Page last updated: 2024-10-27

fluconazole and Infant, Premature, Diseases

fluconazole has been researched along with Infant, Premature, Diseases in 77 studies

Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.

Infant, Premature, Diseases: Diseases that occur in PREMATURE INFANTS.

Research Excerpts

ExcerptRelevanceReference
" The authors conducted the first prospective, randomised controlled trial of nystatin compared with fluconazole for the prevention of fungal colonisation and invasive fungal infection in very low birth weight (VLBW) neonates."9.15Randomised controlled trial of prophylactic fluconazole versus nystatin for the prevention of fungal colonisation and invasive fungal infection in very low birth weight infants. ( Akar, M; Aydemir, C; Dilmen, U; Dizdar, EA; Erdeve, O; Oguz, SS; Sarikabadayi, YU; Saygan, S, 2011)
"This observational pre-post cohort study was performed in preterm infants with a birth weight of < 1,000 g who were given prophylactic fluconazole starting on the first postnatal day at a dose of 3 mg/kg twice a week."7.80Efficacy of prophylactic fluconazole therapy in decreasing the incidence of Candida infections in extremely low birth weight preterm infants. ( Buyukkale, G; Cetinkaya, M; Ercan, TE; Kavuncuoglu, S; Mete, F; Saglam, OK, 2014)
"Although a fluconazole prophylaxis regimen for ELBW infants was effective in preventing invasive candidiasis, an increase in the incidence of conjugated hyperbilirubinemia was observed."7.73Fluconazole prophylaxis in extremely low birth weight infants: association with cholestasis. ( Aghai, ZH; Amendolia, B; Kaki, S; Kemble, N; Longo, D; Mudduluru, M; Nakhla, TA; Saslow, JG; Stahl, GE; Sutsko, R, 2006)
" The authors previously reported an increased incidence of cholestasis with fluconazole prophylaxis in ELBW infants, which led to fluconazole prophylaxis being changed to a less frequent dosing (LFD) schedule of twice a week at their institution."6.76Twice-weekly fluconazole prophylaxis in premature infants: association with cholestasis. ( Aghai, ZH; Amendolia, B; Bhat, V; Fojas, M; Kemble, N; Pyon, K; Sannoh, S; Saslow, JG; Shah, S; Stahl, G, 2011)
" The authors conducted the first prospective, randomised controlled trial of nystatin compared with fluconazole for the prevention of fungal colonisation and invasive fungal infection in very low birth weight (VLBW) neonates."5.15Randomised controlled trial of prophylactic fluconazole versus nystatin for the prevention of fungal colonisation and invasive fungal infection in very low birth weight infants. ( Akar, M; Aydemir, C; Dilmen, U; Dizdar, EA; Erdeve, O; Oguz, SS; Sarikabadayi, YU; Saygan, S, 2011)
"Prophylactic fluconazole reduces the incidence of colonization and invasive candida infection in neonates weighing less than 1500 g at birth."5.12A multicenter, randomized trial of prophylactic fluconazole in preterm neonates. ( Arisio, R; Corona, G; Decembrino, L; Farina, D; Giovannozzi, C; Gomirato, G; Magnani, C; Manzoni, P; Maule, M; Merletti, F; Mosca, F; Mostert, M; Pedicino, R; Pugni, L; Stolfi, I; Stronati, M; Tridapalli, E; Vetrano, G, 2007)
" lusitaniae osteomyelitis in whom treatment was successful with 5-fluorocytosine and fluconazole."4.78Candida lusitaniae osteomyelitis in a premature infant. ( Della-Latta, P; Oleinik, EM; Rinaldi, MG; Saiman, L, 1993)
"This observational pre-post cohort study was performed in preterm infants with a birth weight of < 1,000 g who were given prophylactic fluconazole starting on the first postnatal day at a dose of 3 mg/kg twice a week."3.80Efficacy of prophylactic fluconazole therapy in decreasing the incidence of Candida infections in extremely low birth weight preterm infants. ( Buyukkale, G; Cetinkaya, M; Ercan, TE; Kavuncuoglu, S; Mete, F; Saglam, OK, 2014)
"Although a fluconazole prophylaxis regimen for ELBW infants was effective in preventing invasive candidiasis, an increase in the incidence of conjugated hyperbilirubinemia was observed."3.73Fluconazole prophylaxis in extremely low birth weight infants: association with cholestasis. ( Aghai, ZH; Amendolia, B; Kaki, S; Kemble, N; Longo, D; Mudduluru, M; Nakhla, TA; Saslow, JG; Stahl, GE; Sutsko, R, 2006)
"We successfully characterized the PK of sildenafil and DMS in premature infants and applied the model to inform dosing for a follow-up, phase II study."2.90Population pharmacokinetics of sildenafil in extremely premature infants. ( Ambalavanan, N; Atz, A; Cohen-Wolkowiez, M; Gaedigk, R; Ge, S; Gonzalez, D; Hornik, CD; Hornik, CP; Laughon, MM; Martz, K; Mills, M; Mundakel, G; Poindexter, BB; Smith, PB; Sokol, GM; Stewart, D, 2019)
" The authors previously reported an increased incidence of cholestasis with fluconazole prophylaxis in ELBW infants, which led to fluconazole prophylaxis being changed to a less frequent dosing (LFD) schedule of twice a week at their institution."2.76Twice-weekly fluconazole prophylaxis in premature infants: association with cholestasis. ( Aghai, ZH; Amendolia, B; Bhat, V; Fojas, M; Kemble, N; Pyon, K; Sannoh, S; Saslow, JG; Shah, S; Stahl, G, 2011)
" Pharmacokinetic characteristics of fluconazole were determined after the first, third, and fifth doses."2.67Pharmacokinetics of fluconazole in very low birth weight infants during the first two weeks of life. ( Hoppu, K; Pohjavuori, M; Saxén, H, 1993)
"Fungemia is a serious problem within neonatal intensive care units around the world."2.50Fungal prophylaxis in neonates: a review article. ( Bradshaw, WT; Lollis, TR, 2014)
"Fluconazole is a triazole antifungal agent that is widely used in the nursery."2.48Fluconazole use and safety in the nursery. ( Castagnola, E; Farina, D; Jacqz-Aigrain, E; Kaguelidou, F; Manzoni, P; Maragliano, R; Rizzollo, S; Stronati, M, 2012)
"Fluconazole prophylaxis lower the fungal colonization rate significantly (59."1.43Efficacy and safety of fluconazole prophylaxis in extremely low birth weight infants: multicenter pre-post cohort study. ( Choi, CW; Choi, EH; Choi, JH; Kim, BI; Kim, EK; Kim, HS; Lee, J; Shin, SH, 2016)
"Fluconazole prophylaxis was associated with a significant decrease in candidal BSI (odds ratio, 0."1.38Targeted fluconazole prophylaxis for high-risk very low birth weight infants. ( Klinger, G; Levy, I; Rolnitsky, A; Shalit, I; Sirota, L, 2012)
" The occurrence of LAMB-attributable renal toxicity was investigated; infants withdrawn from treatment for development of adverse effects or toxicity were identified."1.38Liposomal amphotericin B does not induce nephrotoxicity or renal function impairment in premature neonates. ( Antonucci, R; Fanos, V; Farina, D; Franco, C; Galletto, P; Gallo, E; Manzoni, P; Rizzollo, S, 2012)
" However, further studies are warranted to better establish kinetics and appropriate dosing of these agents in premature and term infants, as well as their ability to improve late outcomes of ICI."1.38Correct choices for correct treatments: key issues in the management of Candida infections in preterm neonates. ( Castagnola, E; Farina, D; Jacqz-Aigrain, E; Manzoni, P; Maragliano, R; Rizzollo, S; Ruffinazzi, G; Stronati, M, 2012)
"Fluconazole prophylaxis has been used to control the problem."1.33Emergence of fluconazole resistance in a Candida parapsilosis strain that caused infections in a neonatal intensive care unit. ( Koukila-Kähkölä, P; Luukkainen, P; Lyytikäinen, O; Pfaller, MA; Pujol, C; Richardson, M; Sarvikivi, E; Saxén, H; Soll, DR, 2005)
"Fluconazole was administered to 81% of ELBW infants, who received a median of 8 doses, and 41% of larger infants, who received a median of 5 doses."1.33Targeted short-term fluconazole prophylaxis among very low birth weight and extremely low birth weight infants. ( Brion, LP; Dave, VA; Herring, L; Marsh, J; Nafday, S; Reinersman, GT; Soghier, LM; Uko, S; Vega, M, 2006)
"Oral fluconazole is an alternative to parenteral amphotericin B in the treatment of premature infants, but proof of absorption and an extended treatment period according to prematurity might be warranted."1.31Candida arthritis in a premature infant treated successfully with oral fluconazole for six months. ( Weigl, JA, 2000)
"Oral fluconazole seems to be a safe and effective treatment for Candida albicans septicaemia even in premature infants."1.30Pharmacokinetics of oral fluconazole in premature infants. ( Hörnchen, H; Schefels, J; Skopnik, H; Wenzl, TG, 1998)

Research

Studies (77)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's13 (16.88)18.2507
2000's27 (35.06)29.6817
2010's35 (45.45)24.3611
2020's2 (2.60)2.80

Authors

AuthorsStudies
Gonzalez, D1
Laughon, MM1
Smith, PB3
Ge, S1
Ambalavanan, N1
Atz, A1
Sokol, GM1
Hornik, CD1
Stewart, D1
Mundakel, G1
Poindexter, BB1
Gaedigk, R1
Mills, M1
Cohen-Wolkowiez, M2
Martz, K1
Hornik, CP1
Rundjan, L1
Wahyuningsih, R1
Oeswadi, CA1
Marsogi, M1
Purnamasari, A1
Hanna Pharm, M1
Mazkereth, R1
Fortmann, I1
Hartz, A1
Paul, P1
Pulzer, F1
Müller, A1
Böttger, R1
Proquitté, H1
Dawczynski, K1
Simon, A1
Rupp, J1
Herting, E2
Göpel, W1
Härtel, C1
Silva-Rios, J1
Camargos, P1
Correa, L1
Romanelli, R1
Luparia, M1
Landi, F1
Mesini, A1
Militello, MA1
Galletto, P4
Farina, D10
Castagnola, E3
Manzoni, P11
Austin, N4
Darlow, BA3
McGuire, W8
Maede, Y1
Ibara, S1
Nagasaki, H1
Inoue, T1
Tokuhisa, T1
Torikai, M1
Ishihara, C1
Matsui, T1
Kodaira, Y1
Chioukh, FZ1
Ben Hmida, H1
Ben Ameur, K1
Toumi, A1
Monastiri, K1
Lollis, TR1
Bradshaw, WT1
Costa, S1
Barone, G1
Vento, G2
Tirone, C2
Perelli, S1
Romagnoli, C2
Cetinkaya, M1
Ercan, TE1
Saglam, OK1
Buyukkale, G1
Kavuncuoglu, S1
Mete, F1
Benjamin, DK2
Hudak, ML1
Duara, S1
Randolph, DA1
Bidegain, M1
Mundakel, GT1
Natarajan, G3
Burchfield, DJ1
White, RD1
Shattuck, KE1
Neu, N1
Bendel, CM1
Kim, MR1
Finer, NN1
Stewart, DL1
Arrieta, AC1
Wade, KC1
Kaufman, DA3
Prather, KO1
Testoni, D1
Berezny, KY1
Islam, S1
Singer, M1
Kulhanjian, JA1
Izquierdo, G1
Pansieri, C1
Pandolfini, C1
Jacqz-Aigrain, E4
van den Anker, J1
Bonati, M1
Kirpal, H1
Gathwala, G1
Chaudhary, U1
Sharma, D1
Cleminson, J2
Lee, J1
Kim, HS1
Shin, SH1
Choi, CW1
Kim, EK1
Choi, EH1
Kim, BI1
Choi, JH1
Leonessa, M2
Latino, MA3
Arisio, R3
Maule, M2
Agriesti, G1
Gastaldo, L1
Gallo, E5
Mostert, M5
Kaufman, D2
Vendettuoli, V1
Posteraro, B1
Clerihew, L4
Aziz, M1
Patel, AL1
Losavio, J1
Iyengar, A1
Berven, M1
Schloemer, N1
Jakubowicz, A1
Mathai, T1
McAuley, JB1
Aydemir, C1
Oguz, SS1
Dizdar, EA1
Akar, M1
Sarikabadayi, YU1
Saygan, S1
Erdeve, O1
Dilmen, U1
Bhat, V1
Fojas, M1
Saslow, JG2
Shah, S1
Sannoh, S1
Amendolia, B2
Pyon, K1
Kemble, N2
Stahl, G1
Aghai, ZH2
Tarnow-Mordi, W1
Franco, C3
Spera, AM1
Rizzollo, S6
Decembrino, L4
Stronati, M6
Lanari, M1
Phute, SU1
Bhakre, JB1
Kristóf, K1
Janik, L1
Komka, K1
Harmath, A1
Hajdú, J1
Nobilis, A1
Rozgonyi, F1
Nagy, K1
Rigó, J1
Szabó, D1
Brissaud, O1
Tandonnet, O1
Guichoux, J1
Martin, A1
Pappas, A2
Lulic-Botica, M2
Rolnitsky, A1
Levy, I1
Sirota, L1
Shalit, I1
Klinger, G1
Kaguelidou, F2
Maragliano, R3
Pugni, L2
Stolfi, I2
Vagnarelli, F1
Corona, G2
Tridapalli, E2
Vetrano, G2
Memo, L1
Priolo, C1
Giovannozzi, C2
Pedicino, R2
Barberi, I1
Faldella, G1
Mosca, F2
Saia, OS1
Bollani, L1
Ruffinazzi, G2
Tzialla, C1
Antonucci, R1
Fanos, V1
Hameleers, SJ1
Bergman, KA1
Rulo, HF1
Kuiper, H1
Semmekrot, BA1
Austin, NC1
Darlow, B1
Sarvikivi, E1
Lyytikäinen, O1
Soll, DR1
Pujol, C1
Pfaller, MA1
Richardson, M1
Koukila-Kähkölä, P1
Luukkainen, P1
Saxén, H2
Rongkavilit, C1
Bedard, M1
Freydiere, AM1
Piens, MA1
Andre, JM1
Putet, G1
Picot, S1
Gomirato, G2
Fanaroff, AA1
Uko, S1
Soghier, LM1
Vega, M1
Marsh, J1
Reinersman, GT1
Herring, L1
Dave, VA1
Nafday, S1
Brion, LP1
Mudduluru, M1
Nakhla, TA1
Longo, D1
Kaki, S1
Sutsko, R1
Stahl, GE1
Khan, ZU1
Al-Sweih, NA1
Ahmad, S1
Al-Kazemi, N1
Khan, S1
Joseph, L1
Chandy, R1
Magnani, C1
Merletti, F1
Sobel, JD1
Revankar, SG1
Vain, NE1
Vazquez, LN1
Procianoy, RS1
Silveira, RC1
Parikh, TB1
Nanavati, RN1
Patankar, CV1
Rao, S1
Bisure, K1
Udani, RH1
Mehta, P1
Weitkamp, JH1
Ozdas, A1
LaFleur, B1
Potts, AL1
Kamitsuka, MD1
Nugent, NA1
Conrad, PD1
Swanson, TN1
Weintrub, PS1
Chapman, A1
Piecuch, R1
Hoppu, K1
Pohjavuori, M1
Oleinik, EM1
Della-Latta, P1
Rinaldi, MG1
Saiman, L1
Gürses, N1
Kalayci, AG1
Melville, C1
Kempley, S1
Graham, J1
Berry, CL1
Merchant, RH1
Sanghvi, KP1
Sridhar, N1
Sonigara, S1
Mehta, KP1
Joshi, NC1
Wenzl, TG1
Schefels, J1
Hörnchen, H1
Skopnik, H1
Robinson, LG1
Jain, L1
Kourtis, AP1
Weigl, JA1
Boyle, R1
Hazen, KC1
Patrie, JT1
Robinson, M1
Donowitz, LG1
Dani, C1
Bertini, G1
Pezzati, M1
Casalaz, D1
Harms, K1
Schiffmann, JH1
Speer, CP1
Lee, BE1
Feinberg, M1
Abraham, JJ1
Murthy, AR1
Cruciani, M1
Di Perri, G1
Molesini, M1
Vento, S1
Concia, E1
Bassetti, D1
Wiest, DB1
Fowler, SL1
Garner, SS1
Simons, DR1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Safety of Sildenafil in Premature Infants With Severe Bronchopulmonary Dysplasia[NCT04447989]Phase 2120 participants (Anticipated)Interventional2021-05-27Recruiting
Oral Nystatin Prophylaxis to Prevent Systemic Fungal Infection in Very Low Birth Weight Preterm Infants: a Randomized Controlled Trial[NCT03390374]Phase 495 participants (Actual)Interventional2010-10-31Completed
Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants < 750 Grams Birth[NCT00734539]Phase 3362 participants (Actual)Interventional2008-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Candidiasis

Definite or probable (NCT00734539)
Timeframe: prior to hospital discharge, up to 15 ½ months

Interventionparticipants (Number)
Fluconazole8
Placebo19

Chronic Lung Disease

(NCT00734539)
Timeframe: 36 weeks corrected gestational age

Interventionparticipants (Number)
Fluconazole114
Placebo93

Death or Candidiasis

"The primary endpoint for the study is death or candidiasis.~Death prior to study day 49.~Candidiasis prior to study day 49~Definite: isolation of Candida from normally sterile body fluid (blood, CSF, urine [obtained via sterile catheterization or suprapubic tap], peritoneal fluid).~Probable:~i. > 5 days of consecutive antifungal therapy~AND both:~ii. Thrombocytopenia <150,000/mm3 iii. Positive Candida culture from nonsterile site (ETS, bag urine)" (NCT00734539)
Timeframe: study day 49

Interventionparticipants (Number)
Fluconazole31
Placebo37

Focal Intestinal Perforation

(NCT00734539)
Timeframe: prior to hospital discharge, up to 15 ½ months

Interventionparticipants (Number)
Fluconazole16
Placebo9

Intraventricular Hemorrhage

Grade 3 or 4 (NCT00734539)
Timeframe: prior to hospital discharge, up to 15 ½ months

Interventionparticipants (Number)
Fluconazole33
Placebo31

Length of Hospitalization

(NCT00734539)
Timeframe: prior to hospital discharge, up to 15 ½ months

Interventiondays (Median)
Fluconazole113
Placebo107

Neurodevelopmental Impairment

Bayley-III cognition composite score of less than 70, blindness, deafness, or cerebral palsy (NCT00734539)
Timeframe: 18-22 months corrected gestational age

Interventionparticipants (Number)
Fluconazole27
Placebo23

Patent Ductus Arterious Requiring Surgical Ligation

(NCT00734539)
Timeframe: prior to hospital discharge, up to 15 ½ months

Interventionparticipants (Number)
Fluconazole46
Placebo43

Periventricular Leukomalacia

(NCT00734539)
Timeframe: prior to hospital discharge, up to 15 ½ months

Interventionparticipants (Number)
Fluconazole10
Placebo6

Positive Bacterial Infection From a Sterile Site

(NCT00734539)
Timeframe: prior to hospital discharge, up to 15 ½ months

Interventionparticipants (Number)
Fluconazole109
Placebo100

Retinopathy of Prematurity Requiring Laser Surgery

(NCT00734539)
Timeframe: prior to hospital discharge, up to 15 ½ months

Interventionparticipants (Number)
Fluconazole29
Placebo25

Stage II or Higher Necrotizing Enterocolitis

(NCT00734539)
Timeframe: prior to hospital discharge, up to 15 ½ months

Interventionparticipants (Number)
Fluconazole25
Placebo23

Reviews

15 reviews available for fluconazole and Infant, Premature, Diseases

ArticleYear
Which Patient in the Neonatal Intensive Care Unit should Receive Antifungal Prophylaxis Therapy?
    The Israel Medical Association journal : IMAJ, 2021, Volume: 23, Issue:2

    Topics: Antifungal Agents; Candidiasis, Invasive; Drug Resistance, Fungal; Fluconazole; Humans; Infant, Extr

2021
Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants.
    The Cochrane database of systematic reviews, 2013, Mar-28, Issue:3

    Topics: Administration, Oral; Administration, Topical; Antifungal Agents; Fluconazole; Humans; Infant, Newbo

2013
Fungal prophylaxis in neonates: a review article.
    Advances in neonatal care : official journal of the National Association of Neonatal Nurses, 2014, Volume: 14, Issue:1

    Topics: Administration, Intravenous; Administration, Oral; Amphotericin B; Antifungal Agents; Aspergillosis;

2014
Toxic epidermal necrolysis in a neonate receiving fluconazole.
    Journal of perinatology : official journal of the California Perinatal Association, 2014, Volume: 34, Issue:10

    Topics: Disease Progression; Fatal Outcome; Female; Fluconazole; Humans; Infant, Newborn; Infant, Premature;

2014
Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants.
    The Cochrane database of systematic reviews, 2015, Oct-24, Issue:10

    Topics: Antifungal Agents; Developmental Disabilities; Fluconazole; Humans; Infant, Newborn; Infant, Prematu

2015
Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants.
    The Cochrane database of systematic reviews, 2015, Oct-24, Issue:10

    Topics: Administration, Oral; Administration, Topical; Antifungal Agents; Fluconazole; Humans; Infant, Newbo

2015
Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants.
    The Cochrane database of systematic reviews, 2009, Oct-07, Issue:4

    Topics: Administration, Oral; Antifungal Agents; Candidiasis; Candidiasis, Chronic Mucocutaneous; Fluconazol

2009
The effect of fluconazole prophylaxis in very low birthweight infants is overestimated by before-after studies.
    Archives of disease in childhood. Fetal and neonatal edition, 2010, Volume: 95, Issue:3

    Topics: Antifungal Agents; Fluconazole; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Disea

2010
Clinical use of lactoferrin in preterm neonates: an update.
    Minerva pediatrica, 2010, Volume: 62, Issue:3 Suppl 1

    Topics: Age of Onset; Animals; Bacterial Infections; Bacterial Translocation; Cattle; Fluconazole; Humans; I

2010
Fluconazole use and safety in the nursery.
    Early human development, 2012, Volume: 88 Suppl 2

    Topics: Antifungal Agents; Candida; Candidiasis, Invasive; Fluconazole; Humans; Infant; Infant, Newborn; Inf

2012
"Getting to Zero": preventing invasive Candida infections and eliminating infection-related mortality and morbidity in extremely preterm infants.
    Early human development, 2012, Volume: 88 Suppl 2

    Topics: Antifungal Agents; Candidiasis, Invasive; Fluconazole; Humans; Infant, Newborn; Infant, Premature, D

2012
Antifungal therapy for newborn infants with invasive fungal infection.
    The Cochrane database of systematic reviews, 2012, Jun-13, Issue:6

    Topics: Amphotericin B; Antifungal Agents; Fluconazole; Flucytosine; Humans; Infant, Newborn; Infant, Premat

2012
Prophylactic oral antifungal agents to prevent systemic candida infection in preterm infants.
    The Cochrane database of systematic reviews, 2004, Issue:1

    Topics: Administration, Oral; Antifungal Agents; Candidiasis; Candidiasis, Chronic Mucocutaneous; Fluconazol

2004
Systemic antifungal drugs for invasive fungal infection in preterm infants.
    The Cochrane database of systematic reviews, 2004, Issue:1

    Topics: Amphotericin B; Antifungal Agents; Fluconazole; Humans; Infant, Newborn; Infant, Premature; Infant,

2004
Candida lusitaniae osteomyelitis in a premature infant.
    American journal of perinatology, 1993, Volume: 10, Issue:4

    Topics: Candidiasis; Diseases in Twins; Fluconazole; Flucytosine; Humans; Infant, Newborn; Infant, Premature

1993

Trials

11 trials available for fluconazole and Infant, Premature, Diseases

ArticleYear
Population pharmacokinetics of sildenafil in extremely premature infants.
    British journal of clinical pharmacology, 2019, Volume: 85, Issue:12

    Topics: Administration, Oral; Cohort Studies; Cytochrome P-450 CYP3A; Fluconazole; Gestational Age; Humans;

2019
Oral nystatin prophylaxis to prevent systemic fungal infection in very low birth weight preterm infants: a randomized controlled trial.
    BMC pediatrics, 2020, 04-17, Volume: 20, Issue:1

    Topics: Antifungal Agents; Fluconazole; Humans; Indonesia; Infant; Infant, Newborn; Infant, Premature; Infan

2020
Effect of fluconazole prophylaxis on candidiasis and mortality in premature infants: a randomized clinical trial.
    JAMA, 2014, May-07, Volume: 311, Issue:17

    Topics: Antifungal Agents; Candidiasis, Invasive; Female; Fluconazole; Humans; Infant Mortality; Infant, Low

2014
Prophylactic fluconazole in very low birth weight infants admitted to neonatal intensive care unit: randomized controlled trial.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2016, Volume: 29, Issue:4

    Topics: Antifungal Agents; Candidiasis; Female; Fluconazole; Humans; India; Infant, Newborn; Infant, Prematu

2016
Randomised controlled trial of prophylactic fluconazole versus nystatin for the prevention of fungal colonisation and invasive fungal infection in very low birth weight infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2011, Volume: 96, Issue:3

    Topics: Antifungal Agents; Birth Weight; Disease Progression; Drug Resistance, Fungal; Epidemiologic Methods

2011
Twice-weekly fluconazole prophylaxis in premature infants: association with cholestasis.
    Pediatrics international : official journal of the Japan Pediatric Society, 2011, Volume: 53, Issue:4

    Topics: Antifungal Agents; Candidiasis, Invasive; Cholestasis; Drug Administration Schedule; Female; Flucona

2011
Clinical characteristics and response to prophylactic fluconazole of preterm VLBW neonates with baseline and acquired fungal colonisation in NICU: data from a multicentre RCT.
    Early human development, 2012, Volume: 88 Suppl 2

    Topics: Antifungal Agents; Candida; Candidiasis, Invasive; Female; Fluconazole; Humans; Infant; Infant, Newb

2012
A multicenter, randomized trial of prophylactic fluconazole in preterm neonates.
    The New England journal of medicine, 2007, Jun-14, Volume: 356, Issue:24

    Topics: Antifungal Agents; Candida; Candidiasis; Cholestasis; Double-Blind Method; Female; Fluconazole; Huma

2007
Fluconazole prophylaxis against fungal colonization and invasive fungal infection in very low birth weight infants.
    Indian pediatrics, 2007, Volume: 44, Issue:11

    Topics: Antifungal Agents; Candidiasis; Double-Blind Method; Fluconazole; Humans; Infant, Newborn; Infant, P

2007
Pharmacokinetics of fluconazole in very low birth weight infants during the first two weeks of life.
    Clinical pharmacology and therapeutics, 1993, Volume: 54, Issue:3

    Topics: Candidiasis; Female; Fluconazole; Half-Life; Humans; Infant, Low Birth Weight; Infant, Newborn; Infa

1993
Fluconazole prophylaxis against fungal colonization and infection in preterm infants.
    The New England journal of medicine, 2001, Dec-06, Volume: 345, Issue:23

    Topics: Antifungal Agents; Bacterial Infections; Candida; Candida albicans; Candidiasis; Colony Count, Micro

2001

Other Studies

51 other studies available for fluconazole and Infant, Premature, Diseases

ArticleYear
Antifungal Treatment and Outcome in Very Low Birth Weight Infants: A Population-based Observational Study of the German Neonatal Network.
    The Pediatric infectious disease journal, 2018, Volume: 37, Issue:11

    Topics: Antifungal Agents; Candida; Candidiasis; Child, Preschool; Cohort Studies; Female; Fluconazole; Foll

2018
Prophylactic regimens with fluconazole for candidiasis in neonates under 1.500g: A retrospective chart review of two cohorts.
    Journal of neonatal-perinatal medicine, 2019, Volume: 12, Issue:1

    Topics: Antifungal Agents; Candidiasis, Invasive; Chemoprevention; Female; Fluconazole; Humans; Incidence; I

2019
Fungal Ecology in a Tertiary Neonatal Intensive Care Unit after 16 Years of Routine Fluconazole Prophylaxis: No Emergence of Native Fluconazole-Resistant Strains.
    American journal of perinatology, 2019, Volume: 36, Issue:S 02

    Topics: Antifungal Agents; Candida; Candidiasis; Colony Count, Microbial; Drug Resistance, Fungal; Female; F

2019
Micafungin versus fluconazole for prophylaxis against fungal infections in premature infants.
    Pediatrics international : official journal of the Japan Pediatric Society, 2013, Volume: 55, Issue:6

    Topics: Antifungal Agents; Echinocandins; Female; Fluconazole; Historically Controlled Study; Humans; Infant

2013
[Saccharomyces cerevisiae fungemia in a premature neonate treated receiving probiotics].
    Medecine et maladies infectieuses, 2013, Volume: 43, Issue:8

    Topics: Antifungal Agents; Apnea; Candidemia; Catheter-Related Infections; Diagnosis, Differential; Equipmen

2013
Adrenocortical insufficiency is not a problem in preterm infants treated with antifungal prophylaxis with fluconazole.
    Acta paediatrica (Oslo, Norway : 1992), 2014, Volume: 103, Issue:6

    Topics: Amphotericin B; Antifungal Agents; Antigens, Fungal; Apgar Score; Bronchoalveolar Lavage Fluid; Cand

2014
Efficacy of prophylactic fluconazole therapy in decreasing the incidence of Candida infections in extremely low birth weight preterm infants.
    American journal of perinatology, 2014, Volume: 31, Issue:12

    Topics: Antifungal Agents; Birth Weight; Candidiasis, Invasive; Female; Fluconazole; Gestational Age; Humans

2014
[Prophylaxis with fluconazole on invasive candidiasis and mortality in premature infants].
    Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia, 2014, Volume: 31, Issue:4

    Topics: Antifungal Agents; Candidiasis, Invasive; Female; Fluconazole; Humans; Infant, Premature, Diseases;

2014
Fluconazole prophylaxis in neonates.
    Archives of disease in childhood, 2015, Volume: 100, Issue:1

    Topics: Antifungal Agents; Candidiasis, Invasive; Female; Fluconazole; Humans; Infant, Premature, Diseases;

2015
Efficacy and safety of fluconazole prophylaxis in extremely low birth weight infants: multicenter pre-post cohort study.
    BMC pediatrics, 2016, 05-16, Volume: 16

    Topics: Antifungal Agents; Candidiasis, Invasive; Drug Administration Schedule; Drug Resistance, Fungal; Fem

2016
Why prevent invasive Candida infections?
    Journal of perinatology : official journal of the California Perinatal Association, 2008, Volume: 28, Issue:6

    Topics: Antifungal Agents; Candidiasis; Fluconazole; Humans; Infant, Newborn; Infant, Premature; Infant, Pre

2008
Routine use of fluconazole prophylaxis in a neonatal intensive care unit does not select natively fluconazole-resistant Candida subspecies.
    The Pediatric infectious disease journal, 2008, Volume: 27, Issue:8

    Topics: Antifungal Agents; Candida; Candidiasis; Chemoprevention; Drug Resistance, Fungal; Female; Fluconazo

2008
Fluconazole prophylaxis decreases the combined outcome of invasive Candida infections or mortality in preterm infants.
    Pediatrics, 2008, Volume: 122, Issue:5

    Topics: Antifungal Agents; Candida; Candidiasis; Fluconazole; Humans; Infant, Extremely Low Birth Weight; In

2008
Antifungal prophylaxis: identification of preterm neonates at highest risk for invasive fungal infection.
    Pediatrics, 2009, Volume: 123, Issue:2

    Topics: Antifungal Agents; Candidiasis; Fluconazole; Humans; Infant, Newborn; Infant, Premature, Diseases; I

2009
Efficacy of fluconazole prophylaxis for prevention of invasive fungal infection in extremely low birth weight infants.
    The Pediatric infectious disease journal, 2010, Volume: 29, Issue:4

    Topics: Antibiotic Prophylaxis; Antifungal Agents; Candidiasis; Cholestasis; Female; Fluconazole; Humans; In

2010
Aspergillus fumigatus Meningitis in a Preterm.
    Indian pediatrics, 2010, Volume: 47, Issue:11

    Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Fluconazole; Humans; Infant, Extremely Low

2010
Clinical microbiology of neonatal candidiasis in Hungary.
    Acta microbiologica et immunologica Hungarica, 2010, Volume: 57, Issue:4

    Topics: Amphotericin B; Candida; Candida albicans; Candida glabrata; Candidiasis; Cesarean Section; Female;

2010
[Recent advances in prevention of sepsis in the preterm neonate].
    Recenti progressi in medicina, 2010, Volume: 101, Issue:12

    Topics: Antifungal Agents; Fluconazole; Humans; Infant, Newborn; Infant, Premature, Diseases; Lactoferrin; P

2010
[Invasive candidiasis in neonatal intensive care units].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2011, Volume: 18 Suppl 1

    Topics: Amphotericin B; Antifungal Agents; Candidiasis, Invasive; Catheters; Fluconazole; France; Humans; In

2011
Impact of 'targeted' fluconazole prophylaxis for preterm neonates: efficacy of a highly selective approach?
    Journal of perinatology : official journal of the California Perinatal Association, 2012, Volume: 32, Issue:1

    Topics: Anti-Bacterial Agents; Antifungal Agents; Candidiasis, Invasive; Female; Fluconazole; Humans; Infant

2012
Targeted fluconazole prophylaxis for high-risk very low birth weight infants.
    European journal of pediatrics, 2012, Volume: 171, Issue:10

    Topics: Antibiotic Prophylaxis; Antifungal Agents; Candidiasis; Cohort Studies; Female; Fluconazole; Gestati

2012
Liposomal amphotericin B does not induce nephrotoxicity or renal function impairment in premature neonates.
    Early human development, 2012, Volume: 88 Suppl 2

    Topics: Amphotericin B; Antifungal Agents; Candidiasis; Cohort Studies; Creatinine; Fluconazole; Humans; Hyp

2012
Correct choices for correct treatments: key issues in the management of Candida infections in preterm neonates.
    Early human development, 2012, Volume: 88 Suppl 2

    Topics: Antifungal Agents; Biofilms; Candida; Candidiasis, Invasive; Echinocandins; Fluconazole; Humans; Inf

2012
[Diagnostic image (143). A neonate with a skin disorder. Congenital cutaneous candidiasis].
    Nederlands tijdschrift voor geneeskunde, 2003, Jun-14, Volume: 147, Issue:24

    Topics: Antifungal Agents; Candidiasis, Cutaneous; Female; Fluconazole; Humans; Infant, Newborn; Infant, Pre

2003
Emergence of fluconazole resistance in a Candida parapsilosis strain that caused infections in a neonatal intensive care unit.
    Journal of clinical microbiology, 2005, Volume: 43, Issue:6

    Topics: Antifungal Agents; Candida; Candidiasis; Chemoprevention; Drug Resistance, Fungal; Female; Fluconazo

2005
Experience with caspofungin in the treatment of persistent fungemia in neonates.
    Journal of perinatology : official journal of the California Perinatal Association, 2005, Volume: 25, Issue:12

    Topics: Amphotericin B; Antifungal Agents; Candidiasis; Caspofungin; Drug Therapy, Combination; Echinocandin

2005
Successful treatment of Candida glabrata peritonitis with fluconazole plus flucytosine in a premature infant following in vitro fertilization.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2005, Volume: 24, Issue:10

    Topics: Antifungal Agents; Candida glabrata; Candidiasis; Drug Therapy, Combination; Fertilization in Vitro;

2005
Prophylactic fluconazole is effective in preventing fungal colonization and fungal systemic infections in preterm neonates: a single-center, 6-year, retrospective cohort study.
    Pediatrics, 2006, Volume: 117, Issue:1

    Topics: Antifungal Agents; Aspergillosis; Candida; Candidiasis; Fluconazole; Humans; Infant, Newborn; Infant

2006
Fluconazole for the prevention of fungal infections: get ready, get set, caution.
    Pediatrics, 2006, Volume: 117, Issue:1

    Topics: Antifungal Agents; Candidiasis; Cross Infection; Fluconazole; Humans; Infant, Newborn; Infant, Prema

2006
Targeted short-term fluconazole prophylaxis among very low birth weight and extremely low birth weight infants.
    Pediatrics, 2006, Volume: 117, Issue:4

    Topics: Antibiotic Prophylaxis; Antifungal Agents; Candidiasis; Fluconazole; Health Care Costs; Humans; Infa

2006
Fluconazole prophylaxis in extremely low birth weight infants: association with cholestasis.
    Journal of perinatology : official journal of the California Perinatal Association, 2006, Volume: 26, Issue:9

    Topics: Alkaline Phosphatase; Antibiotic Prophylaxis; Antifungal Agents; Bilirubin; Candidiasis; Case-Contro

2006
Outbreak of fungemia among neonates caused by Candida haemulonii resistant to amphotericin B, itraconazole, and fluconazole.
    Journal of clinical microbiology, 2007, Volume: 45, Issue:6

    Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis; Disease Outbreaks; Drug Resistance, Fungal;

2007
Echinocandins--first-choice or first-line therapy for invasive candidiasis?
    The New England journal of medicine, 2007, Jun-14, Volume: 356, Issue:24

    Topics: Anidulafungin; Antifungal Agents; Candidiasis; Echinocandins; Fluconazole; Fungemia; Humans; Infant,

2007
Antifungal prophylaxis for very low birthweight infants: UK national survey.
    Archives of disease in childhood. Fetal and neonatal edition, 2008, Volume: 93, Issue:3

    Topics: Antifungal Agents; Fluconazole; Health Care Surveys; Humans; Infant, Newborn; Infant, Premature; Inf

2008
Prophylactic fluconazole in preterm neonates.
    The New England journal of medicine, 2007, Sep-27, Volume: 357, Issue:13

    Topics: Anti-Bacterial Agents; Antifungal Agents; Candidiasis; Fluconazole; Humans; Hygiene; Incidence; Infa

2007
Prophylactic fluconazole in preterm neonates.
    The New England journal of medicine, 2007, Sep-27, Volume: 357, Issue:13

    Topics: Antifungal Agents; Candidiasis; Fluconazole; Humans; Infant, Newborn; Infant, Premature; Infant, Pre

2007
Fluconazole prophylaxis for prevention of invasive fungal infections in targeted highest risk preterm infants limits drug exposure.
    Journal of perinatology : official journal of the California Perinatal Association, 2008, Volume: 28, Issue:6

    Topics: Antifungal Agents; Fluconazole; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Disea

2008
Candida albicans brain abscesses in a premature infant treated with amphotericin B, flucytosine and fluconazole.
    The Pediatric infectious disease journal, 1995, Volume: 14, Issue:4

    Topics: Amphotericin B; Brain Abscess; Candidiasis; Drug Therapy, Combination; Female; Fluconazole; Flucytos

1995
Renal fungus ball in a premature infant successfully treated with fluconazole.
    The Pediatric infectious disease journal, 1994, Volume: 13, Issue:12

    Topics: Amphotericin B; Candidiasis; Fluconazole; Humans; Infant, Newborn; Infant, Premature; Infant, Premat

1994
Fluconazole monotherapy for candidal meningitis in a premature infant.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1996, Volume: 23, Issue:3

    Topics: Antifungal Agents; Candidiasis; Fluconazole; Humans; Infant, Newborn; Infant, Premature; Infant, Pre

1996
Early onset systemic Candida infection in extremely preterm neonates.
    European journal of pediatrics, 1996, Volume: 155, Issue:10

    Topics: Antifungal Agents; Candidiasis; Candidiasis, Cutaneous; Female; Fluconazole; Gestational Age; Humans

1996
Nursery outbreak of neonatal fungal arthritis treated with fluconazole.
    Journal of tropical pediatrics, 1997, Volume: 43, Issue:2

    Topics: Antifungal Agents; Arthritis, Infectious; Candidiasis; Disease Outbreaks; Female; Fluconazole; Human

1997
Pharmacokinetics of oral fluconazole in premature infants.
    European journal of pediatrics, 1998, Volume: 157, Issue:8

    Topics: Administration, Oral; Antifungal Agents; Candidiasis; Dose-Response Relationship, Drug; Drug Adminis

1998
Persistent candidemia in a premature infant treated with fluconazole.
    The Pediatric infectious disease journal, 1999, Volume: 18, Issue:8

    Topics: Antifungal Agents; Candida albicans; Candidiasis; Fluconazole; Fungemia; Humans; Infant, Newborn; In

1999
Candida arthritis in a premature infant treated successfully with oral fluconazole for six months.
    Annals of the Academy of Medicine, Singapore, 2000, Volume: 29, Issue:2

    Topics: Administration, Oral; Antifungal Agents; Arthritis, Infectious; Candidiasis; Drug Administration Sch

2000
Fluconazole prophylaxis against fungal infection in preterm infants.
    The New England journal of medicine, 2002, Jun-13, Volume: 346, Issue:24

    Topics: Antifungal Agents; Candida; Diagnostic Errors; Fluconazole; Humans; Infant, Newborn; Infant, Prematu

2002
Fluconazole prophylaxis against fungal infection in preterm infants.
    The New England journal of medicine, 2002, Jun-13, Volume: 346, Issue:24

    Topics: Administration, Oral; Antifungal Agents; Candida; Fluconazole; Humans; Infant, Newborn; Infant, Prem

2002
[Candida infections in premature infants weighing less than 1,500 g. Mucocutaneous colonization and incidence of systemic infections].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1992, Volume: 140, Issue:9

    Topics: Candidiasis, Chronic Mucocutaneous; Cesarean Section; Cross Infection; Cross-Sectional Studies; Drug

1992
Congenital malformations in an infant born to a woman treated with fluconazole.
    The Pediatric infectious disease journal, 1992, Volume: 11, Issue:12

    Topics: Abnormalities, Drug-Induced; Coccidioidomycosis; Congenital Abnormalities; Female; Fluconazole; Huma

1992
Use of fluconazole in the treatment of Candida albicans hydrocephalus shunt infection.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1992, Volume: 11, Issue:10

    Topics: Candidiasis; Female; Fluconazole; Humans; Hydrocephalus; Infant, Newborn; Infant, Premature, Disease

1992
Fluconazole in neonatal disseminated candidiasis.
    Archives of disease in childhood, 1991, Volume: 66, Issue:8

    Topics: Candidiasis; Fluconazole; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases

1991