Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YER184C mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528677Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RSM19 YNR037C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528679Antifungal activity against Saccharomyces cerevisiae BY4741 harboring RPS4A YJR145C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528801Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DPH2 YKL191W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528811Antifungal activity against Saccharomyces cerevisiae BY4741 harboring HEM14 YER014W mutant gene assessed as reduction in fungal growth at 2 ng/ml by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531895Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YKL098W mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528641Antifungal activity against Saccharomyces cerevisiae BY4741 harboring GGC1 YDL198C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531892Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YMR141C mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531906Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YBR255W mutation in unknown gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528674Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRPL37 YBR268W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID417550Antifungal activity against fluconazole-resistant Candida albicans 220092009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
FR290581, a novel sordarin derivative: synthesis and antifungal activity.
AID528659Antifungal activity against Saccharomyces cerevisiae BY4741 harboring DSK2 YMR276W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531905Antifungal activity against Saccharomyces cerevisiae BY4741 harboring YCL042W mutation by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528624Antifungal activity against Saccharomyces cerevisiae BY4741 harboring COQ1 YBR003W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID531889Antifungal activity against Saccharomyces cerevisiae BY4741 harboring MRH1 YDR033W mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
AID528630Antifungal activity against Saccharomyces cerevisiae BY4741 harboring PUF3 YLL013C mutant gene by spectrophotometry2008Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (69)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (1.45)18.7374
1990's11 (15.94)18.2507
2000's39 (56.52)29.6817
2010's14 (20.29)24.3611
2020's4 (5.80)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews4 (5.71%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other66 (94.29%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]